Murine cytomegalovirus influences Foxj1 expression, ciliogenesis, and mucus plugging in mice with allergic airway disease

American Journal of Pathology

Volumn 172, Issue 3, 2008, Pages 714-724

  Wu, Carol A ^a   Peluso, John J ^a   Shanley, John D ^a   Puddington, Lynn ^a   Thrall, Roger S ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOXJ1 PROTEIN; GAMMA INTERFERON; INTERLEUKIN 13; MESSENGER RNA; MUCIN 2; MUCIN 5AC; MUCIN 5B; OVALBUMIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

AEROSOL; ALLERGIC AIRWAY DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LOSS; CILIATED EPITHELIUM; CILIOGENESIS; CONTROLLED STUDY; CYTOLOGY; CYTOMEGALOVIRUS INFECTION; FEMALE; GOBLET CELL; HISTOLOGY; LUNG; LUNG LAVAGE; LUNG PARENCHYMA; METAPLASIA; MOUSE; MUCOCILIARY CLEARANCE; MUCUS; NONHUMAN; PERIODIC ACID SCHIFF STAIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY EPITHELIUM; RESPIRATORY TRACT DISEASE;

EID: 40449129955     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.2353/ajpath.2008.070462     Document Type: Article

References (65)

1. T Takizawa WM Thurlbeck Muscle and mucous gland size in the major bronchi of patients with chronic bronchitis, asthma, and asthmatic bronchitis Am Rev Respir Dis 104 1971 331 336
2. JV Fahy DJ Steiger J Liu CB Basbaum WE Finkbeiner HA Boushey Markers of mucus secretion and DNA levels in induced sputum from asthmatic and from healthy subjects Am Rev Respir Dis 147 1993 1132 1137
3. H Huber K Koessler The pathology of bronchial asthma Arch Intern Med 30 1922 689 760
4. MS Dunnill The pathology of asthma, with special reference to changes in the bronchial mucosa J Clin Pathol 13 1960 27 33
5. P Cardell Death in asthmatics Thorax 14 1959 341 352
6. LM Kuyper PD Pare JC Hogg RK Lambert D Ionescu R Woods TR Bai Characterization of airway plugging in fatal asthma Am J Med 115 2003 6 11
7. PK Jeffery Morphology of the airway wall in asthma and in chronic obstructive pulmonary disease Am Rev Respir Dis 143 1991 1152 1161
8. S Shimura Y Andoh M Haraguchi K Shirato Continuity of airway goblet cells and intraluminal mucus in the airways of patients with bronchial asthma Eur Respir J 9 1996 1395 1401
9. M Wills-Karp J Luyimbazi X Xu B Schofield TY Neben CL Karp DD Donaldson Interleukin-13: central mediator of allergic asthma Science 282 1998 2258 2261
10. G Grünig M Warnock AE Wakil R Venkayya F Brombacher DM Rennick D Sheppard M Mohrs DD Donaldson RM Locksley DB Corry Requirement for IL-13 independently of IL-4 in experimental asthma Science 282 1998 2261 2263
11. L Cohn RJ Homer A Marinov J Rankin K Bottomly Induction of airway mucus production by T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production J Exp Med 186 1997 1737 1747
12. L Cohn RJ Homer H MacLeod M Mohrs F Brombacher K Bottomly Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils J Immunol 162 1999 6178 6183
13. M Zuhdi Alimam FM Piazza DM Selby N Letwin L Huang MC Rose Muc-5/5ac mucin messenger RNA and protein expression is a marker of goblet cell metaplasia in murine airways Am J Respir Cell Mol Biol 22 2000 253 260
14. FW Henderson WA Clyde Jr AM Collier FW Denny RJ Senior CI Sheaffer WG Conley III RM Christian The etiologic and epidemiologic spectrum of bronchiolitis in pediatric practice J Pediatr 95 1979 183 190
15. FD Martinez WJ Morgan AL Wright CJ Holberg LM Taussig Diminished lung function as a predisposing factor for wheezing respiratory illness in infants N Engl J Med 319 1988 1112 1117
16. WW Busse Respiratory infections: their role in airway responsiveness and the pathogenesis of asthma J Allergy Clin Immunol 85 1990 671 683
17. FD Martinez AL Wright LM Taussig CJ Holberg M Halonen WJ Morgan Asthma and wheezing in the first six years of life. The Group Health Medical Associates N Engl J Med 332 1995 133 138
18. SL Johnston PK Pattemore G Sanderson S Smith F Lampe L Josephs P Symington S O'Toole SH Myint DA Tyrrell ST Holgate Community study of role of viral infections in exacerbations of asthma in 9–11 year old children BMJ 310 1995 1225 1229
19. KG Nicholson J Kent DC Ireland Respiratory viruses and exacerbations of asthma in adults BMJ 307 1993 982 986
20. DP Strachan Family size, infection and atopy: the first decade of the “hygiene hypothesis.” Thorax 55 Suppl 1 2000 S2 S10
