Forced expression of the cell cycle inhibitor p57Kip2 in cardiomyocytes attenuates ischemia-reperfusion injury in the mouse heart

BMC Physiology

Volumn 8, Issue 1, 2008, Pages

  Haley, Sheila A ^a   Zhao, Ting ^b,d   Zou, Lijun ^c,d   Klysik, Jan E ^a   Padbury, James F ^b,d   Kochilas, Lazaros K ^c,d  

^a BROWN UNIVERSITY   (United States)

^b WOMEN AND INFANTS HOSPITAL   (United States)

^c RHODE ISLAND HOSPITAL   (United States)

^d BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1C; CARDIOTONIC AGENT; CDKN1C PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; GENOTYPE; HEART FUNCTION; HEART LEFT VENTRICLE CONTRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART RATE; HEART WEIGHT; ISOLATED HEART; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REPERFUSION INJURY; TRANSGENIC MOUSE; ANIMAL; CELL CULTURE; GENETICS; METABOLISM; PATHOLOGY;

ANIMALS; CARDIOTONIC AGENTS; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P57; MICE; MICE, TRANSGENIC; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC;

EID: 40949106956     PISSN: None     EISSN: 14726793     Source Type: Journal    
DOI: 10.1186/1472-6793-8-4     Document Type: Article

References (42)

