Phosphodiesterase 3 inhibitors suppress oocyte maturation and consequent pregnancy without affecting ovulation and cyclicity in rodents

Journal of Clinical Investigation

Volumn 102, Issue 3, 1998, Pages 532-537

  Wiersma, A ^a   Hirsch, B ^b   Tsafriri, A ^b,c   Hanssen, R G J M ^a   Van De Kant, M ^a   Kloosterboer, H J ^a   Conti, M ^b   Hsueh, A J W ^b  

^a NV ORGANON   (Netherlands)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Contraception; Dissociation oocyte maturation ovulation; Germinal vesicle stage oocytes; Immature ovulated oocytes; PDE

Indexed keywords

PHOSPHODIESTERASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; ESTRUS CYCLE; FEMALE; FERTILIZATION; GERMINAL VESICLE; MEIOSIS; MOUSE; NONHUMAN; OOCYTE MATURATION; OVULATION; PRIORITY JOURNAL;

EID: 0032146537     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI2566     Document Type: Article

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