-
1
-
-
0036221471
-
The causal relation between HPV and cervical cancer
-
Bosch, F.X., Lorincz, A., Munoz, N., Meijer, C.J. & Shah, K.V. (2002) The causal relation between HPV and cervical cancer. J. Clin. Pathol. 55, 244-265.
-
(2002)
J. Clin. Pathol.
, vol.55
, pp. 244-265
-
-
Bosch, F.X.1
Lorincz, A.2
Munoz, N.3
Meijer, C.J.4
Shah, K.V.5
-
2
-
-
33646854721
-
TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase
-
Chong-Kopera, H., Inoki, K., Li, Y., Zhu, T., Garcia-Gonzalo, F.R., Rosa, J.L. & Guan, K.L. (2006) TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase. J. Biol. Chem. 281, 8313-8316.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 8313-8316
-
-
Chong-Kopera, H.1
Inoki, K.2
Li, Y.3
Zhu, T.4
Garcia-Gonzalo, F.R.5
Rosa, J.L.6
Guan, K.L.7
-
3
-
-
0024535228
-
The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product
-
Dyson, N., Howley, P.M., Munger, K. & Harlow, E. (1989) The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 243, 934-937.
-
(1989)
Science
, vol.243
, pp. 934-937
-
-
Dyson, N.1
Howley, P.M.2
Munger, K.3
Harlow, E.4
-
4
-
-
0036606329
-
Human Papillomavirus E6-induced degradation of E6TP1 is mediated by E6AP ubiquitin ligase1
-
Gao, Q., Kumar, A., Singh, L., Huibregtse, J.M., Beaudenon, S., Srinivasan, S., Wazer, D.E., Band, H. & Band, V. (2002a) Human Papillomavirus E6-induced degradation of E6TP1 is mediated by E6AP ubiquitin ligase1. Cancer Res. 62, 3315-3321.
-
(2002)
Cancer Res.
, vol.62
, pp. 3315-3321
-
-
Gao, Q.1
Kumar, A.2
Singh, L.3
Huibregtse, J.M.4
Beaudenon, S.5
Srinivasan, S.6
Wazer, D.E.7
Band, H.8
Band, V.9
-
5
-
-
0036712905
-
TSC tumour suppressor proteins antagonize amino-acid-TOR signalling
-
Gao, X., Zhang, Y., Arrazola, P., Hino, O., Kobayashi, T., Yeung, R.S., Ru, B. & Pan, D. (2002b) TSC tumour suppressor proteins antagonize amino-acid-TOR signalling. Nat. Cell Biol. 4, 699-704.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 699-704
-
-
Gao, X.1
Zhang, Y.2
Arrazola, P.3
Hino, O.4
Kobayashi, T.5
Yeung, R.S.6
Ru, B.7
Pan, D.8
-
6
-
-
0038433304
-
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
-
Garami, A., Zwartkruis, F.J.T., Nobukuni, T., Joaquin, M., Roccio, M., Stocker, H., Kozma, S., Hafen, E., Bos, J.L. & Thomas, G. (2003) Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol. Cell 11, 1457-1466.
-
(2003)
Mol. Cell
, vol.11
, pp. 1457-1466
-
-
Garami, A.1
Zwartkruis, F.J.T.2
Nobukuni, T.3
Joaquin, M.4
Roccio, M.5
Stocker, H.6
Kozma, S.7
Hafen, E.8
Bos, J.L.9
Thomas, G.10
-
7
-
-
0033598775
-
Ubiquitin-mediated degradation of active Src tyrosine kinase
-
Harris, K.F., Shoji, I., Cooper, E.M., Kumar, S., Oda, H., & Howley, P.M. (1999) Ubiquitin-mediated degradation of active Src tyrosine kinase. Proc. Natl. Acad. Sci. USA 96, 13738-13743.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 13738-13743
-
-
Harris, K.F.1
Shoji, I.2
Cooper, E.M.3
Kumar, S.4
Oda, H.5
Howley, P.M.6
-
8
-
-
0024804363
-
HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes
-
Hawley-Nelson, P., Vousden, K.H., Hubbert, N.L., Lowy, D.R. & Schiller, J.T. (1989) HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes. EMBO J. 8, 3905-3910.
-
(1989)
EMBO J.
, vol.8
, pp. 3905-3910
-
-
Hawley-Nelson, P.1
Vousden, K.H.2
Hubbert, N.L.3
Lowy, D.R.4
Schiller, J.T.5
-
9
-
-
4043171462
-
Upstream and downstream of mTOR
-
Hay, N. & Sonenberg, N. (2004) Upstream and downstream of mTOR. Genes Dev. 18, 1926-1945.
-
(2004)
Genes Dev.
