메뉴 건너뛰기




Volumn 18, Issue 2-3, 2008, Pages 159-175

MultiCASE expert systems and the REACH initiative

Author keywords

Carcinogenicity; CASE; Environmental; Expert System; FDA; In Silico; MC4PC; MCASE; Mutagenicity; Prediction; QSAR; REACH; Toxicity

Indexed keywords

ACUTE TOXICITY; ALGORITHM; AREA UNDER THE CURVE; CARCINOGENICITY; CHRONIC TOXICITY; COMPUTER PROGRAM; DEVELOPMENTAL BIOLOGY; ENVIRONMENTAL FACTOR; EXPERIMENTAL MODEL; EXPERT SYSTEM; GENOTOXICITY; HUMAN; MOLECULAR DYNAMICS; MUTAGENICITY; NONHUMAN; PRACTICE GUIDELINE; PREDICTIVE VALIDITY; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REVIEW; TOXICOLOGY;

EID: 40949161033     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.1080/15376510701857460     Document Type: Review
Times cited : (37)

References (70)
  • 1
    • 84874806581 scopus 로고    scopus 로고
    • Accelrys. TOPKAT. http://www.accelrys.com/products/topkat/. Accessed October 1, 2007.
    • Accelrys. TOPKAT. http://www.accelrys.com/products/topkat/. Accessed October 1, 2007.
  • 2
    • 0025942595 scopus 로고    scopus 로고
    • Albertini, S., and Zimmermann, F. K. The detection of chemically induced chromosomal malsegregation in Saccharomyces cerevisiae D61.M: a literature survey (1984-1990). Mutat. Res. 258:237-258.
    • Albertini, S., and Zimmermann, F. K. The detection of chemically induced chromosomal malsegregation in Saccharomyces cerevisiae D61.M: a literature survey (1984-1990). Mutat. Res. 258:237-258.
  • 3
    • 0000973407 scopus 로고
    • Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP
    • Ashby, J., and Tennant, R. W. 1991. Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP. Mutat. Res. 257(3):229-306.
    • (1991) Mutat. Res , vol.257 , Issue.3 , pp. 229-306
    • Ashby, J.1    Tennant, R.W.2
  • 4
    • 0003302467 scopus 로고    scopus 로고
    • Use of QSARs in international decision-making frameworks to predict health effects of chemical substances
    • Cronin, M. T. D., Jaworska, J. S., Walker, J. D., Comber, M. H. I., Watts, C. D., and Worth, A. P. 2003b. Use of QSARs in international decision-making frameworks to predict health effects of chemical substances. Environ. Health Perspect. 111(10):1391-1401.
    • (2003) Environ. Health Perspect , vol.111 , Issue.10 , pp. 1391-1401
    • Cronin, M.T.D.1    Jaworska, J.S.2    Walker, J.D.3    Comber, M.H.I.4    Watts, C.D.5    Worth, A.P.6
  • 5
    • 0012959393 scopus 로고    scopus 로고
    • Use of QSARs in international decision-making frameworks to predict ecologic effects and environmental fate of chemical substances
    • Cronin, M. T. D., Walker, J. D., Jaworska, J. S., Comber, M. H. I., Watts, C. D., and Worth, A. P. 2003a. Use of QSARs in international decision-making frameworks to predict ecologic effects and environmental fate of chemical substances. Environ. Health Perspect. 111(10):1376-1390.
    • (2003) Environ. Health Perspect , vol.111 , Issue.10 , pp. 1376-1390
    • Cronin, M.T.D.1    Walker, J.D.2    Jaworska, J.S.3    Comber, M.H.I.4    Watts, C.D.5    Worth, A.P.6
  • 6
    • 0034774710 scopus 로고    scopus 로고
    • Estimating the extent of the health hazard posed by high-production volume chemicals
    • Cunningham, A. R., and Rosenkranz, H. S. 2001. Estimating the extent of the health hazard posed by high-production volume chemicals. Environ. Health Perspect.109:953-956.
    • (2001) Environ. Health Perspect , vol.109 , pp. 953-956
    • Cunningham, A.R.1    Rosenkranz, H.S.2
  • 7
    • 84874802504 scopus 로고    scopus 로고
    • Danish Ministry of the Environment, Environmental Protection Agency, Accessed October 1, 2007
    • Danish Ministry of the Environment, Environmental Protection Agency. 2006. Danish (Q)SAR Database. http://ecb.jrc.it/QSAR./ Accessed October 1, 2007.
