N-terminus of the rat adenine glycosylase MYH affects excision rates and processing of MYH-generated abasic sites

Nucleic Acids Research

Volumn 32, Issue 14, 2004, Pages 4332-4339

  Ma, Huaxian ^a   Lee, Heung M ^a   Englander, Ella W ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE DERIVATIVE; COMPLEMENTARY DNA; DNA GLYCOSYLTRANSFERASE; ISOPROTEIN; ADENINE; DNA; DNA GLYCOSYLASE MUTY; DRUG DERIVATIVE; GUANINE; MAGNESIUM CHLORIDE;

3' UNTRANSLATED REGION; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; APURINIC SITE; ARTICLE; BASE MISPAIRING; CONSERVATION GENETICS; CONTROLLED STUDY; ENZYME DEGRADATION; ESCHERICHIA COLI; EXCISION REPAIR; GENE ACTIVITY; GENE DELETION; GENE FUNCTION; GENE OVEREXPRESSION; GENETIC VARIABILITY; HUMAN; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROCESSING; RAT; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; STATISTICAL SIGNIFICANCE; STEADY STATE; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; GENETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE;

ESCHERICHIA COLI; MAMMALIA; ZIZIPHUS MAURITIANA;

ADENINE; AMINO ACID SEQUENCE; ANIMALS; DNA; DNA GLYCOSYLASES; GUANINE; MAGNESIUM CHLORIDE; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; RATS; SEQUENCE ALIGNMENT; SEQUENCE DELETION;

EID: 4043175685     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkh758     Document Type: Article

References (30)

