Contribution of obesity to pancreatic carcinogenesis

Surgery for Obesity and Related Diseases

Volumn 4, Issue 2, 2008, Pages 186-193

  Gumbs, Andrew A ^a   Bessler, Marc ^a   Milone, Luca ^a   Schrope, Beth ^a   Chabot, John ^a  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; TUMOR MARKER;

ALCOHOL CONSUMPTION; CANCER INCIDENCE; CANCER MORTALITY; CANCER REGISTRY; CARCINOGENESIS; CHRONIC PANCREATITIS; COMORBIDITY; DEATH; DIABETES MELLITUS; ENVIRONMENTAL FACTOR; FAT INTAKE; GENE MUTATION; GLUCOSE METABOLISM; HEREDITY; HUMAN; IMMOBILIZATION; MOLECULAR GENETICS; OBESITY; PANCREAS CANCER; PATHOGENESIS; PREVALENCE; PRIORITY JOURNAL; REVIEW; RISK FACTOR; UNITED STATES;

DIET; GENETIC PREDISPOSITION TO DISEASE; HUMANS; OBESITY; PANCREATIC NEOPLASMS; RISK FACTORS; TUMOR MARKERS, BIOLOGICAL; UNITED STATES;

EID: 40849097551     PISSN: 15507289     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.soard.2007.11.009     Document Type: Review

References (81)

