The A and B variants of the α3 integrin subunit: Tissue distribution and functional characterization

Laboratory Investigation

Volumn 76, Issue 4, 1997, Pages 547-563

  De Melker, Annemieke A ^a   Sterk, Lotus M Th ^b   Delwel, Gepke O ^a   Fles, Daniëlle L A ^a   Daams, Henny ^a   Weening, Jan J ^b   Sonnenberg, Arnoud ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN; LAMININ; LAMININ BINDING PROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN SUBUNIT;

ANIMAL CELL; ANTIGEN RECOGNITION; ARTICLE; BINDING AFFINITY; CATTLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; RNA SPLICING; STRUCTURE ACTIVITY RELATION; TISSUE DISTRIBUTION;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD29; BRAIN; CATTLE; CELL ADHESION; DNA PRIMERS; ENDOTHELIUM, VASCULAR; HUMANS; IMMUNOENZYME TECHNIQUES; INTEGRIN ALPHA3BETA1; INTEGRINS; LAMININ; LEUKEMIA, ERYTHROBLASTIC, ACUTE; MICE; MOLECULAR SEQUENCE DATA; MUSCLE, SKELETAL; MYOCARDIUM; PHOSPHORYLATION; RECEPTORS, LAMININ; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0030975727     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Altruda F, Cervella P, Tarone G, Botta C, Balzac F, Stefanuto G, and Silengo L (1990). A human integrin β1 subunit with a unique cytoplasmic domain generated by alternative mRNA processing. Gene 95:261-266.
2. Bartolazzi A, Cerboni C, Full C, Valentini C, Natali PG, Venturo I, and Bigotti A (1993). Vla-3 distribution in normal and neoplastic non-lymphoid human tissues. Pathol Res Pract 189:387-393.
3. Bray PF, Leung CS, and Shuman MA (1990). Human platelets and megakaryocytes contain alternately spliced glycoprotein IIb mRNAs. J Biol Chem 265:9587-9590.
4. Cattelino A, Longhi R, and Decurtis I (1995). Differential distribution of two cytoplasmic variants of the α6β1 integrin laminin receptor in the ventral plasma membrane of embryonic fibroblasts. J Cell Sci 108:3067-3078.
5. Clarke AS, Lotz MM, and Mercurio AM (1994). A novel structural variant of the human β4 integrin cDNA. Cell Adhes Commun 2:1-6.
6. Collo G, Domanico SZ, Klier G, and Quaranta V (1995). Gradient of integrin α6A distribution in the myocardium during early heart development. Cell Adhes Commun 3:101-113.
7. Collo G, Starr L, and Quaranta V (1993). A new isoform of the laminin receptor integrin α7β1 is developmentally regulated in skeletal muscle. J Biol Chem 268:19019-19024.
8. Cooper HM, Tamura RN, and Quaranta V (1991). The major laminin receptor of mouse embryonic stem cells is a novel isoform of the α6β1 integrin. J Cell Biol 115:843-850.
9. De Curtis I and Gatti G (1994). Identification of a large complex containing the integrin α6β1 laminin receptor in neural retinal cells. J Cell Sci 107:3165-3172.
10. Dedhar S, Jewell K, Rojiani M, and Gray V (1992). The receptor for the basement membrane glycoprotein entactin is the integrin α3β1. J Biol Chem 267:18908-18914.
11. Delwel GO, de Melker AA, Hogervorst F, Jaspars LH, Fles DL, Kuikman I, Lindblom A, Paulsson M, Timpl R, and Sonnenberg A (1994). Distinct and overlapping ligand specificities of the α3Aβ1 and α6Aβ1 integrins: Recognition of laminin isoforms. Mol Biol Cell 5:203-215.
12. Delwel GO, Hogervorst F, Kuikman I, Paulsson M, Timpl R, and Sonnenberg A (1993). Expression and function of the cytoplasmic variants of the integrin α6 subunit in transfected K562 cells: Activation-dependent adhesion and interaction with isoforms of laminin. J Biol Chem 268:25865-25875.
13. Delwel GO, Kuikman I, and Sonnenberg A (1995). An alternatively spliced exon in the extracellular domain of the human α6 integrin subunit: Functional analysis of the α6 integrin variants. Cell Adhes Commun 3:143-161.
14. Delwel GO and Sonnenberg A (1996). Laminin isoforms and their integrin receptors. In: Horton MA, editor: Adhesion receptors as therapeutic targets. Boca Raton: CRC Press, 9-36.
15. DiPersio CM, Shah S, and Hynes RO (1995). α3Aβ1 integrin localizes to focal contacts in response to diverse extracellular matrix proteins. J Cell Sci 108:2321-2336.
16. Djaffar I, Chen YP, Creminon C, Maclouf J, Cieutat AM, Gayet O, and Rosa JP (1994). A new alternative transcript encodes a 60 kDa truncated form of integrin β3. Biochem J 300:69-74.
