Naturally occurring IgM anti-leukocyte autoantibodies (IgM-ALA) inhibit T cell activation and chemotaxis

Journal of Immunology

Volumn 180, Issue 3, 2008, Pages 1780-1791

  Lobo, Peter I ^a,b,c   Schlegel, Kailo H ^a   Spencer, Clinton E ^a   Okusa, Mark D ^a,b   Chisholm, Christopher ^b   Mchedlishvili, Nino ^a   Park, Andrew ^a   Christ, Constance ^a   Burtner, Christopher ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CD28 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CD86 ANTIGEN; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; IMMUNOGLOBULIN M; INTERLEUKIN RECEPTOR; LEUKOCYTE ANTIBODY; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; CYTOKINE; PROTEIN KINASE ZAP 70;

ARTICLE; CELL LINE; CELL LYSATE; CHEMOTAXIS; ENZYME LINKED IMMUNOSORBENT ASSAY; HLA SYSTEM; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INNATE IMMUNITY; LYMPHOCYTE PROLIFERATION; METABOLIC INHIBITION; MONOCYTE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PURIFICATION; REACTIVE INHIBITION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; B LYMPHOCYTE; CELL CULTURE; DOWN REGULATION; DRUG ANTAGONISM; DRUG EFFECT; IMMUNOLOGY; ISOLATION AND PURIFICATION; LEUKOCYTE MIGRATION INHIBITION TEST; LYMPHOCYTE ACTIVATION; METABOLISM; UMBILICAL CORD;

ANTIGENS, CD3; ANTIGENS, CD4; AUTOANTIBODIES; B-LYMPHOCYTES; CELL MIGRATION INHIBITION; CELLS, CULTURED; CHEMOTAXIS; CYTOKINES; DOWN-REGULATION; HUMANS; IMMUNOGLOBULIN M; IMMUNOPRECIPITATION; LYMPHOCYTE ACTIVATION; RECEPTORS, CCR5; RECEPTORS, CXCR4; T-LYMPHOCYTES; UMBILICAL CORD; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 40749114425     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.3.1780     Document Type: Article

References (59)