1. Fraumeni Jr. J.F. Cancers of the pancreas and biliary tract: epidemiological considerations. Cancer Res 35 (1975) 3437-3446
2. Gumbs A.A., Moore P.S., Falconi M., et al. Review of the clinical, histological, and molecular aspects of pancreatic endocrine neoplasms. J Surg Oncol 81 (2002) 45-54
3. Freelove R., and Walling A.D. Pancreatic cancer: diagnosis and management. Am Fam Physician 73 (2006) 485-492
4. Michaud D.S. Epidemiology of pancreatic cancer. Minerva Chir 59 (2004) 99-111
5. Weiderpass E., Partanen T., Kaaks R., et al. Occurrence, trends and environment etiology of pancreatic cancer. Scand J Work Environ Health 24 (1998) 165-174
6. Gumbs A.A., Modlin I.M., and Ballantyne G.H. Changes in insulin resistance following bariatric surgery: role of caloric restriction and weight loss. Obes Surg 15 (2005) 462-473
7. Ballantyne G.H., Gumbs A., and Modlin I.M. Changes in insulin resistance following bariatric surgery and the adipoinsular axis: role of the adipocytokines, leptin, adiponectin and resistin. Obes Surg 15 (2005) 692-699
8. Lynch H.T., Brand R.E., Lynch J.F., et al. Hereditary factors in pancreatic cancer. J Hepatobiliary Pancreat Surg 9 (2002) 12-31
9. Schutte M., Hruban R.H., Geradts J., et al. Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas. Cancer Res 57 (1997) 3126-3130
10. Goggins M., Schutte M., Lu J., et al. Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas. Cancer Res 56 (1996) 5360-5364
11. Su G.H., Hruban R.H., Bansal R.K., et al. Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers. Am J Pathol 154 (1999) 1835-1840
12. Ozcelik H., Schmocker B., Di Nicola N., et al. Germline BRCA2 6174delT mutations in Ashkenazi Jewish pancreatic cancer patients. Nat Genet 16 (1997) 17-18
13. Huang L., Lang D., Geradts J., et al. Molecular and immunochemical analyses of RB1 and cyclin D1 in human ductal pancreatic carcinomas and cell lines. Mol Carcinog 15 (1996) 85-95
14. Hahn S.A., Schutte M., Hoque A.T., et al. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 271 (1996) 350-353
15. Almoguera C., Shibata D., Forrester K., et al. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 53 (1988) 549-554
16. Rozenblum E., Schutte M., Goggins M., et al. Tumor-suppressive pathways in pancreatic carcinoma. Cancer Res 57 (1997) 1731-1734
17. Wallrapp C., Muller-Pillasch F., Solinas-Toldo S., et al. Characterization of a high copy number amplification at 6q24 in pancreatic cancer identifies c-myb as a candidate oncogene. Cancer Res 57 (1997) 3135-3139
18. Larsson S.C., Permert J., Hakansson N., et al. Overall obesity, abdominal adiposity, diabetes and cigarette smoking in relation to the risk of pancreatic cancer in two Swedish population-based cohorts. Br J Cancer 93 (2005) 1310-1315
19. Qiu D., Kurosawa M., Lin Y., et al. Overview of the epidemiology of pancreatic cancer focusing on the JACC Study. J Epidemiol 15 Suppl 2 (2005) S157-S167
20. Lowenfels A.B., Sullivan T., Fiorianti J., et al. The epidemiology and impact of pancreatic diseases in the United States. Curr Gastroenterol Rep 7 (2005) 90-95
21. Lowenfels A.B., and Maisonneuve P. Epidemiologic and etiologic factors of pancreatic cancer. Hematol Oncol Clin North Am 16 (2002) 1-16
22. Ji J., and Hemminki K. Socioeconomic and occupational risk factors for pancreatic cancer: a cohort study in Sweden. J Occup Environ Med 48 (2006) 283-288
23. Ji B.T., Hatch M.C., Chow W.H., et al. Anthropometric and reproductive factors and the risk of pancreatic cancer: a case-control study in Shanghai, China. Int J Cancer 66 (1996) 432-437
24. Guthrie N., and Carroll K.K. Specific versus non-specific effects of dietary fat on carcinogenesis. Prog Lipid Res 38 (1999) 261-271
25. Seitz H.K., and Stickel F. Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stress. Biol Chem 387 (2006) 349-360
26. Schernhammer E.S., Hu F.B., Giovannucci E., et al. Sugar-sweetened soft drink consumption and risk of pancreatic cancer in two prospective cohorts. Cancer Epidemiol Biomarkers Prev 14 (2005) 2098-2105
27. Silverman D.T., Swanson C.A., Gridley G., et al. Dietary and nutritional factors and pancreatic cancer: a case-control study based on direct interviews. J Natl Cancer Inst 90 (1998) 1710-1719
28. Oh S.W., Yoon Y.S., and Shin S.A. Effects of excess weight on cancer incidences depending on cancer sites and histologic findings among men: Korea National Health Insurance Corporation Study. J Clin Oncol 23 (2005) 4742-4754