17. Ehrig K, Leivo I, Argraves WS, Ruoslahti E, and Engvall E (1990). Merosin, a tissue-specific basement membrane protein, is a laminin-like protein. Proc Natl Acad Sci U S A 87:3264-3268.
18. Elices MJ, Urry LA, and Hemler ME (1991). Receptor functions for the integrin VLA-3: Fibronectin, collagen, and laminin binding are differentially influenced by Arg-Gly-Asp peptide and by divalent cations. J Cell Biol 112:169-181.
19. Haring HP, Akamine P, Habermann R, Koziol JA, and Delzoppo GJ (1996). Distribution of integrin-like immunoreactivity on primate brain microvasculature. J Neuropathol Exp Neurol 55:236-245.
20. Hemler ME, Sanchez MF, Flotte TJ, Krensky AM, Burakoff SJ, Bhan AK, Springer TA, and Strominger JL (1984). Glycoproteins of 210,000 and 130,000 MW on activated T cells: Cell distribution and antigenic relation to components on resting cells and T cell lines. J Immunol 132:3011-3018.
21. Hibbs ML, Jakes S, Stacker SA, Wallace RW, and Springer TA (1991). The cytoplasmic domain of the integrin lymphocyte function-associated antigen 1 β subunit: Sites required for binding to intercellular adhesion molecule 1 and the phorbol ester-stimulated phosphorylation site. J Exp Med 174:1227-1238.
22. Hierck BP, Thorsteinsdottir S, Niessen CM, Freund E, Iperen LV, Feyen A, Hogervorst F, Poelmann RE, Mummery CL, and Sonnenberg A (1993). Variants of the α6β1 laminin receptor in early murine development: Distribution, molecular cloning and chromosomal localization of the mouse integrin α6 subunit [published erratum, appears in Cell Adhes Commun 1993;1:190]. Cell Adhes Commun 1:33-53.
23. Hogervorst F, Admiraal LG, Niessen C, Kuikman I, Janssen H, Daams H, and Sonnenberg A (1993a). Biochemical characterization and tissue distribution of the A and B variants of the integrin α6 subunit. J Cell Biol 121:179-191.
24. Hogervorst F, Kuikman I, Noteboom E, and Sonnenberg A. (1993b). The role of phosphorylation in activation of the α6Aβ1 laminin receptor. J Biol Chem 268:18427-18430.
25. Hogervorst F, Kuikman I, van Kessel AG, and Sonnenberg A (1991). Molecular cloning of the human α6 integrin subunit: Alternative splicing of α6 mRNA and chromosomal localization of the α6 and β4 genes. Eur J Biochem 199:425-433.
26. Hogervorst F, Kuikman I, von dem Borne AEGK, and Sonnenberg A (1990). Cloning and sequence analysis of β4 cDNA: An integrin subunit that contains a unique 118 kd cytoplasmic domain. EMBO J 9:765-770.
27. Hynes RO (1992). Integrins: Versatility, modulation, and signaling in cell adhesion (review). Cell 69:11-25.
28. Jiang RL and Grabel LB (1995). Function and differential regulation of the α6 integrin isoforms during parietal endoderm differentiation. Exp Cell Res 217:195-204.
29. Kantor RR, Mattes MJ, Lloyd KO, Old LJ, and Albino AP (1987). Biochemical analysis of two cell surface glycoprotein complexes, very common antigen 1 and very common antigen 2: Relationship to very late activation T cell antigens. J Biol Chem 262:15158-15165.
30. Keizer GD, Te Velde AA, Schwarting R, Figdor CG, and De Vries JE (1987). Role of p150,95 in adhesion, migration, chemotaxis and phagocytosis of human monocytes. Eur J Immunol 17:1317-1322.
31. Languino LR and Ruoslahti E (1992). An alternative form of the integrin β1 subunit with a variant cytoplasmic domain. J Biol Chem 267:7116-7120.
32. Lindblom A, Marsh T, Fauser C, Engel J, and Paulsson M (1994). Characterization of native laminin from bovine kidney and comparison with other laminin variants. Eur J Biochem 219:383-392.
33. Luscinskas FW and Lawler J (1994). Integrins as dynamic regulators of vascular function (review). FASEB J 8:929-938.
34. Miles AJ, Knutson JB, Skubitz APN, Furcht LT, McCarthy JB, and Fields GB (1995). A peptide model of basement membrane collagen α1(iv) 531-543 binds the α3β1 integrin. J Biol Chem 270:29047-29050.
35. Niessen CM, Hogervorst F, Jaspars LH, de Melker AA, Delwel GO, Hulsman EH, Kuikman I, and Sonnenberg A (1994). The α6β4 integrin is a receptor for both laminin and kalinin. Exp Cell Res 211:360-367.
36. Paulsson M, Saladin K, and Engvall E (1991). Structure of laminin variants: The 300-kDa chains of murine and bovine heart laminin are related to the human placenta merosin heavy chain and replace the A chain in some laminin variants. J Biol Chem 266:17545-17551.
