Inhibition of tumor growth by a dominant negative mutant of the insulin- like growth factor I receptor with a bystander effect

Clinical Cancer Research

Volumn 4, Issue 11, 1998, Pages 2647-2655

  Reiss, Krzysztof ^a   D'Ambrosio, Consuelo ^a   Tu, Xiao ^a   Tu, Chi ^a   Baserga, Renato ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SOMATOMEDIN C RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; MALIGNANT TRANSFORMATION; METASTASIS; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; TUMOR GROWTH;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; CULTURE MEDIA, CONDITIONED; GENES, DOMINANT; HUMANS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; PLASMIDS; RECEPTOR, IGF TYPE 1; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED; TUMOR STEM CELL ASSAY;

EID: 0031785253     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. McCubrey, J. A., Stillman, L. S., Mayhew, M. W., Algate, P. A., Dellow, R. A., and Kaleko, M. Growth promoting effects of insulin-like growth factor 1 (IGF-1) on hematopoietic cells. Overexpression of introduced IGF-1 receptor abrogates interleukin-3 dependency of murine factor dependent cells by a ligand dependent mechanism. Blood. 78: 921-929, 1991.
2. Rodriguez-Tarduchy, G., Collins, M. K. L., Garcia, I., and Lopez-Rivas, A. Insulin-like growth factor I inhibits apoptosis in IL-3 dependent hemopoietic cells. J. Immunol., 149: 535-540, 1992.
3. Harrington, E. A., Bennett, M. R., Fanidi, A., and Evan, G. I. c-myc-induced apoptosis in fibroblasts is inhibited by specific cytokines. EMBO J., 13: 3286-3295, 1994.
4. Jung, Y. K., Miura, M., and Yuan, J. Suppression of interleukin-1β converting enzyme-mediated cell death by insulin-like growth factor. J. Biol. Chem., 271: 5112-5117, 1996.
5. L gene product. Endocrinology, 138: 1355-1358, 1997.
6. Dunn, S. E., Hardman, R. A., Kari, F. W., and Barrett, C. J. Insulin-like growth factor 1 (IGF-I) alters drug sensitivity of HBL100 human breast cancer cells by inhibition of apoptosis induced by diverse anticancer drugs. Cancer Res., 57: 2687-2693, 1997.
7. Hsing, A. Y., Kadomatsu, K., Bonham, N. J., and Danielpour, D. Regulation of apoptosis induced by transforming growth factor β1 in nontumorigenic and tumorigenic rat prostatic epithelial cell lines. Cancer Res., 56: 5146-5149, 1996.
8. Sell, C., Baserga, R., and Rubin, R. Insulin-like growth factor I (IGF-I) and the IGF-I receptor prevent etoposide-induced apoptosis. Cancer Res., 55: 303-306, 1995.
9. O'Connor, R., Kauffmann-Zeh, A., Liu, Y., Lehar, S., Evan, G. I., Baserga, R., and Blättler, W. A. The IGF-I receptor domains for protection from apoptosis are distinct from those required for proliferation and transformation. Mol. Cell. Biol., 17: 427-435, 1997.
10. Prisco, M., Hongo, A., Rizzo, M. G., Sacchi, A., and Baserga, R. The IGF-I receptor as a physiological relevant target of p53 in apoptosis caused by interleukin-3 withdrawal. Mol. Cell. Biol., 17: 1084-1092, 1997.
11. Singleton, J. R., Randolph, A. E., and Feldman, E. L. Insulin-like growth factor I receptor prevents apoptosis and enhances neuroblastoma tumorigenesis. Cancer Res., 56: 4522-4529, 1996.
12. Wu, Y., Tewari, M., Cui, S., and Rubin, R. Activation of the insulin-like growth factor I receptor inhibits tumor necrosis factor-induced cell death. J. Cell. Physiol., 168: 499-509, 1996.
