Anticonvulsant phenytoin affects voltage-gated potassium currents in cerebellar granule cells

Brain Research

Volumn 941, Issue 1-2, 2002, Pages 53-61

  Pisciotta, Marzia ^a   Prestipino, Gianfranco ^b  

^a UNIVERSITY OF GENOA   (Italy)

^b CNR   (Italy)

Author keywords

Anticonvulsant; Cerebellum granular cell; Channel inactivation; Patch clamp; Phenytoin; Voltage dependent K+ channel

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZAMIDE; CARBAMAZEPINE; PHENYTOIN; POTASSIUM CHANNEL; TETRYLAMMONIUM;

ANIMAL TISSUE; ARTICLE; CEREBELLUM; CONTROLLED STUDY; DEPOLARIZATION; DISSOCIATION CONSTANT; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ELECTRIC POTENTIAL; GRANULE CELL; KINETICS; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; STEADY STATE;

ANIMALS; ANTICONVULSANTS; CELL CULTURE TECHNIQUES; CEREBELLUM; ELECTROPHYSIOLOGY; PHENYTOIN; POTASSIUM CHANNELS, VOLTAGE-GATED; RATS; RATS, WISTAR;

EID: 0037150758     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)02563-5     Document Type: Article

References (24)

1. Kinetic study and numerical reconstruction of A-type current in granule cells of rat cerebellar slices
2. Nitrendipine block of cardiac calcium channels: High-affinity binding to the inactivated state
3. Modulated anticonvulsant block of sodium channels in nerve and muscle
4. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
5. Local anesthetics: Hydrophilic and hydrofobic pathways for the drug reception reaction
6. A quantitative description of membrane current and its application to conduction and excitation in nerve
7. Slow binding of phenytoin to inactivated sodium channels in rat hippocampal neurons
8. Autoradiographic localization and depolarization-induced release of acidic amino acids in differentiating granule cells cultures
9. Characterization of the block of sodium channels by phenytoin in mouse neuroblastoma cells
10. Multiple actions of phenytoin on mouse spinal cord neurons in cell culture
11. Carbamazepine and 10,11-epoxycarbamazepine produce use- and voltage-dependent limitation of rapidly firing action potentials of mouse central neurons in cell culture
12. Determination of the active form of phenytoin
13. + channels by phenytoin in rat neuroblastoma cells
14. Structure, gating, and clinical implications of the potassium channel
15. A transient voltage-dependent outward current in cultured cerebellar granules
16. Antiepileptic drugs: Pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds
17. Diversity and ubiquity of potassium channels
18. + channels in neuronal cells
19. + channels causes epilepsy
20. Phenytoin and carbamazepine: Potential and frequency dependent block of Na currents in mammalian myelinated nerve fibers
21. Effects of chlordiazepoxide, chlorpromazine, diazepam, diphenylhydantoin, flunitrazepam and haloperidol on the voltage-dependent sodium current of isolated mammalian brain neurons
22. Voltage clamp analysis of the inhibitory actions of diphenylhydantoin and carbamazepine on voltage-sensitive sodium channels in neuroblastoma cells
23. Block of voltage-gated potassium current by anticonvulsant U-54494 in mouse neuroblastoma cells