An aggregate-inducing peripherin isoform generated through intron retention is upregulated in amyotrophic lateral sclerosis and associated with disease pathology

Journal of Neuroscience

Volumn 28, Issue 8, 2008, Pages 1833-1840

  Xiao, Shangxi ^a   Tjostheim, Sonja ^a   Sanelli, Teresa ^a   McLean, Jesse R ^a   Horne, Patrick ^a   Fan, Yuxin ^b   Ravits, John ^b   Strong, Michael J ^c   Robertson, Janice ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b BENAROYA RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

ALS; Intermediate filament; Intron retention; Isoform; Peripherin; Splice variant

Indexed keywords

PERIPHERIN;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; INTRON; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOICHIOMETRY; UPREGULATION; WESTERN BLOTTING;

ADOLESCENT; ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; CELL LINE, TUMOR; CELLS, CULTURED; FEMALE; HUMANS; INTERMEDIATE FILAMENT PROTEINS; INTRONS; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; NERVE TISSUE PROTEINS; PROTEIN ISOFORMS; UP-REGULATION;

EID: 39749188127     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3222-07.2008     Document Type: Article

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