37. Paulus W, Baur I, Schuppan D, and Roggendorf W (1993). Characterization of integrin receptors in normal and neoplastic human brain. Am J Pathol 143:154-163.
38. Shaw LM and Mercurio AM (1993). Regulation of α6β1 integrin laminin receptor function by the cytoplasmic domain of the α6 subunit. J Cell Biol 123:1017-1025.
39. Shaw LM and Mercurio AM (1994). Regulation of cellular interactions with laminin by integrin cytoplasmic domains: The A and B structural variants of the α6β1 integrin differentially modulate the adhesive strength, morphology, and migration of macrophages. Mol Biol Cell 5:679-690.
40. Song WK, Wang W, Sato H, Bielser DA, and Kaufman SJ (1993). Expression of α7 integrin cytoplasmic domains during skeletal muscle development: alternate forms, conformational change, and homologies with serine/threonine kinases and tyrosine phosphatases. J Cell Sci 106:1139-1152.
41. Sonnenberg A (1993). Integrins and their ligands (review). Curr Top Microbiol Immunol 184:7-35.
42. Sonnenberg A, de Melker AA, Martinez de Velasco AM, Janssen H, Calafat J, and Niessen CM (1993). Formation of hemidesmosomes in cells of a transformed murine mammary tumor cell line and mechanisms involved in adherence of these cells to laminin and kalinin. J Cell Sci 106:1083-1102.
43. Sonnenberg A, Hogervorst F, Osterop A, and Veltman FE (1988). Identification and characterization of a novel antigen complex on mouse mammary tumor cells using a monoclonal antibody against platelet glycoprotein Ic. J Biol Chem 263: 14030-14038.
44. Sonnenberg A, Modderman PW, van der Geer P, Aumailley M, and Timpl R (1991). Structure and function of platelet glycoprotein IC-IIA (VLA-6). In: Kaplan-Gouet C, Schlegel N, Salmon C, and McGregor J, editors: Platelet immunology: Fundamental and clinical aspects, vol 206. Paris: Colloques INSERM/John Libbey Eurotext Ltd., 75-95.
45. Sriramarao P, Steffner P and Gehlsen KR (1993). Biochemical evidence for a homophilic interaction of the α3β1 integrin. J Biol Chem 268:22036-22041.
46. Sutherland AE, Calarco PG, and Damsky CH (1993). Developmental regulation of integrin expression at the time of implantation in the mouse embryo. Development 119:1175-1186.
47. Suzuki S and Naitoh Y (1990). Amino acid sequence of a novel integrin β4 subunit and primary expression of the mRNA in epithelial cells. EMBO J 9:757-763.
48. Symington BE, Takada Y, and Carter WG (1993). Interaction of integrins α3β1 and α2β1: Potential role in keratinocyte intercellular adhesion. J Cell Biol 120:523-535.
49. Takada Y, Murphy E, Pil P, Chen C, Ginsberg MH, and Hemler ME (1991). Molecular cloning and expression of the cDNA for α3 subunit of human α3β1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen. J Cell Biol 115:257-266.
50. Tamura RN, Cooper HM, Collo G, and Quaranta V (1991). Cell type-specific integrin variants with alternative α chain cytoplasmic domains. Proc Natl Acad Sci U S A 88:10183-10187.
51. Tamura RN, Rozzo C, Starr L, Chambers J, Reichardt LF, Cooper HM, and Quaranta V (1990). Epithelial integrin α6β4: Complete primary structure of α6 and variant forms of β4. J Cell Biol 111:1593-1604.
52. Timpl R, Paulsson M, Dziadek M, and Fujiwara S (1987). Basement membranes. Methods Enzymol 145:363-391.
53. Van der Flier A, Kuikman I, Baudoin C, Van der Neut R, and Sonnenberg A (1995). A novel β1 integrin isoform produced by alternative splicing: Unique expression in cardiac and skeletal muscle. FEBS Lett 369:340-344.
54. Van Kuppevelt THMSM, Languino LR, Gailit JO, Suzuki S, and Ruoslahti E (1989). An alternative cytoplasmic domain of the integrin β3 subunit. Proc Natl Acad Sci U S A 86:5415-5418.
55. Van Mourik JA, Leeksma OC, Reinders JH, de Groot PG, and Zandbergen-Spaargaren J (1985). Vascular endothelial cells synthesize a plasma membrane protein indistinguishable from the platelet membrane glycoprotein IIa. J Biol Chem 260:11300-11306.
56. Werb Z, Tremble PM, Behrendtsen O, Crowley E, and Damsky CH (1989). Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression. J Cell Biol 109:877-889.
57. Zhidkova NI, Belkin AM, and Mayne R (1995). Novel isoform of β1 integrin expressed in skeletal and cardiac muscle. Biochem Biophys Res Commun 214:279-285.
58. Ziober BL, Vu MP, Waleh N, Crawford J, Lin CS, and Kramer RH (1993). Alternative extracellular and cytoplasmic domains of the integrin α7 subunit are differentially expressed during development. J Biol Chem 268:26773-26783.