Clinical review of the Japanese experience with boron neutron capture therapy and a proposed strategy using epithermal neutron beams

Journal of Neuro-Oncology

Volumn 62, Issue 1, 2003, Pages 87-99

  Nakagawa, Yoshinobu ^a   Pooh, Kyonghon ^a   Kobayashi, Toru ^b   Kageji, Teruyoshi ^c   Uyama, Shinichi ^c   Matsumura, Akira ^d   Kumada, Hiroaki ^e  

^a National Hospital Organization   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKUSHIMA   (Japan)

^d UNIVERSITY OF TSUKUBA   (Japan)

^e JAPAN ATOMIC ENERGY AGENCY   (Japan)

Author keywords

Boron neutron capture therapy; Brain tumor; Glioblastoma; Heavy charged particle; Radiation therapy

Indexed keywords

BORON; BORON 10; CARBON 14; LITHIUM; NITROGEN;

ADULT; ARTICLE; BEAM THERAPY; BRAIN EDEMA; BRAIN TISSUE; BRAIN TUMOR; CANCER RADIOTHERAPY; CONTROLLED STUDY; DEATH; DOSIMETRY; DRUG BLOOD LEVEL; DRUG FATALITY; GAMMA RADIATION; GLIOBLASTOMA; HISTOPATHOLOGY; HUMAN; JAPAN; MAJOR CLINICAL STUDY; MOTOR DYSFUNCTION; NEUTRON CAPTURE THERAPY; NEUTRON RADIATION; RADIATION DOSE; RADIATION NECROSIS; REACTOR; RETROSPECTIVE STUDY; SEIZURE; SPEECH DISORDER; THERMAL EXPOSURE; TREATMENT OUTCOME; TUMOR CELL DESTRUCTION; TUMOR CLASSIFICATION; TUMOR VOLUME; VASCULAR CAPACITY;

EID: 0038707548     PISSN: 0167594X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1023234902479     Document Type: Article

References (38)

