메뉴 건너뛰기




Volumn 20, Issue 3, 2008, Pages 169-173

Should azathioprine and 5-aminosalicylates be coprescribed in inflammatory bowel disease?: An audit of adverse events and outcome

Author keywords

5 aminosalicylates; Adverse reactions; Azathioprine; Inflammatory bowel disease; Relapse

Indexed keywords

AZATHIOPRINE; MESALAZINE; THIOPURINE METHYLTRANSFERASE;

EID: 39849103868     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/MEG.0b013e3282f16d50     Document Type: Article
Times cited : (22)

References (30)
  • 1
    • 4344602852 scopus 로고    scopus 로고
    • Guidelines for the management of inflammatory bowel disease in adults
    • Carter MJ, Lobo AJ, Travis SPL. Guidelines for the management of inflammatory bowel disease in adults. Gut 2004; 53 (Suppl No V):v4.
    • (2004) Gut , vol.53 , Issue.SUPPL. NO V
    • Carter, M.J.1    Lobo, A.J.2    Travis, S.P.L.3
  • 3
    • 0030775667 scopus 로고    scopus 로고
    • Mesalazine in the maintenance treatment of Crohns disease: A meta-analysis adjusted for confounding variables
    • Cama C, Giunta M, Rosselli M, Cottone M. Mesalazine in the maintenance treatment of Crohns disease: a meta-analysis adjusted for confounding variables. Gastroenterology 1997; 113:1465-1473.
    • (1997) Gastroenterology , vol.113 , pp. 1465-1473
    • Cama, C.1    Giunta, M.2    Rosselli, M.3    Cottone, M.4
  • 5
    • 0036278519 scopus 로고    scopus 로고
    • The efficacy of azathioprine for treatment of inflammatory bowel disease: A 30-year review
    • Fraser AG, Orchard TR, Jewell DP. The efficacy of azathioprine for treatment of inflammatory bowel disease: a 30-year review. Gut 2002; 50:485-489.
    • (2002) Gut , vol.50 , pp. 485-489
    • Fraser, A.G.1    Orchard, T.R.2    Jewell, D.P.3
  • 6
    • 29244457275 scopus 로고    scopus 로고
    • Randomised controlled trial of azathioprine and 5-aminosalicylic acid for treatment of steroid dependent ulcerative colitis
    • Ardizzone S, Maconi G, Russo A, Imbesi V, Colombo E, Bianchi Porro G. Randomised controlled trial of azathioprine and 5-aminosalicylic acid for treatment of steroid dependent ulcerative colitis. Gut 2006; 55:47-53.
    • (2006) Gut , vol.55 , pp. 47-53
    • Ardizzone, S.1    MacOni, G.2    Russo, A.3    Imbesi, V.4    Colombo, E.5    Bianchi Porro, G.6
  • 7
    • 0030027701 scopus 로고    scopus 로고
    • Risk factors of colorectal cancer in inflammatory bowel disease
    • Bansal P, Sonnenberg A. Risk factors of colorectal cancer in inflammatory bowel disease. Am J Gastroenterol 1996; 91:44.
    • (1996) Am J Gastroenterol , vol.91 , pp. 44
    • Bansal, P.1    Sonnenberg, A.2
  • 8
    • 0029803955 scopus 로고    scopus 로고
    • Long term therapy with sulphasalazine protects against colorectal cancer in ulcerative colitis: A retrospective study of colorectal cancer risk and compliance with treatment in Leicestershire
    • Moody GA, Jayanthi V, Probert CS, MacKay H, Mayberry JF. Long term therapy with sulphasalazine protects against colorectal cancer in ulcerative colitis: a retrospective study of colorectal cancer risk and compliance with treatment in Leicestershire. Eur J Gastroenterol Hepatol 1996; 8:1179-1183.
    • (1996) Eur J Gastroenterol Hepatol , vol.8 , pp. 1179-1183
    • Moody, G.A.1    Jayanthi, V.2    Probert, C.S.3    MacKay, H.4    Mayberry, J.F.5
  • 9
    • 21344459802 scopus 로고    scopus 로고
    • Will a 5-ASA a day keep the cancer (and dysplasia) away?
    • Rubin DT, Lashner BA. Will a 5-ASA a day keep the cancer (and dysplasia) away? Am J Gastroenterol 2005; 100:1354-1356.
    • (2005) Am J Gastroenterol , vol.100 , pp. 1354-1356
    • Rubin, D.T.1    Lashner, B.A.2
  • 10
    • 0036161781 scopus 로고    scopus 로고
    • Interaction between azathioprine and aminosalicylates: An in vivo study in patients with Crohn's disease
    • Dewit O, Vanheuverzwyn R, Desager JP, Horsmans Y. Interaction between azathioprine and aminosalicylates: an in vivo study in patients with Crohn's disease. Aliment Pharmacol Ther 2002; 16:79-85.
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 79-85
    • Dewit, O.1    Vanheuverzwyn, R.2    Desager, J.P.3    Horsmans, Y.4
