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Volumn 20, Issue 4-5, 2004, Pages 215-224

Role of the pathologist in the diagnosis of hereditary non-polyposis colorectal cancer

Author keywords

diagnosis; HNPCC; pathology; tumor infiltrating lymphocytes

Indexed keywords

PROTEIN ANTIBODY; PROTEIN MLH1; PROTEIN MSH2;

EID: 12844251981     PISSN: 02780240     EISSN: None     Source Type: Journal    
DOI: 10.1155/2004/197484     Document Type: Conference Paper
Times cited : (35)

References (50)
  • 1
    • 74549208765 scopus 로고
    • Heredity with reference to carcinoma as shown by the study of the cases examined in the pathological laboratory of the University of Michigan
    • A.S. Warthin, Heredity with reference to carcinoma as shown by the study of the cases examined in the pathological laboratory of the University of Michigan, Arch Int Med 12 (1913), 546-555.
    • (1913) Arch Int Med , vol.12 , pp. 546-555
    • Warthin, A.S.1
  • 2
    • 0000793005 scopus 로고
    • A review of 17 cases of carcinoma of the thyroid and phaeochromocytoma
    • E.D. Williams, A review of 17 cases of carcinoma of the thyroid and phaeochromocytoma, J Clin Pathol 18 (1965), 288-292.
    • (1965) J Clin Pathol , vol.18 , pp. 288-292
    • Williams, E.D.1
  • 3
    • 34250134720 scopus 로고
    • Tumor and hemihypertrophy associated with Wiedemann-Beckwith's syndrome
    • H.R. Wiedemann, Tumor and hemihypertrophy associated with Wiedemann-Beckwith's syndrome, Eur J Pediatr 141 (1983), 129-131.
    • (1983) Eur J Pediatr , vol.141 , pp. 129-131
    • Wiedemann, H.R.1
  • 4
    • 0015077284 scopus 로고
    • Cancer family "G" revisited: 1895-1970
    • H.T. Lynch and A.J. Krush, Cancer family "G" revisited: 1895-1970, Cancer 27 (1971), 1505-1511.
    • (1971) Cancer , vol.27 , pp. 1505-1511
    • Lynch, H.T.1    Krush, A.J.2
  • 6
    • 0027248156 scopus 로고
    • Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: An updated review
    • H.T. Lynch, T.C. Smyrk and P. Watson et al., Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: An updated review, Gastroenterology 104 (1993), 1535-1549.
    • (1993) Gastroenterology , vol.104 , pp. 1535-1549
    • Lynch, H.T.1    Smyrk, T.C.2    Watson, P.3
  • 7
    • 0029915034 scopus 로고    scopus 로고
    • Overview of natural history, pathology, molecular genetics and mangement of HN-PCC (Lynch syndrome)
    • H.T. Lynch, T. Smyrk and J.F. Lynch, Overview of natural history, pathology, molecular genetics and mangement of HN-PCC (Lynch syndrome), Int J Cancer 69 (1996), 38-43.
    • (1996) Int J Cancer , vol.69 , pp. 38-43
    • Lynch, H.T.1    Smyrk, T.2    Lynch, J.F.3
  • 9
    • 0343399664 scopus 로고    scopus 로고
    • Poorly differentiated colonic adenocarcinoma, medullary type: Clinical, phenotypic, and molecular characteristics
    • J. Rüschoff, W. Dietmaier and J. Lüttges et al., Poorly differentiated colonic adenocarcinoma, medullary type: Clinical, phenotypic, and molecular characteristics, Am J Pathol 150 (1997), 1815-1825.
    • (1997) Am J Pathol , vol.150 , pp. 1815-1825
    • Rüschoff, J.1    Dietmaier, W.2    Lüttges, J.3
  • 10
    • 0017659342 scopus 로고
    • Undifferentiated carcinoma of the large intestine
    • N.M. Gibbs, Undifferentiated carcinoma of the large intestine, Histopathology 1 (1977), 77-84.
    • (1977) Histopathology , vol.1 , pp. 77-84
    • Gibbs, N.M.1
  • 11
    • 0032775053 scopus 로고    scopus 로고
    • Lymphoepithelioma-like carcinoma of the colon in a patient with hereditary nonpolyposis colorectal cancer
    • G. De Petris, R. Lev, D.M. Quirk, P.R. Ferbend, J.R. Butmarc and K. Elenitoba-Johnson, Lymphoepithelioma-like carcinoma of the colon in a patient with hereditary nonpolyposis colorectal cancer, Arch Pathol Lab Med 123 (1999), 720-724.
