Cytoskeletal and adhesion proteins as tumor suppressors

Current Opinion in Cell Biology

Volumn 9, Issue 1, 1997, Pages 99-108

  Ben Ze'ev, Avri ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSKELETON PROTEIN; TRANSCRIPTION FACTOR;

CANCER INHIBITION; CARCINOGENESIS; CELL ADHESION; CELL JUNCTION; CYTOPLASM; EXTRACELLULAR MATRIX; HUMAN; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; REVIEW; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

EID: 0031050310     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(97)80158-5     Document Type: Article

References (96)

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91. 91. Kawanishi J, Kato J, Sasaki K, Fuji S, Watanabe N, Niitsu Y: Loss of E-cadherin-dependent cell-cell adhesion due to mutation of the β-catenin gene in a human cancer cell line. Mol Cell Biol 1995, 15:1175-1181. This study identified a mutation in the β-catenin gene that impairs E-cadherin function in a gastric carcinoma cell line. The study also showed the restoration of normal E-cadherin function upon wild-type β-catenin transfection.
92. 92. Inomata M, Ochiai A, Akimoto S, Kitano S, Hirohashi S: Alteration of β-catenin expression in colonie epithelial cells of familial adenomatous polyposis patients. Cancer Res 1996, 56:2213-2217. Describes an interesting demonstration of β-catenin accumulation in cytoplasm and nuclei in tumors of familial adenomatous polyposis patients. These tumors express mutated APC with no β-catenin-binding site. These results imply aberrant signaling involving β-catenin in these tumors.
93. 93. Aberle H, Bierkamp C, Torchard D, Serova O, Wagener T, Natt E, Wirsching J, Heidkämper C, Montagna M, Lynch HT et al.: The human plakoglobin gene localizes on chromosome 17q21 and is subject to loss of heterozygosity in breast and ovarian cancer. PAOC Natl Acad Sci USA 1995, 92:6384-6388. Previous studies suggesting a correlation between plakoglobin loss and tumorigenesis in several tumor cell types [86,87] are supported by this study which demonstrates a loss of heterozygosity of the plakoglobin gene, which is localized on chromosome 17q21 in the BRCA1 region, in sporadic ovarian and breast cancer.
94. 94. Simcha I, Geiger B, Yehuda-Levenberg S, Salomon D, Ben-Ze'ev A: Suppression of tumorigenicity by plakoglobin: an augmenting effect of N-cadherin. J Cell Biol 1996, 133:199-209. A tumor-suppressive role for plakoglobin is supported by this study, which demonstrates that restoration of plakoglobin expression in cells either lacking or expressing a cadherin/catenin system results in tumor suppression. The transfected plakoglobin was detected in the nuclei of cells that lack a cadherin/catenin system, suggesting that it can confer its tumor-suppressive activity while present in the nuclei of cells.
95. 95. Vermeulen SJ, Bruyneel EA, Van Roy FM, Mareel MM, Bracke ME: Activation of the E-cadherin/catenin complex in human MCF-7 breast cancer cells by all-trans-retinoic acid. Brit J Cancer 1995, 72:1447-1453.
96. 96. Fagotto F, Funayama N, Glück U, Gumbiner BM: Binding to cadherins antagonizes the signaling activity of β-catenin during axis formation in Xenopus. J Cell Biol 1996, 132:1105-1114. This study suggests that the signaling role of β-catenin in Xenopus development and its role in adhesion, by binding to cadherin, antagonize each other. In Drosophila, however, these two functions are partially overlapping [80••].