Molecular and immunochemical analyses of RB1 and cyclin D1 in human ductal pancreatic carcinomas and cell lines

Molecular Carcinogenesis

Volumn 15, Issue 2, 1996, Pages 85-95

  Huang, Lingyi ^a   Lang, Deborah ^a   Geradts, Joseph ^c   Obara, Takeshi ^d   Klein Szanto, Andres J P ^b   Lynch, Henry T ^e   Ruggeri, Bruce A ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b FOX CHASE CANCER CENTER   (United States)

^c UNIVERSITY OF NORTH CAROLINA HOSPITALS   (United States)

^d ASAHIKAWA MEDICAL COLLEGE   (Japan)

^e CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cyclin D1; DNA sequencing; Immunohistochemistry; Pancreatic cancer; Retinoblastoma gene protein; Single strand conformation polymorphism

Indexed keywords

CYCLINE; RETINOBLASTOMA PROTEIN;

ARTICLE; DNA SEQUENCE; GENE MUTATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; PANCREAS CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR SUPPRESSOR GENE;

BASE SEQUENCE; BLOTTING, SOUTHERN; BLOTTING, WESTERN; CARCINOMA, DUCTAL, BREAST; CELL LINE; CYCLIN D1; CYCLINS; GENES, RETINOBLASTOMA; HUMANS; IMMUNOHISTOCHEMISTRY; MOLECULAR SEQUENCE DATA; ONCOGENE PROTEINS; PANCREATIC NEOPLASMS; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; RETINOBLASTOMA PROTEIN; TUMOR CELLS, CULTURED;

EID: 0029932706     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(199602)15:2<85::AID-MC1>3.0.CO;2-Q     Document Type: Article

References (49)

