Glutamate decarboxylase antibodies in non-diabetic pregnancy precedes insulin-dependent diabetes in the mother but not necessarily in the offspring

Autoimmunity

Volumn 26, Issue 4, 1997, Pages 261-269

  Ivarsson, Sten A ^a   Ackefors, Malin ^b   Carlsson, Anneli ^a   Ekberg, Göran ^a   Falorni, Alberto ^b   Kockum, Ingrid ^b   Landin Olsson, Mona ^a   Lernmark, Åke ^c   Lindberg, Bengt ^a   Sundkvist, Göran ^a   Svanberg, Lars ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Autoimmunity; Glutamic acid decarboxylase; HLA; Islet cell autoantibodies; Placental transfer; Pregnancy

Indexed keywords

AUTOANTIBODY; ENZYME ANTIBODY; GLUTAMATE DECARBOXYLASE; PANCREAS ISLET CELL ANTIBODY;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; NON INSULIN DEPENDENT DIABETES MELLITUS; RISK; SWEDEN;

EID: 6844252928     PISSN: 08916934     EISSN: None     Source Type: Journal    
DOI: 10.3109/08916939709008032     Document Type: Article

References (46)

1. Baekkeskov, S., Landin-Olsson, M., Kristensen, J. K., Srikanta, S., Bruining, G. J., Mandrup-Poulsen. T., de Beaufort, C., Soeldner, J. S., Eisenbarth, G. and Lindgren, F. (1987). Antibodies to a Mr 64,000 human islet cell antigen precede the clinical onset of insulin-dependent diabetes. J Clin Invest, 79, 926-934.
2. Zimmet, P. Z., Tuomi, T., Mackay. I. R., Rowley, M. J., Knowles, W., Cohen, M. and Lang, D. A. (1994). Latent autoimmune diabetes mellitus in adults (LADA): The role of antibodies to glutamic acid decarboxylase in diagnosis and prediction of insulin dependency. Diabetic Med., 11, 299-303.
3. Bingley, P. J., Christie, M. R., Bonifacio, E., Bonifanti, R., Shattock, M., Fonte, M. T., Bottazzo, G. F. and Gale, E. A. (1994). Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes, 43, 1304-1310.
4. Gorsuch, A. N., Spencer, K. M., Lister, J., McNally, J. M., Dean, B. M., Bottazzo, G. F. and Cudworth, A. G. (1981). Evidence for a long prediabetic period in Type 1 (insulin-dependent) diabetes mellitus, Lancet, 2, 1363-1365.
5. Tuomilehto, J., Zimmet, P., Mackay, I. R., Koskela, P., Vidgren, G., Tolvanen, L., Tuomilehto-Wolf, E., Kohtamåki, K., Stengård, J. and Rowley, M. J. (1994). Antibodies to glutamic acid decarboxylase as predictors of insulin-dependent diabetes mellitus before clinical onset of disease. Lancet, 343, 1383-1385.
6. Landin-Olsson, M., Palmer, J. P., Lernmark, Å., Blom, L., Sundkvist, G., Nyström, L. and Dahlquist, G. (1992). Predictive value of islet cell and insulin autoantibodies for type I (insulin-dependent) diabetes mellitus in a population-based study of newly-diagnosed diabetic and matched control children. Diabetalogia, 35, 1068-1073.
7. Hagopian, W. A., Sanjeevi, C. B., Kockum, I., Landin-Olsson, M., Karlsen, A. E., Sundkvist, G., Dahlquist, G., Palmer, J. and Lernmark, Å. (1995). Glutamate decarboxylase-, insulin- and islet cell-antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children. J. Clin. Invest., 95, 1505- 1511.
8. Dahlquist, G., Blom, L., Tuvemo, T., Nyström, L., Sandström, A. and Wall, S. (1989). The Swedish Childhood Diabetes Study - results from a nine year case register and one year case-referent study indicating that type 1 (insulin-dependent) diabetes mellitus is associated with both type 2 (non-insulin-dependent) diabetes mellitus and autoimmune disorders. Diabetologia, 32, 2-6.
9. Warram, J. H., Krolewski, A. S., Gottlieb, M. S. and Kahn, C. R. (1984). Differences in risk of insulin-dependent diabetes in offspring of diabetic mothers and diabetic fathers. N. Engl. J. Med., 311, 149-152.
10. Yu, L., Chase, H. P., Falorni, A., Rewers, M., Lernmark, Å. and Eisenbarth, G. S. (1995). Sexual dimorphism in transmission to offspring of expression of islet autoantibodies. Diabetologia, 38, 1353-1357.
11. Ahlfors, K., Ivarsson, S.-A., Johnsson, I. and Svanberg, I. (1982). Primary and secondary maternal cytomegalovirus infections and their relation to congenital infection. Acta Paediatr. Scand., 71, 109-113.
