메뉴 건너뛰기




Volumn 18, Issue 2-3, 2008, Pages 119-135

Computational toxicology methods in public health practice

Author keywords

BMD; Chemical Mixture; Computational Toxicology; CSAF; HGV; MRL; PBPK; QSAR; Risk Assessment; Structure Activity

Indexed keywords

AGRICULTURAL CHEMICAL; ORGANIC SOLVENT; VOLATILE ORGANIC COMPOUND;

EID: 40949145717     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.1080/15376510701857148     Document Type: Review
Times cited : (21)

References (106)
  • 1
    • 0011865905 scopus 로고    scopus 로고
    • Agency for Toxic Substances and Disease Registry ATSDR, PHS ATSDR Atlanta, GA, Accessed October 26, 2007
    • Agency for Toxic Substances and Disease Registry (ATSDR). 2004a Guidance Manual for the Assessment of Joint Toxic Action of Chemical Mixtures, May 2004. U.S. DHHS PHS ATSDR Atlanta, GA. http://www.atsdr.cdc. gov/interactionprofiles/ipga.html. Accessed October 26, 2007.
    • (2004) Guidance Manual for the Assessment of Joint Toxic Action of Chemical Mixtures, May 2004
  • 2
    • 84874816924 scopus 로고    scopus 로고
    • Agency for Toxic Substances and Disease Registry (ATSDR). 2004b. Interaction Profile for Benzene, Toluene, Ethylbenzene, and Xylenes. U.S. DHHS PHS ATSDR. Atlanta, GA. 2004b http://www.atsdr.cdc.gov/ interactionprofiles/ip05.html. Accessed October 26, 2007.
    • Agency for Toxic Substances and Disease Registry (ATSDR). 2004b. Interaction Profile for Benzene, Toluene, Ethylbenzene, and Xylenes. U.S. DHHS PHS ATSDR. Atlanta, GA. 2004b http://www.atsdr.cdc.gov/ interactionprofiles/ip05.html. Accessed October 26, 2007.
  • 3
    • 84874795674 scopus 로고    scopus 로고
    • Agency for Toxic Substances and Disease Registry ATSDR, PHS ATSDR, Atlanta, GA, Accessed October 26, 2007
    • Agency for Toxic Substances and Disease Registry (ATSDR). 2006a. Toxicological Profile for 1,1,2,2-Tetrachloroethane, U.S. DHHS PHS ATSDR, Atlanta, GA. http://www.atsdr.cdc.gov/toxprofiles/tp93.html. Accessed October 26, 2007.
    • (2006) Toxicological Profile for 1,1,2,2-Tetrachloroethane
  • 4
    • 84874803129 scopus 로고    scopus 로고
    • Agency for Toxic Substances and Disease Registry (ATSDR). 2006b. Interaction Profile for Atrazine, Deethylatrazine, Diazinon, Nitrate and Simazine. U.S. DHHS PHS ATSDR Atlanta, GA 2006b http://www.atsdr.cdc.gov/ interactionprofiles/ip10.html. Accessed October 26, 2007.
    • Agency for Toxic Substances and Disease Registry (ATSDR). 2006b. Interaction Profile for Atrazine, Deethylatrazine, Diazinon, Nitrate and Simazine. U.S. DHHS PHS ATSDR Atlanta, GA 2006b http://www.atsdr.cdc.gov/ interactionprofiles/ip10.html. Accessed October 26, 2007.
  • 5
    • 84874802538 scopus 로고    scopus 로고
    • Agency for Toxic Substances and Disease Registry ATSDR, PHS ATSDR. Atlanta, GA, Accessed October 26, 2007
    • Agency for Toxic Substances and Disease Registry (ATSDR). 2007a. Minimal Risk Levels. U.S. DHHS PHS ATSDR. Atlanta, GA. http://www.atsdr.cdc.gov/mrls/index.html. Accessed October 26, 2007.
    • (2007) Minimal Risk Levels
  • 6
    • 84874813167 scopus 로고    scopus 로고
    • Agency for Toxic Substances and Disease Registry (ATSDR). 2007b. Hazardous Substance Release and Health Effects Database (HazDat). U.S. DHHS PHS ATSDR. Atlanta GA. http://www.atsdr.cdc.gov/hazdat.html. Accessed October 26, 2007.
    • Agency for Toxic Substances and Disease Registry (ATSDR). 2007b. Hazardous Substance Release and Health Effects Database (HazDat). U.S. DHHS PHS ATSDR. Atlanta GA. http://www.atsdr.cdc.gov/hazdat.html. Accessed October 26, 2007.
  • 7
    • 47249161406 scopus 로고    scopus 로고
    • Agency for Toxic Substances and Disease Registry ATSDR, PHS ATSDR Atlanta, GA, Accessed October 26, 2007
    • Agency for Toxic Substances and Disease Registry (ATSDR). 2007c. Toxicological Profile for Boron. U.S. DHHS PHS ATSDR Atlanta, GA. http://www.atsdr.cdc.gov/toxprofiles/tp26.html. Accessed October 26, 2007.
    • (2007) Toxicological Profile for Boron
  • 8
    • 84874800357 scopus 로고    scopus 로고
    • Agency for Toxic Substances and Disease Registry ATSDR, PHS ATSDR, Atlanta, GA, Accessed October 26, 2007
    • Agency for Toxic Substances and Disease Registry (ATSDR). 2007d. Interaction Profiles. U.S. DHHS PHS ATSDR, Atlanta, GA. http://www. atsdr.cdc.gov/interactionprofiles. Accessed October 26, 2007.
    • (2007) Interaction Profiles
  • 9
    • 84874790781 scopus 로고    scopus 로고
    • Agency for Toxic Substances and Disease Registry ATSDR, PHS ATSDR, Atlanta, GA, Accessed October 26, 2007
    • Agency for Toxic Substances and Disease Registry (ATSDR). 2007e. Interaction Profile for Chloroform, 1,1-Dichloroethylene, Trichloroethylene, and Vinyl Chloride. U.S. DHHS PHS ATSDR, Atlanta, GA. http://www.atsdr.cdc. gov/interactionprofiles/ip13.html. Accessed October 26, 2007.
