Ex vivo gene therapy to produce bone using different cell types

Clinical Orthopaedics and Related Research

Volumn 378, Issue , 2000, Pages 290-305

  Musgrave, Douglas S ^a   Bosch, Patrick ^a   Lee, Joon Y ^a   Pelinkovic, Dalip ^b   Ghivizzani, Steve C ^a   Whalen, Janey ^a   Niyibizi, Christopher ^a   Huard, Johnny ^a,b,c  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^c CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOENGINEERING; CELL CULTURE; CELL ISOLATION; GENE THERAPY; MOUSE; NONHUMAN; ORTHOPEDIC SURGERY; OSSIFICATION; OSTEOGENESIS IMPERFECTA; PRIORITY JOURNAL;

EID: 0033852160     PISSN: 0009921X     EISSN: 15281132     Source Type: Journal    
DOI: 10.1097/00003086-200009000-00040     Document Type: Article

References (44)

1. Percutaneous spinal fusion using bone morphogenetic protein-2 gene therapy
2. Kinetics and differentiation of marrow stromal cells in diffusion chambers in vivo
3. Effect of rhBMP-2 on the osteogenic potential of bone marrow stromal cells from an osteogenic imperfecta mouse (oim)
4. Osteoprogenitor cells in skeletal muscle
5. Mesenchymal stem cells
6. Recombinant bone morphogenetic protein (BMP)-2 regulates costochondral growth plate chondrocytes and induces expression of BMP-2 and BMP-4 in a cell maturation-dependent manner
7. Possible orthopaedic applications of gene therapy
8. Behavior of articular chondrocytes in cell culture
9. Stimulation of new bone formation by direct transfer of osteogenic plasmid genes
10. Construction of adenovirus vectors through Cre-lox recombination
11. Characterization of cells with osteogenic potential from human marrow
12. The use of bone morphogenetic protein in the treatment of non-union in a canine model
13. Bone morphogenetic protein augmentation grafting of resistant femoral nonunions: A preliminary report
14. Repair of segmental defects of the tibia with cancellous bone grafts augmented with human bone morphogenetic protein: A preliminary report
15. Fibrodysplasia ossificans progressiva: A clue from the fly?
16. Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage
17. Effects of recombinant human bone morphogenetic protein-2 on differentaion of cells isolated from human bone, muscle, and skin
18. Repair of calvarial defects with flap tissue: Role of bone morphogenetic proteins and competent responding tissues
19. The effect of regional gene therapy with bone morphogenetic protein-2 producing bone marrow stromal cells on the repair of segmental femoral defects
20. Regional gene therapy with a BMP-2-producing murine stromal cell line induces heterotopic and orthotopic bone formation in rodents
21. Gene therapy: Adenovirus-mediated human bone morphogenetic protein-2 gene transfer induces mesenchymal progenitor cell proliferation and differentiation in vitro and bone formation in vivo
22. Expression of human bone morphogenetic protein 7 in primary rabbit periosteal cells: Potential utility in gene therapy for osteochondral repair
23. Adenovirus-mediated direct gene therapy with bone morphogenetic protein-2 produces bone
24. Primary mouse myoblast purification, characterization, transplantation for cell-mediated gene therapy
25. Cell biology and biochemistry of endochondral bone development
26. Bone and cartilage differentiation
27. The induction of bone in osteogenic composites of bone matrix and porous hydroxyapatite replicas: An experimental study on the baboon
28. Reconstruction of the bone-bone marrow organ by osteogenin, a bone morphogenetic protein, and demineralized bone matrix in calvarial defects in adult human primates
29. Osteogenic differentiation of hypertrophic chondrocytes involves asymmetric cell divisions and apoptosis
30. Recombinant bone morphogenetic protein-2 maintains the articular chondrocyte phenotype in long-term culture
31. Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos
32. The effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on the healing of full-thickness defects of articular cartilage
33. Bone: Formation by autoinduction
34. Osteogenetic competence
35. Experimental myositis ossificans
36. Recombinant human bone morphogenetic protein induces bone formation
37. A population of cells isolated from rat heart capable of differentiating into several mesodermal phenotypes
38. Novel regulators of bone formation: Molecular clones and activities
39. Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro
40. Expression of bone morphogenetic proteins in human osteosarcoma. Immunohistochemical detection with monoclonal antibody
41. Mesenchymal stem cells reside within the connective tissues of many organs
42. Bone formation with use of rhBMP-2 (recombinant human bone morphogenetic protein)