12. 3H recombinant human ligands. J. Immunol. Meth., 186, 89-99.
13. Grubin, C. E., Daniels, T., Toivola, B., Landin-Olsson, M., Hagopian, W. A., Li, L., Karlsen, A. E., Boel, E., Michelsen, B. and Lernmark, Å. (1994). A novel radioligand binding assay to determine diagnostic accuracy of isoformspecific glutamic acid decarboxylase antibodies in childhood IDDM. Diabetologia, 37, 344-350.
14. Schmidli, R. S., Colman, P. G., Bonifacio, E., Bottazzo, G. F. and Harrison, L. C. (1994). High level of concordance between assays for glutamic acid decarboxylase antibodies. The First International Glutamic Acid Decarboxylase Antibody Workshop. Diabetes, 43, 1005-1009.
15. Schmidli, R. S., Colman, P. G. and Bonifacio, E. (1995). Disease sensitivity and specificity of 52 assays for glutamic acid decarboxylase antibodies. The Second International GADAb Workshop. Diabetes, 44, 636-640.
16. Landin-Olsson, M., Sundkvist, G. and Lernmark, Å.(1987). Prolonged incubation in the two-colour immunofluorescence test increases the prevalence and titres of islet cell antibodies in type 1 (insulin-dependent) diabetes mellitus. Diabetologia, 30, 327-332.
17. Landin-Olsson, M. (1990). Precision of the islet cell antibody assay depends on the pancreas. J Clin Lab Anal, 4, 289-294.
18. Bonifacio, E., Bingley, P. J., Shattock, M., Dean, B. M., Dunger, D., Gale, E. A. M. and Bottazzo, G. F. (1990). Quantification of islet cell antibodies and prediction of insulin dependent diabetes. Lancet, 335, 147-149.
19. Kockum, I., Wassmuth, R., Holmberg, E., Michelsen, B. and Lernmark, Å. (1993). HLA-DQ primarily confers protection and HLA-DR susceptibility in Type 1 (insulin-dependent) diabetes studied in population-based affected families and controls. Am J Human Gen, 53, 150-167.
20. Sanjeevi, C. B., Zeidler, A., Shaw, S., Rotter, R., Nepom, G. T., Costin, G., Raffel, L., Eastman, S., Kockum, I. and Wassmuth, R. (1993). Analysis of HLA-DQA1 and -DQB1 genes in Mexican Americans with insulin-dependent diabetes mellitus. Tissue Antigens, 42, 72-77.
21. Sanjeevi, C. B., Lybrand, T. P., DeWeese, C., Landin-Olsson, M., Kockum, I., Dahlquist, G., Sundkvist, G., Stenger, D. and Lernmark, Å. (1995). Polymorphic amino acid variations in HLA-DQ are associated with systematic physical property changes and occurrence of insulin-dependent diabetes mellitus. Diabetes, 44, 125-131.
22. Kockum, I., Sanjeevi, C. B., Eastman, S., Landin-Olsson, M., Dahlquist, G. and Lernmark, Å. (1995). Population analysis of protection by HLA-DR and DQ genes protection from insulin-dependent diabetes mellitus in Swedish insulin-dependent diabetes children and controls. Eur. J. Immunogenetics, 22, 443-465.
23. Sanjeevi, C. B.,Landin-Olsson, M., Kockum, I., Dahlquist, G. and Lernmark, Å. (1994). Effects of the second HLA-DQ haplotype on the association with childhood insulin dependent diabetes mellitus. Tissue Antigens, 45, 148-152.
24. r autoantibodies as predictors of insulin-dependent diabetes. Lancet, 335, 1357-1360.
25. Vandewalle, C. L., Falorni, A., Svanholm, S., Lernmark, A., Pipeleers, D. G., Gorus, F. K. and Registry, T. B. D. (1995). High diagnostic sensitivity of glutamate decarboxylase autoantibodies in IDDM with clinical onset between age 20 and 40 years. J Clin. Endocrinol. Metab., 80, 846-850.
26. Palmer, J. P. (1994). What is the best way to predict IDDM? Lancet, 343, 1377-1378.
27. Landin-Olsson, M., Karlsson, F. A., Lernmark, Å. and Sundkvist, G. (1992). Islet cell and thyrogastric antibodies in 633 consecutive 15-34 years old patients in the Diabetes Incidence Study in Sweden (DISS). Diabetes, 41, 1022-27.
28. Nyström, L., Dahlquist, G., Östman, J., Wall, S., Arnqvist, H., Blohmé, G., Lithner, F., Littorin, B., Schersten, B. and Wibell, L. (1992). Risk of developing insulin-dependent diabetes mellitus (IDDM) before 35 years of age: Indications of climatological determinants for age at onset. Int. J. Epidemiology, 21, 352-358.