    • (2007) Interaction Profile for Chloroform, 1,1-Dichloroethylene, Trichloroethylene, and Vinyl Chloride
  • 10
    • 0016355478 scopus 로고    scopus 로고
    • Akaike, H. 1974. A new look at the statistical model identification. IEEE T. Automatic Con. 19:716-723.
    • Akaike, H. 1974. A new look at the statistical model identification. IEEE T. Automatic Con. 19:716-723.
  • 11
    • 27744459224 scopus 로고    scopus 로고
    • Dose-dependent liver regeneration in chloroform, trichloroethylene and allyl alcohol ternary mixture hepatotoxicity in rats
    • Anand, S. S., Mumtaz, M. M., and Mehendale, H. M. 2005. Dose-dependent liver regeneration in chloroform, trichloroethylene and allyl alcohol ternary mixture hepatotoxicity in rats. Arch. Toxicol. 79:671-682.
    • (2005) Arch. Toxicol , vol.79 , pp. 671-682
    • Anand, S.S.1    Mumtaz, M.M.2    Mehendale, H.M.3
  • 12
    • 0025981543 scopus 로고
    • Physiologically based pharmacokinetic modeling with dichoromethane, its metabolite, carbon monoxide, and blood carboxyhemoglobin in rats and humans
    • Andersen, M. E., Clewell, H. J., Gargas, M. L., Macnaughton, M. G., Reitz, R. H., Nolan, R. J., and McKenna, M. J. 1991. Physiologically based pharmacokinetic modeling with dichoromethane, its metabolite, carbon monoxide, and blood carboxyhemoglobin in rats and humans. Toxicol. Appl. Pharm. 108:14-27.
    • (1991) Toxicol. Appl. Pharm , vol.108 , pp. 14-27
    • Andersen, M.E.1    Clewell, H.J.2    Gargas, M.L.3    Macnaughton, M.G.4    Reitz, R.H.5    Nolan, R.J.6    McKenna, M.J.7
  • 13
    • 0023158895 scopus 로고
    • Physiologically based pharmacokinetics and the risk assessment process for methylene chloride
    • Andersen, M. E., Clewell, H. J., Gargas, M. L., Smith, F. A., and Reitz, R. H. 1987a. Physiologically based pharmacokinetics and the risk assessment process for methylene chloride. Toxicol. Appl. Pharm. 87:185-205.
    • (1987) Toxicol. Appl. Pharm , vol.87 , pp. 185-205
    • Andersen, M.E.1    Clewell, H.J.2    Gargas, M.L.3    Smith, F.A.4    Reitz, R.H.5
  • 14
    • 0023195488 scopus 로고
    • Quantitative evaluation of the metabolic interactions between trichloroethylene and 1,1-dichloroethylene in vivo using gas uptake methods
    • Andersen, M. E., Gargas, M. L., Clewell, H. J., and Severyn, K. M. 1987b. Quantitative evaluation of the metabolic interactions between trichloroethylene and 1,1-dichloroethylene in vivo using gas uptake methods. Toxicol. Appl. Pharm 89:149-157.
    • (1987) Toxicol. Appl. Pharm , vol.89 , pp. 149-157
    • Andersen, M.E.1    Gargas, M.L.2    Clewell, H.J.3    Severyn, K.M.4
  • 15
    • 0028930174 scopus 로고
    • Chloroethylene mixtures: Pharmacokinetic modeling and in vitro metabolism of vinyl chloride, trichloroethylene, and trans-1,2-dichloroethylene in rat
    • Barton, H. A., Creech, J. R., Godin, C. S., Randall, G. M., and Seckel, C. S. 1995. Chloroethylene mixtures: pharmacokinetic modeling and in vitro metabolism of vinyl chloride, trichloroethylene, and trans-1,2-dichloroethylene in rat. Toxicol. Appl. Pharm. 130:237-247.
    • (1995) Toxicol. Appl. Pharm , vol.130 , pp. 237-247
    • Barton, H.A.1    Creech, J.R.2    Godin, C.S.3    Randall, G.M.4    Seckel, C.S.5
  • 16
    • 1542286121 scopus 로고    scopus 로고
    • Predicting blood:air partition coefficients using theoretical molecular descriptors
    • Basak, S. C., Mills, D., El-Masri, H. A., Mumtaz, M., and Hawkins, D. M. 2004. Predicting blood:air partition coefficients using theoretical molecular descriptors. Environ. Toxicol. Pharm. 16:45-55.
    • (2004) Environ. Toxicol. Pharm , vol.16 , pp. 45-55
    • Basak, S.C.1    Mills, D.2    El-Masri, H.A.3    Mumtaz, M.4    Hawkins, D.M.5
  • 17
    • 0038278532 scopus 로고    scopus 로고
    • Quantitative structure-property relationships for physiologically based pharmacokinetic modeling of volatile organic chemicals in rats
    • Béliveau, M., Tardif, R., and Krishnan, K. 2003. Quantitative structure-property relationships for physiologically based pharmacokinetic modeling of volatile organic chemicals in rats. Toxicol. Appl. Pharm. 189:221-232.
    • (2003) Toxicol. Appl. Pharm , vol.189 , pp. 221-232
    • Béliveau, M.1    Tardif, R.2    Krishnan, K.3
  • 18
    • 0030941637 scopus 로고    scopus 로고
    • Computational predictive programs (expert systems) in toxicology
    • Benfenati, E., and Gini, G. 1997. Computational predictive programs (expert systems) in toxicology. Toxicology 119:213-225.
    • (1997) Toxicology , vol.119 , pp. 213-225
    • Benfenati, E.1    Gini, G.2
  • 19
    • 0030569257 scopus 로고    scopus 로고
    • QSARs of mutagens and carcinogens: Two case studies illustrating problems in the construction of models for noncongeneric chemicals
    • Benigni, R., and Richard, A. M. 1996. QSARs of mutagens and carcinogens: two case studies illustrating problems in the construction of models for noncongeneric chemicals. Mutat. Res. 371:29-46.