    • (1999) Arch Pathol Lab Med , vol.123 , pp. 720-724
    • De Petris, G.1    Lev, R.2    Quirk, D.M.3    Ferbend, P.R.4    Butmarc, J.R.5    Elenitoba-Johnson, K.6
  • 12
    • 0033996393 scopus 로고    scopus 로고
    • Adenocarcinoma of colon differentiating as dome epithelium of gut-associated lymphoid tissue
    • J.R. Jass, L. Constable and R. Sutherland et al., Adenocarcinoma of colon differentiating as dome epithelium of gut-associated lymphoid tissue, Histopathology 36 (2000), 116-120.
    • (2000) Histopathology , vol.36 , pp. 116-120
    • Jass, J.R.1    Constable, L.2    Sutherland, R.3
  • 13
    • 0027285475 scopus 로고
    • Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
    • Y. Ionov, M.A. Peinado, S. Malkhosyan, D. Shibata and M. Perucho, Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis, Nature 363 (1993), 558-561.
    • (1993) Nature , vol.363 , pp. 558-561
    • Ionov, Y.1    Peinado, M.A.2    Malkhosyan, S.3    Shibata, D.4    Perucho, M.5
  • 14
    • 0028851972 scopus 로고
    • Diagnostic use of microsatellite instability in hereditary non-polyposis colorectal cancer
    • J.R. Jass, D.S. Cottier and P Jeevaratnam et al., Diagnostic use of microsatellite instability in hereditary non-polyposis colorectal cancer, Lancet 346 (1995), 1200-1201.
    • (1995) Lancet , vol.346 , pp. 1200-1201
    • Jass, J.R.1    Cottier, D.S.2    Jeevaratnam, P.3
  • 15
    • 0033063711 scopus 로고    scopus 로고
    • New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative Group on HNPCC
    • H.F. Vasen, P. Watson, J.-P. Mecklin and H.T. Lynch, New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative Group on HNPCC, Gastroenterology 116 (1999), 1453-1456.
    • (1999) Gastroenterology , vol.116 , pp. 1453-1456
    • Vasen, H.F.1    Watson, P.2    Mecklin, J.-P.3    Lynch, H.T.4
  • 16
    • 0032231445 scopus 로고    scopus 로고
    • Systematic analysis of hMSH2 and hMLH1 in young colon cancer patients and controls
    • S.M. Farrington, J. Lin-Goerke and J. Ling et al., Systematic analysis of hMSH2 and hMLH1 in young colon cancer patients and controls, Am J Hum Genet 63 (1998), 749-759.
    • (1998) Am J Hum Genet , vol.63 , pp. 749-759
    • Farrington, S.M.1    Lin-Goerke, J.2    Ling, J.3
  • 17
    • 0031023727 scopus 로고    scopus 로고
    • Genetic testing is important in families with a history suggestive of hereditary non-polyposis colorectal cancer even if the Amsterdam criteria are not fulfilled
    • N.B. Beck, I.P.M. Tomlinson, T. Homfray, S.V. Hodgson, C.J. Harocopos and W.F. Bodmer, Genetic testing is important in families with a history suggestive of hereditary non-polyposis colorectal cancer even if the Amsterdam criteria are not fulfilled, Br J Surg 84 (1997), 233-237.
    • (1997) Br J Surg , vol.84 , pp. 233-237
    • Beck, N.B.1    Tomlinson, I.P.M.2    Homfray, T.3    Hodgson, S.V.4    Harocopos, C.J.5    Bodmer, W.F.6
  • 18
    • 0034746963 scopus 로고    scopus 로고
    • Clinical definition of hereditary non-polyposis colorectal cancer: A search for the impossible
    • MJ.W. Berends, Y. Wu and R.H. Sijmons et al., Clinical definition of hereditary non-polyposis colorectal cancer: A search for the impossible, Scand J Gastroenterol 36(234) (2001), 61-67.