    • (2006) Danish (Q)SAR Database
  • 8
    • 84874794535 scopus 로고    scopus 로고
    • European Chemicals Bureau. 2007a. REACH home page. http://ecb.jrc.it/ reach./ Accessed October 1, 2007.
    • European Chemicals Bureau. 2007a. REACH home page. http://ecb.jrc.it/ reach./ Accessed October 1, 2007.
  • 9
    • 84874794483 scopus 로고    scopus 로고
    • Accessed October 1, 2007
    • European Chemicals Bureau. 2007b. ECB - Testing Methods: Annex V. http://ecb.jrc.it/testing-methods/annex5./ Accessed October 1, 2007.
    • (2007) ECB - Testing Methods: Annex V
  • 10
    • 84874799636 scopus 로고    scopus 로고
    • Accessed October 1, 2007
    • European Chemicals Bureau. 2007c. Testing methods. http://ecb.jrc.it/ testing-methods./Accessed October 1, 2007.
    • (2007) Testing methods
  • 12
    • 0022615523 scopus 로고
    • Structure-activity relationships (SARs) among mutagens and carcinogens: A review
    • Frierson, M., Klopman, G., and Rosenkranz, H. S. 1986. Structure-activity relationships (SARs) among mutagens and carcinogens: a review. Env. Mutagens 8(2):283-327.
    • (1986) Env. Mutagens , vol.8 , Issue.2 , pp. 283-327
    • Frierson, M.1    Klopman, G.2    Rosenkranz, H.S.3
  • 16
    • 0024421780 scopus 로고
    • Prediction of risk for human development toxicity: How important are animal studies for hazard identification?
    • Jelovsek, F. R., Mattison, D. R., and Chen, J. J. 1989. Prediction of risk for human development toxicity: how important are animal studies for hazard identification? Obstet. Gynecol. 74:624-636.
    • (1989) Obstet. Gynecol , vol.74 , pp. 624-636
    • Jelovsek, F.R.1    Mattison, D.R.2    Chen, J.J.3
  • 17
    • 0021529312 scopus 로고
    • Artificial intelligence approach to structure-activity studies. Computer automated structure evaluation of biological activity of organic molecules
    • Klopman, G. 1984. Artificial intelligence approach to structure-activity studies. Computer automated structure evaluation of biological activity of organic molecules. J. Am Chem. Soc. 106:7315-7321.
    • (1984) J. Am Chem. Soc , vol.106 , pp. 7315-7321
    • Klopman, G.1
  • 18
    • 0031601429 scopus 로고    scopus 로고
    • The MultiCASE Program II. Baseline Activity Identification Algorithm (BAIA)
    • Klopman, G. 1998. The MultiCASE Program II. Baseline Activity Identification Algorithm (BAIA). J. Chem. Inf. Comput. Sci. 38:78-81.
    • (1998) J. Chem. Inf. Comput. Sci , vol.38 , pp. 78-81
    • Klopman, G.1
  • 19
    • 0024595625 scopus 로고
    • Computer automated structure evaluation (CASE): A study of inhibitors of the thermolysin enzyme
    • Klopman, G., and Bendale, R. D. 1989. Computer automated structure evaluation (CASE): a study of inhibitors of the thermolysin enzyme. J. Theor. Biol. 136(1):67-77.
    • (1989) J. Theor. Biol , vol.136 , Issue.1 , pp. 67-77
    • Klopman, G.1    Bendale, R.D.2
  • 20
    • 0025015151 scopus 로고
    • The structural basis of the mutagenicity of chemicals in Salmonella typhimurium: The Gene-Tox data base
    • Klopman, G., Frierson, M. R., and Rosenkranz, H. S. 1990. The structural basis of the mutagenicity of chemicals in Salmonella typhimurium: the Gene-Tox data base. Mutat. Res. 228:1-50.
    • (1990) Mutat. Res , vol.228 , pp. 1-50
    • Klopman, G.1    Frierson, M.R.2    Rosenkranz, H.S.3
  • 21
    • 84904043359 scopus 로고    scopus 로고
    • MC4PC - an artificial intelligence approach to the discovery of structure toxic activity relationships (STAR)
    • Helma, C, Ed, CRC Press, Boca Raton, pp
    • Klopman, G., Ivanov, J., Saiakhov, R., and Chakravarti, S. 2005. MC4PC - an artificial intelligence approach to the discovery of structure toxic activity relationships (STAR). In: Helma, C. (Ed.), Predictive Toxicology Book, CRC Press, Boca Raton, pp. 423-457.