21. SO Shaheen P Aaby AJ Hall DJ Barker CB Heyes AW Shiell A Goudiaby Measles and atopy in Guinea-Bissau Lancet 347 1996 1792 1796
22. PM Matricardi F Rosmini L Ferrigno R Nisini M Rapicetta P Chionne T Stroffolini P Pasquini R D'Amelio Cross sectional retrospective study of prevalence of atopy among Italian military students with antibodies against hepatitis A virus BMJ 314 1997 999 1003
23. WH Oddy NH de Klerk PD Sly PG Holt The effects of respiratory infections, atopy, and breastfeeding on childhood asthma Eur Respir J 19 2002 899 905
24. J Reisinger A Triendl E Kuchler B Bohle MT Krauth I Rauter P Valent F Koenig R Valenta V Niederberger IFN-gamma-enhanced allergen penetration across respiratory epithelium augments allergic inflammation J Allergy Clin Immunol 115 2005 973 981
25. KS Park JM Wells AM Zorn SE Wert VE Laubach LG Fernandez JA Whitsett Transdifferentiation of ciliated cells during repair of the respiratory epithelium Am J Respir Cell Mol Biol 34 2006 151 157
26. RL Atmar E Guy KK Guntupalli JL Zimmerman VD Bandi BD Baxter SB Greenberg Respiratory tract viral infections in inner-city asthmatic adults Arch Intern Med 158 1998 2453 2459
27. CA Wu L Puddington HE Whiteley CA Yiamouyiannis CM Schramm F Mohammadu RS Thrall Murine cytomegalovirus infection alters Th1/Th2 cytokine expression, decreases airway eosinophilia, and enhances mucus production in allergic airway disease J Immunol 167 2001 2798 2807
28. SC Henry K Schmader TT Brown SE Miller DN Howell GG Daley JD Hamilton Enhanced green fluorescent protein as a marker for localizing murine cytomegalovirus in acute and latent infection J Virol Methods 89 2000 61 73
29. KS Kunert AM Keane-Myers S Spurr-Michaud AS Tisdale IK Gipson Alteration in goblet cell numbers and mucin gene expression in a mouse model of allergic conjunctivitis Invest Ophthalmol Vis Sci 42 2001 2483 2489
30. PJ Busse TF Zhang K Srivastava BP Lin B Schofield SC Sealfon XM Li Chronic exposure to TNF-alpha increases airway mucus gene expression in vivo J Allergy Clin Immunol 116 2005 1256 1263
31. L Lin SL Peng Coordination of NF-kappaB and NFAT antagonism by the forkhead transcription factor Foxd1 J Immunol 176 2006 4793 4803
32. A Nakanishi S Morita H Iwashita Y Sagiya Y Ashida H Shirafuji Y Fujisawa O Nishimura M Fujino Role of gob-5 in mucus overproduction and airway hyperresponsiveness in asthma Proc Natl Acad Sci USA 98 2001 5175 5180
33. JV Fahy Goblet cell and mucin gene abnormalities in asthma Chest 122 2002 320S 326S
34. OW Williams A Sharafkhaneh V Kim BF Dickey CM Evans Airway mucus: from production to secretion Am J Respir Cell Mol Biol 34 2006 527 536
35. BP Hackett SL Brody M Liang ID Zeitz LA Bruns JD Gitlin Primary structure of hepatocyte nuclear factor/forkhead homologue 4 and characterization of gene expression in the developing respiratory and reproductive epithelium Proc Natl Acad Sci USA 92 1995 4249 4253
36. L Lim H Zhou RH Costa The winged helix transcription factor HFH-4 is expressed during choroid plexus epithelial development in the mouse embryo Proc Natl Acad Sci USA 94 1997 3094 3099
37. EN Blatt XH Yan MK Wuerffel DL Hamilos SL Brody Forkhead transcription factor HFH-4 expression is temporally related to ciliogenesis Am J Respir Cell Mol Biol 21 1999 168 176
38. SL Brody XH Yan MK Wuerffel SK Song SD Shapiro Ciliogenesis and left-right axis defects in forkhead factor HFH-4-null mice Am J Respir Cell Mol Biol 23 2000 45 51
39. J Chen HJ Knowles JL Hebert BP Hackett Mutation of the mouse hepatocyte nuclear factor/forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetry J Clin Invest 102 1998 1077 1082
40. T Huang Y You MS Spoor EJ Richer VV Kudva RC Paige MP Seiler JM Liebler J Zabner CG Plopper SL Brody Foxj1 is required for apical localization of ezrin in airway epithelial cells J Cell Sci 116 2003 4935 4945
41. L Lin MS Spoor AJ Gerth SL Brody SL Peng Modulation of Th1 activation and inflammation by the NF-kappaB repressor Foxj1 Science 303 2004 1017 1020
42. L Zhang A Bukreyev CI Thompson B Watson ME Peeples PL Collins RJ Pickles Infection of ciliated cells by human parainfluenza virus type 3 in an in vitro model of human airway epithelium J Virol 79 2005 1113 1124
43. L Zhang ME Peeples RC Boucher PL Collins RJ Pickles Respiratory syncytial virus infection of human airway epithelial cells is polarized, specific to ciliated cells, and without obvious cytopathology J Virol 76 2002 5654 5666
