-
1
-
-
0023552964
-
Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxy-camptothecin, a novel water-soluble derivative of camptothecin, against murine tumors
-
Kunimoto T, Nitta K, Tanaka T et al. Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxy-camptothecin, a novel water-soluble derivative of camptothecin, against murine tumors. Cancer Res 1987 47 : 5944 7.
-
(1987)
Cancer Res
, vol.47
, pp. 5944-7
-
-
Kunimoto, T.1
Nitta, K.2
Tanaka, T.3
-
2
-
-
0034502464
-
Metabolism of CPT-11 impact on activity
-
Rivory LP. Metabolism of CPT-11 impact on activity. Ann N Y Acad Sci 2000 922 : 205 15.
-
(2000)
Ann N Y Acad Sci
, vol.922
, pp. 205-15
-
-
Rivory, L.P.1
-
3
-
-
0034509633
-
Mechanism of action of camptothecin
-
Liu LF, Desai SD, Li TK, Mao Y, Sun M, Sim SP. Mechanism of action of camptothecin. Ann N Y Acad Sci 2000 922 : 1 10.
-
(2000)
Ann N Y Acad Sci
, vol.922
, pp. 1-10
-
-
Liu, L.F.1
Desai, S.D.2
Li, T.K.3
Mao, Y.4
Sun, M.5
Sim, S.P.6
-
4
-
-
0027194943
-
Phase II study of CPT-11, a new camptothecin derivative, in metastatic colorectal cancer. CPT-11 Gastrointestinal Cancer Study Group
-
Shimada Y, Yoshino M, Wakui A et al. Phase II study of CPT-11, a new camptothecin derivative, in metastatic colorectal cancer. CPT-11 Gastrointestinal Cancer Study Group. J Clin Oncol 1993 11 : 909 13.
-
(1993)
J Clin Oncol
, vol.11
, pp. 909-13
-
-
Shimada, Y.1
Yoshino, M.2
Wakui, A.3
-
5
-
-
0032919992
-
Phase II study of a combination of irinotecan and cisplatin against metastatic gastric cancer
-
Boku N, Ohtsu A, Shimada Y et al. Phase II study of a combination of irinotecan and cisplatin against metastatic gastric cancer. J Clin Oncol 1999 17 : 319 23.
-
(1999)
J Clin Oncol
, vol.17
, pp. 319-23
-
-
Boku, N.1
Ohtsu, A.2
Shimada, Y.3
-
6
-
-
0032926512
-
CPT-11 converting carboxylesterase and topoisomerase I activities in tumour and normal colon and liver tissues
-
Guichard S, Terret C, Hennebelle I et al. CPT-11 converting carboxylesterase and topoisomerase I activities in tumour and normal colon and liver tissues. Br J Cancer 1999 80 : 364 70.
-
(1999)
Br J Cancer
, vol.80
, pp. 364-70
-
-
Guichard, S.1
Terret, C.2
Hennebelle, I.3
-
7
-
-
0036023452
-
Irinotecan activation by human carboxylesterases in colorectal adenocarcinoma cells
-
Wu MH, Yan B, Humerickhouse R, Dolan ME. Irinotecan activation by human carboxylesterases in colorectal adenocarcinoma cells. Clin Cancer Res 2002 8 : 2696 700.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 2696-700
-
-
Wu, M.H.1
Yan, B.2
Humerickhouse, R.3
Dolan, M.E.4
-
8
-
-
0034162687
-
Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2
-
Humerickhouse R, Lohrbach K, Li L, Bosron WF, Dolan ME. Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2. Cancer Res 2000 60 : 1189 92.
-
(2000)
Cancer Res
, vol.60
, pp. 1189-92
-
-
Humerickhouse, R.1
Lohrbach, K.2
Li, L.3
Bosron, W.F.4
Dolan, M.E.5
-
9
-
-
0036023423
-
Human carboxylesterase 2 is commonly expressed in tumor tissue and is correlated with activation of irinotecan
-
Xu G, Zhang W, Ma MK, McLeod HL. Human carboxylesterase 2 is commonly expressed in tumor tissue and is correlated with activation of irinotecan. Clin Cancer Res 2002 8 : 2605 11.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 2605-11
-
-
Xu, G.1
Zhang, W.2
Ma, M.K.3
McLeod, H.L.4
-
10
-
-
0025996996
-
Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11
-
Kawato Y, Aonuma M, Hirota Y, Kuga H, Sato K. Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Res 1991 51 : 4187 91.
