Nuclear polyglutamine-containing protein aggregates as active proteolytic centers

Journal of Cell Biology

Volumn 180, Issue 4, 2008, Pages 697-704

  Chen, Min ^a   Singer, Lena ^a   Scharf, Andrea ^a   Von Mikecz, Anna ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DODECYL SULFATE SODIUM; NANOPARTICLE; NUCLEAR PROTEIN; POLYGLUTAMINE; PROTEASOME; SILICON DIOXIDE; UBIQUITIN;

ARTICLE; CELL NUCLEUS INCLUSION BODY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INDUCTION; REGULATORY MECHANISM;

CELL LINE, TUMOR; CELL NUCLEUS; HUMANS; HYDROLYSIS; INTRANUCLEAR INCLUSION BODIES; MULTIENZYME COMPLEXES; NUCLEAR PROTEINS; PEPTIDE HYDROLASES; PEPTIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN FOLDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; UBIQUITIN;

EID: 40849141062     PISSN: 00219525     EISSN: 00219525     Source Type: Journal    
DOI: 10.1083/jcb.200708131     Document Type: Article

References (28)

1. Anton, L.C., U. Schubert, I. Bacik, M.F. P rinciotta, P.A. Wearsch, J. Gibbs, P.M. Day, C. Realini, M.C. Rechsteiner, J.R. Bennink, and J.W. Yewdell. 1999. Intracellular localization of proteasomal degradation of a viral antigen. J. Cell Biol. 146:113-124.
2. Bence, N.F., R.M. Sampat, and R.R. Kopito. 2001. Impairment of the ubiquitin-proteasome system by protein aggregation. Science. 292:1552-1555.
3. Bennett, E.J., N.F. Bence, R. Jayakumar, and R.R. K opito. 2 005. Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation. Mol. Cell. 17: 351-365.
4. 2 nanoparticles. Exp. Cell Res. 305:51-62.
5. Cooper, J.H. 1969. An evaluation of current methods for the diagnostic histochemistry of amyloid. J. Clin. Pathol. 22:410-413.
6. Dahlmann, B., B. Becher, A. Sobek, C. Ehlers, F. Kopp, and L. Kuehn. 1993. In vitro activation of the 20S proteasome. Enzyme Protein. 47:274-284.
7. Ding, Q., J.J. Lewis, K.M. Strum, E. Dimayuga, A.J. Bruce-Keller, J.C. Dunn, and J.N. Keller. 2002. Polyglutamine expansion, protein aggregation, proteasomal activity, and neuronal survival. J. Biol. Chem. 277: 13935-13942.
8. Filimonenko, M., S. Stuffers, C. Raiborg, A. Yamamoto, L. Malerod, E.M.C. Fisher, A. Isaacs, A. Brech, H. Stenmark, and A. Simonsen. 2007. Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease. J. Cell Biol. 179: 485-500.
9. Freemont, P.S. 2000. Ring for destruction. Curr. Biol. 10:R84-R87.
10. He, D.C., J.A. Nickerson, and S. Penman. 1990. Core filaments of the nuclear matrix. J. Cell Biol. 110:569-580.
11. Holmberg, C.I., K.E. Staniszewski, K.N. Mensah, A. Matouschek, and R.I. Morimoto. 2004. Inefficient degradation of truncated polyglutamine proteins by the proteasome. EMBO J. 23:4307-4318.
12. Janer, A., E. Martin, M.-P. Muriel, M. Latouche, H. Fujigasaki, M. Ruberg, A. Brice, Y. Trottier, and A. Sittler. 2006. PML clastosomes prevent nuclear accumulation of mutant ataxin-7 and other polyglutamine proteins. J. Cell Biol. 174:65-76.
13. Klein, F.A.C., A. Pastore, L. Masino, G. Zeder-Lutz, H. Nierengarten, M. Oulad-Abdelghani, D. Altschuh, J.-L. Mandel, and Y. Trottier. 2007. Pathogenic and non-pathogenic polyglutamine tracts have similar structural properties: towards a length-dependent toxicity gradient. J. Mol. Biol. 371:235-244.
14. 3-induced PML or PML/retinoic acid receptor α degradation. J. Exp. Med. 193: 1361-1371.
15. Nash, T., A.C. Allison, and J.S. Harington. 1966. Physico-chemical properties of silica in relation to its toxicity. Nature. 210:259-261.
16. Perez, M.K., H.L. Paulson, S.J. Pendse, S.J. Saionz, N.M. Bonini, and R.N. Pittman. 1998. Recruitment and the role of nuclear localization in polyglutamine-mediated aggregation. J. Cell Biol. 143:1457-1470.
17. Pines, J., and C. Lindon. 2005. Proteolysis: anytime, any place, anywhere? Nat. Cell Biol. 7:731-735.
18. Qin, Q., R. Inatome, A. Hotta, M. Kojima, H. Yamamura, H. Hirai, T. Yoshizawa, H. Tanaka, K. Fukami, and S. Yanagi. 2006. A novel GTPase, CRAG, mediates promyelocytic leukemia protein-associated nuclear body formation and degradation of expanded polyglutamine protein. J. Cell Biol. 172:497-504.
19. Rajan, R.S., M.E. Illing, N.F. Bence, and R.R. Kopito. 2001. Specificity in intracellular protein aggregation and inclusion body formation. Proc. Natl. Acad. Sci. USA. 98:13060-13065.
20. Rockel, T.D., D. Stuhlmann, and A. von Mikecz. 2005. Proteasomes degrade proteins in focal subdomains of the human cell nucleus. J. Cell Sci. 118: 5231-5242.
21. Ross, C.A. 2002. Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and relating disorders. Neuron. 35: 819-822.
22. Ross, C.A., and C.M. Pickart. 2004. The ubiquitin-proteasome pathway in Parkinson's disease and other neurodegenerative diseases. Trends Cell Biol. 14:703-711.
23. Ross, C.A., M.A. Poirier, E.E. Wanker, and M. Amzel. 2003. Polyglutamine fibrillogenesis: the pathway unfolds. Proc. Natl. Acad. Sci. USA. 100:1-3.
24. Venkatraman, P., R. Wetzel, M. Tanaka, N. Nukina, and A.L. Goldberg. 2004. Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins. Mol. Cell. 14:95-104.
25. Voges, D., P. Zwickl, and W. Baumeister. 1999. T he 26S proteasome: a molecular machine designed for controlled proteolysis. Annu. Rev. Biochem. 68:1015-1067.
26. von Mikecz, A. 2006. The nuclear ubiquitin-proteasome system. J. Cell Sci. 119:1977-1984.
27. Wanker, E.E., E. Scherzinger, V. Heiser, A. Sittler, H. Eickhoff, and H. Lehrach. 1999. Membrane filter assay for detection of amyloid-like polyglutamine-containing protein aggregates. Methods Enzymol. 309:375-386.
28. Wojcik, C., and G.N. DeMartino. 2003. Intracellular localization of proteasomes. Int. J. Biochem. Cell Biol. 35:579-589