    • (2001) Scand J Gastroenterol , vol.36 , Issue.234 , pp. 61-67
    • Berends, M.J.W.1    Wu, Y.2    Sijmons, R.H.3
  • 19
    • 0031551963 scopus 로고    scopus 로고
    • A National Cancer Institute Workshop on Hereditary Non-polyposis Colorectal Cancer Syndrome: Meeting Highlights and Bethesda Guidelines
    • M.A. Rodriguez-Bigas, C.R. Boland and S.R. Hamilton et al., A National Cancer Institute Workshop on Hereditary Non-polyposis Colorectal Cancer Syndrome: Meeting Highlights and Bethesda Guidelines, J Natl Cancer Inst 89 (1997), 1758-1762.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 1758-1762
    • Rodriguez-Bigas, M.A.1    Boland, C.R.2    Hamilton, S.R.3
  • 20
    • 0035132202 scopus 로고    scopus 로고
    • Histopathological identification of colon cancer with microsatellite instability
    • J. Alexander, T. Watanabe, W. Tsung-Teh, A. Rashid, S. Li and S.R. Hamilton, Histopathological identification of colon cancer with microsatellite instability, Am J Pathol 158 (2001), 527-535.
    • (2001) Am J Pathol , vol.158 , pp. 527-535
    • Alexander, J.1    Watanabe, T.2    Tsung-Teh, W.3    Rashid, A.4    Li, S.5    Hamilton, S.R.6
  • 21
    • 0025424347 scopus 로고
    • Crohn's-like lymphoid reaction and colorectal carcinoma: A potential histologic prognosticator
    • D.M. Graham and H.D. Appelman, Crohn's-like lymphoid reaction and colorectal carcinoma: a potential histologic prognosticator, Mod Pathol 3 (1990), 332-335.
    • (1990) Mod Pathol , vol.3 , pp. 332-335
    • Graham, D.M.1    Appelman, H.D.2
  • 23
    • 7144256236 scopus 로고    scopus 로고
    • Morphology of sporadic colorectal cancer with DNA replication errors
    • J.R. Jass, K.-A. Do and L.A. Simms et al., Morphology of sporadic colorectal cancer with DNA replication errors, Gut 42 (1998), 673-679.
    • (1998) Gut , vol.42 , pp. 673-679
    • Jass, J.R.1    Do, K.-A.2    Simms, L.A.3
  • 24
    • 0035060624 scopus 로고    scopus 로고
    • Tumour infiltrating lymphocytes and apoptosis are independent features in colorectal cancer stratified according to microsatellite instability status
    • J.M. Michael-Robinson, A.-E. Biemer-Hüttman and D.M. Purdie et al., Tumour infiltrating lymphocytes and apoptosis are independent features in colorectal cancer stratified according to microsatellite instability status, Gut 48 (2001), 360-366.
    • (2001) Gut , vol.48 , pp. 360-366
    • Michael-Robinson, J.M.1    Biemer-Hüttman, A.-E.2    Purdie, D.M.3
  • 25
    • 0034997971 scopus 로고    scopus 로고
    • Microsatellite instability and the clinicopathological features of sporadic colorectal cancer
    • R. Ward, A. Meagher and I. Tomlinson et al., Microsatellite instability and the clinicopathological features of sporadic colorectal cancer, Gut 48 (2001), 821-829.
    • (2001) Gut , vol.48 , pp. 821-829
    • Ward, R.1    Meagher, A.2    Tomlinson, I.3
  • 26
    • 0035875903 scopus 로고    scopus 로고
    • Tumor-infiltrating lymphocytes are a marker for microsatellite instability in colorectal cancer
    • T.C. Smyrk, P. Watson, K. Kaul and H.T. Lynch, Tumor-infiltrating lymphocytes are a marker for microsatellite instability in colorectal cancer, Cancer 91 (2001), 2417-2422.
    • (2001) Cancer , vol.91 , pp. 2417-2422
    • Smyrk, T.C.1    Watson, P.2    Kaul, K.3    Lynch, H.T.4
  • 27
    • 0037408402 scopus 로고    scopus 로고
    • Phenotype of microsatellite unstable colorectal carcinomas
    • J.K. Greenson, J.D. Bonner and O. Ben-Yzhak et al., Phenotype of microsatellite unstable colorectal carcinomas, Am J Surg Pathol 27 (2003), 563-570.