    • (2005) Predictive Toxicology Book , pp. 423-457
    • Klopman, G.1    Ivanov, J.2    Saiakhov, R.3    Chakravarti, S.4
  • 22
    • 0022644866 scopus 로고
    • Quantitative structure-activity relationships of beta-adrenergic agents. Application of the computer automated structure evaluation (CASE) technique of molecular fragment recognition
    • Klopman, G., and Kalos, A. N. 1986. Quantitative structure-activity relationships of beta-adrenergic agents. Application of the computer automated structure evaluation (CASE) technique of molecular fragment recognition. J. Theor. Biol. 118:199-214.
    • (1986) J. Theor. Biol , vol.118 , pp. 199-214
    • Klopman, G.1    Kalos, A.N.2
  • 23
    • 0022412379 scopus 로고
    • Use of the Computer Automated Structure Evaluation program in determining quantitative structure-activity relationships within hallucinogenic phenylalkylamines
    • Klopman, G., and Macina, O. T. 1985. Use of the Computer Automated Structure Evaluation program in determining quantitative structure-activity relationships within hallucinogenic phenylalkylamines. J. Teor. Biol. 113(4):637-648.
    • (1985) J. Teor. Biol , vol.113 , Issue.4 , pp. 637-648
    • Klopman, G.1    Macina, O.T.2
  • 24
    • 0023265431 scopus 로고
    • Computer-automated structure evaluation of antileukemic 9-anilinoacridines
    • Klopman, G., and Macina, O. T. 1987. Computer-automated structure evaluation of antileukemic 9-anilinoacridines. Mol. Pharmacol. 31:457-476.
    • (1987) Mol. Pharmacol , vol.31 , pp. 457-476
    • Klopman, G.1    Macina, O.T.2
  • 26
    • 40949092013 scopus 로고
    • Computer Automated Structure Evaluation of opiate alkaloids
    • Klopman, G., Macina, O. T., Simon, E. J., and Hiller, J. M. 1986. Computer Automated Structure Evaluation of opiate alkaloids. Theochem 134:299-308.
    • (1986) Theochem , vol.134 , pp. 299-308
    • Klopman, G.1    Macina, O.T.2    Simon, E.J.3    Hiller, J.M.4
  • 28
    • 0002063804 scopus 로고
    • Multiple Computer Automated Structure Evaluation methodology as an alternative to in-vivo eye irritation testing
    • Klopman, G., Ptchelintsev, D., Friersen, M., Pennisi, S., Renskers, K., and Dickens, M. 1993. Multiple Computer Automated Structure Evaluation methodology as an alternative to in-vivo eye irritation testing. Altern. Lab. Anim. ATLA 21(1):14-27.
    • (1993) Altern. Lab. Anim. ATLA , vol.21 , Issue.1 , pp. 14-27
    • Klopman, G.1    Ptchelintsev, D.2    Friersen, M.3    Pennisi, S.4    Renskers, K.5    Dickens, M.6
  • 29
    • 0034012820 scopus 로고    scopus 로고
    • Multiple computer-automated structure evaluation study of aquatic toxicity II. Fathead minnow
    • Klopman, G., Saiakhov, R., and Rosenkranz, H. S. 2000. Multiple computer-automated structure evaluation study of aquatic toxicity II. Fathead minnow. Environ. Toxicol. Chem. 19:441-447.
    • (2000) Environ. Toxicol. Chem , vol.19 , pp. 441-447
    • Klopman, G.1    Saiakhov, R.2    Rosenkranz, H.S.3
  • 30
    • 0032718443 scopus 로고    scopus 로고
    • Multiple Computer-Automated Structure Evaluation program study of aquatic toxicity 1: Guppy
    • Klopman, G., Saiakhov, R., Rosenkranz, H. S., and Hermens, J. L. M. 1999. Multiple Computer-Automated Structure Evaluation program study of aquatic toxicity 1: guppy. Environ. Toxicol. Chem. 18(11):2497-2505.