    • (1996) Mutat. Res , vol.371 , pp. 29-46
    • Benigni, R.1    Richard, A.M.2
  • 20
    • 0031698019 scopus 로고    scopus 로고
    • Quantitative structure-based modeling applied to the characterization and prediction of chemical toxicity
    • Benigni, R., and Richard, A. M. 1998. Quantitative structure-based modeling applied to the characterization and prediction of chemical toxicity. Methods 14:264-276.
    • (1998) Methods , vol.14 , pp. 264-276
    • Benigni, R.1    Richard, A.M.2
  • 21
    • 84874807976 scopus 로고    scopus 로고
    • Chemical Abstracts Service, Columbus, OH, Accessed October 26, 2007
    • Chemical Abstracts Service. 2007. Registry Number and Substance Counts, American Chemical Society, Columbus, OH. http://www.cas.org/cgi-bin/ cas/regreport.pl. Accessed October 26, 2007.
    • (2007) Registry Number and Substance Counts
  • 25
    • 33847083523 scopus 로고    scopus 로고
    • A statistical model to assess genetic susceptibility as a risk factor in multifactorial diseases: Lessons from occupational asthma
    • Demchuk, E., Yucesoy, B., Johnson, V. J., Weston, A., Germolec, D., De Rosa, C. T., and Luster, M. I. 2007. A statistical model to assess genetic susceptibility as a risk factor in multifactorial diseases: Lessons from occupational asthma. Environ. Health Persp. 115:231-234.
    • (2007) Environ. Health Persp , vol.115 , pp. 231-234
    • Demchuk, E.1    Yucesoy, B.2    Johnson, V.J.3    Weston, A.4    Germolec, D.5    De Rosa, C.T.6    Luster, M.I.7
  • 26
    • 0029146073 scopus 로고
    • Charge to workshop
    • De Rosa, C. T. 1995. Charge to workshop. Toxicol. Lett. 79:7-8.
    • (1995) Toxicol. Lett , vol.79 , pp. 7-8
    • De Rosa, C.T.1
  • 28
    • 0032447730 scopus 로고    scopus 로고
    • Boron tolerable intake re-evaluation of toxicokinetics for data derived uncertainty factors
    • Dourson, M., Maier, A., Meek, B., Renwick, A., Ohanian, E., and Poirier, K. 1998. Boron tolerable intake re-evaluation of toxicokinetics for data derived uncertainty factors. Biol. Trace. Elem. Res. 66:453-463.
    • (1998) Biol. Trace. Elem. Res , vol.66 , pp. 453-463
    • Dourson, M.1    Maier, A.2    Meek, B.3    Renwick, A.4    Ohanian, E.5    Poirier, K.6
  • 29
    • 0019381759 scopus 로고
    • Serial changes in renal haemodynamics during normal human pregnancy
    • Dunlop, W. 1981. Serial changes in renal haemodynamics during normal human pregnancy. Br. J. Obstet. Gynecol. 88:1-9.
    • (1981) Br. J. Obstet. Gynecol , vol.88 , pp. 1-9
    • Dunlop, W.1
  • 30
    • 0029120678 scopus 로고
    • The identification and testing of interaction patterns (LOAEL)
    • Durkin, P., Hertzberg, R., Stiteler, W., and Mumtaz, M. 1995. The identification and testing of interaction patterns (LOAEL). Toxicol. Lett. 79:251-226.
    • (1995) Toxicol. Lett , vol.79 , pp. 251-226
    • Durkin, P.1    Hertzberg, R.2    Stiteler, W.3    Mumtaz, M.4
  • 31
    • 84874800155 scopus 로고    scopus 로고
    • EC. 2006. Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC. Off. J. Eur. Union 49, L396.
    • EC. 2006. Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC. Off. J. Eur. Union 49, L396.
  • 32
    • 2642698901 scopus 로고
    • Formation of N nitroso compounds from agricultural chemicals and nitrite
    • Bogovski, P, Walker, E. A, and Davis, W, Eds, International Agency for Research on Cancer, Switzerland, pp
    • Eisenbrand, G., Ungerer, O., and Preussmann, R. 1975. Formation of N nitroso compounds from agricultural chemicals and nitrite. In: Bogovski, P., Walker, E. A., and Davis, W. (Eds.), N-nitroso Compounds in the Environment, International Agency for Research on Cancer, Switzerland, pp. 71-74.
    • (1975) N-nitroso Compounds in the Environment , pp. 71-74
    • Eisenbrand, G.1    Ungerer, O.2    Preussmann, R.3
  • 33
    • 0030297476 scopus 로고    scopus 로고
    • Physiologically based pharmacodynamic modeling of an interaction threshold between trichloroethylene and 1,1-dichloroethylene in Fischer 344 rats
    • El-Masri, H. A., Constan, A. A., Ramsdell, H. S., and Yang, R. S. 1996a. Physiologically based pharmacodynamic modeling of an interaction threshold between trichloroethylene and 1,1-dichloroethylene in Fischer 344 rats. Toxicol. Appl. Pharm. 141:124-132.
    • (1996) Toxicol. Appl. Pharm , vol.141 , pp. 124-132
    • El-Masri, H.A.1    Constan, A.A.2    Ramsdell, H.S.3    Yang, R.S.4
  • 34
    • 0036220334 scopus 로고    scopus 로고
    • Applications of computational toxicology methods at the Agency for Toxic Substances and Disease Registry
    • El-Masri, H. A., Mumtaz, M. M., Choudhary, G., Cibulas, W., and De Rosa, C. T. 2002. Applications of computational toxicology methods at the Agency for Toxic Substances and Disease Registry. Int. J. Hyg. Environ. Health 205:63-69.