-
(1991)
Cancer Res
, vol.51
, pp. 4187-91
-
-
Kawato, Y.1
Aonuma, M.2
Hirota, Y.3
Kuga, H.4
Sato, K.5
-
11
-
-
0031058320
-
Glucuronidation of SN-38, the active metabolite of irinotecan, by human hepatic microsomes
-
Haaz M-C, Rivory L, Jantet S, Ratanasavanh D, Robert J. Glucuronidation of SN-38, the active metabolite of irinotecan, by human hepatic microsomes. Pharmacol Toxicol 1997 80 : 91 6.
-
(1997)
Pharmacol Toxicol
, vol.80
, pp. 91-6
-
-
Haaz, M.-C.1
Rivory, L.2
Jantet, S.3
Ratanasavanh, D.4
Robert, J.5
-
12
-
-
13044249156
-
A multidrug resistance transporter from human MCF-7 breast cancer cells
-
Doyle LA, Yang W, Abruzzo LV, Krogmann T, Gao Y, Rishi AK. A multidrug resistance transporter from human MCF-7 breast cancer cells. Proc Natl Acad Sci USA 1998 95 : 15665 70.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 15665-70
-
-
Doyle, L.A.1
Yang, W.2
Abruzzo, L.V.3
Krogmann, T.4
Gao, Y.5
Rishi, A.K.6
-
13
-
-
0033568540
-
Overexpression of the BCRP/MXR/ABCP gene in a topotecan-selected ovarian tumor cell line
-
Maliepaard M, van Gastelen MA, de Jong LA et al. Overexpression of the BCRP/MXR/ABCP gene in a topotecan-selected ovarian tumor cell line. Cancer Res 1999 59 : 4559 63.
-
(1999)
Cancer Res
, vol.59
, pp. 4559-63
-
-
Maliepaard, M.1
Van Gastelen, M.A.2
De Jong, L.A.3
-
14
-
-
0034906472
-
Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918
-
Maliepaard M, van Gastelen MA, Tohgo A et al. Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918. Clin Cancer Res 2001 7 : 935 41.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 935-41
-
-
Maliepaard, M.1
Van Gastelen, M.A.2
Tohgo, A.3
-
15
-
-
0033429542
-
Camptothecin resistance: Role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation in MXR-expressing cells
-
Brangi M, Litman T, Ciotti M et al. Camptothecin resistance: role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation in MXR-expressing cells. Cancer Res 1999 59 : 5938 46.
-
(1999)
Cancer Res
, vol.59
, pp. 5938-46
-
-
Brangi, M.1
Litman, T.2
Ciotti, M.3
-
16
-
-
0029760995
-
Identification and properties of a major plasma metabolite of irinotecan (CPT-11) isolated from the plasma of patients
-
Rivory LP, Riou J-F, Haaz M-C et al. Identification and properties of a major plasma metabolite of irinotecan (CPT-11) isolated from the plasma of patients. Cancer Res 1996 56 : 3689 3694.
-
(1996)
Cancer Res
, vol.56
, pp. 3689-3694
-
-
Rivory, L.P.1
Riou, J.-F.2
Haaz, M.-C.3
-
17
-
-
0031871505
-
Identification of a new metabolite of CPT-11 (irinotecan): Pharmacological properties and activation to SN-38
-
Dodds HM, Haaz M-C, Riou J-F, Robert J, Rivory LP. Identification of a new metabolite of CPT-11 (irinotecan): pharmacological properties and activation to SN-38. J Pharmacol Exp Ther 1998 286 : 578 83.