1. Nakamura, M., S. E., Burastero, Y. Ueki, J. W. Larrick, A. L. Notkins, and P. Casali. 1988. Probing the normal and autoimmune B cell repertoire with Epstein-Barr virus: frequency of B cells producing monoreactive high affinity autoantibodies in patients with Hashimoto's disease and systemic lupus erythematosus. J. Immunol. 141: 4165-4172.
2. Mouthon, L., S. Lacroix-Desmazes, A. Nobrega, C. Barreau, A. Coutinho, and M. D. Kazatchkine. 1996. The self reactive antibody repertoire of normal human serum IgM is acquired in early childhood and remains conserved throughout life. Scand. J. Immunol. 44: 243-251.
3. Dighiero, G., B. Guilbert, J. P. Fermand, P. Lymberi, F. Danon, and S. Avrameas. 1983. Thirty-six human monoclonal immunoglobulins with antibody activity against cytoskeleton proteins, thyroglobulin, and native DNA: immunologic studies and clinical correlations. Blood 62: 264-270.
4. Steele, E. J., and A. J. Cunningham. 1978. High proportion of Ig producing cells making autoantibody in normal mice. Nature 274: 483-486.
5. Hardy, R. R., and K. Hayakawa. 1986. Development and physiology of Ly-1 B and its human homolog, Leu-1 B. Immunol. Rev. 93: 53-79.
6. + B cell precursor in B-1 cell differentiation. J. Exp. Med. 187: 1325-1334.
7. Ailus, K., and T. Palosuo. 1995. IgM class autoantibodies in human cord blood. J. Reprod. Immunol. 29: 61-67.
8. Barbouche, R., M. Forveille, A. Fischer, S. Amraveas, and A. Durandy. 1992. Spontaneous IgM autoantibody production In-vitro by B lymphocytes of normal human neonates. Scand. J. Immunol. 35: 659-667.
9. Fagarasan, S., and T. Honjo. 2000. T-independent immune response: new aspects of B cell biology. Science 290: 89-92.
10. Lacroix-Desmazes, S., S. V. Kaveri, L. Mouthon, A. Ayouba, E. Melanchere, A. Coutinho, and M. D. Kazatchkine. 1998. Self-reactive antibodies (natural autoantibodies) in healthy individuals. J. Immunol. Methods 216: 117-137.
11. + B cells. J. Clin. Invest. 99: 2488-2501.
12. Cervenak, J., K. Kiss, and F. Uher. 1999. Partial characterization of two lymphocyte-specific natural autoantibodies isolated from newborn mice. Acta Microbiol. Immunol. 46: 53-62.
13. Terasaki, P. I., V. D. Mottironi, and E. V. Barnett. 1970. Cytotoxins in disease. N. Engl. J. Med. 283: 724-727.
14. Winfield, J. B., R. J. Winchester, P. Wernet, S. M. Fu, and H. G. Kunkle. 1975. Nature of cold-reactive antibodies to lymphocyte surface. Artritis Rheum. 18: 1-8.
15. Lobo, P. L. 1981. Nature of autolymphocytotoxins present in renal hemodialysis patients: their possible role in controlling alloantibody formation. Transplantation 32: 233-237.
16. Lobo, P. I., and P. M. Surratt. 1979. Studies on the autoantibody to lymphocytes in sarcoidosis. J. Clin. Lab. Immunol. 1: 283-288.
17. Gilbreath, M. J., K. Pavanand, R. P. MacDermott, R. A. Wells, and M. A. Ussery. 1983. Characterization of cold reactive lymphocytotoxic antibodies in malaria. Clin. Exp. Immunol. 51: 232-238.
18. Dorsett, B., W. Cronin, V. Chuma, and H. I. Iochim. 1985. Anti-lymphocyte antibodies in patients with the acquired immune deficiency syndrome. Am. J. Med. 78: 621-626.
19. Williams, R. C., H. Masur, and T. J. Spira. 1984. Lymphocyte reactive antibodies in acquired immune deficiency syndrome. J. Clin. Immunol. 4: 118-123.
20. Griggi, T., R. Bauer, T. Garofalo, S. Kukel, L. Lenti, A. P. Massetti, C. Muller, M. Sorice, and G. M. Pointieri. 1994. Autoantibodies against ganglioside GM3 represents a portion of antilymphocytic antibodies in AIDS patients. Scand. J. Immunol. 40: 77-82.
21. Sorice, M., L. Lenti, R. Misasi, M. A. DiPrima, T. Griggi, L. Cignarella, V. Vullo, and C. Masala,. 1991. Anti-glycosphingolipid antibodies in HIV infection. AIDS 5: 345-346.