    • (1999) Environ. Toxicol. Chem , vol.18 , Issue.11 , pp. 2497-2505
    • Klopman, G.1    Saiakhov, R.2    Rosenkranz, H.S.3    Hermens, J.L.M.4
  • 31
    • 84874806867 scopus 로고    scopus 로고
    • Klopman, G., and Sedykh, A. 2005. META. An expert system for the prediction of metabolic transformations. In: Helma, C. (Ed.), Predictive Toxicology Book, CRC Press, Boca Raton, pp. 458-465.
    • Klopman, G., and Sedykh, A. 2005. META. An expert system for the prediction of metabolic transformations. In: Helma, C. (Ed.), Predictive Toxicology Book, CRC Press, Boca Raton, pp. 458-465.
  • 32
    • 0036891365 scopus 로고    scopus 로고
    • ADME evaluation 2. A computer model for the prediction of intestinal absorption in humans
    • Klopman, G., Stefan, L., and Saiakhov, R. 2002. ADME evaluation 2. A computer model for the prediction of intestinal absorption in humans. Eur. J. Pharm. Sci. 17:253-263.
    • (2002) Eur. J. Pharm. Sci , vol.17 , pp. 253-263
    • Klopman, G.1    Stefan, L.2    Saiakhov, R.3
  • 33
    • 0037372628 scopus 로고    scopus 로고
    • Multiple computer-automated structure evaluation study of aquatic toxicity. III. Vibrio fischeri
    • Klopman, G., and Stuart, S. E. 2003. Multiple computer-automated structure evaluation study of aquatic toxicity. III. Vibrio fischeri. Environ. Toxicol. Chem. 22(3):466-472.
    • (2003) Environ. Toxicol. Chem , vol.22 , Issue.3 , pp. 466-472
    • Klopman, G.1    Stuart, S.E.2
  • 34
    • 0033602543 scopus 로고    scopus 로고
    • Diversity analysis of 14 156 molecules tested by the National Cancer Institute for anti-HIV activity using the quantitative structure-activity relational expert system MCASE
    • Klopman, G., and Tu, M. 1999. Diversity analysis of 14 156 molecules tested by the National Cancer Institute for anti-HIV activity using the quantitative structure-activity relational expert system MCASE. J. Med. Chem. 42(6):992-998.
    • (1999) J. Med. Chem , vol.42 , Issue.6 , pp. 992-998
    • Klopman, G.1    Tu, M.2
  • 35
    • 0022972950 scopus 로고
    • CASE study of in vitro inhibition of sparteine monooxygenase
    • Klopman, G., and Venegas, R. E. 1986. CASE study of in vitro inhibition of sparteine monooxygenase. Acta Pharma. Jugosl. 36:189-208.
    • (1986) Acta Pharma. Jugosl , vol.36 , pp. 189-208
    • Klopman, G.1    Venegas, R.E.2
  • 36
    • 0035273557 scopus 로고    scopus 로고
    • Estimation of the aqueous solubility of organic molecules by the group contribution approach
    • Klopman, G., and Zhu, H. 2001. Estimation of the aqueous solubility of organic molecules by the group contribution approach. J. Chem. Inf. Comput. Sci. 41:439-445.
    • (2001) J. Chem. Inf. Comput. Sci , vol.41 , pp. 439-445
    • Klopman, G.1    Zhu, H.2
  • 37
    • 3242727566 scopus 로고    scopus 로고
    • Searching for an enhanced predictive tool for mutagenicity
    • Klopman, G., Zhu, H., Fuller, M. A., and Saiakhov, R. D. 2004. Searching for an enhanced predictive tool for mutagenicity. SAR QSAR Environ. Res. 15(4):251-263.
    • (2004) SAR QSAR Environ. Res , vol.15 , Issue.4 , pp. 251-263
    • Klopman, G.1    Zhu, H.2    Fuller, M.A.3    Saiakhov, R.D.4
  • 38
    • 0030992633 scopus 로고    scopus 로고
    • Dichotomous relationship between DNA reactivity and the induction of sister chromatid exchanges in vivo and in vitro
    • Labbauf, A., Klopman, G., and Rosenkranz, H. S. 1997. Dichotomous relationship between DNA reactivity and the induction of sister chromatid exchanges in vivo and in vitro. Mutat. Res. Fund. Mol. Mech. Mut. 377(1):37-52.
    • (1997) Mutat. Res. Fund. Mol. Mech. Mut , vol.377 , Issue.1 , pp. 37-52
    • Labbauf, A.1    Klopman, G.2    Rosenkranz, H.S.3
  • 39
    • 0031997697 scopus 로고    scopus 로고
    • Knowledge-based learning in exploratory science: Learning rules to predict rodent carcinogenicity
    • Lee, Y., Buchanan, B. G., and Aronis, J. M. 1998. Knowledge-based learning in exploratory science: Learning rules to predict rodent carcinogenicity. Mach. Learn. 30(2-3):217-240.
