Changes in adhesive and migratory characteristics of hepatocellular carcinoma (HCC) cells induced by expression of α3β1 integrin

Biochimica et Biophysica Acta - General Subjects

Volumn 1780, Issue 3, 2008, Pages 564-570

  Mizuno, Hiromi ^a   Ogura, Masaharu ^a   Saito, Yuta ^a   Sekine, Wakana ^a   Sano, Rikio ^a   Gotou, Toshie ^a   Oku, Teruaki ^a   Itoh, Saotomo ^a   Katabami, Kouji ^a   Tsuji, Tsutomu ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

3 integrin; Cell adhesion; Hepatocellular carcinoma; Invasion; Laminin

Indexed keywords

ALPHA 3A BETA 1 INTEGRIN; ALPHA 3A INTEGRIN; ALPHA 3B BETA 1 INTEGRIN; ALPHA 3B INTEGRIN; ALPHA3 INTEGRIN; COMPLEMENTARY DNA; KALININ; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 3;

ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL ADHESION; CELL FUNCTION; CELL INVASION; CELL MIGRATION; CELL STRAIN HEPG2; CELL STRAIN HEPG2 3A; CELL STRAIN HEPG2 3B; CELL STRAIN HEPG2 M; CHEMOINVASION ASSAY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOASSAY; IN VITRO STUDY; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

CARCINOMA, HEPATOCELLULAR; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; EXTRACELLULAR MATRIX PROTEINS; HUMANS; INTEGRIN ALPHA3BETA1; LIVER NEOPLASMS; NEOPLASM INVASIVENESS; TRANSFECTION;

EID: 40749098889     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbagen.2007.09.007     Document Type: Article

References (33)