  • 11
    • 26244455766 scopus 로고    scopus 로고
    • The pharmacokinetic effect of discontinuation of mesalazine on mercaptopurine metabolite levels in inflammatory bowel disease patients
    • Gilissen LP, Bierau J, Derijks LJ, Bos LP, Hooymans PM, van Gennip A, et al. The pharmacokinetic effect of discontinuation of mesalazine on mercaptopurine metabolite levels in inflammatory bowel disease patients. Aliment Pharmacol Ther 2005; 22:605-611.
    • (2005) Aliment Pharmacol Ther , vol.22 , pp. 605-611
    • Gilissen, L.P.1    Bierau, J.2    Derijks, L.J.3    Bos, L.P.4    Hooymans, P.M.5    Van Gennip, A.6
  • 12
    • 0042830383 scopus 로고    scopus 로고
    • Thiopurine S-methyltransferase (TPMT) genotype does not predict adverse drug reactions to thiopurine drugs in patients with inflammatory bowel disease
    • Gearry RB, Barclay ML, Burt MJ, Collett JA, Chapman BA, Roberts RL, et al. Thiopurine S-methyltransferase (TPMT) genotype does not predict adverse drug reactions to thiopurine drugs in patients with inflammatory bowel disease. Aliment Pharmacol Ther 2003; 18:395-400.
    • (2003) Aliment Pharmacol Ther , vol.18 , pp. 395-400
    • Gearry, R.B.1    Barclay, M.L.2    Burt, M.J.3    Collett, J.A.4    Chapman, B.A.5    Roberts, R.L.6
  • 13
    • 0034780344 scopus 로고    scopus 로고
    • Leucopenia resulting from a drug interaction between azathioprine or 6-mercaptopurine and mesalasine, sulphasalazine, or balsalazide
    • Lowry PW, Franklin CL, Weaver AL. Leucopenia resulting from a drug interaction between azathioprine or 6-mercaptopurine and mesalasine, sulphasalazine, or balsalazide. Gut 2001; 49:656-664.
    • (2001) Gut , vol.49 , pp. 656-664
    • Lowry, P.W.1    Franklin, C.L.2    Weaver, A.L.3
  • 14
    • 12144285961 scopus 로고    scopus 로고
    • Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase)
    • Marinaki AM, Ansari A, Duley JA, Arenes MS, Sumi SA, Lewis CM, et al. Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase). Pharmacogenetics 2004; 14:181-187.
    • (2004) Pharmacogenetics , vol.14 , pp. 181-187
    • Marinaki, A.M.1    Ansari, A.2    Duley, J.A.3    Arenes, M.S.4    Sumi, S.A.5    Lewis, C.M.6
  • 15
    • 0029134702 scopus 로고
    • Azathioprine and 6- mercaptopurine in Crohn's disease. A meta-analysis
    • Pearson DC, May GR, Fick GH, Sutherland LR. Azathioprine and 6- mercaptopurine in Crohn's disease. A meta-analysis. Ann Intern Med 1995; 123:132-142.
    • (1995) Ann Intern Med , vol.123 , pp. 132-142
    • Pearson, D.C.1    May, G.R.2    Fick, G.H.3    Sutherland, L.R.4
  • 16
    • 19144372392 scopus 로고    scopus 로고
    • Increased rate of early adverse reaction to azathioprine in patients with Crohn's disease compared to autoimmune hepatitis: A tertiary referral center experience
    • Jasmohan S, Bajaj MD, Saeian K, Varma RR, Jose Franco MD, Knox JF, et al. Increased rate of early adverse reaction to azathioprine in patients with Crohn's disease compared to autoimmune hepatitis: a tertiary referral center experience. Am J Gastroenterol 2005; 100:1121-1125.
    • (2005) Am J Gastroenterol , vol.100 , pp. 1121-1125
    • Jasmohan, S.1    Bajaj, M.D.2    Saeian, K.3    Varma, R.R.4    Jose Franco, M.D.5    Knox, J.F.6
  • 18
    • 0034093057 scopus 로고    scopus 로고
    • Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy
    • Colombel JF, Ferrari N, Debuysere H, Marteau P, Gendre JP, Bonaz B, et al. Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy. Gastroenterology 2000; 118:1025-1030.
    • (2000) Gastroenterology , vol.118 , pp. 1025-1030
    • Colombel, J.F.1    Ferrari, N.2    Debuysere, H.3    Marteau, P.4    Gendre, J.P.5    Bonaz, B.6
  • 19
    • 18444410760 scopus 로고    scopus 로고
    • Effects of aminosalicylates on thiopurine S-methyltransferase activity: An ex vivo study in patients with inflammatory bowel disease
    • Xin H, Fischer C, Schwab M, Klotz U. Effects of aminosalicylates on thiopurine S-methyltransferase activity: an ex vivo study in patients with inflammatory bowel disease. Aliment pharmacol Ther 2005; 21:1105.
    • (2005) Aliment Pharmacol Ther , vol.21 , pp. 1105
