Gender-dependent differences in the response of human adipocytes to leptin lipolytic action

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 30, Issue 1, 2008, Pages 7-11

  Aguado, M ^a   Martinez Urbistondo D ^a   Solomon, A ^a   Martínez, J Alfredo ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

Author keywords

Gender; Leptin; Lipolysis; Obesity

Indexed keywords

GLYCEROL; LEPTIN;

ADIPOCYTE; ADIPOSE TISSUE; ADULT; AGED; ARTICLE; CONTROLLED STUDY; DRUG DOSE; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; LIPOLYSIS; MALE; SEX DIFFERENCE;

ADIPOCYTES, WHITE; ADULT; AGED; FEMALE; GLYCEROL; HUMANS; LEPTIN; LIPOLYSIS; MALE; MIDDLE AGED; SEX FACTORS;

EID: 40849111531     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2008.30.1.1147772     Document Type: Article

References (55)

1. Kopecky, J., Rossmeils, M., Flachs, P., et al. Energy metabolism of adipose tissue - Physiological aspects and target in obesity treatment. Physiol Res 2004, 3: S225-32.
2. Moreno-Aliaga, M.J., Martínez, J. Adipose tissue: A storage and secretory organ. An Sist Sanit Nav 2002, 25: 29-39.
3. Fortuño, A., Rodriguez, A., Gomez-Ambrosi, J., Frühbeck, G., Diez, J. Adipose tissue as an endocrine organ: Role of leptin and adiponectin in the pathogenesis of cardiovascular diseases. J Physiol Biochem 2003, 59: 51-60.
4. Portillo, M.P., Simon, E., Garcia-Calonge M.A., Del Barrio A.S. Effect of high-fat diet on lipolysis in isolated adipocytes from visceral and subcutaneous WAT. Eur J Nutr 1999, 38: 177-82.
5. Lafontan, M., Langin, D. Cellular aspects of fuel mobilization and selection in white adipocytes. Proc Nutr Soc 1995, 54: 49-63.
6. Pascual, M., Larralde, J., Martinez, J.A. Insulin-like growth factor I (IGF-I) affects plasma lipid profile and inhibits the lipolytic action of growth hormone (GH) in isolated adipocytes. Life Sci 1995, 57: 1213-18.
7. Martínez, J.A., Frühbeck, G. Regulation of energy balance and adiposity: A model with new approaches. J Physiol Biochem 1996, 52: 255-8.
8. Martínez, J.A., Aguado, M., Frühbeck, G. Interactions between leptin and NPY affecting lipid mobilization in adipose tissue. J Physiol Biochem 2000, 56: 1-8.
9. Szkudelsky, T., Szkudelska, K. Streptozotocin induces lipolysis in rat adipocytes in vitro. Physiol Res 2002, 51: 255-9.
10. Rodriguez, V.M., Macarulla, M.T., Echevarria, E., Portillo, M.P. Lipolysis induced by leptin in rat adipose tissue from different anatomical locations. Eur J Nutr 2003, 42: 149-53.
11. Martínez, J.A., Garcia-Granero, M., Fruhbeck, G. Role of fragment peptides from ob protein on body weight and thermogenesis control: A screening. J Physiol Biochem 1996, 52: 123-4.
12. Frühbeck, G. A heliocentric view of leptin. Proc Nutr Soc 2001, 60: 301-18.
13. Frühbeck, G., Gomez-Ambrosi, J., Salvador, J. Leptin-induced lipolysis opposes the tonic inhibition of endogenous adenosine in white adipocytes. FASEB J 2001, 15: 333-40.
14. Marti, A., Berraondo, B., Martínez, J.A. Leptin: Physiological actions. J Physiol Biochem 1999, 55: 43-50.
15. Rodbell, M. Metabolism of isolated fat cells. J Biol Chem 1964, 239: 375-80.
