Studies on the potential for genotoxic carcinogenicity of fragrances and other chemicals

Food and Chemical Toxicology

Volumn 36, Issue 8, 1998, Pages 687-696

  Rosenkranz, H S ^a   Zhang, Y P ^a   Klopman, G ^b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Carcinogenicity; Fragrances; Mutagenicity; SAR

Indexed keywords

FRAGRANCE;

ANIMAL EXPERIMENT; ARTICLE; CARCINOGENICITY; GENOTOXICITY; MOUSE; MUTAGENICITY; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; CHEMISTRY, PHYSICAL; DATABASES, FACTUAL; MICE; MUTAGENICITY TESTS; MUTAGENS; PERFUME; PREDICTIVE VALUE OF TESTS; SALMONELLA TYPHIMURIUM; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; MAMMALIA;

EID: 0031825824     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(98)00031-3     Document Type: Article

References (48)

1. Adams T. B., Hallagan J. B., Putman J. M., Gierke T. L., Doull J., Munro I. C., Newberne P., Portoghese P. S., Smith R. L., Wagner B. M., Weil C. S., Woods L. A., Ford R. A. The FEMA GRAS assessment of alicyclic substances used as flavour ingredients. Food and Chemical Toxicology. 34:1996;763-828.
2. Ames B. N., Gold L. S. Chemical carcinogenesis: Too many rodent carcinogens. Proceedings of the National Academy of Sciences. 87:1990;7772-7776.
3. Andersen M. E., Higginson J., Krewski D., Munro I. C., Pegg A. E., Rosenkranz H. S., Solomon K. R., Weisburger E., Williams G. M., Wogan G. N. Safety assessment procedures for indirect food additives. An overview. Regulatory Toxicology and Pharmacology. 12:1990;2-12.
4. Ashby J., Morrod R. S. Detection of human carcinogens. Nature. 352:1991;185-186.
5. Ashby J., Paton D. The influence of chemical structure on the extent and sites of carcinogenesis for 522 rodent carcinogens and 52 different chemical carcinogen exposures. Mutation Research. 286:1993;3-74.
6. Ashby J., Purchase I. F. H. Will all chemicals be carcinogenic to rodents when adequately evaluated? Mutagenesis. 8:1993;489-493.
7. Ashby J., Tennant R. W. Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U. S. NTP. Mutation Research. 257:1991;229-306.
8. Bartsch H., Malaveille C. Prevalence of genotoxic chemicals among animal and human carcinogens evaluated in the IARC Monograph Series. Cell Biology and Toxicology. 5:1989;115-127.
9. Chankong V., Haimes Y. Y., Rosenkranz H. S., Pet-Edwards J. The Carcinogenicity Prediction and Battery Selection (CPBS) method: A Bayesian approach. Mutation Research. 153:1985;135-166.
10. Cohen S. M. Human relevance of animal carcinogenicity studies. Regulatory Toxicology and Pharmacology. 21:1995;75-80.
11. Cohen S. M., Ellwein L. B. Genetic errors, cell proliferation and carcinogenesis. Cancer Research. 51:1991;6493-6505.
12. Cunningham A., Klopman G., Rosenkranz H. S. A study of the structural basis of the carcinogenicity of tamoxifen, toremifene and their metabolites. Mutation Research. 349:1996;85-94.
13. Cunningham A., Klopman G., Rosenkranz H. S. The carcinogenicity of diethylstilbestrol: Structural evidence for a non-genotoxic mechanism. Archives of Toxicology. 70:1996;356-361.
14. Cunningham A. R., Rosenkranz H. S., Zhang Y. P., Klopman G. Identification of "genotoxic" and "non-genotoxic" alerts for cancer in mice: The carcinogenicity potency data base. Mutation Research. 398:1998;1-17.
15. Dawson R. M. C., Elliott D. C., Elliott W. H. and Jones K. M. (1969) Data for Biochemical Research, 2nd edn. Oxford University Press, New York.
16. Dunkel V., Zeiger E., Brusick D., McCoy E. C., McGregor D., Mortelmans K., Rosenkranz H. S., Simmon V. F. Reproducibility of microbial mutagenicity assays: I. Tests with Salmonella typhimurium and Escherichia coli using a standard protocol. Environmental Mutagenesis. 6:(Suppl. 2):1984;1-251.
17. Dunkel V. C., Zeiger E., Brusick D., McCoy E., McGregor D., Mortelmans K., Rosenkranz H. S., Simmon V. F. Reproducibility of microbial mutagenicity assays: II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escherichia coli. Environmental Mutagenesis. 7:(Suppl. 5):1985;1-248.
18. Ennever F. K., Noonan T. J., Rosenkranz H. S. The predictivity of animal bioassays and short-term genotoxicity tests for carcinogenicity and non-carcinogenicity to humans. Mutagenesis. 2:1987;73-78.
19. Fung V. A., Barrett J. C., Huff J. The carcinogenesis bioassay in perspective: Application in identifying human cancer hazards. Environmental Health Perspectives. 103:1995;680-683.
20. Gold L. S., de Veciana M., Backman G. M., Magaw R., Lopipero P., Smith M., Blumenthal M., Levinson R., Bernstein L., Ames B. N. Chronological supplement to the Carcinogenic Potency Database: Standardized results of animal bioassays published through December 1982. Environmental Health Perspectives. 67:1986;161-200.
21. Gold L. S., Manley N. B., Slone T. H., Garfinkel G. B., Rohrbach L., Ames B. N. The fifth plot of the Carcinogenic Potency Database: Results of animal bioassays published in the general literature through 1988 and by the National Toxicology Program through 1989. Environmental Health Perspectives. 100:1993;65-135.
22. Gold L. S., Sawyer C. B., Magaw R., Backman G. M., de Veciana M., Levinson R., Hooper N. K., Havender W. R., Bernstein L., Peto R., Pike M. C., Ames B. N. A carcinogenic potency database of the standardized results of animal bioassays. Environmental Health Perspectives. 58:1984;9-319.