44. DC Look MJ Walter MR Williamson L Pang Y You JN Sreshta JE Johnson DS Zander SL Brody Effects of paramyxoviral infection on airway epithelial cell Foxj1 expression, ciliogenesis, and mucociliary function Am J Pathol 159 2001 2055 2069
45. M Balthesen M Messerle MJ Reddehase Lungs are a major organ site of cytomegalovirus latency and recurrence J Virol 67 1993 5360 5366
46. S Kurz HP Steffens A Mayer JR Harris MJ Reddehase Latency versus persistence or intermittent recurrences: evidence for a latent state of murine cytomegalovirus in the lungs J Virol 71 1997 2980 2987
47. MS Messina TG O'Riordan GC Smaldone Changes in mucociliary clearance during acute exacerbations of asthma Am Rev Respir Dis 143 1991 993 997
48. DA Kuperman X Huang LL Koth GH Chang GM Dolganov Z Zhu JA Elias D Sheppard DJ Erle Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma Nat Med 8 2002 885 889
49. HC Atherton G Jones H Danahay IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3-kinase regulation Am J Physiol 285 2003 L730 L739
50. JW Tyner EY Kim K Ide MR Pelletier WT Roswit JD Morton JT Battaile AC Patel GA Patterson M Castro MS Spoor Y You SL Brody MJ Holtzman Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals J Clin Invest 116 2006 309 321
51. BN Gomperts LJ Kim SA Flaherty BP Hackett IL-13 regulates cilia loss and foxj1 expression in human airway epithelium Am J Respir Cell Mol Biol 37 2007 339 346
52. JD Li W Feng M Gallup JH Kim J Gum Y Kim C Basbaum Activation of NF-kappaB via a Src-dependent Ras-MAPK-pp90rsk pathway is required for Pseudomonas aeruginosa-induced mucin overproduction in epithelial cells Proc Natl Acad Sci USA 95 1998 5718 5723
53. CE Belcher J Drenkow B Kehoe TR Gingeras N McNamara H Lemjabbar C Basbaum DA Relman The transcriptional responses of respiratory epithelial cells to Bordetella pertussis reveal host defensive and pathogen counter-defensive strategies Proc Natl Acad Sci USA 97 2000 13847 13852
54. HW Chu S Jeyaseelan JG Rino DR Voelker RB Wexler K Campbell RJ Harbeck RJ Martin TLR2 signaling is critical for Mycoplasma pneumoniae-induced airway mucin expression J Immunol 174 2005 5713 5719
55. K Hashimoto BS Graham SB Ho KB Adler RD Collins SJ Olson W Zhou T Suzutani PW Jones K Goleniewska JF O'Neal RS Peebles Jr Respiratory syncytial virus in allergic lung inflammation increases Muc5ac and gob-5 Am J Respir Crit Care Med 170 2004 306 312
56. SH He J Zheng MK Duan Induction of mucin secretion from human bronchial tissue and epithelial cells by rhinovirus and lipopolysaccharide Acta Pharmacol Sinica 25 2004 1176 1181
57. D Inoue M Yamaya H Kubo T Sasaki M Hosoda M Numasaki Y Tomioka H Yasuda K Sekizawa H Nishimura H Sasaki Mechanisms of mucin production by rhinovirus infection in cultured human airway epithelial cells Respir Physiol Neurobiol 154 2006 484 499
58. H Jono T Shuto H Xu H Kai DJ Lim JR Gum Jr YS Kim S Yamaoka XH Feng JD Li Transforming growth factor-beta-Smad signaling pathway cooperates with NF-kappa B to mediate nontypeable Haemophilus influenzae-induced MUC2 mucin transcription J Biol Chem 277 2002 45547 45557
59. H Lemjabbar C Basbaum Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells Nat Med 8 2002 41 46
60. AL Miller RM Strieter AD Gruber SB Ho NW Lukacs CXCR2 regulates respiratory syncytial virus-induced airway hyperreactivity and mucus overproduction J Immunol 170 2003 3348 3356
61. CL Ordonez R Khashayar HH Wong R Ferrando R Wu DM Hyde JA Hotchkiss Y Zhang A Novikov G Dolganov JV Fahy Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression Am J Respir Crit Care Med 163 2001 517 523
62. JV Fahy Remodeling of the airway epithelium in asthma Am J Respir Crit Care Med 164 2001 S46 S51
63. AJ Long JP Sypek R Askew SC Fish LE Mason CM Williams SJ Goldman Gob-5 contributes to goblet cell hyperplasia and modulates pulmonary tissue inflammation Am J Respir Cell Mol Biol 35 2006 357 365
64. A Robichaud SA Tuck S Kargman J Tam E Wong M Abramovitz JR Mortimer HE Burston P Masson J Hirota D Slipetz B Kennedy G O'Neill S Xanthoudakis Gob-5 is not essential for mucus overproduction in preclinical murine models of allergic asthma Am J Respir Cell Mol Biol 33 2005 303 314
65. Y Chen P Thai YH Zhao YS Ho MM DeSouza R Wu Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop J Biol Chem 278 2003 17036 17043