Species differences in metabolism and pharmacokinetics of a sphingosine-1-phosphate receptor agonist in rats and dogs: Formation of a unique glutathione adduct in the rat

Drug Metabolism and Disposition

Volumn 34, Issue 8, 2006, Pages 1367-1375

  Anari, M Reza ^a   Creighton, Mellissa D ^a   Ngui, Jason S ^a   Tschirret Guth, Richard A ^a   Teffera, Yohannes ^a,b   Doss, George A ^a   Tang, Wei ^a   Yu, Nathan X ^a   Ciccotto, Suzanne L ^a   Hobra Jr , Donald F ^a   Coleman, John B ^a   Vincent, Stella H ^a   Evans, David C ^a,c  

^a MERCK RESEARCH LABORATORIES   (United States)

^b AMGEN INC   (United States)

^c Bioanalytical Drug Metabolism   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ALDEHYDE; AZETIDINE; FINGOLIMOD; GLUTATHIONE; LACTAM; TAURINE;

ANIMAL CELL; ARTICLE; BILE FLOW; DEALKYLATION; DRUG METABOLISM; GLUCURONIDATION; NONHUMAN; PRIORITY JOURNAL; RAT; SPECIES DIFFERENCE; STEREOCHEMISTRY;

ADMINISTRATION, ORAL; ANIMALS; AZETIDINES; BILE; BIOTRANSFORMATION; DOGS; FECES; GLUTATHIONE; INJECTIONS, INTRAVENOUS; INTESTINES; MALE; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, LYSOSPHINGOLIPID; SPECIES SPECIFICITY; THIOPHENES;

CANIS FAMILIARIS;

EID: 33746061294     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.105.009027     Document Type: Article

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