-
(1998)
J Pharmacol Exp Ther
, vol.286
, pp. 578-83
-
-
Dodds, H.M.1
Haaz, M.-C.2
Riou, J.-F.3
Robert, J.4
Rivory, L.P.5
-
18
-
-
0032005259
-
Metabolism of irinotecan (CPT-11) by human hepatic microsomes: Participation of cytochrome P-450 3A and drug interactions
-
Haaz M-C, Rivory LP, Riché C, Vernillet L, Robert J. Metabolism of irinotecan (CPT-11) by human hepatic microsomes: participation of cytochrome P-450 3A and drug interactions. Cancer Res 1998 58 : 468 72.
-
(1998)
Cancer Res
, vol.58
, pp. 468-72
-
-
Haaz, M.-C.1
Rivory, L.P.2
Riché, C.3
Vernillet, L.4
Robert, J.5
-
19
-
-
17444443721
-
Metabolism of irinotecan (CPT-11) by CYP3A4 and CYP3A5 in humans
-
Santos A, Zanetta S, Cresteil T et al. Metabolism of irinotecan (CPT-11) by CYP3A4 and CYP3A5 in humans. Clin Cancer Res 2000 6 : 2012 20.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 2012-20
-
-
Santos, A.1
Zanetta, S.2
Cresteil, T.3
-
20
-
-
0031046059
-
CPT-11 in human colon-cancer cell lines and xenografts: Characterization of cellular sensitivity determinants
-
Jansen WJM, Zwart B, Hulscher STM, Giaccone G, Pinedo HM, Boven E. CPT-11 in human colon-cancer cell lines and xenografts: characterization of cellular sensitivity determinants. Int J Cancer 1997 70 : 335 40.
-
(1997)
Int J Cancer
, vol.70
, pp. 335-40
-
-
Jansen, W.J.M.1
Zwart, B.2
Hulscher, S.T.M.3
Giaccone, G.4
Pinedo, H.M.5
Boven, E.6
-
21
-
-
0031800370
-
Determinants of CPT-11 and SN-38 activities in human lung cancer cells
-
van Ark-Otte J, Kedde MA, van der Vijgh WJF et al. Determinants of CPT-11 and SN-38 activities in human lung cancer cells. Br J Cancer 1998 77 : 2171 6.
-
(1998)
Br J Cancer
, vol.77
, pp. 2171-6
-
-
Van Ark-Otte, J.1
Kedde, M.A.2
Van Der Vijgh, W.J.F.3
-
22
-
-
3042569646
-
Phytoestrogens/flavonoids reverse breast cancer resistance protein/ABCG2-mediated multidrug resistance
-
Imai Y, Tsukahara S, Asada S, Sugimoto Y. Phytoestrogens/flavonoids reverse breast cancer resistance protein/ABCG2-mediated multidrug resistance. Cancer Res 2004 64 : 4346 52.
-
(2004)
Cancer Res
, vol.64
, pp. 4346-52
-
-
Imai, Y.1
Tsukahara, S.2
Asada, S.3
Sugimoto, Y.4
-
23
-
-
85008135285
-
Establishment and characterization of human hepatoma cell line (KIM-1)
-
Murakami T. Establishment and characterization of human hepatoma cell line (KIM-1). Acta Hepatol Jpn 1984 25 : 532 9.
-
(1984)
Acta Hepatol Jpn
, vol.25
, pp. 532-9
-
-
Murakami, T.1
-
24
-
-
0022903489
-
A new human hepatocellular carcinoma cell line (KYN-1) with a transformation to adenocarcinoma
-
Yano H, Kojiro M, Nakashima T. A new human hepatocellular carcinoma cell line (KYN-1) with a transformation to adenocarcinoma. In Vitro Cell Dev Biol 1986 22 : 637 46.
-
(1986)
In Vitro Cell Dev Biol
, vol.22
, pp. 637-46
-
-
Yano, H.1
Kojiro, M.2
Nakashima, T.3
-
25
-
-
0023687856
-
A new human pleomorphic hepatocellular carcinoma cell line, KYN-2
-
Yano H, Maruiwa M, Murakami T et al. A new human pleomorphic hepatocellular carcinoma cell line, KYN-2. Acta Pathol Jpn 1988 38 : 953 66.