    • (2002) Int. J. Hyg. Environ. Health , vol.205 , pp. 63-69
    • El-Masri, H.A.1    Mumtaz, M.M.2    Choudhary, G.3    Cibulas, W.4    De Rosa, C.T.5
  • 35
    • 1542286120 scopus 로고    scopus 로고
    • Application of physiologically based pharmacokinetic modeling to investigate the toxicological interaction between chlorpyrifos and parathion in the rat
    • El-Masri, H. A., Mumtaz, M. M., and Yushak, M. L. 2004. Application of physiologically based pharmacokinetic modeling to investigate the toxicological interaction between chlorpyrifos and parathion in the rat. Environ. Toxicol. Pharmacol. 16:57-71.
    • (2004) Environ. Toxicol. Pharmacol , vol.16 , pp. 57-71
    • El-Masri, H.A.1    Mumtaz, M.M.2    Yushak, M.L.3
  • 36
    • 0029971959 scopus 로고    scopus 로고
    • Exploration of an interaction threshold for the joint toxicity of trichloroethylene and 1,1-dichloroethlene: Utilization of a PBPK model
    • El-Masri, H. A., Tessari, J. D., and Yang, R. H. 1996b. Exploration of an interaction threshold for the joint toxicity of trichloroethylene and 1,1-dichloroethlene: utilization of a PBPK model. Arch. Toxicol. 70:527-539.
    • (1996) Arch. Toxicol , vol.70 , pp. 527-539
    • El-Masri, H.A.1    Tessari, J.D.2    Yang, R.H.3
  • 37
    • 84874803362 scopus 로고    scopus 로고
    • Elsevier Information Systems GmbH, Press release, August 20th 2007, Accessed October 26, 2007
    • Elsevier Information Systems GmbH. 2007. CrossFire Beilstein database exceeds ten million compounds. Press release, August 20th 2007. http://www.beilstein.com/PR Beilstein%2010m Final.pdf. Accessed October 26, 2007.
    • (2007) CrossFire Beilstein database exceeds ten million compounds
  • 38
    • 0026034835 scopus 로고
    • Acetaldehyde metabolism in different aldehyde dehydrogenase-2 genotypes
    • Enomoto, N., Takase, S., Yasuhara, M., and Takada, A. 1991. Acetaldehyde metabolism in different aldehyde dehydrogenase-2 genotypes. Alcohol Clin. Exp. Res. 15:141-144.
    • (1991) Alcohol Clin. Exp. Res , vol.15 , pp. 141-144
    • Enomoto, N.1    Takase, S.2    Yasuhara, M.3    Takada, A.4
  • 39
    • 0027849697 scopus 로고
    • The future of toxicity prediction with QSAR
    • Enslein, K. 1993. The future of toxicity prediction with QSAR. In Vitro Toxicol. 6:163-169.
    • (1993) In Vitro Toxicol , vol.6 , pp. 163-169
    • Enslein, K.1
  • 40
    • 0017034397 scopus 로고    scopus 로고
    • Fine, D. H., Rounbehler, D. P., Belcher, N. M., and Epstein, S. S. 1976. N-nitroso compounds in air and water. Environmental N-nitroso Compounds Analysis and Formation: Proceedings of a Working Conference Held at the Polytechnical Institute, Tallinn, Estonian SSR, International Agency for Research on Cancer, WHO, Publication No. 14, Lyon, France, pp. 401-408.
    • Fine, D. H., Rounbehler, D. P., Belcher, N. M., and Epstein, S. S. 1976. N-nitroso compounds in air and water. Environmental N-nitroso Compounds Analysis and Formation: Proceedings of a Working Conference Held at the Polytechnical Institute, Tallinn, Estonian SSR, International Agency for Research on Cancer, WHO, Publication No. 14, Lyon, France, pp. 401-408.
  • 41
    • 0029056227 scopus 로고
    • Pharmacokinetic dose estimates of mercury in children and dose-response curves of performance tests in large epidemiological study
    • Gearhart, J.M., Clewell, H. J., Crump, K. S., Shipp, A.M., and Silvers, A. 1995. Pharmacokinetic dose estimates of mercury in children and dose-response curves of performance tests in large epidemiological study. Water Air Soil Pollut. 80:49-58.
    • (1995) Water Air Soil Pollut , vol.80 , pp. 49-58
    • Gearhart, J.M.1    Clewell, H.J.2    Crump, K.S.3    Shipp, A.M.4    Silvers, A.5
  • 43
    • 0034874732 scopus 로고    scopus 로고
    • A PBPK modeling-based approach to account for interactions in the health risk assessment of chemical mixtures
    • Haddad, S., Béliveau, M., Tardif, R., and Krishnan, K. 2001. A PBPK modeling-based approach to account for interactions in the health risk assessment of chemical mixtures. Toxicol. Sci. 63:125-131.
    • (2001) Toxicol. Sci , vol.63 , pp. 125-131
    • Haddad, S.1    Béliveau, M.2    Tardif, R.3    Krishnan, K.4
  • 44
    • 0034665623 scopus 로고    scopus 로고
    • Validation of a physiological modeling framework for simulating the toxicokinetics of chemicals in mixtures
    • Haddad, S., Charest-Tardif, G., Tardif, R., and Krishnan, K. 2000. Validation of a physiological modeling framework for simulating the toxicokinetics of chemicals in mixtures. Toxicol. Appl. Pharm. 167:199-209.
    • (2000) Toxicol. Appl. Pharm , vol.167 , pp. 199-209
    • Haddad, S.1    Charest-Tardif, G.2    Tardif, R.3    Krishnan, K.4
  • 45
    • 0033572851 scopus 로고    scopus 로고
    • Physiological modeling of the toxicokinetics interactions in a quaternarymixture of aromatic hydrocarbons
    • Haddad, S., Tardif, R., Charest-Tardif, G., and Krishnan, K. 1999. Physiological modeling of the toxicokinetics interactions in a quaternarymixture of aromatic hydrocarbons. Toxicol. Appl. Pharm. 161:249-257.
