Dichotomous relationship between DNA reactivity and the induction of sister chromatid exchanges in vivo and in vitro

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 377, Issue 1, 1997, Pages 37-52

  Labbauf, Abbas ^a   Klopman, Gilles ^b   Rosenkranz, Herbert S ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

DNA reactivity; Genotoxicity; Sister chromatic exchange; Structure activity

Indexed keywords

ALCOHOL; BENZOIC ACID; BLEOMYCIN; CARCINOGEN; CHLORPROPAMIDE; CYCLOPHOSPHAMIDE; DACTINOMYCIN; DAUNORUBICIN; DIETHYLSTILBESTROL; DIHYDRALAZINE; DIMETHYLNITROSAMINE; DOXORUBICIN; DRUG; FOSFESTROL; GOSSYPOL; GRISEOFULVIN; HYDRALAZINE; IPRONIAZID; ISOCARBOXAZID; MITOMYCIN C; NIALAMIDE; PANTOTHENIC ACID; PHENELZINE; PHENYTOIN; PROCARBAZINE; QUININE; RUFOCROMOMYCIN; STYRENE; TOLBUTAMIDE; UNINDEXED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW; CELL CULTURE; DNA DAMAGE; GENOTOXICITY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MUTAGEN TESTING; NONHUMAN; PRIORITY JOURNAL; SISTER CHROMATID EXCHANGE; STRUCTURE ACTIVITY RELATION;

ALGORITHMS; ANIMALS; BONE MARROW; CARCINOGENS; CELLS, CULTURED; CHROMOSOME ABERRATIONS; CYTOCHROME P-450 ENZYME SYSTEM; DNA; HUMANS; INFORMATION SYSTEMS; MICE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MUTAGENS; MUTATION; SISTER CHROMATID EXCHANGE; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP; XENOBIOTICS;

ANIMALIA; CINCHONA PUBESCENS; RODENTIA;

EID: 0030992633     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(97)00056-0     Document Type: Article

References (67)