29. Rapp K., Schroeder J., Klenk J., et al. Obesity and incidence of cancer: a large cohort study of over 145,000 adults in Austria. Br J Cancer 93 (2005) 1062-1067
30. Pezzilli R., Morselli-Labate A.M., Migliori M., et al. Obesity and the risk of pancreatic cancer: an Italian multicenter study. Pancreas 31 (2005) 221-224
31. Mori M., Saitoh S., Takagi S., et al. A review of cohort studies on the association between history of diabetes mellitus and occurrence of cancer. Asian Pacific J Cancer Prev 1 (2000) 269-276
32. Eberle C.A., Bracci P.M., and Holly E.A. Anthropometric factors and pancreatic cancer in a population-based case-control study in the San Francisco Bay area. Cancer Causes Control 16 (2005) 1235-1244
33. Fryzek J.P., Schenk M., Kinnard M., et al. The association of body mass index and pancreatic cancer in residents of southeastern Michigan, 1996-1999. Am J Epidemiol 162 (2005) 222-228
34. Wideroff L., Gridley G., Mellemkjaer L., et al. Cancer incidence in a population-based cohort of patients hospitalized with diabetes mellitus in Denmark. J Natl Cancer Inst 89 (1997) 1360-1365
35. Schapira D.V. Diet, obesity, fat distribution and cancer in women. J Am Med Womens Assoc 46 (1991) 126-130
36. Schapira D.V. Nutrition and cancer prevention. Prim Care 19 (1992) 481-491
37. Patel A.V., Rodriguez C., Bernstein L., et al. Obesity, recreational physical activity, and risk of pancreatic cancer in a large U.S. cohort. Cancer Epidemiol Biomarkers Prev 14 (2005) 459-466
38. Michaud D.S., Giovannucci E., Willett W.C., et al. Physical activity, obesity, height, and the risk of pancreatic cancer. JAMA 286 (2001) 921-929
39. Sinner P.J., Schmitz K.H., Anderson K.E., et al. Lack of association of physical activity and obesity with incident pancreatic cancer in elderly women. Cancer Epidemiol Biomarkers Prev 14 (2005) 1571-1573
40. Berrington de Gonzalez A., Sweetland S., and Spencer E. A meta-analysis of obesity and the risk of pancreatic cancer. Br J Cancer 89 (2003) 519-523
41. Silha J.V., Krsek M., Sucharda P., et al. Angiogenic factors are elevated in overweight and obese individuals. Int J Obes (Lond) 29 (2005) 1308-1314
42. Horiguchi N., Takayama H., Toyoda M., et al. Hepatocyte growth factor promotes hepatocarcinogenesis through c-Met autocrine activation and enhanced angiogenesis in transgenic mice treated with diethylnitrosamine. Oncogene 21 (2002) 1791-1799
43. Samanic C., Chow W.H., Gridley G., et al. Relation of body mass index to cancer risk in 362,552 Swedish men. Cancer Causes Control 17 (2006) 901-909
44. Carroll K.K. Obesity as a risk factor for certain types of cancer. Lipids 33 (1998) 1055-1059
45. Welsch T., Kleeff J., Seitz H.K., et al. Update on pancreatic cancer and alcohol-associated risk. J Gastroenterol Hepatol 21 Suppl 3 (2006) S69-S75
46. de la Torre A., Debiton E., Durand D., et al. Conjugated linoleic acid isomers and their conjugated derivatives inhibit growth of human cancer cell lines. Anticancer Res 25 (2005) 3943-3949
47. Valk E.E., and Hornstra G. Relationship between vitamin E requirement and polyunsaturated fatty acid intake in man: a review. Int J Vitam Nutr Res 70 (2000) 31-42
48. Furstenberger G., Krieg P., Muller-Decker K., et al. What are cyclooxygenases and lipoxygenases doing in the driver's seat of carcinogenesis?. Int J Cancer 119 (2006) 2247-2254
49. Michaud D.S., Skinner H.G., Wu K., et al. Dietary patterns and pancreatic cancer risk in men and women. J Natl Cancer Inst 97 (2005) 518-524
50. Skinner H.G., Michaud D.S., Giovannucci E., et al. Vitamin D intake and the risk for pancreatic cancer in two cohort studies. Cancer Epidemiol Biomarkers Prev 15 (2006) 1688-1695
51. Skinner H.G., Michaud D.S., Giovannucci E.L., et al. A prospective study of folate intake and the risk of pancreatic cancer in men and women. Am J Epidemiol 160 (2004) 248-258
52. Skinner H.G., Michaud D.S., Colditz G.A., et al. Parity, reproductive factors, and the risk of pancreatic cancer in women. Cancer Epidemiol Biomarkers Prev 12 (2003) 433-438
53. Bugianesi E. Review article: steatosis, the metabolic syndrome and cancer. Aliment Pharmacol Ther 22 Suppl 2 (2005) 40-43
54. Friedman G.D., and van den Eeden S.K. Risk factors for pancreatic cancer: an exploratory study. Int J Epidemiol 22 (1993) 30-37