16. Galitzky, J., Reverte, M., Portillo, M., Carpene, C., Lafontan, M., Berlan, M. Coexistence of beta 1-, beta 2-, and beta 3-adrenoceptors in dog fat cells and their differential activation by catecholamines. Am J Physiol 1993, 264: 403-12.
17. Wieland, O. Eine enzymatische methode zur bestimmung von glycerine. Biochem Zeitung 1957, 239: 313-17.
18. Portillo, M.P., del Barrio, A.S., Martinez, J.A. Analysis of the interactions between growth hormone and metaproterenol on lipid mobilization. J Physiol Biochem 1995, 51: 147-54.
19. Dole, V.P., Meinertz, H. Microdetermination of long-chain fatty acids in plasma and tissues. J Biol Chem 1960, 135: 2595-9.
20. Rosenblum, C.I., Vongs, A., Tota, M.R., et al. A rapid, quantitative functional assay for measuring leptin. Mol Cell Endocrinol 1998, 143: 117-23.
21. Ramos, M.P., Crespo, M.D., Del Campo, S., Cacho, J., Herrera, E. Fat accumulation in the rat during early pregnancy is modulated by enhanced insulin responsiveness. Am J Physiol 2003, 285: 318-28.
22. Ramsay, T.G. Fat cells. Endocrinol Metab Clin North Am 1996, 25: 847-70.
23. Frühbeck, G., Aguado, M., Gómez-Ambrosi, J., Martínez, J.A. Lipolytic effect of in vivo leptin administration on adipocytes of lean and ob/ob mice, but not db/db mice. Biochem Biophys Res Commun 1998, 250: 99-102.
24. Bai, Y., Zhang, S., Kim, K.S., Lee, J.K., Kim, K. Obese gene expression alters the ability of preadipocytes to respond to lipogenic hormones. J Biol Chem 1996, 271: 13939-42.
25. Friedman, J.M. The alphabet of weight control. Nature 1997, 385: 119-65.
26. Shimabukuro, M., Koyama, K., Chen, G., et al. Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc Natl Acad Sci 1997, 94: 4637-41.
27. Siegrist-Kaiser, C.A., Pauli, V., Juge-Aubry, C.E., et al. Direct effects of leptin on brown and white adipose tissue. J Clin Investig 1997, 100: 2858-64.
28. Atkinson, L.L., Fischer, M.A., Lopaschuk, G.D. Leptin activates cardiac fatty acid oxidation independent of changes in the AMP-activated protein kinase-acetyl-CoA carboxylase-malonyl-CoA axis. J Biol Chem 2002, 277: 29424-30.
29. Minokoshi, Y., Kim, Y.B., Peroni, O.D., et al. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 2002, 415: 339-43.
30. Auwerx, J., Staels, B. Leptin. Lancet 1998, 351: 737-42.
31. Zabeau, L., Defeau, D., Van der Heyden, J., Iserentant, H., Vandekerckhove, J., Tavernier, J. Functional analysis of leptin receptor activation using a Janus kinase/signal transducer and activator of transcription complementation assay. Mol Endocrinol 2004, 18: 150-61.
32. Marti, A., Aguado, M., Martínez-Anso, E., Martínez, J.A. The MAP kinase pathways mediate leptin-induced lipolysis. J Physiol Biochem 2001, 57: 107-8.
33. Yamashita, T., Murakami, T., Otani, S., Kuwajima, M., Shima, K. Leptin receptor signal transduction: OBRa and OBRb type. Biochem Biophys Res Commun 1998, 246: 752-9.
34. Frühbeck, G., Gomez-Ambrosi, J. Depot-specific differences in the lipolytic effect of leptin on isolated white adipocytes. Med Sci Monitor 2002, 8: 47-55.
35. Frühbeck, G., Gomez-Ambrosi, J. Modulation of the leptin-induced white adipose tissue lipolysis by nitric oxide. Cell Signall 2002, 13: 827-33.
36. Szkudelsky, T., Nowicka, E., Szkudelska, K. Leptin secretion and protein kinase A activity. Physiol Res 2005, 54: 79-85.