-
(1988)
Acta Pathol Jpn
, vol.38
, pp. 953-66
-
-
Yano, H.1
Maruiwa, M.2
Murakami, T.3
-
26
-
-
0027524642
-
In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative
-
Hyafil F, Vergely C, Du Vignaud P, Grand-Perret T. In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative. Cancer Res 1993 53 : 4595 602.
-
(1993)
Cancer Res
, vol.53
, pp. 4595-602
-
-
Hyafil, F.1
Vergely, C.2
Du Vignaud, P.3
Grand-Perret, T.4
-
27
-
-
0028344958
-
A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: An alternative to [3H] thymidine incorporation assay
-
Ahmed SA, Gogal RM Jr., Walsh JE. A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: an alternative to [3H] thymidine incorporation assay. J Immunol Methods 1994 170 : 211 24.
-
(1994)
J Immunol Methods
, vol.170
, pp. 211-24
-
-
Ahmed, S.A.1
Gogal Jr., R.M.2
Walsh, J.E.3
-
28
-
-
0004304241
-
Evaluation of CAR, Smad4, and KAI1 expression in colorectal tumors by an RT-PCR method
-
In: (eds). Elsevier, Tokyo, Japan
-
Mikami T, Ookawa K, Shimoyama T, Fukuda S, Saito H, Munakata A. Evaluation of CAR, Smad4, and KAI1 expression in colorectal tumors by an RT-PCR method. In : Hashimoto I, Shinkawa H, Suda T et al. (eds). Novel Findings of Gene Diagnosis, Regulation of Gene Expression, and Gene Therapy. Elsevier, Tokyo, Japan, 1999 153 8.
-
(1999)
Novel Findings of Gene Diagnosis, Regulation of Gene Expression, and Gene Therapy.
, pp. 153-8
-
-
Mikami, T.1
Ookawa, K.2
Shimoyama, T.3
Fukuda, S.4
Saito, H.5
Munakata, A.6
Hashimoto, I.7
Shinkawa, H.8
Suda, T.9
-
29
-
-
0032695270
-
Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR
-
de Bruin M, Miyake K, Litman T, Robey R, Bates SE. Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR. Cancer Lett 1999 146 : 117 26.
-
(1999)
Cancer Lett
, vol.146
, pp. 117-26
-
-
De Bruin, M.1
Miyake, K.2
Litman, T.3
Robey, R.4
Bates, S.E.5
-
30
-
-
0035734306
-
Inhibition of human CYP3A4 activity by grapefruit flavonoids, furanocoumarins and related compounds
-
Ho P-C, Saville DJ. Inhibition of human CYP3A4 activity by grapefruit flavonoids, furanocoumarins and related compounds. J Pharm Pharm Sci 2001 4 : 217 27.
-
(2001)
J Pharm Pharm Sci
, vol.4
, pp. 217-27
-
-
Ho, P.-C.1
Saville, D.J.2
-
31
-
-
0034778246
-
Human liver UDP-glucuronosyltransferase isoforms involved in the glucuronidation of 7-ethyl-10-hydroxycamptothecin
-
Hanioka N, Ozawa S, Jinno H, Ando M, Saito Y, Sawada Y. Human liver UDP-glucuronosyltransferase isoforms involved in the glucuronidation of 7-ethyl-10-hydroxycamptothecin. Xenobiotica 2001 31 : 687 99.
-
(2001)
Xenobiotica
, vol.31
, pp. 687-99
-
-
Hanioka, N.1
Ozawa, S.2
Jinno, H.3
Ando, M.4
Saito, Y.5
Sawada, Y.6
-
32
-
-
0029073863
-
Cytotoxicity of CPT-11 for gastrointestinal cancer cells cultured on fixed-contact-sensitive plates
-
Matsuoka H, Yano K, Seo Y, Saito T, Tomoda H, Takiguchi S. Cytotoxicity of CPT-11 for gastrointestinal cancer cells cultured on fixed-contact-sensitive plates. Anticancer Drugs 1995 6 : 413 8.
