Local ex vivo gene therapy with bone marrow stromal cells expressing human BMP4 promotes endosteal bone formation in mice

Journal of Gene Medicine

Volumn 6, Issue 1, 2004, Pages 4-15

  Zhang, Xiao S ^a,c   Linkhart, Thomas A ^a,b   Chen, Shin Tai ^a   Peng, Hairong ^a,d   Wergedal, Jon E ^a   Guttierez, Genevieve G ^a   Sheng, Matilda H C ^a   Lau, K H William ^a   Baylink, David J ^a  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LOMA LINDA UNIVERSITY   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d BD BIOSCIENCES   (United States)

Author keywords

Bone marrow transplantation; Bone morphogenetic protein 4; Bone regeneration; Gene therapy; Mouse; Retroviruses; Stromal cells

Indexed keywords

BETA GALACTOSIDASE; BONE MORPHOGENETIC PROTEIN 4; RETROVIRUS VECTOR; BONE MORPHOGENETIC PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE MINERAL; BONE RADIOGRAPHY; CELL COUNT; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORTICAL BONE; DONOR; EX VIVO STUDY; FEASIBILITY STUDY; FEMALE; FEMUR; GENE THERAPY; GENETIC TRANSDUCTION; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HISTOPATHOLOGY; HUMERUS; MEDICAL ASSESSMENT; MOUSE; MURINE LEUKEMIA VIRUS; NONHUMAN; OSSIFICATION; OSTEOLYSIS; OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RECIPIENT; TRABECULAR BONE; TREATMENT OUTCOME; VERTEBRA; VIRAL GENE DELIVERY SYSTEM; ANIMAL; BIOSYNTHESIS; BONE DEVELOPMENT; BONE MARROW CELL; C57BL MOUSE; DRUG EFFECT; GENE VECTOR; GENETICS; METHODOLOGY; RETROVIRUS; STROMA CELL;

ANIMALS; BETA-GALACTOSIDASE; BONE DENSITY; BONE MARROW CELLS; BONE MORPHOGENETIC PROTEINS; GENE THERAPY; GENETIC VECTORS; MICE; MICE, INBRED C57BL; OSTEOGENESIS; OSTEOPOROSIS; RETROVIRIDAE; STROMAL CELLS; TRANSDUCTION, GENETIC;

EID: 4043162582     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.477     Document Type: Article

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