, vol.18
, pp. 1926-1945
-
-
Hay, N.1
Sonenberg, N.2
-
10
-
-
0026550131
-
Efficiency of binding the retinoblastoma protein correlates with the transforming capacity of the E7 oncoproteins of the human papillomaviruses
-
Heck, D.V., Yee, C.L., Howley, P.M. & Munger, K. (1992) Efficiency of binding the retinoblastoma protein correlates with the transforming capacity of the E7 oncoproteins of the human papillomaviruses. Proc. Natl. Acad. Sci. USA 89, 4442-4446.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 4442-4446
-
-
Heck, D.V.1
Yee, C.L.2
Howley, P.M.3
Munger, K.4
-
11
-
-
0025191335
-
Immortalization and altered differentiation of human keratinocytes in vitro by the E6 and E7 open reading frames of human papillomavirus type 18
-
Hudson, J.B., Bedell, M.A., McCance, D.J. & Laiminis, L.A. (1990) Immortalization and altered differentiation of human keratinocytes in vitro by the E6 and E7 open reading frames of human papillomavirus type 18. J. Virol. 64, 519-526.
-
(1990)
J. Virol.
, vol.64
, pp. 519-526
-
-
Hudson, J.B.1
Bedell, M.A.2
McCance, D.J.3
Laiminis, L.A.4
-
12
-
-
0028907874
-
A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase
-
Huibregtse, J.M., Scheffner, M., Beaudenon, S. & Howley, P. (1995) A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Proc. Natl. Acad. Sci. USA 92, 2563-2567.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 2563-2567
-
-
Huibregtse, J.M.1
Scheffner, M.2
Beaudenon, S.3
Howley, P.4
-
13
-
-
0025932933
-
A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18
-
Huibregtse, J.M., Scheffner, M. & Howley, P.M. (1991) A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18. EMBO J. 10, 4129-4135.
-
(1991)
EMBO J.
, vol.10
, pp. 4129-4135
-
-
Huibregtse, J.M.1
Scheffner, M.2
Howley, P.M.3
-
14
-
-
0027396829
-
Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53
-
Huibregtse, J.M., Scheffner, M. & Howley, P.M. (1993a) Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53. Mol. Cell. Biol. 13, 775-784.
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 775-784
-
-
Huibregtse, J.M.1
Scheffner, M.2
Howley, P.M.3
-
15
-
-
0027169680
-
Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53 ubiquitination of associated proteins
-
Huibregtse, J.M., Scheffner, M. & Howley, P.M. (1993b) Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53 ubiquitination of associated proteins. Mol. Cell. Biol. 13, 4918-4927.
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 4918-4927
-
-
Huibregtse, J.M.1
Scheffner, M.2
Howley, P.M.3
-
16
-
-
33645738458
-
Complexity of the TOR signaling network
-
Inoki, K. & Guan, K. (2006) Complexity of the TOR signaling network. Trends Cell Biol. 16, 206-212.
-
(2006)
Trends Cell Biol.
, vol.16
, pp. 206-212
-
-
Inoki, K.1
Guan, K.2
-
17
-
-
0043127125
-
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
-
Inoki, K., Li, Y., Xu, T. & Guan, K.L. (2003) Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 17, 1829-1834.
-
(2003)
Genes Dev.
, vol.17
, pp. 1829-1834
-
-
Inoki, K.1
Li, Y.2
Xu, T.3
Guan, K.L.4
-
18
-
-
14744275857
-
The global transcriptional effects of the human papillomavirus E6 protein in cervical carcinoma cell lines are mediated by the E6AP ubiquitin ligase
-
Kelley, M.L., Keiger, K.E., Lee, C.J. & Huibregtse, J.M. (2005) The global transcriptional effects of the human papillomavirus E6 protein in cervical carcinoma cell lines are mediated by the E6AP ubiquitin ligase. J. Virol. 79, 3737-3747.
-
(2005)
J. Virol.
, vol.79
, pp. 3737-3747
-
-
Kelley, M.L.1
Keiger, K.E.2
Lee, C.J.3
Huibregtse, J.M.4
-
19
-
-
0032545368
-
E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box
-
Kuhne, C. & Banks, L. (1998) E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box. J. Biol. Chem. 273, 34302-34309.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 34302-34309
-
-
Kuhne, C.1
Banks, L.2
-
20
-
-
0033603339
-
Identification of HHR23A as a substrate for E6-associated protein-mediated ubiquitination
-
Kumar, S., Talis, A.L. & Howley, P.M. (1999) Identification of HHR23A as a substrate for E6-associated protein-mediated ubiquitination. J. Biol. Chem. 274, 18785-18792.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 18785-18792
-
-
Kumar, S.1
Talis, A.L.2
Howley, P.M.3
-
21
-
-
0041758428
-
Tuberous sclerosis: From tubers to mTOR
-
Kwiatkowski, D.J. (2003) Tuberous sclerosis: From tubers to mTOR. Ann. Hum. Genet. 67, 87-96.