    • (1999) Toxicol. Appl. Pharm , vol.161 , pp. 249-257
    • Haddad, S.1    Tardif, R.2    Charest-Tardif, G.3    Krishnan, K.4
  • 46
    • 0029080388 scopus 로고
    • The expanding role of quantitative structure-activity relationships (QSAR) in toxicology
    • Hansch, C., Hoekman, D., Leo, A., Zhang, L., and Li, P. 1995. The expanding role of quantitative structure-activity relationships (QSAR) in toxicology. Toxicol. Lett. 79:45-53.
    • (1995) Toxicol. Lett , vol.79 , pp. 45-53
    • Hansch, C.1    Hoekman, D.2    Leo, A.3    Zhang, L.4    Li, P.5
  • 52
    • 4444246492 scopus 로고    scopus 로고
    • Visualization-based analysis for a mixed-inhibition binary PBPK model: Determination of inhibition mechanism
    • Isaacs, K. K., Evans, M. V., and Harris, T. R. 2004. Visualization-based analysis for a mixed-inhibition binary PBPK model: determination of inhibition mechanism. J. Pharmacokinet. Pharmacodyn. 31:215-242.
    • (2004) J. Pharmacokinet. Pharmacodyn , vol.31 , pp. 215-242
    • Isaacs, K.K.1    Evans, M.V.2    Harris, T.R.3
  • 53
    • 40949111951 scopus 로고
    • Application of chromosomal aberration tests in vitro to the primary screening for chemicals with carcinogenic and/or genetic hazards
    • Garattini, S, Ed, Centre de Recherches Clin Midy, Montpellier, France, pp
    • Ishidate, M. 1983. Application of chromosomal aberration tests in vitro to the primary screening for chemicals with carcinogenic and/or genetic hazards. In: Garattini, S. (Ed.), Tests courts de cancérogénèse: Quo vadis?, Centre de Recherches Clin Midy, Montpellier, France, pp. 57-79.
    • (1983) Tests courts de cancérogénèse: Quo vadis , pp. 57-79
    • Ishidate, M.1
  • 54
    • 0002312703 scopus 로고
    • Chromosomal aberration tests in vitro as a primary screening tool for environmental mutagens and/or carcinogens
    • Ishidate, M., Sofuni, T., and Yoshikawa, K. 1981. Chromosomal aberration tests in vitro as a primary screening tool for environmental mutagens and/or carcinogens. GANN Monogr. Cancer Res. 27:95-108.
    • (1981) GANN Monogr. Cancer Res , vol.27 , pp. 95-108
    • Ishidate, M.1    Sofuni, T.2    Yoshikawa, K.3
  • 56
    • 0031417434 scopus 로고    scopus 로고
    • The toxicologic hazard of superfund hazardous waste sites
    • Johnson, B. L., and De Rosa, C. T. 1997. The toxicologic hazard of superfund hazardous waste sites. Rev. Environ. Health 12:235-251.
    • (1997) Rev. Environ. Health , vol.12 , pp. 235-251
    • Johnson, B.L.1    De Rosa, C.T.2
  • 58
    • 0035894424 scopus 로고    scopus 로고
    • In vivo interaction between chlorpyrifos and parathion in adult rats: Sequence of administration canmarkedly influence toxic outcome
    • Karanth, S., Olivier, K., Liu, J., and Pope, C. 2001. In vivo interaction between chlorpyrifos and parathion in adult rats: sequence of administration canmarkedly influence toxic outcome. Toxicol. Appl. Pharmacol. 177:247-255.
    • (2001) Toxicol. Appl. Pharmacol , vol.177 , pp. 247-255
    • Karanth, S.1    Olivier, K.2    Liu, J.3    Pope, C.4
  • 59
    • 0017754460 scopus 로고
    • Distribution, movement, persistence, and metabolism of N nitrosoatrazine in soils and a model aquatic ecosystem
    • Kearney, P. C., Oliver, J. E., Helling, C. S., Isensee, A. R., and Kontson, A. 1977. Distribution, movement, persistence, and metabolism of N nitrosoatrazine in soils and a model aquatic ecosystem. J. Agric. Food Chem. 25:1177-1181.
    • (1977) J. Agric. Food Chem , vol.25 , pp. 1177-1181
    • Kearney, P.C.1    Oliver, J.E.2    Helling, C.S.3    Isensee, A.R.4    Kontson, A.5
  • 60
    • 0021529312 scopus 로고
    • Artificial intelligence approach to structure-activity studies. Computer automated structure evaluation of biological activity of organic molecules
    • Klopman, G. 1984. Artificial intelligence approach to structure-activity studies. Computer automated structure evaluation of biological activity of organic molecules. J. Amer. Chem. Soc. 106:7315-7320.
    • (1984) J. Amer. Chem. Soc , vol.106 , pp. 7315-7320
    • Klopman, G.1
  • 61
    • 0018958812 scopus 로고
    • The analysis of N-nitrosoatrazine and N-nitrosocarbaryl in whole mice
    • Krull, I. S., Mills, K., Hoffman, G., and Fine, D. H. 1980. The analysis of N-nitrosoatrazine and N-nitrosocarbaryl in whole mice. J. Anal. Toxicol. 4:260-262.
    • (1980) J. Anal. Toxicol , vol.4 , pp. 260-262
    • Krull, I.S.1    Mills, K.2    Hoffman, G.3    Fine, D.H.4
  • 62
    • 0026721954 scopus 로고
    • Glomerular filtration rate in pregnancy; a study in normal subjects and in patients with hypertension, preeclampsia and diabetes
    • Krutzen, F., Olofsson, P., Back, S. E., and Nilsson-Ehle, P. 1992. Glomerular filtration rate in pregnancy; a study in normal subjects and in patients with hypertension, preeclampsia and diabetes. Scand. J. Clin. Lab. Invest. 52:387-392.