    • (2003) Am J Surg Pathol , vol.27 , pp. 563-570
    • Greenson, J.K.1    Bonner, J.D.2    Ben-Yzhak, O.3
  • 28
    • 0037249071 scopus 로고    scopus 로고
    • APC mutation and tumour budding in colorectal cancer
    • J.R. Jass, M. Barker and L. Fraser et al., APC mutation and tumour budding in colorectal cancer, J Clin Pathol 56 (2003), 69-73.
    • (2003) J Clin Pathol , vol.56 , pp. 69-73
    • Jass, J.R.1    Barker, M.2    Fraser, L.3
  • 29
    • 0036224279 scopus 로고    scopus 로고
    • Distinction between familial and sporadic forms of colorectal cancer showing DNA microsatellite instability
    • J.R. Jass, M.D. Walsh, M. Barker, L.A. Simms, J. Young and B.A. Leggett, Distinction between familial and sporadic forms of colorectal cancer showing DNA microsatellite instability, Eur J Cancer 38 (2002), 858-866.
    • (2002) Eur J Cancer , vol.38 , pp. 858-866
    • Jass, J.R.1    Walsh, M.D.2    Barker, M.3    Simms, L.A.4    Young, J.5    Leggett, B.A.6
  • 30
    • 0035185894 scopus 로고    scopus 로고
    • Features of colorectal cancers with high-level microsatellite instability occurring in familial and sporadic settings: Parallel pathways of tumorigenesis
    • J. Young, L.A. Simms and K.G. Biden et al., Features of colorectal cancers with high-level microsatellite instability occurring in familial and sporadic settings: Parallel pathways of tumorigenesis, Am. J. Pathol. 159 (2001), 2107-2116.
    • (2001) Am. J. Pathol. , vol.159 , pp. 2107-2116
    • Young, J.1    Simms, L.A.2    Biden, K.G.3
  • 31
    • 0026511623 scopus 로고
    • Evolution of hereditary non-polyposis colorectal cancer
    • J.R. Jass and S.M. Stewart, Evolution of hereditary non-polyposis colorectal cancer, Gut 33 (1992), 783-786.
    • (1992) Gut , vol.33 , pp. 783-786
    • Jass, J.R.1    Stewart, S.M.2
  • 32
    • 0036182102 scopus 로고    scopus 로고
    • Proximal adenomas in hereditary non-polyposis colorectal cancer are prone to rapid malignant transformation
    • F.E. Rijcken, H. Hollema and J.H. Kleibeuker, Proximal adenomas in hereditary non-polyposis colorectal cancer are prone to rapid malignant transformation, Gut 50 (2002), 382-386.
    • (2002) Gut , vol.50 , pp. 382-386
    • Rijcken, F.E.1    Hollema, H.2    Kleibeuker, J.H.3
  • 34
    • 0033914750 scopus 로고    scopus 로고
    • DNA microsatellite instability and mismatch repair protein loss in adenomas presenting in hereditary non-polyposis colorectal cancer
    • H. Iino, L.A. Simms and J. Young et al., DNA microsatellite instability and mismatch repair protein loss in adenomas presenting in hereditary non-polyposis colorectal cancer, Gut 47 (2000), 37-42.
    • (2000) Gut , vol.47 , pp. 37-42
    • Iino, H.1    Simms, L.A.2    Young, J.3
  • 35
    • 0028276666 scopus 로고
    • Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences
    • H. Kim, J. Jen, B. Vogelstein and S.R. Hamilton, Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences, Am J Pathol 145 (1994), 148-156.
    • (1994) Am J Pathol , vol.145 , pp. 148-156
    • Kim, H.1    Jen, J.2    Vogelstein, B.3    Hamilton, S.R.4
  • 36
    • 0034669608 scopus 로고    scopus 로고
    • Sporadic colorectal adenocarcinomas with high-frequency microsatellite instability
    • R. Gafa, I. Maestri and M. Matteuzzi et al., Sporadic colorectal adenocarcinomas with high-frequency microsatellite instability, Cancer 89 (2000), 2025-2037.