1. Ennever, F.K., T.J. Noonan and H.S. Rosenkranz (1987) The predictivity of animal bioassays and short-term genotoxicity tests for carcinogenicity and non-carcinogenicity to humans, Mutagenesis, 2, 73-78.
2. Shelby, M.D. (1988) The genetic toxicity of human carcinogens and its implications, Mutation Res., 204, 3-15.
3. Bartsch, H. and C. Malaveille (1989) Prevalence of genotoxic chemicals among animal and human carcinogens evaluated in the IARC Monograph Series, Cell Biol. Toxicol., 5, 115-127.
4. Ardito, G., L. Lamberti, E. Ansaldi and P. Ponzetto (1980) Sister chromatid exchange in cigarette-smoking human females and their newborns, Mutation Res., 78, 208-212.
5. Ashby, J. and C.R. Richardson (1985) Tabulation and assessment of 113 human surveillance cytogenetic studies conducted between 1965 and 1984, Mutation Res., 154, 111-133.
6. Al-Sabti, K., D.C. Lloyd, A.A. Edwards and P. Stegnar (1992) A survey of lymphocyte chromosomal damage in Slovenian workers exposed to occupational clastogens, Mutation Res., 280, 215-223.
7. Apelt, F., J. Kolin-Gerresheim and M. Bauchinger (1981) Azathioprine, a clastogen in human somatic cells? Analysis of chromosome damage and SCE in lymphocytes after exposure in vivo and in vitro, Mutation Res., 88, 61-72.
8. Aronson, M.M., R.C. Miller, R.B. Hill, W.W. Nichols and A.T. Meadows (1982) Acute and long-term cytogenetic effects of treatment of childhood cancer: sister-chromatid exchanges and chromosome aberrations, Mutation Res., 92, 291-307.
9. Gennart, J.Ph., C. Baleux, Ch. Verellen-Dumoulin, J.P. Buchet, R. De Meyer and R. Lauwerys (1993) Increased sister chromatid exchanges and tumor markers in workers exposed to elemental chromium-, cobalt- and nickel-containing dusts, Mutation Res., 299, 55-61.
10. Motykiewicz, G., J. Michalska, J. Pendzich, F.P. Perera and M. Chora̧ży (1992) A cytogenetic study of men environmentally and occupationally exposed to airborne pollutants, Mutation Res., 280, 253-259.
11. Lakhanisky, T., D. Bazzoni, P. Jadot, I. Joris, C. Laurent, M. Ottogali, A. Pays, C. Planard, Y. Ros and C. Vleminckx (1993) Cytogenetic monitoring of a village population potentially exposed to a low level of environmental pollutants. Phase 1: SCE analysis, Mutation Res., 319, 317-323.
12. Scott, D. (1993) Cytogenetic studies of workers exposed to styrene: a review, in: M. Sorsa, K. Peltonen, H. Vainio and K. Hemminki (Eds.), Butadiene and Styrene: Assessment of Health Hazards IARC Scientific Publications No. 127, International Agency for Research on Cancer, Lyon, pp. 275-286.
13. Seshadri, R., E. Baker and G.R. Sutherland (1982) Sister chromatid exchange (SCE) analysis in mothers exposed to DNA-damaging agents and their newborn infants, Mutation Res., 97, 139-146.
14. Wulf, H.C. (1990) Monitoring of genotoxic exposure of humans by the sister chromatid exchange test, Dan. Med. Bull., 37, 132-143.
15. Tucker, J.D., A. Auletta, M.C. Cimino, K.L. Dearfield, D. Jacobson-Kram, R.R. Tice and A.V. Carrano (1993) Sister-chromatid exchange: second report of the Gene-Tox program, Mutation Res., 297, 101-180.
16. Liu, M., N. Sussman, G. Klopman and H.S. Rosenkranz (1996) Estimation of the optimal data base size for structure-activity analyses: the Salmonella mutagenicity data base, Mutation Res., 358, 63-72.
17. Yang, W.-L., G. Klopman and H.S. Rosenkranz (1992) Structural basis of the in vivo induction of micronuclei, Mutation Res., 272, 111-124.
18. Ashby, J., R.W. Tennant, E. Zeiger and S. Stasiewicz (1989) Classification according to chemical structure, mutagenicity to Salmonella and level of carcinogenicity of a further 42 chemicals tested for carcinogenicity by the U.S. National Toxicology Program, Mutation Res., 223, 73-103.
19. Dunkel, V., E. Zeiger, D. Brusick, E.C. McCoy, D. McGregor, K. Mortelmans, H.S. Rosenkranz and V.F. Simmon (1984) Reproducibility of microbial mutagenicity assays: I. Tests with Salmonella typhimurium and Escherichia coli using a standard protocol, Environ. Mutagen., 6 (Suppl. 2), 1-251.
20. Dunkel, V.C., E. Zeiger, D. Brusick, E. McCoy, D. McGregor, K. Mortelmans, H.S. Rosenkranz and V.F. Simmon (1985) Reproducibility of microbial mutagenicity assays: II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escherichia coli, Environ. Mutagen., 7 (Suppl. 5), 1-248.
21. Mortelmans, K., S. Haworth, T. Lawlor, W.T. Speck, B. Tainer and E. Zeiger (1986) Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals, Environ. Mutagen., 8, 1-119.