    • (1992) Scand. J. Clin. Lab. Invest , vol.52 , pp. 387-392
    • Krutzen, F.1    Olofsson, P.2    Back, S.E.3    Nilsson-Ehle, P.4
  • 67
    • 0028557504 scopus 로고
    • Involvement of genetic polymorphism of alcohol and aldehyde dehydrogenases in individual variation of alcohol metabolism
    • Mizoi, Y., Yamamoto, K., Ueno, Y., Fukunaga, T., and Harada, S. 1994. Involvement of genetic polymorphism of alcohol and aldehyde dehydrogenases in individual variation of alcohol metabolism. Alcohol Alcohol 29:707-710.
    • (1994) Alcohol Alcohol , vol.29 , pp. 707-710
    • Mizoi, Y.1    Yamamoto, K.2    Ueno, Y.3    Fukunaga, T.4    Harada, S.5
  • 68
    • 0027000809 scopus 로고
    • A weight-of-evidence approach for assessing interactions in chemical mixtures
    • Mumtaz, M. M., and Durkin, P. R. 1992. A weight-of-evidence approach for assessing interactions in chemical mixtures. Toxicol. Ind. Health 8:377-406.
    • (1992) Toxicol. Ind. Health , vol.8 , pp. 377-406
    • Mumtaz, M.M.1    Durkin, P.R.2
  • 69
    • 0029082966 scopus 로고
    • Assessment of effect levels of chemicals from quantitative structure-activity relationship (QSAR) models. I. Chronic lowest-observed- adverse-effect level (LOAEL)
    • Mumtaz, M. M., Knauf, L. A., Reisman, D. J., Peirano, W. B., De Rosa, C. T., Gombar, V. K., Enslein, K., Carter, J. R., Blake, B. W., and Huque, K. I. 1995. Assessment of effect levels of chemicals from quantitative structure-activity relationship (QSAR) models. I. Chronic lowest-observed- adverse-effect level (LOAEL). Toxicol. Lett. 79:131-143.
    • (1995) Toxicol. Lett , vol.79 , pp. 131-143
    • Mumtaz, M.M.1    Knauf, L.A.2    Reisman, D.J.3    Peirano, W.B.4    De Rosa, C.T.5    Gombar, V.K.6    Enslein, K.7    Carter, J.R.8    Blake, B.W.9    Huque, K.I.10
  • 70
    • 34548404819 scopus 로고    scopus 로고
    • Toxicity assessment of unintentional exposure to multiple chemicals
    • Mumtaz, M. M., Ruiz, P., and De Rosa, C. T. 2007. Toxicity assessment of unintentional exposure to multiple chemicals. Toxicol. Appl. Pharm. 223:104-113.
    • (2007) Toxicol. Appl. Pharm , vol.223 , pp. 104-113
    • Mumtaz, M.M.1    Ruiz, P.2    De Rosa, C.T.3
  • 72
    • 0004158548 scopus 로고
    • National Research Council, National Academies Press, Washington DC, p
    • National Research Council. 1994a. Science and Judgment in Risk Assessment, National Academies Press, Washington DC, p. 79.
    • (1994) Science and Judgment in Risk Assessment , pp. 79
  • 73
    • 0004158548 scopus 로고
    • National Research Council, National Academies Press, Washington DC, p
    • National Research Council. 1994b. Science and Judgment in Risk Assessment, National Academies Press, Washington DC, p. 144.
    • (1994) Science and Judgment in Risk Assessment , pp. 144
  • 74
    • 85011385846 scopus 로고    scopus 로고
    • National Research Council, National Academies Press, Washington DC
    • National Research Council. 2006. Human Biomonitoring for Environmental Chemicals, National Academies Press, Washington DC.
    • (2006) Human Biomonitoring for Environmental Chemicals
  • 76
    • 84874809513 scopus 로고    scopus 로고
    • Department of Health and Human Services, Accessed October 26, 2007
    • The National Toxicology Program. 2007. National Toxicology Program. Department of Health and Human Services. http://ntp.niehs.nih.gov. Accessed October 26, 2007.
    • (2007)
  • 77
    • 0028100624 scopus 로고
    • Studies on the correlation between cholinesterase inhibition and target tissue inhibition in pesticide-treated rats
    • Padilla, S., Wilson, V. Z., and Bushnell, P. J. 1994. Studies on the correlation between cholinesterase inhibition and target tissue inhibition in pesticide-treated rats. Toxicology 92:11-25.
    • (1994) Toxicology , vol.92 , pp. 11-25
    • Padilla, S.1    Wilson, V.Z.2    Bushnell, P.J.3
  • 78
    • 0035070087 scopus 로고    scopus 로고
    • The effect of pregnancy on renal clearance of boron in humans: A study based on normal dietary intake of boron
    • Pahl, M. V., Culver, B. D., Strong, P. L., Murray, F. J., and Vaziri, N. D. 2001. The effect of pregnancy on renal clearance of boron in humans: a study based on normal dietary intake of boron. Toxicol. Sci. 60:252-256.
    • (2001) Toxicol. Sci , vol.60 , pp. 252-256
    • Pahl, M.V.1    Culver, B.D.2    Strong, P.L.3    Murray, F.J.4    Vaziri, N.D.5
  • 79
    • 0031172737 scopus 로고    scopus 로고
    • Using structural information to create physiologically based pharmacokinetic models for all polychlorinated biphenyls: I. Tissue:blood partition coefficients
    • Parham, F. M., Kohn, M. C., Matthews, H. B., De Rosa, C. T., and Portier, C. J. 1997. Using structural information to create physiologically based pharmacokinetic models for all polychlorinated biphenyls: I. Tissue:blood partition coefficients. Toxicol. Appl. Pharm. 144:340-334.
    • (1997) Toxicol. Appl. Pharm , vol.144 , pp. 340-334
    • Parham, F.M.1    Kohn, M.C.2    Matthews, H.B.3    De Rosa, C.T.4    Portier, C.J.5
  • 82
    • 85033049722 scopus 로고    scopus 로고
    • Developmental toxicity NOAEL and postnatal recovery in rats fed boric acid during gestation
    • Price, C. J., Strong, P. L., Marr, M. C., Myers, C. B., and Murray, F. J. 1996. Developmental toxicity NOAEL and postnatal recovery in rats fed boric acid during gestation. Fund. Appl. Toxicol. 32:179-193.
