PPARG Pro12Ala genotype and risk of cognitive decline in elders? Maybe with diabetes

Neuroscience Letters

Volumn 434, Issue 1, 2008, Pages 50-55

  Johnson, Wendy ^a,b   Harris, Sarah E ^a   Starr, John M ^a   Whalley, Lawrence J ^c   Deary, Ian J ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF MINNESOTA   (United States)

^c UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Cognitive ageing; Cognitive function; IQ; Peroxisome proliferator activated receptor gamma; Pro12Ala PPARG

Indexed keywords

ALANINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROLINE;

AGED; AGING; ALLELE; ARTICLE; BODY MASS; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; DNA POLYMORPHISM; FEMALE; GENETIC ASSOCIATION; GENOTYPE; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SCHOOL CHILD; SENESCENCE;

AGED; AGED, 80 AND OVER; AGING; AMINO ACID SUBSTITUTION; CHILD; COGNITION DISORDERS; DEMENTIA; DIABETES COMPLICATIONS; DNA MUTATIONAL ANALYSIS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; GENOTYPE; HETEROZYGOTE; HUMANS; MALE; MUTATION; NEUROPSYCHOLOGICAL TESTS; POLYMORPHISM, GENETIC; PPAR GAMMA; RISK FACTORS;

EID: 40649104295     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.01.027     Document Type: Article

References (25)

1. Altshuler D., Hirschhorn J.N., Klannemark M., Lindgren C.M., Vohl M.C., Nemesh J., Lane C.R., Schaffer S.F., Bolk S., Brewer C., Tuomi T., Gaudet D., Hudson T.J., Daly M., Groop L., and Lander E.S. The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat. Genet. 26 1 (2000) 76-80
2. Combs C.K., Johnson D.E., Karlo J.C., Cannady S.B., and Landreth G.E. Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists. J. Neurosci. 20 2 (2000) 558-567
3. Craft S., and Watson G.S. Insulin and neurodegenerative disease: shared and specific mechanisms. Lancet Neurol. 3 March (2004) 169-178
4. Deary I.J., Whalley L.J., St. Clair D., Breen G., Leaper S., Hayward C., and Starr J.M. The influence of the E4 allele of the apolipoprotein E gene on childhood IQ, nonverbal reasoning in old age, and lifetime cognitive change. Intelligence 31 (2004) 85-92
5. Deary I.J., Whiteman M.C., Pattie A., Starr J.M., Wright A.F., Carothers A., and Whalley L.J. Cognitive change and the APOE e4 allele. Nature 418 (2002) 932
6. Deary I.J., Whiteman M.C., Pattie A., Starr J.M., Wright A.F., Visscher P.M., Tynan M.C., and Whalley L.J. Apolipoprotein E gene variability and cognitive functions at age 79: follow-up of the Scottish Mental Survey 1932. Psychol. Aging (2004) 367-371
7. Deary I.J., Whiteman M.C., Starr J.M., Whalley L.J., and Fox H.C. The impact of childhood intelligence on later life: following up the Scottish Mental Surveys of 1932 and 1947. J. Pers. Soc. Psychol. 86 (2004) 130-147
8. Folstein M.F., Folstein S.E., and McHugh P.R. Mini Mental State: a practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 12 (1975) 189-198
9. Fornage M., Jacobs D.R., Steffes M.W., Gross M.D., Bray M.S., and Schreiner P.J. Inverse effects of the PPARG(gamma) 2 Pro12Ala polymorphism on measures of adiposity over 15 years in African Americans and Whites-the Cardia Study. Metabolism 54 7 (2005) 910-917
10. Grodstein F., Chen J., Wilson R.S., and Manson J.E. Type 2 diabetes and cognitive function in community-dwelling elderly women. Diabetes Care 24 6 (2001) 1060-1065
11. Heneka M.T., Klockgether T., and Feinstein D.L. Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo. J. Neurosci. 20 18 (2000) 6862-6867
12. Lezak M. Neuropsychological Testing (1995), Oxford University Press, Oxford, England
13. Luchsinger J.A., Tang M.X., Shea S., and Mayeux R. Hyperinsulinemia and risk of Alzheimer disease. Neurology 63 7 (2004) 1187-1192
14. Masud S., and Ye S. Effect of the peroxisome proliferator-activated receptor-gamma gene Pro12Ala variant on Body Mass Index: a meta-analysis. J. Med. Genet. 40 (2003) 773-780
15. Raven J.C., Court J.H., and Raven J. Manual for Raven's Progressive Matrices and Vocabulary Scales (1977), H.K. Lewis, London
16. Scacchi R., Pinto A., Gambina G., Rosano A., and Corbo R.M. The peroxisome proliferator-activated receptor gamma (PPAR-gamma2) Pro12Ala polymorphism is associated with higher risk for Alzheimer's disease in octogenarians. Brain Res. 139 (2007) 1-5
17. Schafer J.L., and Graham J.W. Missing data: our view of the state of the art. Psychol. Methods 7 (2002) 147-177
18. Scottish Council for Research in Education. The Intelligence of Scottish Children: A National Survey of an Age Group (1933), University of London Press, London
19. Stumvoll M., and Haring H. The peroxisome proliferator activated receptor-gamma2 Pro12Ala polymorphism. Diabetes 51 8 (2002) 2341-2347
20. Watson G.S., Cholerton B.A., Reger M.A., Baker L.D., Plymate S.R., Asthana S., Fishel M.A., Kulstad J.J., Green P.S., Cook D.G., Kahn S.E., Keeling M.L., and Craft S. Preserved cognition in patients with early Alzheimer's disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study. Am. J. Geriatr. Psychiatry 13 11 (2005) 950-958
21. Wechsler D. Wechsler Memory Scale-Revised (1987), Psychological Corporation, New York
22. Whitmer R.A., Gunderson E.P., Barrett-Connor E., Queensberry J.C.P., and Yaffe K. Obesity in middle age and future risk of dementia. Br. Med. J. 330 7504 (2005) 1360
23. Yaffe K., Blackwell T., Kanaya A.M., Davidowitz N., Barrett-Connor E., and Krueger K. Diabetes, impaired fasting glucose, and development of cognitive impairment in older women. Neurology 63 4 (2004) 658-663
24. Yaffe K., Kanaya A.M., Lindquist K., Hsueh W.C., Cummings S.R., Beamer B., Newman A., Rosano C., Li R., and Harris T. PPARG Pro12Ala genotype and risk of cognitive decline in elders. Neurobiol. Aging 29 (2008) 78-83
25. Zigmond A.S., and Snaith R.P. The Hospital Anxiety and Depression Scales. Acta Psychiatr. Scand. 67 (1983) 361-370