Evidence that TDP-43 is not the major ubiquitinated target within the pathological inclusions of amyotrophic lateral sclerosis

Journal of Neuropathology and Experimental Neurology

Volumn 66, Issue 12, 2007, Pages 1147-1153

  Sanelli, Teresa ^a   Xiao, Shangxi ^a   Horne, Patrick ^a   Bilbao, Juan ^b   Zinman, Lorne ^b   Robertson, Janice ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Amyotrophic lateral sclerosis; Deconvolution; Inclusion; TDP 43; Ubiquitinated

Indexed keywords

DNA BINDING PROTEIN;

ADULT; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CLINICAL ARTICLE; FEMALE; HUMAN; HUMAN TISSUE; MALE; NEUROIMAGING; PRIORITY JOURNAL; UBIQUITINATION;

AGED; AMYOTROPHIC LATERAL SCLEROSIS; DNA-BINDING PROTEINS; FEMALE; HUMANS; INCLUSION BODIES; INTERMEDIATE FILAMENT PROTEINS; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; NERVE TISSUE PROTEINS; UBIQUITIN;

EID: 37349034999     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/nen.0b013e31815c5edd     Document Type: Article

References (26)

1. Bruijn LI, Miller TM, Cleveland DW. Unraveling the mechanisms involved in motor neuron degeneration in ALS. Annu Rev Neurosci 2004;27:723-49
2. Rosen DR, Siddique T, Patterson D, et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 1993;362:59-62
3. Hays AP. Pathology of amyotrophic lateral sclerosis. In: Mitsumoto H, Przedborski S, Gordon PH, eds. Amyotrophic Lateral Sclerosis. New York: Taylor and Francis Group, 2006:43-80
4. Ince PG, Tomkins J, Slade JY, et al. Amyotrophic lateral sclerosis associated with genetic abnormalities in the gene encoding Cu/Zn superoxide dismutase: Molecular pathology of five new cases, and comparison with previous reports and 73 sporadic cases of ALS. J Neuropathol Exp Neurol 1998;57:895-904
5. Hays AP, Naini A, He CZ, et al. Sporadic amyotrophic lateral sclerosis and breast cancer: Hyaline conglomerate inclusions lead to identification of SOD1 mutation. J Neurol Sci 2006;242:67-69
6. Arai T, Hasegawa M, Akiyama H, et al. TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochem Biophys Res Commun 2006;351:602-11
7. Neumann M, Sampathu DM, Kwong LK, et al. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science 2006;314:130-33
8. Schumacher A, Friedrich P, Diehl-Schmid J, et al. No association of TDP-43 with sporadic frontotemporal dementia. Neurobiol Aging, 2007;28:1789-90.
9. Suzuki T, Tate G, Ikeda K, Mitsuya T. A novel multicolor immuno-fluorescence method using heat treatment. Acta Med Okayama 2005;59:145-51
10. Neumann M, Mackenzie IR, Cairns NJ, et al. TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations. J Neuropathol Exp Neurol 2007;66:152-57
11. Mackenzie IR, Bigio EH, Ince PG, et al. Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations. Ann Neurol 2007;61:427-34
12. He CZ, Hays AP. Expression of peripherin in ubiquinated inclusions of amyotrophic lateral sclerosis. J Neurol Sci 2004;217:47-54
13. Robertson J, Sanelli T, Xiao S, et al. Lack of TDP-43 abnormalities in mutant SOD1 transgenic mice shows disparity with ALS. Neurosci Lett 2007;420:128-32
14. Bendotti C, Atzori C, Piva R, et al . Activated p38MAPK is a novel component of the intracellular inclusions found in human amyotrophic lateral sclerosis and mutant SOD1 transgenic mice. J Neuropathol Exp Neurol 2004;63:113-19
15. Hishikawa N, Niwa J, Doyu M, et al. Dorfin localizes to the ubiquitylated inclusions in Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosis. Am J Pathol 2003;163:609-19
16. Mizuno Y, Amari M, Takatama M, et al. Immunoreactivities of p62, an ubiquitin-binding protein, in the spinal anterior horn cells of patients with amyotrophic lateral sclerosis. J Neurol Sci 2006;249:13-18
17. Buratti E, Dork T, Zuccato E, et al. Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping. EMBO J 2001;20:1774-84
18. Ou SH, Wu F, Harrich D, et al. Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs. J Virol 1995;69:3584-96
19. Strong MJ, Volkening K, Hammond R, et al. TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein. Mol Cell Neurosci 2007;35:320-27
20. Cairns NJ, Neumann M, Bigio EH, et al. TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions. Am J Pathol 2007;171:227-40
21. Davidson Y, Kelley T, Mackenzie IR, et al. Ubiquitinated pathological lesions in frontotemporal lobar degeneration contain the TAR DNA - binding protein, TDP-43. Acta Neuropathol (Berl) 2007;113:521-33
22. Dickson DW, Josephs KA, Amador-Ortiz C. TDP-43 in differential diagnosis of motor neuron disorders. Acta Neuropathol (Berl) 2007;114:71-79
23. Tan CF, Eguchi H, Tagawa A, et al. TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation. Acta Neuropathol (Berl) 2007;113:535-42
24. Xiao S, McLean J, Robertson J. Neuronal intermediate filaments and ALS: A new look at an old question. Biochim Biophys Acta 2006;1762:1001-12
25. Johnston JA, Ward CL, Kopito RR. Aggresomes: A cellular response to misfolded proteins. J Cell Biol 1998;143:1883-98
26. Robertson J, Doroudchi MM, Nguyen MD, et al. A neurotoxic peripherin splice variant in a mouse model of ALS. J Cell Biol 2003;160:939-49