1. Beckman,K.B. and Ames,B.N. (1997) Oxidative decay of DNA. J. Biol. Chem., 272, 19633-19636.
2. Mitra,S., Hazra,T.K., Roy,R., Ikeda,S., Biswas,T., Lock,J., Boldogh,I. and Izumi,T. (1997) Complexities of DNA base excision repair in mammalian cells. Mol. Cell, 7, 305-312.
3. Dianov,G., Bischoff,C., Piotrowski,J. and Bohr,V.A. (1998) Repair pathways for processing of 8-oxoguanine in DNA by mammalian cell extracts. J. Biol. Chem., 273, 33811-33816.
4. Michaels,M.L., Cruz,C., Grollman,A.P. and Miller,J.H. (1992) Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA. Proc. Natl Acad. Sci. USA, 89, 7022-7025.
5. Michaels,M.L., Tchou,J., Grollman,A.P. and Miller,J.H. (1992) A repair system for 8-oxo-7,8-dihydrodeoxyguanine. Biochemistry, 31, 10964-10968.
6. Hazra,T.K., Hill,J.W., Izumi,T. and Mitra,S. (2001) Multiple DNA glycosylases for repair of 8-oxoguanine and their potential in vivo functions. Prog. Nucleic Acid Res. Mol. Biol., 68, 193-205.
7. McGoldrick,J.P., Yeh,Y.C., Solomon,M., Essigmann,J.M. and Lu,A.L. (1995) Characterization of a mammalian homolog of the Escherichia coli MutY mismatch repair protein. Mol. Cell. Biol., 15, 989-996.
8. Slupska,M.M., Baikalov,C., Luther,W.M., Chiang,J.H., Wei,Y.F. and Miller,J.H. (1996) Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damage. J. Bacteriol., 178, 3885-3892.
9. Ohtsubo,T., Nishioka,K., Imaiso,Y., Iwai,S., Shimokawa,H., Oda,H., Fujiwara,T. and Nakabeppu,Y. (2000) Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria. Nucleic Acids Res., 28, 1355-1364.
10. Yang,H., Clendenin,W.M., Wong,D., Demple,B., Slupska,M.M., Chiang,J.H. and Miller,J.H. (2001) Enhanced activity of adenine-DNA glycosylase (Myh) by apurinic/apyrimidinic endonuclease (Ape1) in mammalian base excision repair of an A/GO mismatch. Nucleic Acids Res., 29, 743-752.
11. Lee,H.M., Wang,C., Hu,Z., Greeley,G.H., Makalowski,W., Hellmich,H.L. and Englander,E.W. (2002) Hypoxia induces mitochondrial DNA damage and stimulates expression of a DNA repair enzyme, the Escherichia coli MutY DNA glycosylase homolog (MYH), in vivo, in the rat brain. J. Neurochem., 80, 928-937.
12. Takao,M., Aburatani,H., Kobayashi,K. and Yasui,A. (1998) Mitochondrial targeting of human DNA glycosylases for repair of oxidative DNA damage. Nucleic Acids Res., 26, 2917-2922.
13. Takao,M., Zhang,Q.M., Yonei,S. and Yasui,A. (1999) Differential subcellular localization of human MutY homolog (hMYH) and the functional activity of adenine:8-oxoguanine DNA glycosylase. Nucleic Acids Res., 27, 3638-3644.
14. Tsai-Wu,J.J., Su,H.T., Wu,Y.L., Hsu,S.M. and Wu,C.H. (2000) Nuclear localization of the human mutY homologue hMYH. J. Cell Biochem., 77, 666-677.
15. Parker,A., Gu,Y., Mahoney,W., Lee,S.H., Singh,K.K. and Lu,A.L. (2001) Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repair. J. Biol. Chem., 276, 5547-5555.
16. Parker,A.R., O'Meally,R.N., Sahin,F., Su,G.H., Racke,F.K., Nelson,W.G., DeWeese,T.L. and Eshleman,J.R. (2003) Defective human MutY phosphorylation exists in colorectal cancer cell lines with wild-type MutY alleles. J. Biol. Chem., 278, 47937-47945.
17. Gu,Y. and Lu,A.L. (2001) Differential DNA recognition and glycosylase activity of the native human MutY homolog (hMYH) and recombinant hMYH expressed in bacteria. Nucleic Acids Res., 29, 2666-2674.
18. Ichinoe,A., Behmanesh,M., Tominaga,Y., Ushijima,Y., Hirano,S., Sakai,Y., Tsuchimoto,D., Sakumi,K., Wake,N. and Nakabeppu,Y. (2004) Identification and characterization of two forms of mouse MUTYH proteins encoded by alternatively spliced transcripts. Nucleic Acids Res., 32, 477-487.
19. Hill,J.W., Hazra,T.K., Izumi,T. and Mitra,S. (2001) Stimulation of human 8-oxoguanine-DNA glycosylase by AP-endonuclease: potential coordination of the initial steps in base excision repair. Nucleic Acids Res., 29, 430-438.
20. Pope,M.A., Porello,S.L. and David,S.S. (2002) Escherichia coli apurinic-apyrimidinic endonucleases enhance the turnover of the adenine glycosylase MutY with G:A substrates. J. Biol. Chem., 277, 22605-22615.
21. Fromme,J.C., Banerjee,A., Huang,S.J. and Verdine,G.L. (2004) Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase. Nature, 427, 652-656.
22. Guan,Y., Manuel,R.C., Arvai,A.S., Parikh,S.S., Mol,C.D., Miller,J.H., Lloyd,S. and Tainer,J.A. (1998) MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamily. Nature Struct. Biol., 5, 1058-1064.
23. Bhakat,K.K., Izumi,T., Yang,S.H., Hazra,T.K. and Mitra,S. (2003) Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene. EMBO J., 22, 6299-6309.
24. Parker,A., Gu,Y. and Lu,A.L. (2000) Purification and characterization of a mammalian homolog of Escherichia coli MutY mismatch repair protein from calf liver mitochondria. Nucleic Acids Res., 28, 3206-3215.
25. Manuel,R.C. and Lloyd,R.S. (1997) Cloning, overexpression, and biochemical characterization of the catalytic domain of MutY. Biochemistry, 36, 11140-11152.
26. Chmiel,N.H., Livingston,A.L. and David,S.S. (2003) Insight into the functional consequences of inherited variants of the hMYH adenine glycosylase associated with colorectal cancer: complementation assays with hMYH variants and pre-steady-state kinetics of the corresponding mutated E.coli enzymes. J. Mol. Biol., 327, 431-443.
27. Yeh,Y.C., Chang,D.Y., Masin,J. and Lu,A.L. (1991) Two nicking enzyme systems specific for mismatch-containing DNA in nuclear extracts from human cells. J. Biol. Chem., 266, 6480-6484.
28. Slupska,M.M., Luther,W.M., Chiang,J.H., Yang,H. and Miller,J.H. (1999) Functional expression of hMYH, a human homolog of the Escherichia coli MutY protein. J. Bacteriol., 181, 6210-6213.
29. Mol,C.D., Izumi,T., Mitra,S. and Tainer,J.A. (2000) DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination. Nature, 403, 451-456.
30. Wilson,S.H. and Kunkel,T.A. (2000) Passing the baton in base excision repair. Nature Struct. Biol., 7, 176-178.