Influence of retinoic acid on adhesion complexes in human hepatoma cells: A clue to its antiproliferative effects

Cell Communication and Adhesion

Volumn 11, Issue 1, 2004, Pages 13-23

  Ara, Carmen ^a   Conti DeVirgiliis, Laura ^a   Massimi, Mara ^a  

^a UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

catenin; E cadherin; HepG2; Occludin; ZO 1

Indexed keywords

BETA CATENIN; OCCLUDIN; PROTEIN ZO1; RETINOIC ACID; UVOMORULIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL ADHESION; CELL DIFFERENTIATION; CELL JUNCTION; CELL MEMBRANE; CELL PROLIFERATION; CELL STRAIN HEPG2; CELL SURFACE; CELL TRANSFORMATION; COMPLEX FORMATION; CONTROLLED STUDY; DRUG MECHANISM; HEPATOMA CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; IN VITRO STUDY; LIVER CELL; MODULATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

BETA CATENIN; CADHERINS; CELL ADHESION; CELL DIVISION; CELL LINE, TUMOR; CYTOSKELETAL PROTEINS; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; MACROMOLECULAR SUBSTANCES; MEMBRANE PROTEINS; MICROSCOPY, FLUORESCENCE; PHOSPHOPROTEINS; TRANS-ACTIVATORS; TRETINOIN;

INSERTION SEQUENCES;

EID: 4043120540     PISSN: 15419061     EISSN: None     Source Type: Journal    
DOI: 10.1080/15419060490471757     Document Type: Article

References (54)

