Screening for small molecule inhibitors of insulin-like growth factor receptor (IGF-1R) kinase: Comparison of homogeneous time-resolved fluorescence and 33P-ATP plate assay formats

Journal of Experimental Therapeutics and Oncology

Volumn 4, Issue 2, 2004, Pages 111-119

  Wang, Yan ^a   Malkowski, Michael ^a   Hailey, Judith ^a   Turek Etienne, Tammy ^a   Tripodi, Tom ^a   Pachter, Jonathan A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

HTRF; IGF 1R; IGF I; Insulin like growth factor; Kinase inhibitor; Screening; Steptavidin Flashplate assay

Indexed keywords

ADENOSINE TRIPHOSPHATE; INSULIN RECEPTOR SUBSTRATE 1; PROTEIN KINASE B; PROTEIN SHC; PROTEIN TYROSINE KINASE INHIBITOR; RAF PROTEIN; RAS PROTEIN; SOMATOMEDIN B; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; STREPTAVIDIN;

ARTICLE; AUTOPHOSPHORYLATION; BREAST CANCER; CELL STRAIN MCF 7; CONTROLLED STUDY; FLUORESCENCE; GENE OVEREXPRESSION; HOMOGENEOUS TIME RESOLVED FLUORESCENCE ASSAY; HUMAN; HUMAN CELL; IC 50; IMMUNOPRECIPITATION; INSECT CELL; LUNG CANCER; MALIGNANT TRANSFORMATION; NEPHROBLASTOMA; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UTERINE CERVIX CANCER; WESTERN BLOTTING;

BREAST NEOPLASMS; CELL LINE, TUMOR; FLUORESCENCE; HUMANS; LABORATORY TECHNIQUES AND PROCEDURES; NEOPLASM TRANSPLANTATION; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; RECEPTOR, IGF TYPE 1; SIGNAL TRANSDUCTION;

EID: 4043099007     PISSN: 13594117     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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