1. Davis FG, Freels S, Grutsch J, Barlas S, Brem S: Survival rates in patients with primary malignant brain tumors stratified by patient age and tumor histological type: An analysis based on Surveillance, Epidemiology, and End Results (SEER) data, 1973-1991. J Neurosurg 88: 1-10, 1998
2. Fulton DS, Urtason RC, Scott-Brown I, Johnson ES, Mielke B, Carry B: Increasing radiation dose intensity using hyperfractionation in patients with malignant glioma. J Neuro-Oncol 14: 63-72, 1992
3. Blasberg RG, Groothuis DR: Chemotherapy of brain tumors: Physiological and pharmacokinetic considerations. Semin Oncol 13: 70-82, 1986
4. Castro JR, Phillips TL, Prados M, Gutin P, Larson DA, Petti PL, Daftari IK, Collier JM, Lillis-Hearne P: Neon heavy charged particle radiotherapy of glioblastoma of the brain. Int J Radiat Oncol Biol Phys 38: 257-261, 1997
5. Nakagawa Y, Hatanaka H: Boron neutron capture therapy - Clinical brain tumor study. J Neuro-Oncol 33: 105-115, 1997
6. Hatanaka H: Clinical experience of boron-neutron capture therapy for glioma - A comparison with conventional chemo-immuno-radiotherapy: Boron. In: Hatanaka H (ed) Neutron Capture Therapy for Tumors. Nishimura & Co., Niigata City, 1986, pp 349-379
7. Nakagawa Y, Kageji T, Hatanaka H: Thermal neutron capture therapy for brain stem and skull base tumors; Heavy water and multiportal neutron delivery. In: Soloway AH, Barth RF, Carpenter DE (eds) Advances in Neutron Capture Therapy. Plenum Press, New York, 1993, pp 671-676
8. Blagojevic N, Storr GJ, Allen B, Hatanaka H, Nakagawa Y: Role of heavy water in boron neutron capture therapy. In: Zammenhof RG (ed) Topics in Dosimetry & Treatment Planning for Boron Neutron Capture Therapy. Advanced Medical Publishing, Madison, 1994, pp 125-134
9. Nakagawa Y: What were important factors in patients treated by BNCT in Japan? In: Larsson B (ed) Neutron Capture Therapy, Vol 1, Medicine and Physics. Elsevier, Amsterdam, 1997, pp 65-70
10. 11SH) in patients with intracranial tumors. J Neuro-Oncol 33: 117-130, 1997
11. Kobayashi T, Sakurai Y, Kanda K, Fujita Y, Ono K: The more modelling and basic characteristics of the heavy water neutron irradiation facility of the Kyoto University research reactor mainly for neutron capture therapy. Nucl Technol 131: 354-378, 2001
12. Holland EC: Glioblastoma multiforme: The terminator. Proc Natl Acad Sci (USA) 97: 6242-6244, 2000
13. Burger P, Vogel S, Green S, Strike T: Glioblastoma multiforme and anaplastic astrocytoma, pathologic criteria and prognostic implications. Cancer 56: 1106-1111, 1985
14. 7Li reaction. Radiat Res 61: 304-315, 1975
15. Rydin RA, Deutsch OL, Murray BW: The effect of geometry on capillary wall dose for boron neutron capture therapy. Phys Med Biol 21: 134-138, 1976
16. Kageji T, Nagahiro S, Kitamura K, Nakagawa Y, Hatanaka H, Haritz D, Grochulla F, Haselsberger K, Gabel D: Optimal timing of neutron irradiation for boron neutron capture therapy after intravenous infusions of sodium borocaptate in patients with glioblastoma. Int J Radiat Oncol Biol Phys 51: 120-130, 2001
17. Kumada H, Yamamoto K, Torii Y, Matsumura A, Yamamoto T, Nakagawa Y, Horiguchi Y: Development of computational dosimetry system and measurement of dose distribution in water head phantom for BNCT in JAERI. In: Proceedings of the 2000 Workshop on Utilization of Research Reactors. JAERI-Conf 2001. 17: 357-362, 2001
18. Mehta MP, Masciopinto J, Rozental J, Levin A, Chappel R, Bastine K, Miles J, Turski P, Kubsad S, Mackie T, Kinsella T: Stereotactic radiosurgery for glioblastoma multiforme: Report of a postoperative study evaluating prognostic factors and analyzing long-term survival advantage. Int J Radiat Oncol Biol Phys 30: 541-549, 1994
19. Kumar PP, Good RR, Jones EO, Patil AA, Leibrock LG, McComb RD: Survival of patients with glioblastoma multiforme treated by intraoperative high-activity cobalt 60 endocurie therapy. Cancer 64(7): 1409-1413, 1989
20. Tagian A, Ramsay J, Turner JA, Budach W, Gioloso D, Pardo F, Okuniff P, Bleehen N, Urtasun R, Suit H: Int J Radiat Oncol Biol Phys 25: 243-249, 1993
21. Locher GL: Biological effects and therapeutic possibilities of neutrons. Am J Roentgenol 36: 1-13, 1936
22. Sweet WH, Javid M: The possible use of neutron-capturing isotopes such as boron-10 in the treatment of neoplasms. I. Intracranial tumor. J Neurosurg 9: 200-209, 1952
23. Javid M, Brownell GL, Sweet WH: The possible use of neutron-capturing isotopes such as boron-10 in the treatment of neoplasms. II. Computation of the radiation energy and estimates of effects in normal and neoplastic brain. J Clin Invest 31: 603-610, 1952
24. Farr LE, Sweet WH, Robertson JS, Foster CG, Locksley HB, Sutherland DL, Mendelsohn ML, Stickley EE: Neutron capture therapy with boron in the treatment of glioblastoma multiforme. AJR 71: 279-293, 1954
25. Soloway AH, Hatanaka H, Davis MA: Penetration of brain and brain tumor. Tumor-binding sulfhydryl boron compounds. J Med Chem 10: 714-717, 1971
26. Hatanaka H, Amano K, Kanemitsu H, Ikeuchi I, Yoshizaki T: Boron uptake by human brain tumors and quality control of boron compounds. In: Hatanaka H (ed) Neutron Capture Therapy for Tumors. Nishimura & Co., Niigata City, 1986, pp 77-106
27. Nakagawa Y, Pooh K, Sone M, Kageji T, Nakamichi M, Takahashi H, Amemiya K, Gabel D: Determination of BSH absorbed in tumor tissue. In: Hawthorne MF, Shelly K, Wiersema J (eds) Frontiers in Neutron Capture Therapy, Kluwer Acad/Plenum Publishers, New York, 2001, pp 933-937
28. Amemiya K, Takahashi H, Nakazawa M, Shimizu H, Majima T, Nakagawa Y, Yasuda N, Yamamoto M, Kageji T, Nakamichi M, Hasegawa T, Kobayashi T, Sakurai Y, Ogura K: Soft X ray imaging using CR-39 plastics with AFM readout. Nucl Instrum Meth Phys Res B 187: 361-366, 2002
29. Hatanaka H: Boron-neutron capture therapy for tumors. In: Karim ABM, Laws, ER Jr (eds) Glioma. Springer-Verlag, Berlin, 1991, pp 233-249
30. Laramore GE, Spence AM: Boron neutron capture therapy (BNCT) for high grade glioma of the brain: A cautionary note. Int J Radiat Oncol Biol Phys 36: 241-246, 1996
31. Higashi H, Matsumoto K, Ono Y, Shinohara C, Nakagawa M, Tsuno K, Furuta T, Ohmoto T: Patterns of recurrence in malignant gliomas after brachytherapy. No Shinkei Geka 22(4): 321-326, 1994
32. Coderre JA, Elowitz EH, Chaha M, Bergland R, Capala J, Joel DD, Liu HB, Slatkin DN, Chanana AD: Boron neutron capture therapy for glioblastoma multiforme using p-boronophenylalanine and epithermal neutrons: Trial design and early results. J Neurosurg 33: 141-152, 1997
33. Sauerwein W: The clinical project at HFR Petten: A status report. In: Larsson B, Crawford J, Weinreich R (eds) Advances in Neutron Capture Therapy: Medicine and Physics. Elsevier, Amsterdam, 1997, pp 77-84
34. 7Li reaction in cells and tissue and its implication for boron neutron capture therapy. Radiat Res 111: 25-36, 1987
35. Coderre JA, Makar MA: Radiobiology of boron neutron capture therapy: Problems with the concept of relative biological effectiveness. In: Allen B, Moore D, Harrington B (eds) Progress in Neutron Capture Therapy for Cancer. Plenum Press, New York, 1992, pp 463-468
36. Morris GM, Coderre JA, Hopewell JW, Micca PL, Rezvani M: Response of rat skin to boron neutron capture therapy with p-boronophenylalanine or borocaptate sodium. Radiother Oncol 32: 144-153, 1994
37. Broerse JJ, Barendren GW: Relative biological effectiveness of fast neutron for effects on normal tissues. Curr Top Radiat Res Q8: 305-350, 1973
38. Ward JF: The yield of DNA double-strand breaks produced intracellularly by ionizing radiation: A review. Int J Radiat Biol 57(6): 1141-1150, 1990