Morphological examination of bone synthesis via direct administration of basic fibroblast growth factor into rat bone marrow

Microscopy Research and Technique

Volumn 41, Issue 4, 1998, Pages 313-322

  Amizuka, Norio ^a   Yamada, Marie ^b   Watanabe, Jun Ichi ^a   Hoshi, Kazuto ^a   Fukushi, Mariko ^a   Oda, Kimimitsu ^a   Ikehara, Yukio ^c   Ozawa, Hidehiro ^a  

^a NIIGATA UNIVERSITY   (Japan)

^b TOKYO DENTAL COLLEGE   (Japan)

^c FUKUOKA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

bFGF; Bone formation; Immunohistochemistry; Osteopontin; TNAPase

Indexed keywords

CELL CULTURE; CEMENTS; DIRECT INJECTION; FIBROBLASTS; HISTOLOGY; PHOSPHATASES; RATS; WEAVING;

ALKALINE PHOSPHATASE; BASIC FIBROBLAST GROWTH FACTOR; BONE FORMATION; BONE RESORPTION; FIBROUS TISSUE; IMMUNOHISTOCHEMISTRY; OSTEOPONTIN; RAT BONE MARROW; TISSUE- NONSPECIFIC ALKALINE PHOSPHATASE;

BONE;

ALKALINE PHOSPHATASE; BASIC FIBROBLAST GROWTH FACTOR; OSTEOPONTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW; CONTROLLED STUDY; EXTRACELLULAR MATRIX; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 0032523868     PISSN: 1059910X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0029(19980515)41:4<313::AID-JEMT4>3.0.CO;2-R     Document Type: Article

References (53)