-
(1995)
Anticancer Drugs
, vol.6
, pp. 413-8
-
-
Matsuoka, H.1
Yano, K.2
Seo, Y.3
Saito, T.4
Tomoda, H.5
Takiguchi, S.6
-
33
-
-
0033883625
-
Hepatotoxicity of camptothecin derivatives in a primary culture system of rat hepatocytes
-
Fulco RA, Costa C, Germano MP et al. Hepatotoxicity of camptothecin derivatives in a primary culture system of rat hepatocytes. J Chemother 2000 12 : 345 51.
-
(2000)
J Chemother
, vol.12
, pp. 345-51
-
-
Fulco, R.A.1
Costa, C.2
Germano, M.P.3
-
34
-
-
0032946239
-
ATP-dependent efflux of CPT-11 and SN-38 by the multidrug resistance protein (MRP) and its inhibition by PAK-104P
-
Chen Z-S, Furukawa T, Sumizawa T, Ono K, Ueda K, Seto K. ATP-dependent efflux of CPT-11 and SN-38 by the multidrug resistance protein (MRP) and its inhibition by PAK-104P. Mol Pharmacol 1999 55 : 921 8.
-
(1999)
Mol Pharmacol
, vol.55
, pp. 921-8
-
-
Chen, Z.-S.1
Furukawa, T.2
Sumizawa, T.3
Ono, K.4
Ueda, K.5
Seto, K.6
-
35
-
-
0028973416
-
The fate of naringin in humans: A key to grapefruit juice-drug interactions?
-
Fuhr U, Kummert AL. The fate of naringin in humans: A key to grapefruit juice-drug interactions? Clin Pharmacol Ther 1995 58 : 365 73.
-
(1995)
Clin Pharmacol Ther
, vol.58
, pp. 365-73
-
-
Fuhr, U.1
Kummert, A.L.2
-
37
-
-
0035150315
-
Plasma kinetics and urinary excretion of the flavanones naringenin and hesperetin in humans after ingestion of orange and grapefruit juice
-
Erlund I, Meririnne E, Alfthan G, Aro A. Plasma kinetics and urinary excretion of the flavanones naringenin and hesperetin in humans after ingestion of orange and grapefruit juice. J Nutr 2001 131 : 235 41.
-
(2001)
J Nutr
, vol.131
, pp. 235-41
-
-
Erlund, I.1
Meririnne, E.2
Alfthan, G.3
Aro, A.4
-
38
-
-
0033786665
-
Complete remission of unresectable hepatocellular carcinoma on healthy liver by the combination of aggressive surgery and high-dose-intensity chemotherapy by CPT-11
-
Gornet J-M, Azoulay D, Duclos-Vallée J-C, Goldwasser F. Complete remission of unresectable hepatocellular carcinoma on healthy liver by the combination of aggressive surgery and high-dose-intensity chemotherapy by CPT-11. Anticancer Drugs 2000 11 : 649 52.
-
(2000)
Anticancer Drugs
, vol.11
, pp. 649-52
-
-
Gornet, J.-M.1
Azoulay, D.2
Duclos-Vallée, J.-C.3
Goldwasser, F.4
-
39
-
-
0036184765
-
Continuous administration of irinotecan by hepatic arterial infusion: A phase I and pharmacokinetic study
-
van Riel JMGH, van Groeningen CJ, Kedde MA et al. Continuous administration of irinotecan by hepatic arterial infusion: a phase I and pharmacokinetic study. Clin Cancer Res 2002 8 : 405 12.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 405-12
-
-
Riel Jmgh, V.1
Van Groeningen, C.J.2
Kedde, M.A.3
-
40
-
-
0035174274
-
A phase II study of irinotecan in patients with advanced hepatocellular carcinoma
-
O'Reilly EM, Stuart KE, Sanz-Altamira PM et al. A phase II study of irinotecan in patients with advanced hepatocellular carcinoma. Cancer 2001 91 : 101 5.
-
(2001)
Cancer
, vol.91
, pp. 101-5
-
-
O'Reilly, E.M.1
Stuart, K.E.2
Sanz-Altamira, P.M.3
|