    • (2000) Cancer , vol.89 , pp. 2025-2037
    • Gafa, R.1    Maestri, I.2    Matteuzzi, M.3
  • 37
    • 0033068047 scopus 로고    scopus 로고
    • Histologic comparison of hereditary nonpolyposis colorectal cancer associated with MSH2 and MLH1 and colorectal cancer from the general population
    • M. Shashidharan, T. Smyrk and K.M. Lin et al., Histologic comparison of hereditary nonpolyposis colorectal cancer associated with MSH2 and MLH1 and colorectal cancer from the general population, Dis Colon Rectum 42 (1999), 722-726.
    • (1999) Dis Colon Rectum , vol.42 , pp. 722-726
    • Shashidharan, M.1    Smyrk, T.2    Lin, K.M.3
  • 38
    • 0028141683 scopus 로고
    • Hereditary non-polyposis colorectal cancer: Morphologies, genes and mutations
    • J.R. Jass, S.M. Stewart, J. Stewart and M.R. Lane, Hereditary non-polyposis colorectal cancer: morphologies, genes and mutations, Mutat Res 290 (1994), 125-133.
    • (1994) Mutat Res , vol.290 , pp. 125-133
    • Jass, J.R.1    Stewart, S.M.2    Stewart, J.3    Lane, M.R.4
  • 39
    • 0344548768 scopus 로고    scopus 로고
    • Immunohistochemical staining patterns of MUC1, MUC2, MUC4, and MUC5AC mucins in hyperplastic polyps, serrated adenomas, and traditional adenomas of the colorectum
    • A.-E. Biemer-Hüttmann, M.D. Walsh and M.A. McGuckin et al., Immunohistochemical staining patterns of MUC1, MUC2, MUC4, and MUC5AC mucins in hyperplastic polyps, serrated adenomas, and traditional adenomas of the colorectum, J Histochem Cytochem 47 (1999), 1039-1047.
    • (1999) J Histochem Cytochem , vol.47 , pp. 1039-1047
    • Biemer-Hüttmann, A.-E.1    Walsh, M.D.2    McGuckin, M.A.3
  • 40
    • 0008996922 scopus 로고    scopus 로고
    • Pathology of hereditary non-polyposis colorectal cancer with clinical and molecular genetic correlations
    • (in press), S. Baba, ed., Japan: Churchill Livingstone
    • J.R. Jass, D.S. Cottier, P. Jeevaratnam, V. Pokos and P. Browett, Pathology of hereditary non-polyposis colorectal cancer with clinical and molecular genetic correlations, in: New Strategies for Treatment of Hereditary Colorectal Cancer, Vol. (in press), S. Baba, ed., Japan: Churchill Livingstone, 1996.
    • (1996) New Strategies for Treatment of Hereditary Colorectal Cancer
    • Jass, J.R.1    Cottier, D.S.2    Jeevaratnam, P.3    Pokos, V.4    Browett, P.5
  • 41
    • 0030936767 scopus 로고    scopus 로고
    • Mixed epithelial polyps in association with hereditary non-polyposis colorectal cancer providing an alternative pathway of cancer histogenesis
    • J.R. Jass, D.S. Cottier, V. Pokos, S. Parry and I.M. Winship, Mixed epithelial polyps in association with hereditary non-polyposis colorectal cancer providing an alternative pathway of cancer histogenesis, Pathology 29 (1997), 28-33.
    • (1997) Pathology , vol.29 , pp. 28-33
    • Jass, J.R.1    Cottier, D.S.2    Pokos, V.3    Parry, S.4    Winship, I.M.5
  • 42
    • 0037099602 scopus 로고    scopus 로고
    • A hereditary nonpolyposis colorectyal carcinoma case associated with hypermethylation of the MLH1 gene in normal human tissue and loss of heterozygosity of the unmethylated allele in the resulting microsatellite instability-high tumor
    • I. Gazzoli, M. Loda, J. Garber, S. Syngal and R.D. Kolodner, A hereditary nonpolyposis colorectyal carcinoma case associated with hypermethylation of the MLH1 gene in normal human tissue and loss of heterozygosity of the unmethylated allele in the resulting microsatellite instability-high tumor, Cancer Res 62 (2002), 3925-3928.