1. Alisi A, Leoni S, Piacentani A, Conti Devirgiliis L (2003). Retinoic acid modulates the cell cycle in fetal rat hepatocytes and Hep G2 cells by regulating cyclin-CDK activities. Liver Int 23: 179-186.
2. Anderson JM, Van Itallie CM (1995). Tight junctions and the molecular basis for regulation of paracellular permeability. Am J Physiol 269: G476-G475.
3. Ando-Akatsuka Y, Yonemura S, Itoh M, Furuse M, Tsukita S (1999). Differential behavior of E-cadherin and occludin in their colocalization with ZO-1 during the establishment of epithelial cell polarity, J Cell Physiol 179: 115-125.
4. Aplin AE, Howe A, Alamari SK, Juliano RL (1998). Signal transduction and signal modulation by cell adhesion receptors: The role of integrins, cadherins immunoglobulin-cell adhesion molecules and selectins. Am Soc Farmacol Exp Therap 50: 197-252.
5. Ara C, Massimi M, Conti Devirgiliis L (2002). Retinoic acid modulation of gap junctional intercellular communication in hepatocytes and hepatoma cells. Cell Mol Life Sci 59: 1-8.
6. Ben-Ze'ev A (1997). Cytoskeletal and adhesion protein as tumor suppressors. Curr Opin Cell Biol 9: 99-108.
7. Behrens JL, Vakaet R, Friis R, Winterhager E, Van Roy F, Mareel MM, Birchmeier W (1993). Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorilation of the E-cadherin/β-catenin complex in cells transformed with a temperature sensitive v-SRC gene. J Cell Biol 120: 757-766.
8. Birchmeier W, Beherens J (1994). Cadherin expression in carcinomas: Role in the formation of cell junctions and the prevention of invasiveness. Biochim Biophys Acta 1198: 11-26.
9. Clevers H, van de Wetering M (1997). TCF/LEF factor earn their wings. Trends Genet 13: 485-489.
10. Collares-Buzzato CB, Jepson MA, Simmons NL, Hirst BH (1998). Increased tyrosine phosphorylation causes redistribution of adherens junction and tight junction proteins and perturbs paracellular barrier function in MDCK epithelia. Eur J Cell Biol 123: 1777-1788.
11. Cowin P, Burke B (1996). Cytoskeleton-membrane interactions. Curr Opin Cell Biol 8: 56-85.
12. De La Coste A, Romagnolo B, Billuart P, Renard CA, Buendia MA, Soubranes O, Fabre M, Chelly J, Beldjord C, Khan A, Perret C (1998). Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas. Proc Natl Acad Sci USA 95: 8847-8851.
13. Devereux TR, Anna CH, Foley JF, White CM, Sills RC, Barret JC (1999). Mutation of beta-catenin is an early event in chemically induced mouse hepatocellular carcinogenesis. Oncogene 18: 4726-4733.
14. Easwaran V, Pishvaian M, Salimuddin, Byers S (1999). Cross-regulation of β-catenin-LEF/TCF and retinoid signaling. Curr Biol 9: 1415-1418.
15. Endo K, Lueda T, Veyama J, Ohta T, Terada T (2000).Immunoreactive E-cadherin, α-catenin, β-catenin and γ-catenin proteins in hepatocellular carcinoma: Relationships with tumor grade, clinicopathologic parameters and patients survival, Hum Pathol 31: 558-565.
16. Falasca L, Favale A, Gualandi G, Maietta G, Conti Devirgiliis L (1998a). Retinoid acid treatment induces apoptosis or expression of a more differentiated phenotype on different fractions of cultured fetal rat hepatocytes. Hepatology 28: 727-737.
17. Falasca L, Favale A, Serafino A, Ara C, Conti Devirgiliis L (1998b). The effect of retinoic acid on the re-establishment of specific hepatic phenotype in primary culture. Cell Tissue Res 293: 337-347.
18. Falasca L, Marcellini P, Ara C, Rufo A, Conti Devirgiliis L (1999). Growth inhibition and induction of specific hepatic phenotype expression by retinoic acid in Hep-G2 cells. Anticancer Res 19: 3283-3292.
19. Fanning AS, Ma TY, Anderson JM (2002). Isolation and functional characterization of the actin binding region in the tight junction protein ZO-1. FASEB J 16: 1835-1837.
20. Fujimoto K, Nagafuchi A, Tsukita S, Kuraoka A, Ohokuma A, Shibata Y (1997). Dynamics of connexins, E-cadherin and α-catenin on cell membranes during gap junction formation. J Cell Sci 110: 311-322.
21. Galbiati F, Volonte D, Brown AM, Weinstein DE, Ben-Ze'ev A, Pestell RG, Lisanti MP (2000). Caveolin-1 expression inhibits Wnt/β-catenin/LEF-1 signaling by recruiting β-catenin to caveolae membrane domains. J Biol Chem 275: 23368-23377.
22. Gofuku J, Shiozaky H, Doki Y, Inoue M, Hirao M, Fukuki N, Monden M (1998). Characterization of soluble E-cadherin as a disease marker in gastric cancer patients. Br J Cancer 78: 1095-1101.
23. Gottardi CJ, Arpin M, Fanning AS, Louvard D (1996). The junction-associated protein, zonula occludens-1, localizes to the nucleus before the maturation and during the remodeling of cell-cell contacts. Proc Natl Acad Sci USA 93: 10779-10784.
