Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through activation of the Jak2 tyrosine kinase pathway in vascular endothelial cells

International Journal of Biochemistry and Cell Biology

Volumn 40, Issue 4, 2008, Pages 755-765

  Shimizu, Shunichi ^a   Hiroi, Toshihito ^a   Ishii, Masakazu ^a   Hagiwara, Tamio ^b   Wajima, Teruaki ^a   Miyazaki, Akira ^b   Kiuchi, Yuji ^a  

^a SHOWA UNIVERSITY   (Japan)

^b SHOWA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

GTP cyclohydrolase I; H2O2; Jak2; Tetrahydrobiopterin; Vascular endothelial cells

Indexed keywords

FLUDARABINE; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; HYDROGEN PEROXIDE; JANUS KINASE 2; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PROTEIN TYROSINE KINASE; STAT PROTEIN; TETRAHYDROBIOPTERIN;

ARTICLE; ATTENUATION; CELL; DNA BINDING; PHOSPHORYLATION; PROTEIN DEPLETION; STIMULATION; SYNTHESIS; VASCULAR ENDOTHELIAL CELL;

ANIMALS; BIOPTERIN; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELLS, CULTURED; ENDOTHELIAL CELLS; ENZYME ACTIVATION; ENZYME INHIBITORS; GTP CYCLOHYDROLASE; HYDROGEN PEROXIDE; JANUS KINASE 2; MICE; NF-KAPPA B; OXIDANTS; PHOSPHORYLATION; PROTEIN BINDING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; TYRPHOSTINS;

EID: 39649083792     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2007.10.011     Document Type: Article

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