-
(2003)
Ann. Hum. Genet.
, vol.67
, pp. 87-96
-
-
Kwiatkowski, D.J.1
-
22
-
-
4143098350
-
Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin
-
Lu, Z., Hu, X., Li, Y., Zheng, L., Zhou, Y., Jiang, H., Ning, T., Basang, Z., Zhang, C. & Ke, Y. (2004) Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin. J. Biol. Chem. 279, 35664-35670.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 35664-35670
-
-
Lu, Z.1
Hu, X.2
Li, Y.3
Zheng, L.4
Zhou, Y.5
Jiang, H.6
Ning, T.7
Basang, Z.8
Zhang, C.9
Ke, Y.10
-
23
-
-
17444431201
-
Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis
-
Ma, L., Chen, Z., Erdjument-Bromage, H., Tempst, P. & Pandolfi, P.P. (2005) Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell 121, 179-193.
-
(2005)
Cell
, vol.121
, pp. 179-193
-
-
Ma, L.1
Chen, Z.2
Erdjument-Bromage, H.3
Tempst, P.4
Pandolfi, P.P.5
-
25
-
-
0035956215
-
The human papillomavirus E6 protein and its contribution to malignant progression
-
Mantovani, F. & Banks, L. (2001) The human papillomavirus E6 protein and its contribution to malignant progression. Oncogene 20, 7874-7887.
-
(2001)
Oncogene
, vol.20
, pp. 7874-7887
-
-
Mantovani, F.1
Banks, L.2
-
26
-
-
0033861013
-
The TSC1 gene product, hamartin, negatively regulates cell proliferation
-
Miloloza, A., Rosner, M., Nellist, M., Halley, D., Bernaschek, G. & Hengstschläger, M. (2000) The TSC1 gene product, hamartin, negatively regulates cell proliferation. Hum. Mol. Genet. 9, 1721-1727.
-
(2000)
Hum. Mol. Genet.
, vol.9
, pp. 1721-1727
-
-
Miloloza, A.1
Rosner, M.2
Nellist, M.3
Halley, D.4
Bernaschek, G.5
Hengstschläger, M.6
-
27
-
-
0024809865
-
Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product
-
Munger, K., Werness, B.A., Dyson, N., Phelps, W.C., Harlow, E. & Howley, P.M. (1989) Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. EMBO J. 8, 4099-4105.
-
(1989)
EMBO J.
, vol.8
, pp. 4099-4105
-
-
Munger, K.1
Werness, B.A.2
Dyson, N.3
Phelps, W.C.4
Harlow, E.5
Howley, P.M.6
-
28
-
-
0033776810
-
Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase
-
Nakagawa, S. & Huibregtse, J.M. (2000) Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase. Mol. Cell. Biol. 20, 8244-8253.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 8244-8253
-
-
Nakagawa, S.1
Huibregtse, J.M.2
-
29
-
-
0033578418
-
Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination
-
Oda, H., Kumar, S. & Howley, P. (1999) Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination. Proc. Natl. Acad. Sci. USA 96, 9557-9562.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 9557-9562
-
-
Oda, H.1
Kumar, S.2
Howley, P.3
-
30
-
-
8644265820
-
Proteins interacting with the tuberous sclerosis gene products
-
Rosner, M., Freilinger, A. & Hengstschläger, M. (2004) Proteins interacting with the tuberous sclerosis gene products. Amino Acids 27, 119-128.
-
(2004)
Amino Acids
, vol.27
, pp. 119-128
-
-
Rosner, M.1
Freilinger, A.2
Hengstschläger, M.3
-
31
-
-
0043068043
-
Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38
-
Rosner, M., Hofer, K., Kubista, M. & Hengstschläger, M. (2003) Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38. Oncogene 22, 4786-4798.
-
(2003)
Oncogene
, vol.22
, pp. 4786-4798
-
-
Rosner, M.1
Hofer, K.2
Kubista, M.3
Hengstschläger, M.4
-
32
-
-
4544384577
-
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
-
Roux, P.P., Balliff, B.A., Anjum, R., Gygi, S.P. & Blenis, J. (2004) Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proc. Natl. Acad. Sci. USA 101, 13489-13494.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 13489-13494
-
-
Roux, P.P.1
Balliff, B.A.2
Anjum, R.3
Gygi, S.P.4
Blenis, J.5
-
33
-
-
0038643484
-
Rheb promotes cell growth as a component of the insulin/TOR signalling network
-
Saucedo, L.J., Gao, X., Chiarelli, D.A., Li, L., Pan, D. & Edgar, B.A. (2003) Rheb promotes cell growth as a component of the insulin/TOR signalling network. Nat. Cell Biol. 5, 566-571.