22. Strickler, R. B., T. M. McHugh, D. J. Moody, W. J. W. Morrow, D. P. Stites, M. A. Shuman, and J. A. Levy. 1987. An AIDS-related cytotoxic autoantibody reacts with a specific antigen on stimulated CD4 cells. Nature 327: 710-713.
23. Warren, R. Q., E. A. Johnson, R. P. Donnelly, M. F. Lavia, and K. Y. Tsang. 1988. Specificity of anti-lymphocyte antibodies in sera from patients with AIDS-related complex (ARC) and healthy homosexuals. Clin. Exp. Immunol. 73: 168-173.
24. Minota, S. W. 1987. Identification of three major target molecules of IgM antilymphocytic autoantibodies in SLE. J. Immunol. 139: 3644-3651.
25. Mimura, T., P. Fernsten, W. Jarjour, and J. B. Winfield. 1994. Autoantibodies specific for different isoforms of CD45 in SLE. J. Exp. Med. 172: 653-656.
26. Stimmler, M. M., F. P. J. Quismorio, W. G. McGehee, T. Boylen, and O. P. Sharma. 1989. Anticardiolipin antibodies in acquired immunodeficiency syndrome. Arch. Intern. Med. 149: 1833-1835.
27. Klouda, P. T., and M. Jeannet. 1976. Cold and warm antibodies and graft survival in kidney allograft recipients. Lancet 1: 876-878.
28. Lobo, P. I., L. Rudolf, and F. B. Westervelt. 1977. Enhanced kidney allograft survival across a positive crossmatch (Cx) arising from B-cell specific and cold reactive antibodies. Proc. Dial. Transpl. Forum. 7: 4-6.
29. Iwaki, Y., P. I. Terasaki, M. S. Park, and R. Billing. 1978. Enhancement of human kidney allografts by cold B-lymphocyte cytotoxins. Lancet 1: 1228-1229.
30. Kerman, R. H., B. Susskind, and I. Buyse. 1999. Flow cytometry-detected IgG is not a contraindication to renal transplantation: IgM may be beneficial to outcome. Transplantation 68: 1855-1858.
31. Przybylowski, P., M. Balogna, B. Radovancevic, O. H. Frazier, B. Susskind, C. Van Buren S. Katz, B. D. Kahan, and R. Kerman. 1999. The role of flow cytometry-detected IgG and IgM anti-donor antibodies in cardiac allograft recipients. Transplantation 67: 258-262.
32. Lobo, P. I., C. E. Spencer, W. C. Stevenson, C. McCullough, and T. L. Pruett. 1995. The use of pronase-digested human leukocytes to improve specificity of the flow cytometric crossmatch. Transpl. Int. 8: 472-480.
33. Chabot, D. J., H. Chen, D. S. Dimitrov, and C. C. Broder. 2000. N-linked glycosylation of CXCR4 masks coreceptor function for CCR5-dependent human immunodeficiency virus type 1 isolates. J. Virol. 74: 4404-4413.
34. Mirzabekov, T., N. Bannert, M. Farzan, W. Hofmann, P. Kolchinsky, L. Wu, R. Wyatt, and J. Sodroski. 1999. Enhanced expression, native purification, and characterization of CCR5, a principal HIV-1 coreceptor. J. Biol. Chem. 274: 28745-28750.
35. Burastero, S. E., D. Gafffi, L. Lopalco, G. Tambussi, B. Borgonovo, C. De Santis, C. Abecasis, P. Robbioni, A. Gasparri, A. Lazzarin, et al. 1996. Autoantibodies to CD4 in HIV type 1-exposed seronegative individuals. AIDS Res. Hum. Retroviruses 12: 273-280.
36. Lobo, P. I., F. B. Westervelt, L. Rudolf, and C. White. 1980. Cold lymphocytotoxins: an important cause of acute tubular necrosis (ATN) occurring immediately post-transplant. Lancet 2: 879-882.
37. Bernaman, A., T. Ternynck, S. Avrameas. 1992. Natural mouse IgG reacts with self antigens including molecules involved in the immune response. Eur. J. Immunol. 22: 625-633.
38. Lynch, G. W., M. Dearden, A. J. Sloane, I. Humphrey-Smith, and A. L. Cunningham. 1996. Analysis of recombinant and native CD4 by one-and two-dimensional gel electrophroesis. Electrophoresis 17: 227-234.
39. Rao, P. E., W. Newman, E. Meyer, B. Fahmy, M. A. Talle, and V. A. Fanning. 1992. Identification of anti-CD3 antibodies that do not modulate antigen but induce mitogenesis and block the mixed lymphocyte reaction. Hum. Immunol. 33: 275-283.