    • (1996) Fund. Appl. Toxicol , vol.32 , pp. 179-193
    • Price, C.J.1    Strong, P.L.2    Marr, M.C.3    Myers, C.B.4    Murray, F.J.5
  • 83
    • 40949113705 scopus 로고    scopus 로고
    • Addressing Priority Data Needs for Methylene Chloride with Physiologically Based Pharmacokientic Modeling, RHR Consulting Services, Midland, MI, and ChemRisk Division, McLaren/Hart, Cleveland, OH
    • Reitz, R. H., Hays, S. M., and Gargas, M. L. 1997. Addressing Priority Data Needs for Methylene Chloride with Physiologically Based Pharmacokientic Modeling, RHR Consulting Services, Midland, MI, and ChemRisk Division, McLaren/Hart, Cleveland, OH. Prepared for ATSDR on behalf of the Halogenated Solvents Industry Alliance, 1-38.
    • (1997) Prepared for ATSDR on behalf of the Halogenated Solvents Industry Alliance , pp. 1-38
    • Reitz, R.H.1    Hays, S.M.2    Gargas, M.L.3
  • 84
    • 0023751819 scopus 로고
    • Incorporation of in vitro enzyme data into the physiologically-based pharmacokinetic (PB-PK) model for methylene chloride: Implications for risk assessment
    • Reitz, R. H., Mendrala, A. L., Park, C. N., Andersen, M. E., and Guengerich, F. P. 1988. Incorporation of in vitro enzyme data into the physiologically-based pharmacokinetic (PB-PK) model for methylene chloride: implications for risk assessment. Toxicol. Lett 43:97-116.
    • (1988) Toxicol. Lett , vol.43 , pp. 97-116
    • Reitz, R.H.1    Mendrala, A.L.2    Park, C.N.3    Andersen, M.E.4    Guengerich, F.P.5
  • 86
    • 0025863682 scopus 로고
    • Computer prediction of possible toxic action from chemical structure; the DEREK system
    • Sanderson, D. M., and Earnshaw, C. G. 1991. Computer prediction of possible toxic action from chemical structure; the DEREK system. Hum. Exp. Toxicol. 10:261-273.
    • (1991) Hum. Exp. Toxicol , vol.10 , pp. 261-273
    • Sanderson, D.M.1    Earnshaw, C.G.2
  • 87
    • 13844315559 scopus 로고    scopus 로고
    • CYP2C9 gene variants, drug dose, and bleeding risk in warfarin-treated patients: A HuGEnet systematic review and meta-analysis
    • Sanderson, S., Emery, J., and Higgins, J. 2005. CYP2C9 gene variants, drug dose, and bleeding risk in warfarin-treated patients: a HuGEnet systematic review and meta-analysis. Genet. Med. 7:97-104.
    • (2005) Genet. Med , vol.7 , pp. 97-104
    • Sanderson, S.1    Emery, J.2    Higgins, J.3
  • 88
    • 0021699083 scopus 로고
    • Human pharmacokinetics and safety of boric acid
    • Schou, J. S., Jansen, J. A., and Aggerbeck, B. 1984. Human pharmacokinetics and safety of boric acid. Arch. Toxicol. 7:232-235.
    • (1984) Arch. Toxicol , vol.7 , pp. 232-235
    • Schou, J.S.1    Jansen, J.A.2    Aggerbeck, B.3
  • 89
    • 0016795112 scopus 로고
    • The effects of maternally inhaled trichloroethylene, perchloroethane, methyl chloroform, and methylene chloride on embryonal and fetal development in mice and rats
    • Schwetz, B. A., Leong, P. J., and Gehring, P. J. 1975. The effects of maternally inhaled trichloroethylene, perchloroethane, methyl chloroform, and methylene chloride on embryonal and fetal development in mice and rats. Toxicol. Appl. Pharm. 32:84-96.
    • (1975) Toxicol. Appl. Pharm , vol.32 , pp. 84-96
    • Schwetz, B.A.1    Leong, P.J.2    Gehring, P.J.3
  • 90
    • 35848950758 scopus 로고    scopus 로고
    • Genetic heterogeneity and its effect on susceptibility to environmental factors
    • Scinicariello, F., and De Rosa, C. T. 2007. Genetic heterogeneity and its effect on susceptibility to environmental factors. Eur. J. Oncol. 12:155-170.
    • (2007) Eur. J. Oncol , vol.12 , pp. 155-170
    • Scinicariello, F.1    De Rosa, C.T.2
  • 92
    • 0031149782 scopus 로고    scopus 로고
    • Physiologically based pharmacokinetic modeling of a ternary mixture of alkyl benzenes in rats and humans
    • Tardif, R., Charest-Tarif, G., Brodeur, J., and Krishnan, K. 1997. Physiologically based pharmacokinetic modeling of a ternary mixture of alkyl benzenes in rats and humans. Toxicol. Appl. Pharmacol. 144:120-134.
    • (1997) Toxicol. Appl. Pharmacol , vol.144 , pp. 120-134
    • Tardif, R.1    Charest-Tarif, G.2    Brodeur, J.3    Krishnan, K.4
  • 93
    • 2442637546 scopus 로고    scopus 로고
    • U.S. Census Bureau, US Census Bureau, Washington DC
    • U.S. Census Bureau. 2002. Census 2000 Basics. US Census Bureau, Washington DC.
    • (2002) Census 2000 Basics
  • 94
    • 84874796170 scopus 로고    scopus 로고
    • Accessed October 26, 2007
    • U.S. Census Bureau. 2006. http://quickfacts.census.gov/qfd. Accessed October 26, 2007.
