Human papillomavirus E6-induced degradation of E6TP1 is mediated by E6AP ubiquitin ligase

Cancer Research

Volumn 62, Issue 11, 2002, Pages 3315-3321

  Gao, Qingshen ^a   Kumar, Ajay ^a   Singh, Latika ^a   Srinivasan, Seetha ^a   Wazer, David E ^a   Band, Vimla ^a,b   Huibregtse, Jon M ^c   Beaudenon, Sylvie ^c   Band, Hamid ^d  

^a TUFTS MEDICAL CENTER   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; E6AP UBIQUITIN LIGASE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; LIGASE; MUTANT PROTEIN; PROTEIN E6; PROTEIN E6TP1; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; BINDING SITE; BREAST CARCINOGENESIS; BREAST CARCINOMA; BREAST EPITHELIUM; CARBOXY TERMINAL SEQUENCE; CELL IMMORTALIZATION; CHO CELL; COMPLEX FORMATION; CONTROLLED STUDY; CORRELATION FUNCTION; DELETION MUTANT; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; VIRUS CARCINOGENESIS; WART VIRUS;

ANIMALS; CELL LINE; CHO CELLS; CRICETINAE; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; GTPASE-ACTIVATING PROTEINS; HUMANS; LEUPEPTINS; LIGASES; MULTIENZYME COMPLEXES; MUTATION; ONCOGENE PROTEINS, VIRAL; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; REPRESSOR PROTEINS; TEMPERATURE; TRANSFECTION; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 0036606329     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (61)

1. Association between an oncogene and an antioncogene: The adenovirus E1A proteins bind to the retinoblastoma gene product
2. SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family
3. Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein
4. SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene
5. Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product
6. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
7. Association of human papillomavirus types 16 and 18 E6 proteins with p53
8. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product
9. Papillomaviruses in human cancer
10. The Papillomaviruses
11. Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines
12. Structure and transcription of human papillomavirus sequences in cervical carcinoma cells
13. HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes
14. The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes
15. Enhanced degradation of p53 protein in HPV-6 and BPV-1 E6-immortalized human mammary epithelial cells
16. Loss of p53 protein in human papillomavirus type 16 E6-immortalized human mammary epithelial cells
17. Immortalization of distinct human mammary epithelial cell types by human papilloma virus 16 E6 or E7
18. E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway
19. p53, the cellular gatekeeper for growth and division
20. p53: From inductive signal to cellular effect
21. Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein
22. The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton
23. Binding of human virus oncoproteins to hD1g/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein
24. Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein
25. E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box
26. Human papillomavirus oncoprotein E6 binds to the C-terminal region of human minichromosome maintenance 7 protein
27. Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity
28. Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway
29. Inhibition of Bak-induced apoptosis by HPV-18 E6
30. Human papillomavirus (HPV) E6 interactions with Bak are conserved amongst E6 proteins from high and low risk HPV types
31. The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein. E6TP1, and target it for degradation
32. The human papillomavirus type 16 E6 oncoprotein can down-regulate p53 activity by targeting the transcriptional coactivator CBP/p300
33. The E6 protein of human papillomavirus type 16 binds to and inhibits co-activation by CBP and p300
34. The human papilloma virus (HPV)-18 E6 oncoprotein physically associates with Tyk2 and impairs Jak-STAT activation by interferon-α
35. Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase
36. PKN binds and phosphorylates human papillomavirus E6 oncoprotein
37. Multi-PDZ domain protein MUPPI is a cellular target for both adenovirus E4-ORFI and high-risk papillomavirus type 18 E6 oncoproteins
38. Interactions of the PDZ-protein MAGI-1 with adenovirus E4-ORFI and high-risk papillomavirus E 6 oncoproteins
39. Gps2, a protein partner for human papillomavirus E6 proteins
40. Telomerase activation by the E6 gene product of human papillomavirus type 16
41. The human papillomavirus type 16 E6 and E7 oncoproteins dissociate cellular telomerase activity from the maintenance of telomere length
42. Human papillomavirus type 16 E6-induced degradation of E6TP1 correlates with its ability to immortalize human mammary epithelial cells
43. Multiple genetic changes are required for efficient immortalization of different subtypes of normal human mammary epithelial cells
44. Specific association of human telomerase activity with immortal cells and cancer
45. A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18
46. Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53
47. HPV E6 targeted degradation of the discs large protein: Evidence for the involvement of a novel ubiquitin ligase
48. cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway
49. Mitogenic and oncogenic properties of the small G protein Rap1b
50. The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells
51. Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases
52. DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells
53. Growth hormone-induced signal transduction depends on an intact ubiquitin system
54. Themes and variations on ubiquitynation
55. Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo
56. Mdm2 promotes the rapid degradation of p53
57. Regulation of p53 stability by Mdm2
58. Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins
59. Identification of an α helical motif sufficient for association with papillomavirus E6
60. The bovine papillomavirus E6 protein binds to the LD motif repeats of paxillin and blocks its interaction with vinculin and the focal adhesion kinase
61. The identification of a conserved binding motif within human papillomavirus type 16 E6 binding peptides, E6AP and E6BP