Transforming growth factor-β1 upregulates transcription of α3 integrin gene in hepatocellular carcinoma cells via Ets-transcription factor-binding motif in the promoter region

Clinical and Experimental Metastasis

Volumn 22, Issue 7, 2005, Pages 539-548

  Katabami, Kouji ^a   Mizuno, Hiromi ^a   Sano, Rikio ^a   Saito, Yuta ^a   Ogura, Masaharu ^a   Itoh, Saotomo ^a   Tsuji, Tsutomu ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

3 integrin; Ets transcription factor; Hepatocellular carcinoma; Luciferase assay; Transforming growth factor

Indexed keywords

ALPHA3 INTEGRIN; DNA; KALININ; LUCIFERASE; NUCLEAR PROTEIN; OLIGONUCLEOTIDE; TRANSCRIPTION FACTOR ELK 1; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; ASSAY; CANCER CELL; DNA FLANKING REGION; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; LIVER CANCER; MOLECULAR PROBE; MOUSE; MUTATION; NONHUMAN; PHENOTYPE; PROMOTER REGION; UPREGULATION;

BASE SEQUENCE; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL MOVEMENT; DNA PRIMERS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; HUMANS; INTEGRIN ALPHA3; LIVER NEOPLASMS; MOLECULAR SEQUENCE DATA; NEOPLASM INVASIVENESS; PLASMIDS; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEIN C-ETS-1; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 32544447712     PISSN: 02620898     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10585-005-5260-x     Document Type: Article

References (50)