    • (1998) Mach. Learn , vol.30 , Issue.2-3 , pp. 217-240
    • Lee, Y.1    Buchanan, B.G.2    Aronis, J.M.3
  • 40
    • 84874810791 scopus 로고    scopus 로고
    • Lhasa Ltd. 2007. Predicting toxicity and metabolic fate. DEREK: general information. http://www.lhasalimited.org/index.php?cat=2&sub_cat=64. Last modified October 31, 2007.
    • Lhasa Ltd. 2007. Predicting toxicity and metabolic fate. DEREK: general information. http://www.lhasalimited.org/index.php?cat=2&sub_cat=64. Last modified October 31, 2007.
  • 41
    • 0031007374 scopus 로고    scopus 로고
    • Structural basis of sensory irritation
    • Macina, O. T., Klopman, G., and Rosenkranz, H. S. 1997. Structural basis of sensory irritation. Inhal. Toxicol. 9(5):465-476.
    • (1997) Inhal. Toxicol , vol.9 , Issue.5 , pp. 465-476
    • Macina, O.T.1    Klopman, G.2    Rosenkranz, H.S.3
  • 42
    • 0032458218 scopus 로고    scopus 로고
    • A new highly specific method for predicting the carcinogenic potential of pharmaceuticals in rodents using enhanced MCASE QSAR-ES software
    • Matthews, E. J., and Contrera, J. F. 1998. A new highly specific method for predicting the carcinogenic potential of pharmaceuticals in rodents using enhanced MCASE QSAR-ES software. Regul. Toxicol. Pharm. 28(3):242-264.
    • (1998) Regul. Toxicol. Pharm , vol.28 , Issue.3 , pp. 242-264
    • Matthews, E.J.1    Contrera, J.F.2
  • 43
    • 33846880679 scopus 로고    scopus 로고
    • A comprehensive model for reproductive and developmental toxicity hazard identification: II. Construction of QSAR models to predict activities of untested chemicals
    • Matthews, E. J., Kruhlak, N. L., Benz, R. D., Ivanov, J., Klopman, G., and Contrera, J. F. 2007. A comprehensive model for reproductive and developmental toxicity hazard identification: II. Construction of QSAR models to predict activities of untested chemicals. Reg. Toxicol. Pharm. 47:136-155.
    • (2007) Reg. Toxicol. Pharm , vol.47 , pp. 136-155
    • Matthews, E.J.1    Kruhlak, N.L.2    Benz, R.D.3    Ivanov, J.4    Klopman, G.5    Contrera, J.F.6
  • 44
    • 32544452551 scopus 로고    scopus 로고
    • An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: I. Identification of carcinogens using surrogate endpoints
    • Matthews, E. J., Kruhlak, N. L., Cimino, M. C., Benz, R. D., and Contrera, J. F. 2006a. An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: I. Identification of carcinogens using surrogate endpoints. Reg. Toxicol. Pharm. 44:83-96.
    • (2006) Reg. Toxicol. Pharm , vol.44 , pp. 83-96
    • Matthews, E.J.1    Kruhlak, N.L.2    Cimino, M.C.3    Benz, R.D.4    Contrera, J.F.5
  • 45
    • 32544435283 scopus 로고    scopus 로고
    • An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: II. Identification of genotoxicants, reprotoxicants, and carcinogens using in silico methods
    • Matthews, E. J., Kruhlak, N. L., Cimino, M. C., Benz, R. D., and Contrera, J. F. 2006b. An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: II. Identification of genotoxicants, reprotoxicants, and carcinogens using in silico methods. Reg. Toxicol. Pharm. 44:97-110.
    • (2006) Reg. Toxicol. Pharm , vol.44 , pp. 97-110
    • Matthews, E.J.1    Kruhlak, N.L.2    Cimino, M.C.3    Benz, R.D.4    Contrera, J.F.5
  • 46
    • 0025352906 scopus 로고
    • The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of the U.S. Environmental Protection Agency Gene-Tox Program
    • Mavournin, K. H., Blakey, D. H., Cimino, M. C., Salomone, M. F., and Heddle, J. A. 1990. The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutat. Res 239:29-80.