37. Nedvidkova, J., Smitra, K., Kopsky, V., Hainer, V. Adiponectin, an adipocyte-derived protein. Physiol Res 2005, 54: 133-40.
38. Frühbeck, G., Aguado, M., Martínez, J.A. In vitro lipolytic effect of leptin on mouse adipocytes: Evidence for a possible autocrine/paracrine role of leptin. Biochem Biophys Res Commun 1997, 240: 590-4.
39. Lee, G.H., Proenca, R., Montez, J.M., et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996, 379: 632-5.
40. Muller, G., Ertl, J., Gerl, M., Preibisch, G. Leptin impairs metabolic actions of insulin in isolated rat adipocytes. J Biol Chem 1997, 272: 10585-93.
41. Campfield, L.A., Smith, F.J., Guisez, Y., Devos, R., Burn, P. OB protein: Evidence for a peripheral signal linking adiposity and central neural networks. Science 1995, 269: 546-9.
42. Elimann, A., Kamel, A., Marcus, C. In vitro effects of leptin on human adipocyte metabolism. Horm Res 2002, 58: 88-93.
43. Havel, P.J. Update on adipocyte hormones: Regulation of energy balance and carbohydrate/lipid metabolism. Diabetes 2004, 53: S143-51.
44. Reynisdottir, S., Dauzats, M., Thorne, A., Langin, D. Comparison of hormone-sensitive lipase activity in visceral and subcutaneous human adipose tissue. J Clin Endocrinol Metab 1987, 82: 4162-6.
45. Rebuffe-Scrive, M., Andersson, B., Olbe, L., Bjorntorp, P. Metabolism of adipose tissue in intraabdominal depots of non-obese men and women. Metabolism 1989, 38: 453-8.
46. Lofgren, P., Hoffstedt, J., Ryden, M., et al. Major gender differences in the lypolytic capacity of abdominal subcutaneous fat cells in obesity observed before and after long-term weight reduction. J Clin Endocrinol Metabol 2002, 87: 764-71.
47. Gullicksen, P.S., Della-Fera, M.A., Baile, C.A. Leptin-induced adipose apoptosis: Implications for body weight regulation. Apoptosis 2003, 8: 327-35.
48. Wagoner, B., Hausman, D.B., Harris, R.B. Direct and indirect effects of leptin on preadipocyte proliferation and differentiation. Am J Physiol 2006, 290: R1557-64.
49. Chan, J.L., Bluher, S., Yiannakouris, N., Suchard, M.A., Kratzsch, J., Mantzoros, C.S. Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: Observational and interventional studies in humans. Diabetes 2002, 51: 2105-12.
50. Tchernof, A., Desmeules, A., Richard, C., Daris, M. Ovarian hormone status and abdominal visceral adipose tissue metabolism. J Clin Endocrinol Metab 2004, 89: 3425-30.
51. Magni, P., Liuzzi, A., Ruscica, M., et al. Free and bound plasma leptin in normal weight and obese men and women: Relationship with body composition, resting energy expenditure, insulin-sensitivity, lipid profile and macronutrient preference. Clin Endocrinol 2005, 62: 189-96.
52. Bayes, M., Rabasseda, X., Prous, J.R. Gateways to clinical trials. Methods Find Exp Clin Pharmacol 2006, 28: 121-42.
53. Foster-Schubert, K.E., Cummings, D.E. Emerging therapeutic strategies for obesity. Endocr Rev 2006, 27: 779-93.
54. Rosado, E.L., Monteiro, J.B., Chaia, V., do Lago, M.F. Effect of leptin in the treatment of obesity and influences of diet in the secretion and action of hormone. Nutr Hosp 2006, 21: 686-93.
55. Correia, M.L., Haynes, W.G. Lessons from Leptin's molecular biology: Potential therapeutic actions of recombinant leptin and leptin-related compounds. Mini Rev Med Chem 2007, 7: 31-8.