22. Tennant, R.W. and J. Ashby (1991) Classification according to chemical structure, mutagenicity to Salmonella and level of carcinogenicity of a further 39 chemicals tested for carcinogenicity by the U.S. National Toxicology Program, Mutation Res., 257, 209-227.
23. Zeiger, E. (1987) Carcinogenicity of mutagens: Predictive capability of the Salmonella mutagenesis assay for rodent carcinogenicity, Cancer Res., 47, 1287-1296.
24. Zeiger, E., B. Anderson, S. Haworth, T. Lawlor, K. Mortelmans and W. Speck (1987) Salmonella mutagenicity tests: III. Results from 255 chemicals, Environ. Mutagen., 9 (Suppl. 9), 1-109.
25. Zeiger, E., B. Anderson, S. Haworth, T. Lawlor and K. Mortelmans (1988) Salmonella mutagenicity tests: IV. Results from the testing of 300 chemicals, Environ. Mol. Mutagen., 11 (Suppl. 12), 1-157.
26. Ashby, J. and D. Paton (1993) The influence of chemical structure on the extent and sites of carcinogenesis for 522 rodent carcinogens and 52 different chemical carcinogen exposures, Mutation Res., 286, 3-74.
27. Ashby, J. and R.W. Tennant (1991) Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP, Mutation Res., 257, 229-306.
28. Mavournin, K.H., D.H. Blakey, M.C. Cimino, M.F. Salamone and J.A. Heddle (1990) The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of the U.S. Environmental Protection Agency Gene-Tox Program, Mutation Res., 239, 29-80.
29. Anderson, B.E., E. Zeiger, M.D. Shelby, M.A. Resnick, D.K. Gulati, J.L. Ivett and K.S. Loveday (1990) Chromosome aberration and sister chromatid exchange test results with 42 chemicals, Environ. Mol. Mutagen., 16 (Suppl. 18), 555-1-37.
30. Galloway, S.M., A.D. Bloom, M. Resnick, B.H. Margolin, F. Nakamura, P. Archer and E. Zeiger (1985) Development of a standard protocol for in vitro cytogenetic testing with Chinese hamster ovary cells: comparison of results for 22 compounds in two laboratories, Environ. Mutagen., 7, 1-51.
31. Galloway, S.M., M.J. Armstrong, C. Reuben, S. Colman, B. Brown, C. Cannon, A.D. Bloom, F. Nakamura, M. Ahmed, S. Duk, J. Rimpo, B.H. Margolin, M.A. Resnick, B. Anderson and E. Zeiger (1987) Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluation of 108 chemicals, Environ. Mol. Mutagen., 10 (Suppl. 10), 1-175.
32. Gulati, D.K., K. Witt, B. Anderson, E. Zeiger and M.D. Shelby (1989) Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. III: Results with 27 chemicals, Environ. Mol. Mutagen., 13, 133-193.
33. Loveday, K.S., M.H. Lugo, M.A. Resnick, B.E. Anderson and E. Zeiger (1989) Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro: II. Results with 20 chemicals, Environ. Mol. Mutagen., 13, 60-94.
34. Graf, U., F.E. Würgler, A.J. Katz, H. Frei, H. Juon, C.B. Hall and P.G. Kale (1984) Somatic mutation and recombination test in Drosophila melanogaster, Environ. Mutagen., 6, 153-188.
35. Vogel, E.W. and J.A. Zijlstra (1987) Mechanistic and methodological aspects of chemically induced somatic mutation and recombination in Drosophila melanogaster, Mutation Res., 182, 243-264.
36. Vogel, E.W. (1992) Test for recombinagens in somatic cells of Drosophila, Mutation Res., 284, 159-175.
37. Würgler, F.E. and E.W. Vogel (1986) In vivo mutagenicity testing using somatic cells of Drosophila melanogaster, in: F.J. de Serres (Ed.), Chemical Mutagens, Vol. 10, Plenum Press, New York, pp. 1-59.
38. Vogel, E.W. and M.J.M. Nivard (1993) Performance of 181 chemicals in a Drosophila assay predominantly monitoring interchromosomal mitotic recombination, Mutagenesis, 8, 57-81.
39. Matthews, E.J., J.W. Spalding and R.W. Tennant (1993) Transformation of BALB/c-3T3 cells: V. Transformation responses of 168 chemicals compared with mutagenicity in Salmonella and carcinogenicity in rodent bioassays, Environ. Health Perspect., 101 (Suppl. 2), 347-482.
40. Swenberg, J.A., B. Short, S. Borghoff, J. Strasser and M. Charbonneau (1989) The comparative pathobiology of 2-globulin nephropathy, Toxicol. Appl. Pharmacol., 97, 35-46.
41. Rosenkranz, H.S. and G. Klopman (1990) The structural basis of the mutagenicity of chemicals in Salmonella typhimurium: The National Toxicology Program data base, Mutation Res., 228, 51-80.
42. Rosenkranz, H.S. and G. Klopman (1990) Structural basis of carcinogenicity in rodents of genotoxicants and non-genotoxicants, Mutation Res., 228, 105-124.
43. Rosenkranz, H.S. and G. Klopman (1990) Structural alerts to genotoxicity: the interaction of human and artificial intelligence, Mutagenesis, 5, 333-361.
