Visualization-based analysis for a mixed-inhibition binary PBPK model: Determination of inhibition mechanism

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 31, Issue 3, 2004, Pages 215-242

  Isaacs, Kristin K ^a   Evans, Marina V ^b   Harris, Thomas R ^a  

^a VANDERBILT UNIVERSITY   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

binary exposures; chloroform; identifiability analysis; mixtures; PBPK models; sensitivity analysis; trichloroethylene

Indexed keywords

CHLOROFORM; ORGANIC SOLVENT; TRICHLOROETHYLENE;

ACCURACY; ANALYTIC METHOD; ARTICLE; BINDING AFFINITY; ENZYME INHIBITION; EXPERIMENTAL TEST; EXPOSURE; MATHEMATICAL COMPUTING; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; MOLECULAR MODEL; PARAMETER; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SOLVATION;

ANIMALS; CHLOROFORM; DRUG INTERACTIONS; ENZYME INHIBITORS; MALE; MODELS, BIOLOGICAL; MODELS, CHEMICAL; PROTEIN BINDING; RATS; RATS, INBRED F344; SOLVENTS; TISSUE DISTRIBUTION; TRICHLOROETHYLENE;

EID: 4444246492     PISSN: 1567567X     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:JOPA.0000039565.11358.94     Document Type: Article

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