Preselection of retrovirally transduced bone marrow avoids subsequent stem cell gene silencing and age-dependent extinction of expression of human β-globin in engrafted mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 10, 2000, Pages 5411-5415

  Kalberer, Christian P ^a   Pawliuk, Robert ^b   Imren, Suzan ^a   Bachelot, Thomas ^b   Takekoshi, Ken J ^b   Fabry, Mary ^c   Eaves, Connie J ^a,d   London, Irving M ^b   Humphries, R Keith ^a,d   Leboulch, Philippe ^b,e  

^a BRITISH COLUMBIA CANCER AGENCY   (Canada)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Gene therapy; Green fluorescent protein; Retrovirus; Sickle cell disease; Thalassemia

Indexed keywords

BETA GLOBIN; GREEN FLUORESCENT PROTEIN; PHOSPHOGLYCERATE KINASE; VIRUS VECTOR;

ANIMAL EXPERIMENT; ARTICLE; GENE LOCUS; GENE SILENCING; GENE THERAPY; GENE TRANSFER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RETROVIRUS; SICKLE CELL ANEMIA;

ANIMALS; BONE MARROW CELLS; ERYTHROCYTES; GENE SILENCING; GENETIC VECTORS; GLOBINS; GREEN FLUORESCENT PROTEINS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HUMANS; LOCUS CONTROL REGION; LUMINESCENT PROTEINS; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, INBRED STRAINS; PHOSPHOGLYCERATE KINASE; PROMOTER REGIONS (GENETICS); RECOMBINANT FUSION PROTEINS; RETROVIRIDAE; RNA, MESSENGER; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

ANIMALIA; RODENTIA; UNIDENTIFIED RETROVIRUS;

EID: 12944254524     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.100082597     Document Type: Article

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