13. Ohlsson, C., Kley, N., Werner, H., and LeRoith, D. p53 regulates insulin-like growth factor I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1. Endocrinology. 139: 1101-1107, 1998.
14. Kulik, G., Klippel, A., and Weber, M. J. Antiapoptotic signaling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol. Cell. Biol., 17: 1595-1606, 1997.
15. Turner, B. C., Haffty, B. G., Narayanan, L., Yuan, J., Havre, P. A., Gumbs, A. A, Kaplan, L., Burgaud, J. L., Carter, D., Baserga, R., and Glazer, P. M. Insulin-like growth factor 1 receptor overexpression mediates cellular resistance and local breast cancer recurrence after lumpectomy and radiation. Cancer Res., 57: 3079-3083, 1997.
16. Nakamura, S., Watanabe, H., Miura, M., and Sasaki, T. Effect of the insulin-like growth factor I receptor on ionizing radiation-induced cell death in mouse embryo fibroblasts. Exp. Cell Res., 235: 287-294, 1997.
17. D'Ambrosio, C, Valentinis, B., Prisco, M., Reiss, K., Rubini, M., and Baserga, R. Protective effect of the IGF-I receptor on apoptosis induced by okadaic acid. Cancer Res., 57: 3264-3271, 1997.
18. Resnicoff, M., Abraham, D., Yutanawiboonchai, W., Rotman, H., Kajstura, J., Rubin, R., Zoltick, P., and Baserga, R. The insulin-like growth factor I receptor protects tumor cells from apoptosis in vivo. Cancer Res., 55: 2463-2469, 1995.
19. Resnicoff, M., Sell, C., Rubini, M., Coppola, D., Ambrose, D., Baserga, R., and Rubin, R. Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor I (IGF-I) receptor are non-tumorigenic and induce regression of wild-type tumors. Cancer Res., 54: 2218-2222, 1994.
20. Resnicoff, M., Coppola, D., Sell, C., Rubin, R., Ferrone, S., and Baserga, R. Growth inhibition of human melanoma cells in nude mice by antisensense strategies to the type 1 insulin-like growth factor receptor. Cancer Res., 54: 4848-4850, 1994.
21. Resnicoff, M., Burgaud, J-L., Rotman, H. L., Abraham, D., and Baserga, R. Correlation between apoptosis, tumorigenesis and levels of insulin-like growth factor I receptors. Cancer Res., 55: 3739-3741, 1995.
22. Shapiro, D. N., Jones, B. G., Shapiro, L. H., Dias, P., and Houghton, P. J. Antisense-mediated reduction in insulin-like growth factor 1 receptor expression suppresses the malignant phenotype of a human alveolar rhabdomyosarcoma. J. Clin. Invest., 94: 1235-1242, 1994.
23. Neuenschwander, S., Roberts, C. T., Jr, and LeRoith, D. Growth inhibition of MCF-7 breast cancer cells by stable expression of an insulin-like growth factor 1 receptor antisense ribonucleic acid. Endocrinology. 136: 4298-4303, 1995.
24. Valentinis, B., and Baserga, R. The IGF-I receptor protects tumor cells from apoptosis induced by high concentrations of serum. Biochem. Biophys. Res. Commun., 224: 362-368, 1996.
25. Lee, C. T., Wu, S., Gabrivolich, D., Chen, H., Nadaf-Rahrov, S., Ciernick, I. F., and Carbone, D. P. Antitumor effect of an Adenovirus expressing antisense insulin-like growth factor I receptor on human lung cancer cell lines. Cancer Res., 56: 3038-3041, 1996.
26. Pass, H. L., Mew, D. J. Y., Carbone, M., Matthews, W. A., Domington, J. S., Baserga, R., Walker, C. L., Resnicoff, M., and Steinberg, S. M. Inhibition of hamster mesothelioma tumorigenesis by an antisense expression plasmid to the insulin-like growth factor I receptor. Cancer Res., 56: 4044-4048, 1996.