1. Sizing up the heart: development redux in disease. EN Olson MD Schneider, Genes Dev 2003 17 16 1937 1956 10.1101/gad.1110103 12893779
2. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. NV Iyer LE Kotch F Agani SW Leung E Laughner RH Wenger M Gassmann JD Gearhart AM Lawler AY Yu GL Semenza, Genes Dev 1998 12 2 149 162 9436976 10.1101/gad.12.2.149
3. Regulation of cardiovascular development and physiology by hypoxia-inducible factor 1. GL Semenza F Agani N Iyer L Kotch E Laughner S Leung A Yu, Ann N Y Acad Sci 1999 874 262 268 10.1111/j.1749-6632.1999.tb09241.x 10415537
4. Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development. F Li X Wang JM Capasso AM Gerdes, J Mol Cell Cardiol 1996 28 8 1737 1746 10.1006/jmcc.1996.0163 8877783
5. Cardiomyocyte DNA synthesis and binucleation during murine development. MH Soonpaa KK Kim L Pajak M Franklin LJ Field, Am J Physiol 1996 271 5 Pt 2 H2183 9 8945939
6. CDK inhibitors: positive and negative regulators of G1-phase progression. CJ Sherr JM Roberts, Genes Dev 1999 13 12 1501 1512 10.1101/gad.13.12.1501 10385618
7. Cell-cycle inhibitors: three families united by a common cause. A Vidal A Koff, Gene 2000 247 1-2 1 15 10.1016/S0378-1119(00)00092-5 10773440
8. Arresting developments in the cardiac myocyte cell cycle: role of cyclin-dependent kinase inhibitors. G Brooks RA Poolman JM Li, Cardiovasc Res 1998 39 2 301 311 10.1016/S0008-6363(98)00125-4 9798515
9. Role of cyclin-dependent kinases and their inhibitors in cellular differentiation and development. SP Chellappan A Giordano PB Fisher, Curr Top Microbiol Immunol 1998 227 57 103 9479826
10. Cardiomyocyte cell cycle regulation. KB Pasumarthi LJ Field, Circ Res 2002 90 10 1044 1054 10.1161/01.RES.0000020201.44772.67 12039793
11. Mice lacking a CDK inhibitor, p57Kip2, exhibit skeletal abnormalities and growth retardation. K Takahashi K Nakayama K Nakayama, J Biochem (Tokyo) 2000 127 1 73 83 10731669
12. Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development. Y Yan J Frisen MH Lee J Massague M Barbacid, Genes Dev 1997 11 8 973 983 10.1101/gad.11.8.973 9136926
13. Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome. P Zhang NJ Liegeois C Wong M Finegold H Hou JC Thompson A Silverman JW Harper RA DePinho SJ Elledge, Nature 1997 387 6629 151 158 10.1038/387151a0 9144284
14. p57Kip2 expression is enhanced during mid-cardiac murine development and is restricted to trabecular myocardium. LK Kochilas J Li F Jin CA Buck JA Epstein, Pediatr Res 1999 45 5 Pt 1 635 642 10.1203/00006450-199905010-00004 10231856
15. Dynamic temporal and spatial regulation of the cdk inhibitor p57(kip2) during embryo morphogenesis. J Westbury M Watkins AC Ferguson-Smith J Smith, Mech Dev 2001 109 1 83 89 10.1016/S0925-4773(01)00512-3 11677056
16. Cyclin-dependent kinase inhibitor expression in human heart failure. A comparison with fetal development. PB Burton MH Yacoub PJ Barton, Eur Heart J 1999 20 8 604 611 10.1053/euhj.1998.1231 10337545
17. p57KIP2 modulates stress-activated signaling by inhibiting c-Jun NH2-terminal kinase/stress-activated protein Kinase. TS Chang MJ Kim K Ryoo J Park SJ Eom J Shim KI Nakayama K Nakayama M Tomita K Takahashi MJ Lee EJ Choi, J Biol Chem 2003 278 48 48092 48098 10.1074/jbc.M309421200 12963725
18. The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia. MO Leonard DC Cottell C Godson HR Brady CT Taylor, J Biol Chem 2003 278 41 40296 40304 10.1074/jbc.M302560200 12885785
19. Inhibition of hypoxia-induced apoptosis by modulation of retinoblastoma protein-dependent signaling in cardiomyocytes. L Hauck G Hansmann R Dietz R von Harsdorf, Circ Res 2002 91 9 782 789 10.1161/01.RES.0000041030.98642.41 12411392
20. Downregulation of cyclin-dependent kinase inhibitors p21 and p27 in pressure-overload hypertrophy. JM Li G Brooks, Am J Physiol 1997 273 3 Pt 2 H1358 67 9321826
21. Ventricular muscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis. J Chen SW Kubalak KR Chien, Development 1998 125 10 1943 1949 9550726
22. Sodium-calcium exchanger is initially expressed in a heart-restricted pattern within the early mouse embryo. SV Koushik J Bundy SJ Conway, Mech Dev 1999 88 1 119 122 10.1016/S0925-4773(99)00177-X 10525196
23. Formation of human myocardium in the rat heart from human embryonic stem cells. MA Laflamme J Gold C Xu M Hassanipour E Rosler S Police V Muskheli CE Murry, Am J Pathol 2005 167 3 663 671 16127147
24. Periodic expression of the cyclin-dependent kinase inhibitor p57(Kip2) in trophoblast giant cells defines a G2-like gap phase of the endocycle. N Hattori TC Davies L Anson-Cartwright JC Cross, Mol Biol Cell 2000 11 3 1037 1045 10712518
25. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part III: cellular and molecular clues to heart and arterial aging. EG Lakatta, Circulation 2003 107 3 490 497 10.1161/01.CIR.0000048894.99865.02 12551876
26. Mitogen-activated protein kinases mediate heat shock-induced delayed protection in mouse heart. D Tekin L Xi T Zhao MI Tejero-Taldo S Atluri RC Kukreja, Am J Physiol Heart Circ Physiol 2001 281 2 H523 32 11454553
27. Inducible nitric oxide synthase mediates delayed myocardial protection induced by activation of adenosine A(1) receptors: evidence from gene-knockout mice. T Zhao L Xi J Chelliah JE Levasseur RC Kukreja, Circulation 2000 102 8 902 907 10952960
28. Protein kinase C-delta mediates adenosine A3 receptor-induced delayed cardioprotection in mouse. TC Zhao RC Kukreja, Am J Physiol Heart Circ Physiol 2003 285 1 H434 41 12793983
29. Cdkn1c (p57Kip2) is the major regulator of embryonic growth within its imprinted domain on mouse distal chromosome 7. SC Andrews MD Wood SJ Tunster SC Barton MA Surani RM John, BMC Dev Biol 2007 7 53 17517131 10.1186/1471-213X-7-53
30. Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation. T Kamura T Hara S Kotoshiba M Yada N Ishida H Imaki S Hatakeyama K Nakayama KI Nakayama, Proc Natl Acad Sci U S A 2003 100 18 10231 10236 12925736 10.1073/pnas.1831009100
31. Signal-induced ubiquitination of p57(Kip2) is independent of the C-terminal consensus Cdk phosphorylation site. MP Leibovitch C Kannengiesser SA Leibovitch, FEBS Lett 2003 543 1-3 125 128 10.1016/S0014-5793(03)00425-3 12753918
32. Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. ZQ Zhao JS Corvera ME Halkos F Kerendi NP Wang RA Guyton J Vinten-Johansen, Am J Physiol Heart Circ Physiol 2003 285 2 H579 88 12860564
33. Toll-like receptor 4 mediates ischemia/reperfusion injury of the heart. AJ Chong A Shimamoto CR Hampton H Takayama DJ Spring CL Rothnie M Yada TH Pohlman ED Verrier, J Thorac Cardiovasc Surg 2004 128 2 170 179 10.1016/j.jtcvs.2003.11.036 15282452
34. Genetic inhibition or activation of JNK1/2 protects the myocardium from ischemia-reperfusion-induced cell death in vivo. RA Kaiser Q Liang O Bueno Y Huang T Lackey R Klevitsky TE Hewett JD Molkentin, J Biol Chem 2005 280 38 32602 32608 10.1074/jbc.M500684200 16043490
35. Akt1 in the cardiovascular system: friend or foe? BT O'Neill ED Abel, J Clin Invest 2005 115 8 2059 2064 16075047 10.1172/JCI25900
36. Cardiac adaptation to ischemia-reperfusion injury. JG Kingma Jr., Ann N Y Acad Sci 1999 874 83 99 10.1111/j.1749-6632.1999.tb09227.x 10415523
37. Roles for alphaB-crystallin and HSPB2 in protecting the myocardium from ischemia-reperfusion-induced damage in a KO mouse model. LE Morrison RJ Whittaker RE Klepper EF Wawrousek CC Glembotski, Am J Physiol Heart Circ Physiol 2004 286 3 H847 55 10.1152/ajpheart.00715.2003 14592939
38. Transgene overexpression of alphaB crystallin confers simultaneous protection against cardiomyocyte apoptosis and necrosis during myocardial ischemia and reperfusion. PS Ray JL Martin EA Swanson H Otani WH Dillmann DK Das, Faseb J 2001 15 2 393 402 10.1096/fj.00-0199com 11156955
39. Increased expression of HSP27 protects canine myocytes from simulated ischemia-reperfusion injury. RS Vander Heide, Am J Physiol Heart Circ Physiol 2002 282 3 H935 41 11834489
40. BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. H Chen S Shi L Acosta W Li J Lu S Bao Z Chen Z Yang MD Schneider KR Chien SJ Conway MC Yoder LS Haneline D Franco W Shou, Development 2004 131 9 2219 2231 10.1242/dev.01094 15073151
41. Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. S Srinivas T Watanabe CS Lin CM William Y Tanabe TM Jessell F Costantini, BMC Dev Biol 2001 1 4 11299042 10.1186/1471-213X-1-4
42. Generalized lacZ expression with the ROSA26 Cre reporter strain. P Soriano, Nat Genet 1999 21 1 70 71 10.1038/5007 9916792