1. Amizuka, N., Karaplis, A.C., Henderson, J.E., Warshawsky, H., Lipman, M.L., Matsuki, Y., Ejiri, S., Tanaka, M., Izumi, N., Ozawa, H., and Goltzman, D. (1996) Haploinsufficiency of parathyroid hormonerelated peptide (PTHrP) results in abnormal postnatal bone development. Dev. Biol., 175:166-176
2. Amsel, S., Maniatis, A., Tavassoli, M., and Crosby, W.H. (1969) The significance of intramedullary cancellous bone formation in the repair of bone marrow tissue. Anat. Rec., 164:101-112.
3. Aspenberg, P., Throngren, K., and Lohmander, L.S. (1991) Dose-dependent stimulation of bone induction by basic fibroblast growth factor in rats. Acta Orthop. Scand., 62(5):481-484.
4. Baron, J., Klein, K.O., Yanovski, J.A., Novosad, J.A., Bacher, J.D., Bolander, M.E., and Cutler, GB Jr. (1994) Induction of growth plate cartilage ossification by basic fibroblast growth factor. Endocrinology, 135:2790-2793.
5. Baron, R. (1977) Importance of the intermediate phases between resorption and formation in the measurement and understanding of the bone remodeling sequence. In: Bone Histomorphomertry. P.J. Meunier, ed. Lab. Armour Montagu, Paris, pp. 179-183.
6. Brunner, G., Nguyen, Hm., Gabrilove, J., Rifkin, D.B., and Wilson, L. (1993) Basic fibroblast factor expression in human bone marrow and peripheral blood cells. Blood, 3:631-638.
7. Burstone, M.S. (1958) Histochemical demonstration of acid phosphatase with naphtol AS-phospahte. J. Natl. Cancer Inst., 21:523-539.
8. Canalis, E., Centrella, M., and McCarthy, T. (1988) Effects of basic fibroblast growth factor on bone formation in vitro. J. Clin. Invest., 81:1572-1577.
9. Chuxia, D., Wynshaw-Boris, A., Zhou, F., Kuo, A., and Leder. P. (1996) Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell, 84:911-921.
10. Fleisch, H., and Neuman, W.F. (1961) Mechanisms of calcification: Role of collagen, polyphosphates, and phosphate. Am. J. Physiol., 200:1296-1300.
11. Flores, M., Norgard, M., Heinegard, D., Rheinholt, F.P., and Andersson, G. (1992) RGD-directed attachment of isolated rat osteoclasts to osteopontin, bone sialoprotein and fibronectin. Exp. Cell Res., 201:526-530.
12. Furusawa, T. (1993) The repair process of intramedullary tissue after ablation of the tibial cavity of rat. Jikeikai Med. J. (Tokyo), 108:591-607.
13. Giachelli, C.M., Schwartz, S.M., and Liaw, L. (1995) Molecular and cellualr biology of osteopontin. Trends Cardiovasc. Med., 3:88-95.
14. Globus, R.K., Patterson-Buckendahl, P., and Gospodarowicz, D. (1988) Regulation of bovine bone cell proliferation by fibroblast growth factor and transforming growth factor. Endocrinology, 123:98-105.
15. Hoshi, K., Amizuka, N., Oda, K., Ikehara, Y., and Ozawa, H. (1997) Immunolocalization of tissue non-specific alkaline phosphatase in mice. Histochem. Cell Biol., 107:183-191.
16. Hynes, R.O. (1992) Integrins: Versatility, modulation and signaling in cell adhesion. Cell, 69:11-25.
17. Ikeda, T., Nomura, S., Yamaguchi, A., Suda, T., and Yoshiki, S. (1992) In situ hybridization of bone matrix proteins in undecalcified adult bone sections. J. Histochem. Cytochem., 40:1079-1088.
18. Iwasaki, M., Nakata, K., Nakahara, H., Nakase, T., Kimura, T., Kimata, K., Caplan, A.I., and Ono, K. (1993) Transforming growth factor βl stimulates chondrogenesis and inhibits osteogenesis in high density culture of periosteum-derived cells. Endocrinology, 132:1603-1608.
19. Iwasaki, M., Nakahara, H., Nakase, T., Kimura, T., Takaoka, K., Caplan, A.I., and Ono, K. (1994) Bone morphogenetic protein 2 stimulates osteogenesis but does not affect chondrogenesis in osteochondrogenic differentiation of periosteum-derived cells. J. Bone Miner. Res., 9:1195-1204.
20. Kawaguchi, H., Pilbeam, C., Gronowicz, G., Abreu, C., Fletcher, B.S., Herschman, H.R., Harrison, J.R., Raisz, L., and Hurley, M.M. (1995) Transcriptional induction of prostgrandin G/H synthetase-2 by basic fibroblast growth factor. J. Clin. Invest., 96:923-930.
21. Maeda, H., Kukita, T., Akaime, A., Kukita, A., and IIjima, T. (1994) Localization of osteopontin in resorption laccunae formed by osteoclast-like cells: A study for novel monoclonal antibody which recognizes rat osteopontin. Histechemistry, 102:247-252.
22. Mark, M.R., Butler, W.T., Prince, C.W., Finkleman, R.D., and Ruch, J.-V. (1988) Developmental expression of 44-kDa phosphoprotein (osteopontin) and bone γ-carboxyglutamic acid (Gla)-containing protein (osteocalcin) in calcifying tissues of rat. Differentiation, 37:123-136.
23. Matsuki, Y., Nakashima, N., Amizuka, N., Warshawsky, H., Goltzman, D., Yamada, K.M., and Yamada, Y.A. (1995) Compilation of partial sequences of randomly selected cDNA clones from the rat incisor. J. Dent. Res., 74:307-312.
24. McKee, M.D., and Nanci, A. (1995a) Post-embedding colloidal-gold immunocytochemistry of noncollagenous extracellualr matrix proteins in mineralized tissues. Microsc. Res. Tech., 31:44-62.
25. McKee, M.D., and Nanci, A. (1995b) Osteopontin and the bone remodeling sequences: Colloidal-gold immunocytochemistry of an interfacial extracellular matrix protein. Ann. N.Y. Acad. Sci., 760: 177-189.
26. McKee, M.D., and Nanci, A. (1996) Osteopontin at mineralized tisue interfaces in bone teeth and osteointegrated implants: Ultrastructural distribution and implications for mineralized tissue formation, turnover and repair. Microsc. Res. Tech. 33:141-164.