    • (2002) Cancer Res , vol.62 , pp. 3925-3928
    • Gazzoli, I.1    Loda, M.2    Garber, J.3    Syngal, S.4    Kolodner, R.D.5
  • 43
    • 0037443773 scopus 로고    scopus 로고
    • Frequency of loss of hMLH 1 expression in colorectal carcinoma increases with advancing age
    • S. Kakar, L.J. Burgart and S.N. Thibodeau et al., Frequency of loss of hMLH 1 expression in colorectal carcinoma increases with advancing age, Cancer 2002 (2003), 1421-1427.
    • (2003) Cancer , vol.2002 , pp. 1421-1427
    • Kakar, S.1    Burgart, L.J.2    Thibodeau, S.N.3
  • 44
    • 0034642605 scopus 로고    scopus 로고
    • Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer
    • R. Gryfe, H. Kim and E.T.K. Hsieh et al., Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer, N Eng J Med 342 (2000), 69-77.
    • (2000) N Eng J Med , vol.342 , pp. 69-77
    • Gryfe, R.1    Kim, H.2    Hsieh, E.T.K.3
  • 45
    • 10744233937 scopus 로고    scopus 로고
    • Revised Bethesda Guidelines for heriditary nonpolyposis colorectal cancer (Lynch Syndrome) and microsatellite instability
    • A. Umar, C.R. Boland, J.P. Terdiman et al., Revised Bethesda Guidelines for heriditary nonpolyposis colorectal cancer (Lynch Syndrome) and microsatellite instability, J. Natl. Cancer Inst. 96 (2004), 261-268.
    • (2004) J. Natl. Cancer Inst. , vol.96 , pp. 261-268
    • Umar, A.1    Boland, C.R.2    Terdiman, J.P.3
  • 46
    • 0032852979 scopus 로고    scopus 로고
    • Immunohistochemistry for hMLH1 and hMSH2: A practical test for DNA mismatch repair-deficient tumors
    • V.A. Marcus, L. Madlensky and R. Gryfe et al., Immunohistochemistry for hMLH1 and hMSH2: a practical test for DNA mismatch repair-deficient tumors, Am J Surg Pathol 23 (1999), 1248-1255.
    • (1999) Am J Surg Pathol , vol.23 , pp. 1248-1255
    • Marcus, V.A.1    Madlensky, L.2    Gryfe, R.3
  • 47
    • 0035727554 scopus 로고    scopus 로고
    • MLH1 and MSH2 protein immunohistochemistry is useful for detection of hereditary non-polyposis colorectal cancer in young patients
    • F. Paraf, M. Gilquin and M. Longy et al., MLH1 and MSH2 protein immunohistochemistry is useful for detection of hereditary non-polyposis colorectal cancer in young patients, Histopathology 39 (2001), 250-258.
    • (2001) Histopathology , vol.39 , pp. 250-258
    • Paraf, F.1    Gilquin, M.2    Longy, M.3
  • 48
    • 0037083484 scopus 로고    scopus 로고
    • Immunohistochemistry versus microsatellite instability testing in phenotyping colorectal tumors
    • N.M. Lindor, L.J. Burgart and O. Leontovich et al., Immunohistochemistry versus microsatellite instability testing in phenotyping colorectal tumors, J. Clin. Oncol. 20 (2002), 1043-1048.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 1043-1048
    • Lindor, N.M.1    Burgart, L.J.2    Leontovich, O.3
  • 49
    • 0032522658 scopus 로고    scopus 로고
    • Microsatellite instability in colorectal cancer: Different mutator phenotypes and the principle involvement of hMLH1
    • S.N. Thibodeau, A.J. French and J.M. Cunningham et al., Microsatellite instability in colorectal cancer: Different mutator phenotypes and the principle involvement of hMLH1, Cancer Res 58 (1998), 1713-1718.
    • (1998) Cancer Res , vol.58 , pp. 1713-1718
    • Thibodeau, S.N.1    French, A.J.2    Cunningham, J.M.3
  • 50
    • 0032925168 scopus 로고    scopus 로고
    • Failure to diagnose hereditary nonpolyposis colorectal cancer case
    • H.T. Lynch, J. Paulson, M. Severin, J. Lynch and P. Lynch, Failure to diagnose hereditary nonpolyposis colorectal cancer case, Dis Colon Rectum 42 (1999), 31-35.
    • (1999) Dis Colon Rectum , vol.42 , pp. 31-35
    • Lynch, H.T.1    Paulson, J.2    Severin, M.3    Lynch, J.4    Lynch, P.5


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