Natural products from ginseng inhibit [3H]batrachotoxinin A 20-α-benzoate binding to Na+ channels in mammalian brain

European Journal of Pharmacology

Volumn 530, Issue 1-2, 2006, Pages 9-14

  Duan, Yin ^a   Zheng, Jian ^a,b   Law, Vanessa ^a   Nicholson, Russell ^a  

^a SIMON FRASER UNIVERSITY   (Canada)

^b CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

20(S)protopanaxadiol; 20(S)protopanaxatriol; 3H Batrachotoxinin; Brain; Rh2; Synaptoneurosomes

Indexed keywords

AGLYCONE; BATRACHOTOXININ A 20ALPHA BENZOATE; GINSENG EXTRACT; GINSENOSIDE RH 2; NATURAL PRODUCT; NEUROTOXIN; PROTOPANAXADIOL; PROTOPANAXATRIOL; UNCLASSIFIED DRUG; VERATRIDINE; VOLTAGE GATED SODIUM CHANNEL;

ALLOSTERISM; ANIMAL TISSUE; ARTICLE; BINDING ASSAY; BINDING SITE; BRAIN; CHEMICAL MODIFICATION; CONTROLLED STUDY; DISSOCIATION; IC 50; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SCATCHARD PLOT;

ANIMALS; BATRACHOTOXINS; BINDING, COMPETITIVE; CELL MEMBRANE; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; GINSENOSIDES; KINETICS; MALE; MICE; MOLECULAR STRUCTURE; NEURONS; PANAX; PLANT EXTRACTS; RADIOLIGAND ASSAY; SAPOGENINS; SODIUM CHANNELS; SOLUBILITY; SYNAPTOSOMES; TRITERPENES; TRITIUM;

EID: 29844452310     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.11.022     Document Type: Article

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