29. Hagopian, W. A., Karlsen, A. E., Gottsater, A., Landin-Olsson, M., Grubin, C. E., Sundvist, G., Petersen, J. S., Boel, E., Dyrberg, T. and Lernmark, Å. (1993). Quantitative assay using recombinant human islet glutamic acid decarboxylase (GAD-64) showed 64K autoantibody positivity at onset predicts diabetes type. J. Clin. Invest., 91, 368-374.
30. Tuomi, T., Groop, L. C., Zimmet, P. Z., Rowley, M. J., Knowles, W. and Mackay, I. R. (1993). Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin-dependent onset of disease. Diabetes, 42, 359-362.
31. Groop, L. C., Miettinen, A., Groop, P.-H., Men, S., Koskimies, S. and Bottazzo, G. F. (1988). Organ-specific autoimmunity and HLA-DR antigens as markers for β-cell destruction in patients with type II diabetes. Diabetes, 37, 99-103.
32. Irvine, W. J., Sawers, J. S. A., Feek, C. M., Prescott, R. J. and Duncanc, J. P. (1979). The value of islet cell antibody in predicting secondary failure of oral hypoglycemic agent therapy in diabetes mellitus. J Clin Immunol, 2, 23-26.
33. Landin-Olsson, M., Nilsson, K. O., Lernmark, Å. and Sundkvist, G. (1990). Islet cell antibodies and fasting C-peptide predict insulin requirement at diagnosis of diabetes mellitus. Diabetologia, 33, 561-568.
34. Gottsäter, A., Landin-Olsson, M., Lernmark, Å., Fernlund, P., Sundkvist, G. and Hagopian, W. A. (1995). Glutamate decarboxylase antibody levels predict rate of beta-cell decline in adult onset diabetes. Diabetes Res Clin Practice, 27, 133-140.
35. Sundkvist, G., Bergqvist, A., Weibull, H., Bergqvist, D., Fait, K., Landin-Olsson, M. and Lernmark, Å. (1991). Islet cell antibodies react with human fetal islets. Diabetes Res. Clin. Practice, 14, 1-8.
36. [36| Gamlen, T. R., Aynsley-Green, A., Irvine, W. J. and McCallum, C. J. (1977). Immunological studies in the neonate of a mother with Addison's disease and diabetes mellitus. Clin. Exp. Immunol., 28, 192-195.
37. Roll, U., Christie, M. R., Standl, E. and Ziegler, A-G. (1994). Association of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of Type 1 diabetic patients. Diabetes, 43, 154-160.
38. Baisch, J. M., Weeks, T., Giles, R., Hoover, M., Stastny, P. and Capra, J. D. (1990). Analysis of HLA-DQ genotypes and susceptibility in insulin-dependent diabetes mellitus. New England Journal of Medicine, 322, 1836-1882.
39. Sanjeevi, C. B., Kockum, I. and Lernmark, Å. (1995). The role of major histocompatibility complex in insulin-dependent diabetes mellitus. Current Science, 2, 3-11.
40. Phelan, D., Hadley, G., Duffy, B., Mohanam, S. and Mohanakumar, T. (1991). Anti idiotypic antibodies to HLA class I alloantibodies in normal individuals: a mechanism of tolerance to noninherited maternal HLA antigens. Hum Immuno, 31, 1 -6.
41. Landor, M. (1995). Maternal-fetal transfer of immunoglobulins. Ann Allergy Asthma Immunol, 74, 279-83.
42. Kockum, I., Wassmuth, R., Holmberg, E., Michelsen, B. and Lernmark, Å. (1994). Inheritance of MHC class II genes in IDDM studied in population-based affected and control families. Diabetologia, 37, 1105- 1112.
43. Rubinstein, P., Walker, M. E., Fedun, B., Witt, M. E., Cooper, L. Z. and Ginsburg-Fellner, F. (1982). The HLA system in congenital rubella patients with and without diabetes. Diabetes, 31, 1088-1091.
44. Ginberg-Fellner, F., Witt, M. E., Yagihashi, S., Dobersen, M. J., Taub, F., Fedun, B., McEvoy, R. C., Roman, S. H., Davies, T. F. and Cooper, L. Z. (1984). Congenital rubella syndrome as a model for Type 1 (insulin-dependent) diabetes mellitus: increased prevalence of islet cell surface antibodies. Diabetologia, 27, 87-89.
45. Hyöty, H., Hiltunen, M., Knip, M., Laakkonen, M , Vahasalo, P., Karjalainen, J., Koskela, P., Roivainen, M., Leinikki, P. and Hovi, T. (1995). A prospective study of the role of coxsackie B and other enterovirus infections in the pathogenesis of IDDM. Childhood Diabetes in Finland (DiMe) Study. Diabetes, 44, 652-657.
46. Dahlquist, G., Ivarsson, S., Lindberg, B. and Forsgren, M. (1995). Maternal enteroviral infection during pregnancy as a risk factor for childhood IDDM. Diabetes, 44, 408-413.