An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: II. Identification of genotoxicants, reprotoxicants, and carcinogens using in silico methods

Regulatory Toxicology and Pharmacology

Volumn 44, Issue 2, 2006, Pages 97-110

  Matthews, Edwin J ^a   Kruhlak, Naomi L ^a   Cimino, Michael C ^b   Benz, R Daniel ^a   Contrera, Joseph F ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Carcinogenicity; Computational toxicology; Genetic toxicity; Genetox; MC4PC; Predictive modeling; Quantitative structure activity relationships; Reproductive and developmental toxicity; Reprotox; Rodent carcinogenicity bioassay; Surrogate

Indexed keywords

CARCINOGEN; GENOTOXICANT; REPROTOXICANT; TOXIC SUBSTANCE; UNCLASSIFIED DRUG;

AMES TEST; ARTICLE; BIOASSAY; CARCINOGENICITY; COMPUTER MODEL; COMPUTER PROGRAM; CORRELATION ANALYSIS; DEVELOPMENTAL DISORDER; GENETIC TOXICOLOGY; GENOTOXICITY; PREDICTION; PRIORITY JOURNAL; REPRODUCTIVE TOXICITY; SENSITIVITY AND SPECIFICITY; TOXICITY TESTING; VALIDATION STUDY;

ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; COMPUTER SIMULATION; EVALUATION STUDIES; MODELS, BIOLOGICAL; MUTAGENICITY TESTS; PREDICTIVE VALUE OF TESTS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; REPRODUCTION; SENSITIVITY AND SPECIFICITY; SOFTWARE; TOXICITY TESTS, CHRONIC;

RODENTIA; SALMONELLA;

EID: 32544435283     PISSN: 02732300     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yrtph.2005.10.004     Document Type: Article

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