1. Warshaw AL, del Castillo CF Pancreatic carcinoma. N Engl J Med 326 455-465, 1992.
2. Mihara K, Cao X-R, Yen A, et al. Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product Science 246, 1300-1303, 1989.
3. Buchkovich K, Duffy LA, Harlow E. The retinoblastoma protein is phosphorylated during specific phases of the cell cycle Cell 58 1097-1105, 1989
4. Hinds PW, Mittnacht S, Dulic V, Arnold A, Reed SI, Weinberg RA. Regulation of retinoblastoma protein functions by ectopic expression of human cyclms Cell 70 993-1006, 1992
5. Ewen ME, Sluss HK, Sherr CJ, Matsushime H, KatoJY, Livingston OM Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell 73487-497, 1993
6. Dowdy SF, Hinds PW, Louie K, Reed SI, Arnold A, Weinberg RA Physical interaction of the retinoblastoma protein with human D-cyclins Cell 73.499-511, 1993
7. DeCaprio JA, Ludlow JW, Lynch D, et al. The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element. Cell 58:1085-1095, 1989.
8. Horowitz JM. Regulation of transcription by the retinoblastoma protein Genes Chromosom Cancer 6.124-131, 1993
9. Chellappan SP, Hiebert S, Mudryj M, Horowitz JM, Nevins JR The E2F transcription factor is a cellular target for the RB protein. Cell 65 1053-1061, 1991
10. Helin K, Harlow E. The retinoblastoma protein as a transcriptional repressor Trends Cell Biol 3.43-45, 1993
11. Hamel PA, Phillips RA, Munccaster M, Gallie BL Speculations on the roles of RB-1 in tissue-specific differentiation, tumor initiation, and tumor progression FASEB J 7 846-854, 1993
12. Horowitz JM, Park S-H, Bogenmann E, et al. Frequent mactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells. Proc Natl Acad Sci USA 87 2775-2779, 1990
13. Goodrich DW, Lee W-H Molecular characterization of the ret-inoblastoma susceptibility gene. Biochim Biophys Acta 1155:43-61, 1993
14. Ruggeri B, Zhang S-Y, Caamano J, DiRado M, Flynn SD, Klein-Szanto AJP. Human pancreatic carcinomas and cell lines reveal frequent and multiple alterations in the p53 and Rb-1 tumor suppressor genes. Oncogene 7:1503-1511, 1992
15. Motokura T, Bloom T, Kim HG, et al. A novel cyclin encoded by a bcl-1-linked candidate oncogene. Nature 350.512-515, 1991.
16. Xiong Y, Connolly T, Futcher B, Beach D. Human D-type cyclin. Cell 65:691-699, 1991
17. Schuuring E, Verhoeven E, van Tinteren H, et al. Amplification of genes within the chromosome 11 of 13 region is indicative of poor prognosis in patients with operable breast cancer Cancer Res 52:5229-5234, 1992
18. Nishida N, Fukuda Y, Komeda T, et al Amplification and overexpression of the cychn D1 gene in aggressive human hepatocellular carcinoma. Cancer Res 54:3107-3110, 1994.
19. Jiang W, Zhang Y-J, Kahn SM, et al. Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer. Proc Natl Acad Sci USA 90 9026-9030, 1993.
20. Berenson JR, Yang J, Mickel RA Frequent amplification of the bcl-1 locus in head and neck squamous cell carcinomas. Oncogene 4:1111-1116, 1989.
21. Muller H, Lukas J, Schneider A, et al. Cyclin D1 expression is regulated by the retinoblastoma protein. Proc Natl Acad Sci USA 91.2945-2949, 1994.
22. Bates S, Parry D, Bonetta L, Vousden K, Dickson C, Peters G. Absence of cyclin D/cdk complexes in cells lacking function ret-inoblastoma protein Oncogene 9:1633-1640, 1994.
23. Lynch HT, Fitzsimmons ML, Smyrk TC, et al Familial pancreatic cancer. Clinicopathologic study of 18 nuclear families. Am J Gastroenterol 85:54-60, 1990.
24. Beahrs OH, Henson DE, Hutter RVP, Myers MH (eds). Manual for Staging of Cancer, 3rd ed. J.B. Lippincott Co , Philadelphia, 1988, pp. 109-113
25. Xu HJ, Hu S-X, Cagle PT, Moore GE, Benedict WF. Absence of retinoblastoma protein expression in primary non-small cell lung carcinomas. Cancer Res 51:2735-2739, 1991.
26. Zhang SY, Caamano J, Cooper F, Guo X, Klein-Szanto AJP. Immunohistochemistry of cyclin D1 in human breast cancer Am J Clin Pathol 102:695-698, 1994.
27. Logothetis CJ, Xu H-J, Ro JY, et al Altered expression of retinoblastoma protein and known prognostic variables in locally advanced bladder cancer. J Natl Cancer Inst 84:1256-1261, 1992.
28. Smith KJ, Johnson KA, Bryan TM, et al. The APC gene product in normal and tumor cells Proc Natl Acad Sci USA 90:2846-2850, 1993.
29. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning A Laboratory Manual, 2nd ed Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 1989.
30. Sun Y, Hegamyer G, Colburn NH. Nasopharyngeal carcinoma shows no detectable retinoblastoma susceptibility gene alterations. Oncogene 8:791-795, 1993
31. Hogg A, Onadim Z, Baird PN, Cowell JK. Detection of heterozygous mutations in the RB-1 gene in retinoblastoma patients using single-strand conformation polymorphism analysis and polymerase chain reaction sequencing Oncogene 7.1445-1451, 1992.
32. McGee TL, Yandell BW, Dryja TP. Structure and partial genomic sequence of the human retinoblastoma susceptibility gene. Gene 80:119-128, 1989.
33. Martinez JC, Piris MA, Sanchez-Beato M, et al. Retinoblastoma (Rb) gene product expression in lymphomas Correlation with ki67 growth fraction J Pathol 169.405-412, 1993.
34. Zhang X, Xu H-J, Murakami Y, et al Deletions of chromosome 13q, mutations in retinoblastoma 1, and retinoblastoma protein state in human hepatocellular carcinoma Cancer Res 54:4177-4182, 1994.
35. Hogg A, Bia B, Onadim Z, Cowell JK. Molecular mechanisms of oncogenic mutations in tumors from patients with bilateral and unilateral retinoblastoma Proc Natl Acad Sci USA 90:7351-7355, 1993.
36. Barton CM, McKie AB, Hogg A, et al. Abnormalities of the RB1 and DCC tumor suppressor genes: Uncommon in human pancreatic adenocarcinoma. Mol Carcinog 13:61-69, 1995
37. Dins SF, Habib NA, Delhanty JDA, et al Loss of heterozygosity on chromosomes 1 and 11 in carcinoma of the pancreas Br J Cancer 65:809-812, 1992
38. Cance WG, Brennan MF, Dudas ME, Huang C-M, Cordon-Cardo C. Altered expression of the retinoblastoma gene product in human sarcomas. N Engl J Med 323:1457-1462, 1990.
39. Cordon-Cardo C, Wartinger D, Petrylak D, et al. Altered expression of the retinoblastoma gene product: Prognostic indicator in bladder cancer. J Natl Cancer Inst 84:1251-1256, 1992
40. Varley JM, Armour J, Swallow JE, et al. The retinoblastoma gene is frequently altered leading to loss of expression in primary breast tumors Oncogene 4:725-729, 1989
41. Trudel M, Mulligan L, Cavenee W, Margolese R, Cote J, Gariepy G. Retinoblastoma and p53 gene product expression in breast carcinoma Immunohistochemical analysis and clinicopathologic correlation Hum Pathol 23:1388-1394, 1992
42. Harbour JW, Lai S-L, Whang-Peng J, Gazdar AF, Minna JD, Kaye FJ. Abnormalities in structure and expression of the human retinoblastoma gene in SCLC. Science 241:353-357, 1988.
43. Hensel CH, Hsieh C-L, Gazdar AF, et al. Altered structure and expression of the human retinoblastoma susceptibility gene in small cell lung cancer. Cancer Res 50:3067-3072, 1990.
44. Ali AA, Marcus JN, Harvey JP, et al RB-1 protein in normal and malignant human colorectal tissue and colon cancer cell lines. FASEB J 7:931-937, 1993.
45. Leach FRS, Elledge SJ, Sherr CJ, et al. Amplification of cyclin genes in colorectal carcinomas. Cancer Res 53 1986-1989, 1993.
46. Bartkova J, Lukas J, Strauss M, Bartek J. The Prad-1/cyclin D1 oncogene product accumulates aberrantly in a subset of colorectal carcinomas, Int J Cancer 58:568-673, 1994
47. Serano M, Hannon GJ, Beach D A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 366.704-707, 1993.
48. Kamb A, Gruis NA, Weaver-Feldhaus J, et al. A cell-cycle regulator potentially involved in genesis of many tumor types. Science 264:436-440, 1994.
49. Caldas C, Hahn SA, daCosta LT, et al Frequent somatic mutations and homozygous deletions of the p16 (MTS-1) gene in pancreatic adenocarcinoma. Nat Genet 8 27-32, 1994.