Exploration of an interaction threshold for the joint toxicity of trichloroethylene and 1,1 dichloroethylene: Utilization of a PBPK model

Archives of Toxicology

Volumn 70, Issue 9, 1996, Pages 527-539

  El Masri, Hisham A ^a   Tessari, John D ^a   Yang, Raymond S H ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

1,1 Dichloroethylene; Chlorinated hydrocarbons; Models; Pharmacokinetic; Trichloroethylene

Indexed keywords

CHLORINATED HYDROCARBON; TRICHLOROETHYLENE; VINYLIDENE CHLORIDE;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL INTERACTION; MALE; MODEL; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; RAT; TOXICOKINETICS; XENOBIOTIC METABOLISM;

ANIMALS; ATMOSPHERE EXPOSURE CHAMBERS; BINDING, COMPETITIVE; DICHLOROETHYLENES; DRUG INTERACTIONS; MALE; MODELS, BIOLOGICAL; PULMONARY GAS EXCHANGE; RATS; RATS, INBRED F344; TRICHLOROETHYLENE;

ANIMALIA;

EID: 0029971959     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040050310     Document Type: Article

References (14)

1. Agency for Toxic Substance and Disease Registry (ATSDR) (1989) Toxicology profile for trichloroethylene. ATSDR 1-139
2. Andersen ME, Gargas ML, Jones RA, Jenkins Jr L (1979) The use of inhalation techniques to assess the kinetic constants of 1,1-dichloroethylene metabolism. Toxicol Appl Pharmacol 47: 395-409
3. Andersen ME, Gargas ML, Clewell III HJ, Severyn KM (1987) Quantitative evaluation of the metabolic interaction between trichloroethylene and 1,1-dichloroethylene in vivo using gas uptake methods. Toxicol Appl Pharmacol 89: 149-157
4. Costa AK, Ivanetich KM (1982) Vinylidene chloride. Its metabolism by hepatic microsomal cytochrome P450 in vivo. Biochem Pharmacol 30: 2083-2092
5. Dekant W, Metzler M, Henschler D (1984) Novel metabolites of trichloroethylene through dechlorination reactions in rats, mice and humans. Biochem Pharmacol 33: 2021-2027
6. Dresen MD, Hoffman F (1986) Volatile organic compounds in groundwater west of LLNL, UCRL-53740. Lawrence Livermore National Laboratory, Livermore, Calif. (available form NTIS as DE860 14651)
7. Fisher JW, Gargas ML, Allen BC, Andersen ME (1991) Physiologically based pharmacokinetic modeling with trichloroethylene and its metabolite trichloroacetic acid in the rat and mouse. Toxicol Appl Pharmacol 109: 183-196
8. Gargas ML, Andersen ME, Clewell III HJ (1986) A physiologically based simulation approach for determining metabolic constants form gas uptake data. Toxicol Appl Pharmacol 86: 341-352
9. Grimsud EP, Rasmussen RA (1975) Survey and analysis of hydrocarbons in the atmosphere by gas chromatography mass spectroscopy. Atmos Environ 9: 1014-1017
10. Hushon J, Korneich M (1978) In advances in pharmacology and therapeutics Proc. 7th International conference in pharmacology. Toxicology 9: 123-130
11. Nakajima T, Wang R, Lovaara E, Park SS, Gelboin HV, Vainio H (1992) A comparative study on the contribution of cytochrome P450 isoenzymes to metabolism of benzene, toluene and trichloroethylene in rat liver. Biochem Pharmacol 43[2]: 251-257
12. Sato A, Nakajima T, Koyama Y (1980) Effects of chronic ethanol consumption on hepatic metabolism of aromatic and chlorinated hydrocarbons in rats. Br J Ind Med 37: 382-388
13. World Health Organization (WHO) (1985) Environmental health criteria 50, Trichloroethylene. WHO, Geneva
14. World Health Organization (WHO) (1990) Environmental Health Criteria 100, Vinylidene chloride, ICPS. WHO, Geneva