1. Carter G., and Hakomori S. Isolation and partial characterization of "galactoprotein a" (LETS) and "galactoprotein b" from hamster embryo fibroblasts. Biochem. Biophys. Res. Commun. 76 (1976) 299-308
2. Tsuji T., Yamamoto F., Miura Y., Takio K., Titani K., Pawar S., Osawa T., and Hakomori S. Characterization through cDNA cloning of galactoprotein b3 (Gap b3), a cell surface membrane glycoprotein showing enhanced expression on oncogenic transformation. Identification of Gap b3 as a member of the integrin superfamily. J. Biol. Chem. 265 (1990) 7016-7021
3. Tsuji T T., Hakomori S., and Osawa T. Identification of human galactoprotein b3, an oncogenic transformation-induced membrane glycoprotein, as VLA-3 α subunit: the primary structure of human integrin α3. J. Biochem. (Tokyo) 109 (1991) 659-665
4. Holly S.P., Larson M.K., and Parise L.V. Multiple roles of integrins in cell motility. Exp. Cell Res. 261 (2000) 69-74
5. Hood J.D., and Cheresh D.A. Role of integrins in cell invasion and migration. Nat. Rev., Cancer 2 (2002) 91-100
6. Felding-Habermann B. Integrin adhesion receptors in tumor metastasis. Clin. Exp. Metastasis 20 (2003) 203-213
7. Kreidberg J.A. Functions of α3β1 integrin. Curr. Opin. Cell Biol. 12 (2000) 548-553
8. Tsuji T. Physiological and pathological roles of α3β1 integrin. J. Membr. Biol. 200 (2004) 115-132
9. Giannelli G., Astigiano S., Antonaci S., Morini M., Barbieri O., Noonan D.M., and Albini A. Role of the α3β1 and α6β4 integrins in tumor invasion. Clin. Exp. Metastasis 19 (2002) 217-223
10. Ura H., Denno R., Hirata K., Yamaguchi K., and Yasosima T. Separate functions of α2β1 and α3β1 integrins in the metastatic process of human gastric carcinoma. Surg. Today 28 (1998) 1001-1006
11. Takatsuki H., Komatsu S., Sano R., Takada Y., and Tsuji T. Adhesion of gastric carcinoma cells to peritoneum mediated by α3β1 integrin (VLA-3). Cancer Res. 64 (2004) 6065-6570
12. Tsuji T., Kawada Y., Kai-Murozono M., Komatsu S., Han S.A., Takeuchi K., Mizushima K., and Irimura T. Regulation of melanoma cell migration and invasion by laminin-5 and α3β1 integrin (VLA-3). Clin. Exp. Metastasis 19 (2002) 127-134
13. Kishima H., Shimizu K., Tamura K., Miyao Y., Mabuchi E., Tominaga E., Matsuzaki J., and Hayakawa T. Monoclonal antibody ONS-M21 recognizes integrin α3 in gliomas and medulloblastomas. Br. J. Cancer 79 (1999) 333-339
14. Giannelli G., Bergamini C., Fransvea E., Marinosci F., Quaranta V., and Antonaci S. Human hepatocellular carcinoma (HCC) cells require both α3β1 integrin and matrix metalloproteinases activity for migration and invasion. Lab. Invest. 81 (2001) 613-627
15. Bergsland E.K., and Venook A.P. Hepatocellular carcinoma. Curr. Opin. Oncol. 12 (2000) 357-361
16. Izumi R., Shimizu K., Ii T., Yagi M., Matsui O., Nonomura A., and Miyazaki I. Prognostic factors of hepatocellular carcinoma in patients undergoing hepatic resection. Gastroenterology 106 (1994) 720-727
17. Giannelli G., Fransvea E., Marinosci F., Bergamini C., Colucci S., Schiraldi O., and Antonaci S. Transforming growth factor-β1 triggers hepatocellular carcinoma invasiveness via α3β1 integrin. Am. J. Pathol. 161 (2002) 183-193
18. Katabami K., Mizuno H., Sano R., Saito Y., Ogura M., Itoh S., and Tsuji T. Transforming growth factor-β1 upregulates transcription of α3 integrin gene in hepatocellular carcinoma cells via Ets-transcription factor-binding motif in the promoter region. Clin. Exp. Metastasis 22 (2005) 539-548
19. Abou-Shady M., Baer K.U., Friess H., Berberat P., Zimmermann A., Graber H., Gold L.I., Korc M., and Buchler M.W. Transforming growth factor betas and their signaling receptors in human hepatocellular carcinoma. Am. J. Surg. 177 (1999) 209-215
20. Tamura R.N., Cooper H.M., Collo G., and Quaranta V. Cell type-specific integrin variants with alternative α chain cytoplasmic domains. Proc. Natl. Acad. Sci. U. S. A. 88 (1991) 10183-10187
21. Jones S.D., van der Flier A., and Sonnenberg A. Genomic organization of the human α3 integrin subunit gene. Biochem. Biophys. Res. Commun. 248 (1998) 896-898
22. Tsuji T., Han S.A., Takeuchi K., Takahashi N., Hakomori S., and Irimura T. Characterization of mouse integrin α3 subunit gene. J. Biochem. (Tokyo) 125 (1999) 1183-1188
23. Miyazaki K., Kikkawa Y., Nakamura A., Yasumitsu H., and Umeda M. A large cell-adhesive scatter factor secreted by human gastric carcinoma cells. Proc. Natl. Acad. Sci. U. S. A. 90 (1993) 11767-11771
24. Takeuchi K., Tsuji T., Hakomori S., and Irimura T. Intercellular adhesion induced by anti-α3 integrin (VLA-3) antibodies. Exp. Cell Res. 211 (1994) 133-141
25. Takada Y., Murphy E., Pil P., Chen C., Ginsberg M.H., and Hemler M.E. Molecular cloning and expression of the cDNA for α3 subunit of human α3β1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen. J. Cell Biol. 115 (1991) 257-266
26. Chomczynski P., and Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162 (1987) 156-159
27. Mizushima H., Koshikawa N., Moriyama K., Takamura H., Nagashima Y., Hirahara F., and Miyazaki K. Wide distribution of laminin-5 γ2 chain in basement membranes of various human tissues. Horm. Res. 50 Suppl 2 (1998) 7-14
28. Giannelli G., Fransvea E., Bergamini C., Marinosci F., and Antonaci S. Laminin-5 chains are expressed differentially in metastatic and nonmetastatic hepatocellular carcinoma. Clin. Cancer Res. 9 (2003) 3684-3691
29. de Melker A.A., Sterk L.M., Delwel G.O., Fles D.L., Daams H., Weening J.J., and Sonnenberg A. The A and B variants of the α3 integrin subunit: tissue distribution and functional characterization. Lab. Invest. 76 (1997) 547-563
30. Coppolino M.G., Woodside M.J., Demaurex N., Grinstein S., St-Arnaud R., and Dedhar S. Calreticulin is essential for integrin-mediated calcium signalling and cell adhesion. Nature 386 (1997) 843-847
31. Ito H., Seyama Y., and Kubota S. Calreticulin is directly involved in anti-α3 integrin antibody-mediated secretion and activation of matrix metalloprotease-2. Biochem. Biophys. Res. Commun. 283 (2001) 297-302
32. Hogervorst F., Admiraal L.G., Niessen C., Kuikman I., Janssen H., Daams H., and Sonnenberg A. Biochemical characterization and tissue distribution of the A and B variants of the integrin α6 subunit. J. Cell Biol. 121 (1993) 179-191
33. Tennenbaum T., Belanger A.J., Glick A.B., Tamura R., Quaranta V., and Yuspa S.H. A splice variant of α6 integrin is associated with malignant conversion in mouse skin tumorigenesis. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 7041-7045