    • (1990) Mutat. Res , vol.239 , pp. 29-80
    • Mavournin, K.H.1    Blakey, D.H.2    Cimino, M.C.3    Salomone, M.F.4    Heddle, J.A.5
  • 47
    • 84874815393 scopus 로고    scopus 로고
    • MultiCASE Inc. 2007. Bioactivity Software. www.multicase.com. Last modified July 25, 2007.
    • MultiCASE Inc. 2007. Bioactivity Software. www.multicase.com. Last modified July 25, 2007.
  • 50
    • 84874804255 scopus 로고    scopus 로고
    • Organisation for Economic Cooperation and Development (OECD). 2007. Chemicals Testing: OECD Guidelines for the Testing of Chemicals - Sections 1-5. http://www.oecd.org/document/22/0,2340,en_2649_34377_1916054_1_1_1_1,00.html. Accessed October 1, 2007.
    • Organisation for Economic Cooperation and Development (OECD). 2007. Chemicals Testing: OECD Guidelines for the Testing of Chemicals - Sections 1-5. http://www.oecd.org/document/22/0,2340,en_2649_34377_1916054_1_1_1_1,00.html. Accessed October 1, 2007.
  • 51
    • 0035468216 scopus 로고    scopus 로고
    • Integration of computational analysis as a sentinel tool in toxicological assessments
    • Pearl, G. M., Livingston-Carr, S., and Durham, S. 2001. Integration of computational analysis as a sentinel tool in toxicological assessments. Curr. Top. Med. Chem. 1:247-255.
    • (2001) Curr. Top. Med. Chem , vol.1 , pp. 247-255
    • Pearl, G.M.1    Livingston-Carr, S.2    Durham, S.3
  • 52
    • 0033381969 scopus 로고    scopus 로고
    • Chemical carcinogenicity: Can it be predicted from knowledge of mutagenicity and allergic contact dermatitis?
    • Rosenkranz, H. S., and Karol, M. H. 1999. Chemical carcinogenicity: can it be predicted from knowledge of mutagenicity and allergic contact dermatitis?. Mutat. Res. Fund. Mol. M. 431(1):81-91.
    • (1999) Mutat. Res. Fund. Mol. M , vol.431 , Issue.1 , pp. 81-91
    • Rosenkranz, H.S.1    Karol, M.H.2
  • 53
    • 0025123548 scopus 로고
    • Biophores to genotoxicity: The interaction of human and artificial intelligence
    • Rosenkranz, H. S., and Klopman, G. 1990a. Biophores to genotoxicity: the interaction of human and artificial intelligence. Mutagenesis 5:333-362.
    • (1990) Mutagenesis , vol.5 , pp. 333-362
    • Rosenkranz, H.S.1    Klopman, G.2
  • 54
    • 0024426830 scopus 로고
    • Structural basis of the mutagenicity of phenylazoaniline dyes
    • Rosenkranz, H. S., and Klopman, G. 1990b. Structural basis of the mutagenicity of phenylazoaniline dyes. Mutat. Res. 221:217-234.
    • (1990) Mutat. Res , vol.221 , pp. 217-234
    • Rosenkranz, H.S.1    Klopman, G.2
  • 55
    • 0025058476 scopus 로고
    • Structural basis of the mutagenicity of chemicals in Salmonella typhimurium: The National Toxicology Program
    • Rosenkranz, H. S., and Klopman, G. 1990c. Structural basis of the mutagenicity of chemicals in Salmonella typhimurium: the National Toxicology Program. Mutat. Res. 228:51-80.
    • (1990) Mutat. Res , vol.228 , pp. 51-80
    • Rosenkranz, H.S.1    Klopman, G.2
  • 56
    • 0027478917 scopus 로고
    • Structural relationships between mutagenicity, maximum tolerated dose, and carcinogenicity in rodents
    • Rosenkranz, H. S., and Klopman, G. 1993. Structural relationships between mutagenicity, maximum tolerated dose, and carcinogenicity in rodents. Environ. Mol. Mutagen.21:193-206.
    • (1993) Environ. Mol. Mutagen , vol.21 , pp. 193-206
    • Rosenkranz, H.S.1    Klopman, G.2
  • 58
    • 0033381968 scopus 로고    scopus 로고
    • SOS chromotest and mutagenicity in Salmonella: Evidence for mechanistic differences
    • Rosenkranz, H. S., Mersch-Sundermann, V., and Klopman, G. 1999b. SOS chromotest and mutagenicity in Salmonella: evidence for mechanistic differences. Mutat. Res. Fund. Mol. M. 431(1):31-38.