27. McKee, M.D., Farach-Carson, M.C., Butler, W.T., Hauschka, P.V., and Nanci, A. (1993) Ultrastructural immunolocalization of noncollagenous (osteopontin and osteocalcin) and plasma (albumin and α2HS-glycoprotein) proteins in rat bone. J. Bone Miner. Res., 8:485-496.
28. Merry, K., Dodds, R., Littlewood, A., and Gowen, M. (1993) Expression of osteopontin mRNA by osteoclasts and osteoblasts in modeling adult human bone. J. Cell Sci., 104:1013-1020.
29. Miki, A., Tanaka, Y., Ogata, S., and Ikehara, Y. (1986) Selective preparation and characterization of membranous and soluble forms of alkaline phosphatase from rat tissues. A comparison with the serum enzyme. Eur. J. Biochem., 160:41-48.
30. Nagai, H., Tsukuda, R., and Mayahara, H. (1995) Effects of basic fibroblast growth factor (bFGF) on bone formation in growing rats. Bone, 16:367-373.
31. Nakamura, T., Hanada, K., Tamura, M., Shibanushi, H., Tagawa, M., Fukumoto, S., and Matsumoto, T. (1995) Stimulation of endosteal bone formation by systemic injections of recombinant basic fibroblast grouth factor in rats. Endocrinology, 136:1276-1284.
32. Nakamura, H., Yamada, M., Fukae, M., and Ozawa, H. (1997) The localization of CD44 and moesin in osteoclasts after calcitonin administration in mouse tibiae. J. Bone Miner. Metab., 15:184-192.
33. Noda, M., and Vogel, R. (1989) Fibroblast growth factor enhances type βl transforming growth factor gene expression in osteoblast-like cells. J. Cell Biol., 109:2529-2535.
34. Oguro, I., and Ozawa, H. (1988) The histochemical localization of acid phosphatase activity in BMU. J. Bone Miner. Metab., 6:190-195.
35. Oguro, I., and Ozawa, H. (1989) Cytochemical studies of the cellular events in bone remodeling: Cytological evidence for a coupling mechanism. J. Bone Miner. Metab., 7:30-36.
36. Oldberg, A., Franzen, A., and Hienegard, D. (1986) Cloning and sequence analysis for rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence. Proc. Natl. Acad. Sci. USA, 83:8819-8823.
37. Peters, K.G., Werner, S., Chen, G., and Williams, L.T. (1992) Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse. Development, 114:233-243.
38. Peters, K., Ornitz, D., Werner, S., and Williams, L. (1993) Unique expression pattern of the FGF receptor 3 gene during mouse organogenesis. Dev. Biol., 155:423-430.
39. Reinholt, F.P., Hultenby, K., Oldberg, A., and Heinegard, D. (1990) Osteopontin-a possible anchor of osteoclasts in bone, Proc. Natl. Acad. Sci. USA, 87:4473-4475.
40. Robinson, R. (1923) The possible significance of hexoaephosphoric esters in ossification. Biochem. J., 17:286-293.
41. Rodan, S.B., Weslowski, G., Thomas, K., and Rodan, G.A. (1989) Opposing effects of fibroblast growth factor and pertussis toxin on alkaline phosphatase, osteopontin, osteocalcin, and type I collagen mRNA levels in ROS 17/2.8 cells. J. Biol. Chem., 264:19934-19941.
42. Ross, F.P., Chappel, J., Alvarez, J.I., Snader, D., Butler, W.T., Farac-Carson, M.C., Mintz, K.A., Robey, P.G., Teitelbaum, S.L., and Chertesh, D.A. (1993) Interactions between the bone matrix protein osteopontin and bone sialoprotein and osteoclast integrin αVβ3 potentiate bone resorption. J. Biol. Chem., 268:9901-9907.
43. Shen, V., Kohler, G., Huang, S.S., and Peck, W.A. (1989) An acidic fibroblast growth factor stimulates DNA synthesis, inhibits collagen and alkaline phosphatase synthesis and induces resorption in bone Bone Miner., 7:205-219.
44. Simmons, H.A., and Raisz, L.G. (1991) Effects of acid and basic fibroblast growth factor and heparin on resorption of cultured fetal rat long bone. J. Bone Miner. Res., 6:1301-1305.
45. Suva, L.J., Seedor, G., Endo, N., Quartuccio, H.A., Thompson, D.D., Bab, I., and Rodan, G.A. (1993) Pattern of gene expression following rat tibial marrow ablation. J. Bone Miner. Res., 8:379-388.
46. Tanaka, M., Amizuka, N., Kim, K.J., Itoh, T., and Ozawa, H. (1997) Histochemical examination odf ectopic bone formation induced in rat bone marrow. J. Bone Miner. Metab., 15:67-76.
47. Takahashi, N., Akatsu, T., Udagawa, N., Sasaki, T., Yamaguchi, A., Moseley, J.M., Martin, T.J., and Suda, T (1988) Osteoblastic cells are involved in osteoclast formation. Endocrinology, 123:2600-2602.
48. Takahashi, N., Udagawa, N., Akatsu, T., Tanaka, H., Shinnome, M., and Suda, T. (1991) Role of colony-stimulating factors in osteoclast development. J. Bone Miner. Res., 6:977-985.
49. Udagawa, N., Takahashi, N., Akatsu, T., Sasaki, T., Yamaguchi, A., Kodama, H., Martin, T.J., and Suda, T. (1989) The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclastlike cell differentiation in cocultures with mouse spleen cells. Endocrinology, 125:1805-1813.
50. Udagawa, N., Takahashi, N., Akatsu, T., Tanaka, H., Sasaki, T., Nishihara, T., Koga, T., Martin, T.J., and Suda, T. (1990) The origin of osteoclasts: Mature monocyte-macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-stromal cells. Proc. Natl. Acad. Sci. USA, 87:7260-7264.
51. Vignery, A., and Baron, R. (1980) Dynamic histomorphometry of alveolar bone remodeling in the adult rat. Anat. Rec., 196:191-200.
52. Wang, J.S., and Aspenberg, P. (1993) Basic fibroblast growth factor and bone induction in rats. Acta Orthop. Scand., 64:557-561.
53. Wildburger, R., Zarkovic, N., Egger, G., Petek, W., Zarkovic, K., and Hofer, H.P. (1994) Basic fibroblast growth factor (bFGF) immunoreactivity as a possible link between head injury and impaired bone fracture healing. Bone Miner., 27:183-193.