23. Gold L. S., Slone T. H., Backman G. M., Eisenberg S., DaCosta M., Wong M., Manley N. B., Rohrbach L., Ames B. N. Third chronological supplement to the Carcinogenic Potency Database: Standardized results of animal bioassays published through December 1986 and by the National Toxicology Program through June 1987. Environmental Health Perspectives. 84:1990;215-286.
24. Gold L. S., Slone T. H., Backman G. M., Magaw R., Da Costa M., Lopipero P., Blumenthal M., Ames B. N. Second chronological supplement to the carcinogenic potency database: Standardized results of animal bioassays published through December 1984 and by the National Toxicology Program through May 1986. Environmental Health Perspectives. 74:1987;237-329.
25. Graham C. (1998) Development of structure-activity relationship models of chemical sensitization: Characteristics that distinguish respiratory from dermal activity, PhD Dissertation. Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA.
26. Houser J. J., Klopman G. A new tool for the rapid estimation of charge distribution. Journal of Computational Chemistry. 9:1988;893-904.
27. Houser J. J., Klopman G. The rapid estimation of charge distribution. II. Heteroatoms. Journal of Computational Chemistry. 13:1992;990-996.
28. Klopman G. Artificial intelligence approach to structure(activity studies. Computer automated structure evaluation of biological activity of organic molecules. Journal of the American Chemical Society. 106:1984;7315-7321.
29. Klopman G. MULTICASE 1. A Hierarchical Computer Automated Structure Evaluation Program. Quantitative Structure Activity Relationships. 11:1992;176-184.
30. Klopman G., Rosenkranz H. S. Prediction of carcinogenicity/mutagenicity using MULTICASE. Mutation Research. 305:1994;33-46.
31. Liu M., Sussman N., Klopman G., Rosenkranz H. S. Estimation of the optimal data base size for structure-activity analyses: The Salmonella mutagenicity data base. Mutation Research. 358:1996;63-72.
32. Macina O. T., Zhang Y. P. and Rosenkranz H. S. (1998) Improved predictivity of carcinogens: The use of a battery of SAR Models. In Testing, Predicting and Interpreting Carcinogenicity, ed. K. T. Kitchin. Marcel Dekker, New York. In press.
33. Miller J. A. and Miller E. C. (1977) Ultimate chemical carcinogens as reactive mutagenic eletrophiles. In Origins of Human Cancer, ed. H. H. Hiatt, J. D. Watson and J. A. Winsten, pp. 605-627. Cold Spring Harbor Laboratory, Cold Spring Harbor.
34. Mortelmans K., Haworth S., Lawlor T., Speck W. T., Tainer B., Zeiger E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals. Environmental Mutagenesis. 8:1986;1-119.
35. NAS (1984) Toxicity Testing. Strategies to Determine Needs and Priorities. National Academy of Sciences. National Academy Press, Washington, DC.
36. Rosenkranz H. S., Cunningham A., Klopman G. Identification of a 2-D geometric descriptor associated with non-genotoxic carcinogens and some estrogens and antiestrogens. Mutagenesis. 11:1996;95-100.
37. Rosenkranz H. S., Klopman G. The structural basis of the mutagenicity of chemicals in Salmonella typhimurium: The National Toxicology Program data base. Mutation Research. 228:1990;51-80.
38. Rosenkranz H. S., Klopman G. Structural basis of carcinogenicity in rodents of genotoxicants and non-genotoxicants. Mutation Research. 228:1990;105-124.
39. Rosenkranz H. S., Zhang Y. P., Klopman G. Risk identification using structural concepts: The potential carcinogenicity of praziquantel. Regulatory Toxicology and Pharmacology. 22:1995;152-161.
40. Shelby M. D. The genetic toxicity of human carcinogens and its implications. Mutation Research. 204:1988;3-15.
41. Sober H. A. (1970) Handbook of Biochemistry, 2nd edn. The Chemical Rubber Co, Cleveland, OH.
42. Swenberg J. A. Bioassay design and MTD setting: Old methods and new approaches. Regulatory Toxicology and Pharmacology. 21:1995;44-51.
43. Williams G. M. (1987) Definition of a human cancer hazard. In Nongenotoxic Mechanisms in Carcinogenesis, Banbury Report 25, ed. B. E. Butterworth and T. H. Slaga, pp. 367-380. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
44. Zeiger E. Carcinogenicity of mutagens: Predictive capability of the Salmonella mutagenesis assay for rodent carcinogenicity. Cancer Research. 47:1987;1287-1296.
45. Zeiger E., erson B., Haworth S., Lawlor T., Mortelmans K., Speck W. Salmonella mutagenicity tests: III. Results from 255 chemicals. Environmental Mutagenesis. 9:(Suppl. 9):1987;1-109.
46. Zeiger E., erson B., Haworth S., Lawlor T., Mortelmans K. Salmonella mutagenicity tests: IV. Results from the testing of 300 chemicals. Environmental and Molecular Mutagenesis. 11:(Suppl. 12):1988;1-157.
47. Zeiger E., Ashby J., Bakale G., Enslein K., Klopman G., Rosenkranz H. S. Prediction of Salmonella mutagenicity. Mutagenesis. 11:1996;471-484.
48. Zhang Y. P., Sussman N., Macina O. T., Rosenkranz H. S., Klopman G. Prediction of the carcinogenicity of a second group of chemicals undergoing carcinogenicity testing. Environmental Health Perspectives. 104:(Suppl. 5):1996;1045-1050.