55. Noy A., and Bilezikian J.P. Clinical review 63: Diabetes and pancreatic cancer: clues to the early diagnosis of pancreatic malignancy. J Clin Endocrinol Metab 79 (1994) 1223-1231
56. Jee S.H., Ohrr H., Sull J.W., et al. Fasting serum glucose level and cancer risk in Korean men and women. JAMA 293 (2005) 194-202
57. Stolzenberg-Solomon R.Z., Graubard B.I., Chari S., et al. Insulin, glucose, insulin resistance, and pancreatic cancer in male smokers. JAMA 294 (2005) 2872-2878
58. Hanley A.J., Johnson K.C., Villeneuve P.J., et al. Physical activity, anthropometric factors and risk of pancreatic cancer: results from the Canadian enhanced cancer surveillance system. Int J Cancer 94 (2001) 140-147
59. Boyd D.B. Insulin and cancer. Integr Cancer Ther 2 (2003) 315-329
60. Spector S.A., Olson E.T., Gumbs A.A., et al. Human insulin receptor and insulin signaling proteins in hepatic disease. J Surg Res 83 (1999) 32-35
61. Schneider M.B., Matsuzaki H., Haorah J., et al. Prevention of pancreatic cancer induction in hamsters by metformin. Gastroenterology 120 (2001) 1263-1270
62. Stattin P., Lukanova A., Biessy C., et al. Obesity and colon cancer: does leptin provide a link?. Int J Cancer 109 (2004) 149-152
63. Somasundar P., Yu A.K., Vona-Davis L., et al. Differential effects of leptin on cancer in vitro. J Surg Res 113 (2003) 50-55
64. Iwakura H., Hosoda K., Doi R., et al. Ghrelin expression in islet cell tumors: augmented expression of ghrelin in a case of glucagonoma with multiple endocrine neoplasm type I. J Clin Endocrinol Metab 87 (2002) 4885-4888
65. Duxbury M.S., Waseem T., Ito H., et al. Ghrelin promotes pancreatic adenocarcinoma cellular proliferation and invasiveness. Biochem Biophys Res Commun 309 (2003) 464-468
66. Bassi C., Salvia R., Gumbs A.A., et al. The value of standard serum tumor markers in differentiating mucinous from serous cystic tumors of the pancreas: CEA, CA19-9, CA125, CA15-3. Langenbecks Arch Surg 387 (2002) 281-285
67. Hiyama E., Kodama T., Shinbara K., et al. Telomerase activity is detected in pancreatic cancer but not in benign tumors. Cancer Res 57 (1997) 326-331
68. Lilley M., and Gilchrist D. The hereditary spectrum of pancreatic cancer: the Edmonton experience. Can J Gastroenterol 18 (2004) 17-21
69. Bueno de Mesquita H.B., Moerman C.J., Runia S., et al. Are energy and energy-providing nutrients related to exocrine carcinoma of the pancreas?. Int J Cancer 46 (1990) 435-444
70. Howe G.R., Jain M., and Miller A.B. Dietary factors and risk of pancreatic cancer: results of a Canadian population-based case-control study. Int J Cancer 45 (1990) 604-608
71. Ghadirian P., Simard A., Baillargeon J., et al. Nutritional factors and pancreatic cancer in the francophone community in Montreal, Canada. Int J Cancer 47 (1991) 1-6
72. Zatonski W., Przewozniak K., Howe G.R., et al. Nutritional factors and pancreatic cancer: a case-control study from southwest Poland. Int J Cancer 48 (1991) 390-394
73. Friedman G.D., and van den Eeden S.K. Risk factors for pancreatic cancer: an exploratory study. Int J Epidemiol 22 (1993) 30-37
74. Shibata A., Mack T.M., Paganini-Hill A., et al. A prospective study of pancreatic cancer in the elderly. Int J Cancer 58 (1994) 46-49
75. Silverman D.T., Swanson C.A., Gridley G., et al. Dietary and nutritional factors and pancreatic cancer: a case-control study based on direct interviews. J Natl Cancer Inst 90 (1998) 1710-1719
76. Gapstur S.M., Gann P.H., Lowe W., et al. Abnormal glucose metabolism and pancreatic cancer mortality. JAMA 283 (2000) 2552-2558
77. Hanley A.J., Johnson K.C., Villeneuve P.J., et al. Physical activity, anthropometric factors and risk of pancreatic cancer: results from the Canadian enhanced cancer surveillance system. Int J Cancer 94 (2001) 140-147
78. Lee I.M., Sesso H.D., Oguma Y., et al. Physical activity, body weight, and pancreatic cancer mortality. Br J Cancer 88 (2003) 679-683
79. Calle E.R., Rodriguez C., Walker-Thurmond K., et al. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of US adults. N Engl J Med 348 (2003) 1625-1638
80. Duell E.J., Casella D.P., Burk R.D., et al. Inflammation, genetic polymorphisms in proinflammatory genes TNF-A, RANTES, and CCR5, and risk of pancreatic adenocarcinoma. Cancer Epidemiol Biomarkers Prev 15 (2006) 726-731
81. Service G.J., Thompson G.B., Service F.J., et al. Hyperinsulinemic hypoglycemia with nesidioblastosis after gastric-bypass surgery. N Engl J Med 353 (2005) 249-254