    • Xin, H.1    Fischer, C.2    Schwab, M.3    Klotz, U.4
  • 21
    • 9244237558 scopus 로고    scopus 로고
    • Lack of association between the ITPA 94C > A polymorphism and adverse effects from azathioprine
    • Gearry RB, Roberts RL, Barclay ML, Kennedy MA. Lack of association between the ITPA 94C > A polymorphism and adverse effects from azathioprine. Pharmacogenetics 2004; 14:779-781.
    • (2004) Pharmacogenetics , vol.14 , pp. 779-781
    • Gearry, R.B.1    Roberts, R.L.2    Barclay, M.L.3    Kennedy, M.A.4
  • 22
    • 15444367938 scopus 로고    scopus 로고
    • ITPA genotyping does not improve detection of Crohn's disease patients at risk of azathioprine/6-mercaptopurine induced myelosuppression
    • Allorge D, Hamdoan R, Broly F, Libersa C, Colombel JF. ITPA genotyping does not improve detection of Crohn's disease patients at risk of azathioprine/6-mercaptopurine induced myelosuppression. Gut 2005; 54:565.
    • (2005) Gut , vol.54 , pp. 565
    • Allorge, D.1    Hamdoan, R.2    Broly, F.3    Libersa, C.4    Colombel, J.F.5
  • 24
    • 0031663491 scopus 로고    scopus 로고
    • Clinical implications of thiopurine methyltransferase-optimization of drug dosage and potential drug interactions
    • Lennaed L. Clinical implications of thiopurine methyltransferase- optimization of drug dosage and potential drug interactions. Ther Drug Monit 1998; 20:527-531.
    • (1998) Ther Drug Monit , vol.20 , pp. 527-531
    • Lennaed, L.1
  • 25
    • 0028917479 scopus 로고
    • Sulphasalazine inhibition of thiopurine methyltransferase: Possible mechanism for interaction with 6- mercaptopurine and azathioprine
    • Szumlanski CL, Weinshilboum RM. Sulphasalazine inhibition of thiopurine methyltransferase: possible mechanism for interaction with 6- mercaptopurine and azathioprine. Br J Clin Pharmacol 1995; 39:456-459.
    • (1995) Br J Clin Pharmacol , vol.39 , pp. 456-459
    • Szumlanski, C.L.1    Weinshilboum, R.M.2
  • 26
    • 3142660552 scopus 로고    scopus 로고
    • A prospective randomized observer-blind 2-year trial of azathioprine monotherapy versus azathioprine and olsalazine for the maintenance of remission of steroid dependent ulcerative colitis
    • Mantzaris-Gerassimos J, Sfakianakis M, Archavlis E, Petraki K, Christidou A, Angeliki K, et al. A prospective randomized observer-blind 2-year trial of azathioprine monotherapy versus azathioprine and olsalazine for the maintenance of remission of steroid dependent ulcerative colitis. The Am J Gastroenterol 2004; 99:1122-1128.
    • (2004) The Am J Gastroenterol , vol.99 , pp. 1122-1128
    • Mantzaris-Gerassimos, J.1    Sfakianakis, M.2    Archavlis, E.3    Petraki, K.4    Christidou, A.5    Angeliki, K.6
  • 27
    • 2942696613 scopus 로고    scopus 로고
    • Inflammatory bowel diseases, 5-aminosalicylic acid and sulphasalazine treatment and risk of acute pancreatitis: A population-based case-control study
    • Munk EM, Pedersen-Lars FA, Norgard B, Rasmussen HH, Sorensen-Henrik T. Inflammatory bowel diseases, 5-aminosalicylic acid and sulphasalazine treatment and risk of acute pancreatitis: a population-based case-control study. The Am J Gastroenterol 2004; 99:884-888.
    • (2004) The Am J Gastroenterol , vol.99 , pp. 884-888
    • Munk, E.M.1    Pedersen-Lars, F.A.2    Norgard, B.3    Rasmussen, H.H.4    Sorensen-Henrik, T.5
  • 29
    • 0035037703 scopus 로고    scopus 로고
    • Rational dosing of azathioprine and 6-mercaptopurine
    • Sandborn WJ. Rational dosing of azathioprine and 6-mercaptopurine. Gut 2001; 48:591-592.
    • (2001) Gut , vol.48 , pp. 591-592
    • Sandborn, W.J.1
  • 30
    • 0035204639 scopus 로고    scopus 로고
    • Effective maintenance of inflammatory bowel disease remission by azathioprine does not require concurrent 5-aminosalicylate therapy
    • Campbell S, Ghosh S. Effective maintenance of inflammatory bowel disease remission by azathioprine does not require concurrent 5-aminosalicylate therapy. Eur J Gastroenterol Hepatol 2001; 13:1297-1301.
    • (2001) Eur J Gastroenterol Hepatol , vol.13 , pp. 1297-1301
    • Campbell, S.1    Ghosh, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.