40. Signoret, N., J. Oldridge, A. Pelchen-Matthews, P. J. Klasse, T. Tran, L. F. Brass, M. M. Rosenkilde, T. W. Schwartz, W. Homes, W. Dallas, et al. 1997. Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4. J. Cell Biol. 139: 651-664.
41. Winfield, J. B., and T. Mimura. 1992. Pathogenetic significance of antilymphocyte autoantibodies in systemic lupus erythematosus. Clin. Immunol. Immunopathol. 63: 13-16.
42. Boes, M., T. Schmidt, K. Linkemann, B. C. Beaudette, A. Marshak-Rothstein, and J. Z. Chen. 2000. Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgM. Proc. Natl. Acad. Sci. USA 97: 1184-1189.
43. Ehrenstein, M. R., H. T. Cook, and M. S. Neuberger. 2000. Deficiency in serum immunoglobulin (Ig)M predisposes to development of IgG autoantibodies. J. Exp. Med. 191: 1253-1258.
44. Girndt, M., M. Sester, U. Kau, and H. Kohler. 2001. Molecular aspects of T- and B-cell function in uremia. Kidney Int. 78 (Suppl.): 78: S206-S211.
45. McDevitt, H., S. Munson, R. Ettinger, and A. Wu. 2002. Multiple roles for tumor necrosis factor-α and lymphotoxin αβ in immunity and autoimmunity. Arthritis Res. 4 (Suppl. 3l): S141-S152.
46. Pascher, A., J. Klupp, J. M. Langreher, and P. Neuhas. 2005. Anti-TNF α therapy for acute rejection in intestinal transplantation. Transplant Proc. 37: 1635-1636.
47. Pullar, C. E., P. J. Morris, and K. J. Wood. 2003. Altered proximal T-cell receptor signaling events in mouse CD4- T cells in the presence of anti-CD4 monoclonal antibodies: evidence for reduced phosphorylation of Zap-70 and LAT. Scand. J. Immunol. 57: 333-341.
48. Peacock, J. W., and F. R. Jirik. 1999. TCR activation inhibits chemotaxis toward stromal cell-derived factor-1: evidence for reciprocal regulation between CXCR4 and the TCR. J. Immunol. 162: 215-223.
49. Ticchioni, M., C. Charvet, N. Noraz, L. Lamy, M. Steinberg, A. Bernard, and M. Deckert. 2002. Signaling through ZAP-70 is required for CXCL12-mediated T-cell transendothelial migration. Blood 99: 3111-3118.
50. Freitas, A. A., and B. Rocha. 2000. Population biology of lymphocytes: the flight for survival. Annu. Rev. Immunol. 18: 83-111.
51. Jiang, H., and L. Chess. 2006. Regulation of immune responses by T cells. N. Eng. J. Med. 354: 1166-1176.
52. Munn, D. H., and A. L. Mellor. 2003. Macrophages and the regulation of selfreactive T cells. Curr. Pharm. Des. 9: 257-264.
53. Sakaguchi, S., N. Sakaguchi, J. Shimizu, S. Yamazaki, T. Sakihama M. Itoh, Y. Kuniyasu, T. Nomura, M. Toda, and T. Takahashi. 2001. Immunologic tolerance maintained by CD25- CD4- regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol. Rev. 182: 18-32.
54. Shevach, E. M. 2002. CD4- CD25- suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2: 389-400.
55. Ludewig, B., P. Krebs, T. Junt, and G. Bocharov. 2003. Dendritic cell homeostasis in the regulation of self-reactivity. Curr. Pharm. Des. 9: 221-231.
56. Nelson, B. H. 2004. IL-2, regulatory T cells, and tolerance. J. Immunol. 172: 3983-3988.
57. Judge, T. A., Z. Wu, X. G. Zheng, A. H. Sharpe, M. H. Sayegh, and L. A. Turka. 1999. The role of CD80, CD86, and CTLA4 in alloimmune responses and the induction of long-term allograft survival. J. Immunol. 162: 1947-1951.
58. Sayegh, M. H., and L. A. Turka. 1998. The role of T-cell costimulatory activation pathways in transplant rejection. N. Engl. J. Med. 338: 1813-1821.
59. Lapham, C. K., T. Romantseva, E. Petricoin, L. R. King, J. Manischewitz, M. B. Zaitseva, and H. Golding. 2002. CXCR4 heterogeneity in primary cells: possible role of ubiquitination. J. Leukocyte Biol. 72: 1206-1214.