    • (1999) Mutat. Res. Fund. Mol. M , vol.431 , Issue.1 , pp. 31-38
    • Rosenkranz, H.S.1    Mersch-Sundermann, V.2    Klopman, G.3
  • 59
    • 0344172556 scopus 로고    scopus 로고
    • Structural determinants of developmental toxicity in hamsters
    • Rosenkranz, H. S., Mersch-Sundermann, V., and Klopman, G. 1999c. Structural determinants of developmental toxicity in hamsters. Teratology 60(4):190-205.
    • (1999) Teratology , vol.60 , Issue.4 , pp. 190-205
    • Rosenkranz, H.S.1    Mersch-Sundermann, V.2    Klopman, G.3
  • 60
    • 0031825824 scopus 로고    scopus 로고
    • Studies on the potential for genotoxic carcinogenicity of fragrances and other chemicals
    • Rosenkranz, H. S., Zhang, Y. P., and Klopman, G. 1998. Studies on the potential for genotoxic carcinogenicity of fragrances and other chemicals. Food Chem. Toxicol. 36(8):687-696.
    • (1998) Food Chem. Toxicol , vol.36 , Issue.8 , pp. 687-696
    • Rosenkranz, H.S.1    Zhang, Y.P.2    Klopman, G.3
  • 61
    • 0027323749 scopus 로고
    • Development of a database for sensory irritants and its use in establishing occupational exposure limits
    • Schaper, M. 1993. Development of a database for sensory irritants and its use in establishing occupational exposure limits. Am. Ind. Hyg. Assoc. J. 54:488-544.
    • (1993) Am. Ind. Hyg. Assoc. J , vol.54 , pp. 488-544
    • Schaper, M.1
  • 63
    • 33746910590 scopus 로고    scopus 로고
    • A structural analogue approach to the prediction of the octanol-water partition coefficient
    • Sedykh, A. Y., and Klopman, G. 2006. A structural analogue approach to the prediction of the octanol-water partition coefficient. J. Chem. Inf. Modeling 46(4):1598-1603.
    • (2006) J. Chem. Inf. Modeling , vol.46 , Issue.4 , pp. 1598-1603
    • Sedykh, A.Y.1    Klopman, G.2
  • 66
    • 36048982732 scopus 로고    scopus 로고
    • Experimental toxicology in-silico
    • Tichý, M. 2005. Experimental toxicology in-silico. Biomed. Pap. Med. Fac. 149(2):217-219.
    • (2005) Biomed. Pap. Med. Fac , vol.149 , Issue.2 , pp. 217-219
    • Tichý, M.1
  • 68
    • 84874811599 scopus 로고    scopus 로고
    • Accessed October 1, 2007
    • U.S. Environmental Protection Agency. 2007. ECOTOX Databases Mid-Continent Ecology Division. http://www.epa.gov/med/Prods Pubs/ecotox.htm. Accessed October 1, 2007.
    • (2007) ECOTOX Databases Mid-Continent Ecology Division
  • 69
    • 0019966132 scopus 로고
    • Reliability of the hepatocyte primary culture/DNA repair test in testing of coded carcinogens and noncarcinogens
    • Williams, G. M., Laspia, M. F., and Dunkel, V. C. 1982. Reliability of the hepatocyte primary culture/DNA repair test in testing of coded carcinogens and noncarcinogens. Mutat. Res. 97(5):359-370.
    • (1982) Mutat. Res , vol.97 , Issue.5 , pp. 359-370
    • Williams, G.M.1    Laspia, M.F.2    Dunkel, V.C.3
  • 70
    • 0032997760 scopus 로고    scopus 로고
    • Thalidomide and metabolites: Indications of the absence of 'genotoxic' carcinogenic potentials
    • Zhu, X. Y., Zhang, Y. P., Klopman, G., and Rosenkranz, N. S. 1999. Thalidomide and metabolites: indications of the absence of 'genotoxic' carcinogenic potentials. Mutat. Res. Fund. Mol. M. 425(1):153-167.
    • (1999) Mutat. Res. Fund. Mol. M , vol.425 , Issue.1 , pp. 153-167
    • Zhu, X.Y.1    Zhang, Y.P.2    Klopman, G.3    Rosenkranz, N.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.