44. Rosenkranz, H.S., F.K. Ennever, M. Dimayuga and G. Klopman (1990) Significant differences in the structural basis of the induction of sister chromatid exchanges and chromosomal aberrations in Chinese hamster ovary cells, Environ. Mol. Mutagen., 16, 149-177.
45. Rosenkranz, H.S. and G. Klopman (1993) Structural relationships between mutagenicity, maximum tolerated dose, and carcinogenicity in rodents, Environ. Mol. Mutagen., 21, 193-206.
46. Rosenkranz, H.S., E.J. Matthews and G. Klopman (1993) Commonalities in the structural determinants of toxicity in fish and mammals, Ecotoxicol. Environ. Safety, 25, 296-299.
47. Klopman, G. (1984) Artificial intelligence approach to structure-activity studies. Computer automated structure evaluation of biological activity of organic molecules, J. Am. Chem. Soc., 106, 7315-7321.
48. Klopman, G. (1992) MULTICASE 1. A Hierarchical Computer Automated Structure Evaluation Program, Quant. Struct. Act. Rel., 11, 176-184.
49. Klopman, G. and H.S. Rosenkranz (1994) Prediction of carcinogenicity/mutagenicity using MULTICASE, Mutation Res., 305, 33-46.
50. Chankong, V., Y.Y. Haimes, H.S. Rosenkranz and J. Pet-Edwards (1985) The Carcinogenicity Prediction and Battery Selection (CPBS) method, A Bayesian approach, Mutation Res., 153, 135-166.
51. Zhang, Y.P., N. Sussman, O.T. Macina, H.S. Rosenkranz and G. Klopman (1996) Prediction of the carcinogenicity of a second group of chemicals undergoing carcinogenicity testing, Environ. Health Perspect., 104 (Suppl. 5), 1045-1050.
52. Macina, O.T., Y.P. Zhang and H.S. Rosenkranz (1997) Improved predictivity of carcinogens, The use of a battery of SAR Models, in: K.T. Kitchin (Ed.), Testing, Predicting and Interpreting Carcinogenicity, in press.
53. Takihi, N., Y.P. Zhang, G. Klopman and H.S. Rosenkranz (1993) An approach for evaluating and increasing the informational content of mutagenicity and clastogenicity data bases, Mutagenesis, 8, 257-264.
54. Rosenkranz, H.S., Y.P. Zhang and G. Klopman (1994) Evidence that cell toxicity may contribute to the genotoxic response, Regul. Toxicol. Pharmacol., 19, 176-182.
55. Rosenkranz, H.S. and G. Klopman (1993) Structural evidence for a dichotomy in rodent carcinogenesis: involvement of genetic and cellular toxicity, Mutation Res., 303, 83-89.
56. Liu, M., N. Sussman, G. Klopman and H.S. Rosenkranz (1996) Structure-activity and mechanistic relationships: the effects of chemical overlap on structural overlap in data bases of varying size and composition, Mutation Res., in press.
57. Klopman, G. and H.S. Rosenkranz (1991) Structure-activity relations: maximizing the usefulness of mutagenicity and carcinogenicity data bases, Environ. Health Perspect., 96, 67-75.
58. Rosenkranz, H.S., N. Takihi and G. Klopman (1991) Structure activity-based predictive toxicology. An efficient and economical method for generating non-congeneric data bases, Mutagenesis, 6, 391-394.
59. Ashby, J. and R.S. Morrod (1991) Detection of human carcinogens, Nature, 352, 185-186.
60. Ashby, J. and I.F.H. Purchase (1993) Will all chemicals be carcinogenic to rodents when adequately evaluated?, Mutagenesis, 8, 489-493.
61. Andersen, M.E., J. Higginson, D. Krewski, I.C. Munro, A.E. Pegg, H.S. Rosenkranz, K.R. Solomon, E. Weisburger, G.M. Williams and G.N. Wogan (1990) Safety assessment procedures for indirect food additives. An Overview, Regulat. Toxicol. Pharmacol., 12, 2-12.
62. Miller, J.A. and E.C. Miller (1977) Ultimate chemical carcinogens as reactive mutagenic eletrophiles, in: H.H. Hiatt, J.D. Watson and J.A. Winsten (Eds.), Origins of Human Cancer, Cold Spring Harbor Laboratory, Cold Spring Harbor, pp. 605-627.
63. Ames, B.N. and L.S. Gold (1990) Chemical carcinogenesis: too many rodent carcinogens, Proc. Natl. Acad. Sci. USA, 87, 7772-7776.
64. Cohen, S.M. and L.B. Ellwein (1991) Genetic errors, cell proliferation and carcinogenesis, Cancer Res., 51, 6493-6505.
65. ter Haar, E., B.W. Day and H.S. Rosenkranz (1996) Direct tubulin polymerization perturbation contributes significantly to the induction of micronuclei in vivo, Mutation Res., 350, 331-337.
66. Tennant, R.W., B.H. Margolin, M.D. Shelby, E. Zeiger, J.K. Haseman, J. Spalding, W. Caspary, M. Resnick, S. Stasiewicz, B. Anderson and R. Minor (1987) Prediction of chemical carcinogenicity in rodents from in vitro genotoxicity assays, Science, 236, 933-941.
67. Zeiger, E., J.K. Haseman, M.D. Shelby, B.H. Margolin and R.W. Tennant (1990) Evaluation of four in vitro genetic toxicity tests for predicting rodent carcinogenicity: confirmation of earlier results with 41 additional chemicals, Environ. Mol. Mutagen., 16 (Suppl. 18), 1-14.