A unique human blood-derived cell population displays high potential for producing insulin

Biochemical and Biophysical Research Communications

Volumn 360, Issue 1, 2007, Pages 205-211

  Zhao, Yong ^a   Huang, Zhihua ^a   Lazzarini, Ping ^a   Wang, Yong ^b   Di, Anke ^b   Chen, Meiling ^b  

^a Section of Endocrinology Diabetes and Metabolism   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Blood; Diabetes; Insulin producing cell; Stem cell

Indexed keywords

CD34 ANTIGEN; CD45 ANTIGEN; CD9 ANTIGEN; HORMONE PRECURSOR; INSULIN; OCTAMER TRANSCRIPTION FACTOR 4; STEM CELL FACTOR RECEPTOR;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL POPULATION; CONTROLLED STUDY; DIABETES MELLITUS; EMBRYONIC STEM CELL; FEMALE; HEMATOPOIESIS; HUMAN; HUMAN CELL; HYPERGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; INSULIN RELEASE; LYMPHOCYTE; MACROPHAGE; MALE; MONOCYTE; MOUSE; NONHUMAN; NORMAL HUMAN; PANCREAS ISLET BETA CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL TRANSPLANTATION;

ADULT; ANIMALS; CELLS, CULTURED; FEASIBILITY STUDIES; FEMALE; HUMANS; INSULIN; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MICE; MICE, SCID; MIDDLE AGED;

MUS;

EID: 34250900952     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.06.035     Document Type: Article

References (19)

1. Hussain M.A., and Theise N.D. Stem-cell therapy for diabetes mellitus. Lancet 364 (2004) 203-205
2. Vats A., Bielby R.C., Tolley N.S., Nerem R., and Polak J.M. Stem cells. Lancet 366 (2005) 592-602
3. D'Amour K.A., Bang A.G., Eliazer S., Kelly O.G., Agulnick A.D., Smart N.G., Moorman M.A., Kroon E., Carpenter M.K., and Baetge E.E. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat. Biotechnol. 24 (2006) 1392-1401
4. Bradley J.A., Bolton E.M., and Pedersen R.A. Stem cell medicine encounters the immune system. Nat. Rev. Immunol. 2 (2002) 859-871
5. Melton D.A., Daley G.Q., and Jennings C.G. Altered nuclear transfer in stem-cell research-a flawed proposal. N. Engl. J. Med. 351 (2004) 2791-2792
6. Bonde J., Hess D.A., and Nolta J.A. Recent advances in hematopoietic stem cell biology. Curr. Opin. Hematol. 11 (2004) 392-398
7. Zhao Y., Glesne D., and Huberman E. A human peripheral blood monocyte-derived subset acts as pluripotent stem cells. Proc. Natl. Acad. Sci. USA 100 (2003) 2426-2431
8. Zhao Y., Wang Y.H., and Mazzone T. Identification of stem cells from human umbilical cord blood with embryonic and hematopoietic characteristics. Exp. Cell Res. 312 (2006) 2454-2464
9. Sun B., Roh K.H., Lee S.R., Lee Y.S., and Kang K.S. Induction of human umbilical cord blood-derived stem cells with embryonic stem cell phenotypes into insulin producing islet-like structure. Biochem. Biophys. Res. Commun. 354 (2007) 919-923
10. Voltarelli J.C., Couri C.E., Stracieri A.B., Oliveira M.C., Moraes D.A., Pieroni F., Coutinho M., Malmegrim K.C., Foss-Freitas M.C., Simoes B.P., Foss M.C., Squiers E., and Burt R.K. Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus. JAMA 297 (2007) 1568-1576
11. Zhao Y., and Mazzone T. Human umbilical cord blood-derived f-macrophages retain pluripotentiality after thrombopoietin expansion. Exp. Cell Res. 310 (2005) 311-318
12. Yi H., Leunissen J., Shi G., Gutekunst C., and Hersch S. A novel procedure for pre-embedding double immunogold-silver labeling at the ultrastructural level. J. Histochem. Cytochem. 49 (2001) 279-284
13. Rogers I., Yamanaka N., Bielecki R., Wong C.J., Chua S., Yuen S., and Casper R.F. Identification and analysis of in vitro cultured CD45-positive cells capable of multi-lineage differentiation. Exp. Cell Res. 313 (2007) 1839-1852
14. Edlund H. Pancreatic organogenesis-developmental mechanisms and implications for therapy. Nat. Rev. Genet. 3 (2002) 524-532
15. Taylor N.A., Van De Ven W.J., and Creemers J.W. Curbing activation: proprotein convertases in homeostasis and pathology. FASEB J. 17 (2003) 1215-1227
16. Rajagopal J., Anderson W.J., Kume S., Martinez O.I., and Melton D.A. Insulin staining of ES cell progeny from insulin uptake. Science 299 (2003) 17
17. Orkin S.H. Chipping away at the embryonic stem cell network. Cell 122 (2005) 828-830
18. Gaber A.O., Fraga D., Kotb M., Sabek O., and Latif K. Human islet graft function in NOD-SCID mice predicts clinical response in islet transplant recipients. Transplant. Proc. 36 (2004) 1108-1110
19. Kayali A.G., Van Gunst K., Campbell I.L., Flodstrom-Tullberg A., and Sarvetnick N. The stromal cell-derived factor-1alpha/CXCR4 ligand-receptor axis is critical for progenitor survival and migration in the pancreas. J. Cell Biol. 163 (2003) 859-869