24. Gumbiner BM (1996). Cell adhesion: The molecular basis of tissue architecture and morphogenesis. Cell 84: 345-357.
25. Gumbiner B (1997). Signal transduction by β-catenin. Curr Opin Cell Biol 7: 634-640.
26. He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B, Kinzler KW (1998). Identification of c-myc as a target of the APC pathway. Science 281: 1509-1512.
27. Hubbard AL, Barr VA, Scott LJ (1994). Hepatocyte surface polarity, In: The Liver: Biology and Pathobiology, Arias MI, Boyer J, Fausto N, Jakoby BM, Schachter D, Shafritz AD (eds.), Raven Press, Ltd, New York.
28. Itoh M, Nagafuchi A, Moroi S, Tsukita S (1997). Involvement of ZO-1 in cadherin-based cell adhesion through its direct binding to α-catenin and actin filaments, J Cell Biol 138: 181-192.
29. Kinzler KW, Vogelstein B (1996). Lesson from hereditary colorectal cancer. Cell 87: 159-170.
30. Kojima T, Sawada N, Chiba H, Kokai Y, Yamamoto M, Urban M, Lee GH, Hertzberg EL, Mochizuky, Spray DC (1999). Induction of tight junctions in human connexin-32 (hCx32)-transfected mouse hepatocytes: Connexin-32 interacts with occludin. Biochem Biophys Res Commun 266: 222-229.
31. Laemmli UK (1970). Cleavage of structural proteins during the assembly of the head of Bacteriophage T4. Nature 227: 680-685.
32. Liu C, Li Y, Semenov M, Han C, Baeg GH, Tan Y, Zhang Z, Lin X, He X (2002). Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108: 837-847.
33. Niles RM (2000). Recent advances in the use of vitamin A (retinoids) in the prevention and treatment of cancer. Nutrition 16: 1084-1090.
34. Nollet F, Berx G, van Roy F (1999). The role of the E-cadherin/catenin adhesion complex in the development and progression of cancer. Mol Cell Biol Res Commun 2: 77-85.
35. Orford K, Orford CC, Byers SW (1999). Exogenous expression of beta-catenin regulates contact inhibition, anchorage-independent growth, anoikis and radiation-induced cell cycle arrest. J Cell Biol 146: 855-868.
36. Rajasekaran AK, Hojo M, Huima T, Rodriguez-Boulan E (1996). Catenins and zonula occludens-1 form a complex during early stages in the assembly of tight junctions. J Cell Biol 132: 451-463.
37. Roura S, Miravet S, Piedra J, Garcia de Herreros A, Dunach M (1999). Regulation of E-cadherin/catenin association by tyrosine phosphorylation. J Biol Chem 274: 46-62.
38. Rubinfeld B, Robbins P, El-Gamil M, Albert I, Porfiri E, Polakis P (1997). Stabilization of β-catenin by genetic defects in melanoma cell lines. Science 275: 1790-1792.
39. Saitou M, Ando-Akatsuka Y, Itoh M, Furuse M, Inazawa J, Fujimoto K (1997). Mammalian occludin in epithelial cells: Its expression and subcellular distribution. Eur J Cell Biol 73: 222-231
40. Schmutzler C, Kohrle J (2000). Retinoic acid redifferentiation therapy for thyroid cancer. Thyroid 10: 393-406.
41. Shah S, Pishvaian MJ, Easwaran V, Brown PH, Byers SW (2002). The role of cadherin, beta-catenin, and AP-1 in retinoid-regulated carcinoma cell differentiation and proliferation. J Biol Chem 277: 25313-25322.
42. Shah S, Hecht A, Pestell R, Byers SW (2003). Trans-repression of β-catenin activity by nuclear receptors. J Biol Chem 278: 48137-48145.
43. Shtutman M, Zhurinsky J, Simcha I, Albanese C, D'Amico M, Pestell R, Ben-Ze'ev A (1999). The cyclin gene is a target of the β-catenin/LEF-1 pathway. Proc Natl Acad Sci USA 96: 5522-5527.
44. Sporn M, Roberts A, Goodman M (1994). The retinoids, biology, chemistry and medicine. Plenum Press, New York.
45. Stamatoglou SC, Hughes RC (1994). Cell adhesion molecules in liver function and patter formation. FASEB J 8: 420-427.
46. Stevenson BR, Keon BH (1998). The tight junctions: Morphology to molecules. Ann Rev Cell Dev Biol 14: 89-109.
47. Takeichi M (1991). Cadherin cell adhesion receptors as a morphogenetic regulator. Science 251: 1451-1455.
48. Takeichi M (1993). Cadherins in cancer: Implications for invasion and metastasis. Curr Opin Cell Biol 5: 806-811.
49. Tamura S (1997). The cadherin-mediated cell-cell-adhesion system in human cancers. Br J Surg 84: 899-900.
50. Towbin H, Staehelin T, Gordon J (1979). Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some application. Proc Natl Acad Sci USA 76: 4350-4354.
51. Van Es JH, Barker N, Clevers H (2003). You Wnt some, you lose some: Oncogenes in the Wnt signaling pathway. Curr Opin Genet Dev 13: 28-33.
52. Vleminchx K, Vakaet L, Jr Mareel M, Fiers W, Van Roy F (1991). Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell 66: 107-119.
53. Wijnhoven BP, Dinjens WN, Pignatelli M (2000). E-cadherin-catenin cell-cell adhesion complex and human cancer. Br J Surg 87: 992-1005.
54. Yamada K, Geiger B (1997). Molecular interactions in cell adhesion complexes. Curr Opin Cell Biol 9: 76-85.