1. EK Bergsland AP Venook 2000 Hepatocellular carcinoma Curr Opin Oncol 12 357 61
2. R Izumi K Shimizu T Ii 1994 Prognostic factors of hepatocellular carcinoma in patients undergoing hepatic resection Gastroenterology 106 720 7
3. SP Holly MK Larson LV Parise 2000 Multiple roles of integrins in cell motility Exp Cell Res 261 69 74
4. JD Hood DA Cheresh 2002 Role of integrins in cell invasion and migration Nat Rev Cancer 2 91 100
5. B Felding-Habermann 2003 Integrin adhesion receptors in tumor metastasis Clin Exp Metastasis 20 203 13
6. G Giannelli C Bergamini E Fransvea 2001 Human hepatocellular carcinoma (HCC) cells require both α3β1 integrin and matrix metalloproteinases activity for migration and invasion Lab Invest 81 613 27
7. JA Kreidberg 2000 Functions of α3β1 integrin Curr Opin Cell Biol 12 548 53
8. T Tsuji 2004 Physiological and pathological roles of α3β1 integrin J Membr Biol 200 115 32
9. G Giannelli S Astigiano S Antonaci 2002 Role of the α3β1 and α6β4 integrins in tumor invasion Clin Exp Metastasis 19 217 23
10. H Ura R Denno K Hirata 1998 Separate functions of α2β1 and α3β1 integrins in the metastatic process of human gastric carcinoma Surg Today 28 1001 6
11. H Takatsuki S Komatsu R Sano 2004 Adhesion of gastric carcinoma cells to peritoneum mediated by α3β1 integrin (VLA-3) Cancer Res 64 6065 70
12. T Tsuji Y Kawada M Kai-Murozono 2002 Regulation of melanoma cell migration and invasion by laminin-5 and α3β1 integrin (VLA-3) Clin Exp Metastasis 19 127 34
13. H Kishima K Shimizu K Tamura 1999 Monoclonal antibody ONS-M21 recognizes integrin α3 in gliomas and medulloblastomas Br J Cancer 79 333 9
14. S Kagami T Kuhara K Yasutomo 1996 Transforming growth factor-β (TGF-β) stimulates the expression of β1 integrins and adhesion by rat mesangial cells Exp Cell Res 229 1 6
15. K Miyake S Kimura M Nakanishi 2000 Transforming growth factor-β1 stimulates contraction of human glioblastoma cell-mediated collagen lattice through enhanced α2 integrin expression J Neuropathol Exp Neurol 59 18 28
16. CF Lai X Feng R Nishimura 2000 Transforming growth factor-β up-regulates the β5 integrin subunit expression via Sp1 and Smad signaling J Biol Chem 275 36400 6
17. D Wang GH Zhou TM Birkenmeier 1995 Autocrine transforming growth factor β1 modulates the expression of integrin α5β1 in human colon carcinoma FET cells J Biol Chem 270 14154 9
18. RG. Wells 2000 Fibrogenesis. V. TGF-β signaling pathway Am J Physiol Gastrointest Liver Physiol 279 845 50
19. M Bauer D Schuppan 2001 TGFβ1 in liver fibrosis: time to change paradigms? FEBS Lett 502 4 10
20. R Bataller DA Brenner 2005 Liver fibrosis J Clin Invest 115 209 18
21. G Giannelli E Fransvea F Marinosci 2002 Transforming growth factor-β1 triggers hepatocellular carcinoma invasiveness via α3β1 integrin Am J Pathol 161 183 93
22. M Abou-Shady HU Baer H Friess 1999 Transforming growth factor betas and their signaling receptors in human hepatocellular carcinoma Am J Surg 177 209 15
23. K Miyazaki Y Kikkawa A Nakamura 1993 A large cell-adhesive scatter factor secreted by human gastric carcinoma cells Proc Natl Acad Sci USA 90 11767 71
24. K Takeuchi T Tsuji S Hakomori T Irimura 1994 Intercellular adhesion induced by anti-α3 integrin (VLA-3) antibodies Exp Cell Res 211 133 41
25. P Chomczynski N Sacchi 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction Anal Biochem 162 156 9
26. I Kitajima K Yamamoto K Sato 1991 Detection of human T cell lymphotropic virus type I proviral DNA and its gene expression in synovial cells in chronic inflammatory arthropathy J Clin Invest 88 1315 22
27. T Kato K Katabami H Takatsuki 2002 Characterization of the promoter for the mouse α3 integrin gene Eur J Biochem 269 4524 32
28. MP Weiner GL Costa W Schoettlin 1994 Site-directed mutagenesis of double-stranded DNA by the polymerase chain reaction Gene 151 119 23
29. JH Ko E Miyoshi K Noda 1999 Regulation of the GnT-V promoter by transcription factor Ets-1 in various cancer cell lines J Biol Chem 274 22941 8
30. RN Tamura HM Cooper G Collo V. Quaranta 1991 Cell type-specific integrin variants with alternative α chain cytoplasmic domains Proc Natl Acad Sci USA 88 10183 7
31. H Watanabe P Carmi V Hogan 1991 Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor J Biol Chem 266 13442 8
32. E Wingender X Chen E Fricke 2001 The TRANSFAC system on gene expression regulation Nucleic Acids Res 29 281 3
33. RL Elliott GC Blobe 2005 Role of transforming growth factor beta in human cancer J Clin Oncol 23 2078 93
34. M Oft KH Heider H Beug 1998 TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis Curr Biol. 8 1243 52
35. W Rossmanith R Schulte-Hermann 2001 Biology of transforming growth factor β in hepatocarcinogenesis Microsc Res Tech 52 430 6
36. T Torimura T Ueno M Kin 1997 Coordinated expression of integrin α6β1 and laminin in hepatocellular carcinoma Hum Pathol 28 1131 8
37. T Torimura T Ueno M Kin 1999 Integrin α6β1 plays a significant role in the attachment of hepatoma cells to laminin J Hepatol 31 734 40
38. D Kita T Takino M Nakada 2001 Expression of dominant-negative form of Ets-1 suppresses fibronectin-stimulated cell adhesion and migration through downregulation of integrin α5 expression in U251 glioma cell line Cancer Res 61 7985 91
39. A Tajima Y Miyamoto H Kadowaki M Hayashi 2000 Mouse integrin α v promoter is regulated by transcriptional factors Ets and Sp1 in melanoma cells Biochim Biophys Acta. 1492 377 84
40. Y Izumiyama Y Ohiro F Higashino 2005 E1AF expression is closely correlated with malignant phenotype of tongue squamous cell carcinoma through activation of MT1-MMP gene promoters Oncol Rep 13 715 20
41. K Nosho M Yoshida H Yamamoto 2005 Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis Carcinogenesis 26 892 9
42. H Ito M Duxbury E Benoit 2004 Prostaglandin E2 enhances pancreatic cancer invasiveness through an Ets-1-dependent induction of matrix metalloproteinase-2 Cancer Res 64 7439 46
43. N Koshikawa G Giannelli V Cirulli 2000 Role of cell surface metalloprotease MT1-MMP in epithelial cell migration over laminin-5 J Cell Biol. 148 615 24
44. S Itoh F Itoh MJ Goumans P Ten Dijke 2000 Signaling of transforming growth factor-β family members through Smad proteins Eur J Biochem. 267 6954 57
45. M Jinnin H Ihn Y Asano 2004 Tenascin-C upregulation by transforming growth factor-β in human dermal fibroblasts involves Smad3, Sp1, and Ets1 Oncogene 23 1656 67
46. MJ Shi SR Park PH Kim J Stavnezer 2001 Roles of Ets proteins, NF-κB and nocodazole in regulating induction of transcription of mouse germline Ig α RNA by transforming growth factor-β1 Int Immunol. 13 733 46
47. BA Hocevar TL Brown PH Howe 1999 TGF-β induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway EMBO J 18 1345 56
48. 9 myoblasts FEBS Lett 513 282 8
49. B Wasylyk J Hagman A Gutierrez-Hartmann 1998 Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway Trends Biochem Sci 23 213 6
50. HP Kim MS Lee J Yu 2004 TGF-β1 (transforming growth factor-β1)-mediated adhesion of gastric carcinoma cells involves a decrease in Ras/ERKs (extracellular-signal-regulated kinases) cascade activity dependent on c-Src activity Biochem J 379 141 50