27. Prager, D., Li, H. L., Asa, S., and Melmed, S. Dominant negative inhibition of tumorigenesis in vivo by human insulin-like growth factor receptor mutant. Proc. Natl. Acad. Sci. USA. 91: 2181-2185, 1994.
28. D'Ambrosio, C., Ferber, A., Resnicoff, M., and Baserga, R. A soluble insulin-like growth factor I receptor that induces apoptosis of tumor cells in vivo and inhibits tumorigenesis. Cancer Res., 56: 4013-4020, 1996.
29. Rininsland, F., Johnson, T. R., Chernicky, C. L., Schulze, E., Burfeind, B., Ilan, J., and Ilan, J. Suppression of insulin-like growth factor I receptor by a triple-helix strategy inhibits IGF-I transcription and tumorigenic potential of rat C6 glioblastoma cells. Proc. Natl. Acad. Sci. USA. 94: 5854-5859, 1997.
30. Long, L., Rubin, R., Baserga, R., and Brodt, P. Loss of the metastatic phenotype in murine carcinoma cells expressing an antisense RNA to the insulin-like growth factor I receptor. Cancer Res., 55: 1006-1009, 1995.
31. Burfeind, P., Chernicky, C. L., Rininsland, F., Ilan, J., and Ilan, J. Antisense RNA to the type I insulin-like growth factor receptor suppresses tumor growth and prevents invasion by rat prostate cancer cells in vivo. Proc. Natl. Acad. Sci. USA, 93: 7263-7268, 1996.
32. Kauffmann-Zeh, A., Rodriguez-Viciana, P., Ulrich, E., Gilbert, C., Coffer, P., Downward, J., and Evan, G. Suppression of c-myc-induced apoptosis by ras signalling through PI(3)K and PKB. Nature (Lond.), 385: 544-548, 1997.
33. Baserga, R., Kongo, A., Rubini, M., Prisco, M., and Valentinis, B. The IGF-I receptor in cell growth, transformation and apoptosis. Biochim. Biophys. Acta, 1332: 105-126, 1997.
34. Burgaud, J-L., Resnicoff, M., and Baserga, R. Mutant IGF-I receptors as dominant negatives for growth and transformation. Biophys. Biochem. Res. Commun., 214: 475-481, 1995.
35. Ullrich, A., Gray, A., Tam, A. W., Yang-Feng, T., Tsubokawa, M., Collins, C., Henzel, W., Le Bon, T., Kahuria, S., Chen, E., Jakobs, S., Francke, U., Ramachandran, J., and Fujita-Yamaguchi, Y. Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. EMBO J., 5: 503-2512, 1986.
36. Chomczynski, P., and Sacchi, N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chlorotbrm extraction. Ann. Biochem., 162: 156-159, 1987.
37. Thomas, P. S. Hybridization of denatured RNA transferred on dotted nitrocellulose paper. Methods Enzymol., 100: 255-266, 1983.
38. Rubini, M., Hongo, A., D-Ambrosio, C., and Baserga, R. The IGF-I receptor in mitogenesis and transformation of mouse embryo cells: role of receptor number. Exp. Cell Res., 230: 284-292, 1997.
39. Dricu, A., Carlberg, M., Wang, M., and Larsson, O. Inhibition of N-linked glycosylation using tunicamycin causes cell death in malignant cells: role of down-regulation of the insulin-like growth factor 1 receptor in induction of apoptosis. Cancer Res., 57: 543-548, 1997.
40. Baserga, R. The price of independence. Exp. Cell Res., 236: 1-3, 1997.
41. Huppa, J. B., and Ploegh, H. L. The eS-ence of - SH in the ER. Cell, 92: 145-148, 1998.
42. Baserga, R., Resnicoff, M., and Dews, M. The IGF-I receptor and cancer. Endocrine, 7: 99-102.