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 566-571
-
-
Saucedo, L.J.1
Gao, X.2
Chiarelli, D.A.3
Li, L.4
Pan, D.5
Edgar, B.A.6
-
34
-
-
0025639158
-
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
-
Scheffner, M., Werness, B.A., Huibregtse, J.M., Levine, A.J. & Howley, P.M. (1990) The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63, 1129-1136.
-
(1990)
Cell
, vol.63
, pp. 1129-1136
-
-
Scheffner, M.1
Werness, B.A.2
Huibregtse, J.M.3
Levine, A.J.4
Howley, P.M.5
-
35
-
-
0037325976
-
Human papillomavirusinduced carcinogenesis and the ubiquitin-proteasome system
-
Scheffner, M. & Whitaker, N.J. (2003) Human papillomavirusinduced carcinogenesis and the ubiquitin-proteasome system. Semin. Cancer Biol. 13, 59-67.
-
(2003)
Semin. Cancer Biol.
, vol.13
, pp. 59-67
-
-
Scheffner, M.1
Whitaker, N.J.2
-
36
-
-
33745307617
-
3K and mTOR signalling controls tumour cell growth
-
3K and mTOR signalling controls tumour cell growth. Nature 441, 424-430.
-
(2006)
Nature
, vol.441
, pp. 424-430
-
-
Shaw, R.J.1
Cantley, L.C.2
-
37
-
-
0032580368
-
A role of the tuberous sclerosis gene-2 product during neuronal differentiation
-
Soucek, T., Hölzl, G., Bernaschek, G. & Hengstschläger, M. (1998a) A role of the tuberous sclerosis gene-2 product during neuronal differentiation. Oncogene 16, 2197-2204.
-
(1998)
Oncogene
, vol.16
, pp. 2197-2204
-
-
Soucek, T.1
Hölzl, G.2
Bernaschek, G.3
Hengstschläger, M.4
-
38
-
-
0030663735
-
Role of the tuberous sclerosis gene-2 product in cell cycle control. Loss of the tuberous sclerosis gene-2 induces quiescent cells to enter S phase
-
Soucek, T., Pusch, O., Wienecke, R., DeClue, J.E. & Hengstschläger, M. (1997) Role of the tuberous sclerosis gene-2 product in cell cycle control. Loss of the tuberous sclerosis gene-2 induces quiescent cells to enter S phase. J. Biol. Chem. 272, 29301-29308.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 29301-29308
-
-
Soucek, T.1
Pusch, O.2
Wienecke, R.3
DeClue, J.E.4
Hengstschläger, M.5
-
39
-
-
0032430241
-
Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2
-
Soucek, T., Yeung, R.S. & Hengstschläger, M. (1998b) Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2. Proc. Natl. Acad. Sci. USA 95, 15653-15658.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 15653-15658
-
-
Soucek, T.1
Yeung, R.S.2
Hengstschläger, M.3
-
40
-
-
0038304516
-
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
-
Stocker, H., Radimerski, T., Schindelholz, B., Wittwer, F., Belawat, P., Daram, P., Breuer, S., Thomas, G. & Hafen, E. (2003) Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nat. Cell Biol. 5, 559-565.
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 559-565
-
-
Stocker, H.1
Radimerski, T.2
Schindelholz, B.3
Wittwer, F.4
Belawat, P.5
Daram, P.6
Breuer, S.7
Thomas, G.8
Hafen, E.9
-
41
-
-
0032513114
-
The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells
-
Talis, A.L., Huibregtse, J.M. & Howley, P.M. (1998) The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells. J. Biol. Chem. 273, 6439-6445.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 6439-6445
-
-
Talis, A.L.1
Huibregtse, J.M.2
Howley, P.M.3
-
42
-
-
0032506698
-
Inhibition of Bak-induced apoptosis by HPV-18 E6
-
Thomas, M. & Banks, L. (1998) Inhibition of Bak-induced apoptosis by HPV-18 E6. Oncogene 17, 2943-2954.
-
(1998)
Oncogene
, vol.17
, pp. 2943-2954
-
-
Thomas, M.1
Banks, L.2
-
43
-
-
0025271203
-
Association of human papillomavirus types 16 and 18 E6 proteins with p53
-
Werness, B.A., Levine, A.J. & Howley, P.M. (1990) Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science 248, 76-79.
-
(1990)
Science
, vol.248
, pp. 76-79
-
-
Werness, B.A.1
Levine, A.J.2
Howley, P.M.3
-
44
-
-
0036559896
-
Papillomaviruses and cancer: From basic studies to clinical application
-
zur Hausen, H. (2002) Papillomaviruses and cancer: From basic studies to clinical application. Nat. Rev. Cancer 2, 342-350.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 342-350
-
-
zur Hausen, H.1
|