    • (2006)
  • 95
    • 0001372176 scopus 로고
    • Guidelines for the Health Risk Assessment of Chemical Mixtures
    • U.S. Environmental Protection Agency
    • U.S. Environmental Protection Agency. 1986. Guidelines for the Health Risk Assessment of Chemical Mixtures. Federal Register, vol 51 185, 34014-34025.
    • (1986) Federal Register , vol.51 , Issue.185 , pp. 34014-34025
  • 96
    • 84874806827 scopus 로고    scopus 로고
    • U.S. Environmental Protection Agency. 2002. Supplementary Guidance for Conducting Heath Risk Assessment of Chemical Mixtures. EPA/630/R-00/002. 2000a. http://cfpub.epa.gov/ncea/raf/chem mix.cfm. Accessed October 26, 2007.
    • U.S. Environmental Protection Agency. 2002. Supplementary Guidance for Conducting Heath Risk Assessment of Chemical Mixtures. EPA/630/R-00/002. 2000a. http://cfpub.epa.gov/ncea/raf/chem mix.cfm. Accessed October 26, 2007.
  • 97
    • 84874793884 scopus 로고    scopus 로고
    • U.S. EPA, Washington, DC, Accessed October 26, 2007
    • U.S. Environmental Protection Agency. 2007a. National Priorities List Sites in the United States, U.S. EPA, Washington, DC. http://www.epa.gov/ superfund/sites/npl/npl.htm. Accessed October 26, 2007.
    • (2007) National Priorities List Sites in the United States
  • 98
    • 79954425652 scopus 로고    scopus 로고
    • U.S. EPA, Washington, DC, Accessed October 26, 2007
    • U.S. Environmental Protection Agency. 2007b. High Production Volume (HPV) Challenge Program, U.S. EPA, Washington, DC. http://www.epa.gov/hpv/ index.htm. Accessed October 26, 2007.
    • (2007) High Production Volume (HPV) Challenge Program
  • 99
    • 0028589394 scopus 로고
    • Use of inductively coupled plasma-mass spectrometry in boron-10 stable isotope experiments with plants, rats, and humans
    • Vanderpool, R. A., Hof, D., and Johnson, P. E. 1994. Use of inductively coupled plasma-mass spectrometry in boron-10 stable isotope experiments with plants, rats, and humans. Environ. Health Perspect. 102(Suppl 7):13-20.
    • (1994) Environ. Health Perspect , vol.102 , Issue.SUPPL. 7 , pp. 13-20
    • Vanderpool, R.A.1    Hof, D.2    Johnson, P.E.3
  • 101
    • 40949108059 scopus 로고    scopus 로고
    • Evaluation of PCB exposure routes in Anniston, Alabama: Assessment of fish consumption using PBPK modeling of PCB congeners in locally-caught fish
    • Welsh, C. J., Moffet, D., El-Masri, H., Fowler, D., and Moore, S. 2003. Evaluation of PCB exposure routes in Anniston, Alabama: assessment of fish consumption using PBPK modeling of PCB congeners in locally-caught fish. Toxicologist 72:364.
    • (2003) Toxicologist , vol.72 , pp. 364
    • Welsh, C.J.1    Moffet, D.2    El-Masri, H.3    Fowler, D.4    Moore, S.5
  • 102
    • 0030316831 scopus 로고    scopus 로고
    • Investigating ratios of health effect levels using ATSDR's HazDat database: Extrapolation methodologies in quantitative risk assessment
    • Williams-Johnson, M. M., Henriques, W., and Fay, R. M. 1996. Investigating ratios of health effect levels using ATSDR's HazDat database: Extrapolation methodologies in quantitative risk assessment. J. Clean. Technol. Environ. Toxicol. Occup. Med. 5:347-360.
    • (1996) J. Clean. Technol. Environ. Toxicol. Occup. Med , vol.5 , pp. 347-360
    • Williams-Johnson, M.M.1    Henriques, W.2    Fay, R.M.3
  • 103
    • 40949123490 scopus 로고    scopus 로고
    • The use of decision-support tools to enhance health risk assessments at the Agency for Toxic Substances and Disease Registry
    • De Rosa, C. T, Holler, J. S, and Mehlman, M. A, Eds, International Toxicology Books, Inc, Princeton, NJ, pp
    • Wilson, J. D., Cibulas, W., Choudhary, G., Mumtaz, M. M., and De Rosa, C. T. 2002. The use of decision-support tools to enhance health risk assessments at the Agency for Toxic Substances and Disease Registry. In: De Rosa, C. T., Holler, J. S., and Mehlman, M. A. (Eds.), Impact of Hazardous Chemicals on Public Health, Policy and Service, International Toxicology Books, Inc., Princeton, NJ, pp. 179-200.
    • (2002) Impact of Hazardous Chemicals on Public Health, Policy and Service , pp. 179-200
    • Wilson, J.D.1    Cibulas, W.2    Choudhary, G.3    Mumtaz, M.M.4    De Rosa, C.T.5
  • 104
    • 0345534851 scopus 로고
    • Behavioral effects of methylene chloride and carbon monoxide as assessed by sensory and psychomotor performance
    • Xintaras, C, Johnson, B. L, and de Groot, I, Eds, U.S. Government Printing Office, Washington DC, pp
    • Winneke, G. 1974. Behavioral effects of methylene chloride and carbon monoxide as assessed by sensory and psychomotor performance. In: Xintaras, C., Johnson, B. L., and de Groot, I. (Eds.), Behavioral Toxicology, U.S. Government Printing Office, Washington DC, pp. 130-144.
    • (1974) Behavioral Toxicology , pp. 130-144
    • Winneke, G.1
  • 106
    • 0029153221 scopus 로고
    • Development of structure-activity relationship rules for predicting carcinogenic potential of chemicals
    • Woo, Y., Lai, D., Argus, M., and Arcos, J. 1995. Development of structure-activity relationship rules for predicting carcinogenic potential of chemicals. Toxicol. Lett. 79:219-228.
    • (1995) Toxicol. Lett , vol.79 , pp. 219-228
    • Woo, Y.1    Lai, D.2    Argus, M.3    Arcos, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.