Updated therapy in elderly patients with knee osteoarthritis

International Journal of Gerontology

Volumn 1, Issue 1, 2007, Pages 31-39

  Chen, Der Yuan ^a,b,c  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^c TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Disease modifying osteoarthritis drug; Elderly; Knee osteoarthritis; Taiwan; Therapy

Indexed keywords

AGGRECANASE; CAPSAICIN; CHONDROITIN SULFATE; COLLAGENASE 3; CORTICOSTEROID; CYCLOOXYGENASE 2 INHIBITOR; DIACETYLRHEIN; DOXYCYCLINE; GELATINASE A; GELATINASE B; GLUCOSAMINE; HYALURONIC ACID; INDOMETACIN; INTERLEUKIN 1; INTERLEUKIN 1BETA; INTERSTITIAL COLLAGENASE; NEUTROPHIL COLLAGENASE; NONSTEROID ANTIINFLAMMATORY AGENT; NORADRENALIN; PARACETAMOL; PARACETAMOL PLUS TRAMADOL; PIASCLEDINE; PLACEBO; SEROTONIN; SIGMA OPIATE RECEPTOR; TETRACYCLINE DERIVATIVE; TRAMADOL; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; UNINDEXED DRUG;

ANTIINFLAMMATORY ACTIVITY; BLEEDING; BODY MASS; BODY POSTURE; BODY WEIGHT; BRACE; CARTILAGE DEGENERATION; CATABOLISM; CENTRAL NERVOUS SYSTEM DISEASE; CLINICAL TRIAL; CONFUSION; COST EFFECTIVENESS ANALYSIS; DIARRHEA; DIGESTIVE SYSTEM ULCER; DISEASE COURSE; DISEASE PREDISPOSITION; DRUG EFFICACY; DRUG FATALITY; DRUG MECHANISM; DRUG SAFETY; ESTROGEN DEFICIENCY; EXERCISE; GASTROINTESTINAL TOXICITY; GERIATRIC CARE; HEADACHE; HEART FAILURE; HEREDITY; HUMAN; JOINT STIFFNESS; KIDNEY DYSFUNCTION; KNEE INJURY; KNEE OSTEOARTHRITIS; KNEE PAIN; KNEE RADIOGRAPHY; LIFESTYLE MODIFICATION; MUSCLE WEAKNESS; OBESITY; OSTEOSCLEROSIS; PATIENT EDUCATION; PHYSICAL ACTIVITY; POPLITEAL CYST; POST HOC ANALYSIS; PRIORITY JOURNAL; PROPRIOCEPTION; PROTEOGLYCAN SYNTHESIS; QUALITY OF LIFE; RANGE OF MOTION; RECOMMENDED DRUG DOSE; REVIEW; SPLINT; TAIWAN; THROMBOSIS; ULTRASOUND THERAPY; UNSPECIFIED SIDE EFFECT; VERTIGO; WEIGHT REDUCTION;

EID: 39549118676     PISSN: 18739598     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1873-9598(08)70021-8     Document Type: Review

References (95)

1. Chinese source.
2. Centers for Disease Control and Prevention (CDC). Arthritis prevalence and activity limitations - United States, 1990. MMWR Morb Mortal Wkly Rep 1994; 43: 433-8.
3. Lawrence RC, Helmick CG, Arnett FC, Deyo RA, Felson DT, Giannini EH, et al. Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis Rheum 1998; 41: 778-83.
4. Zhang Y, Xu L, Nevitt MC, Aliabadi P, Yu W, Qin M, et al., eds. Principles of Geriatric Medicine and Gerontology, 4th edition. New York: McGraw Hill, 1999: 1097-111.
5. Zhang Y, Xu L, Nevitt MC, Aliabadi P, Yu W, Qin M, et al. Comparison of the prevalence of knee osteoarthritis between the elderly Chinese population in Beijing and whites in the United States: The Beijing Osteoarthritis Study. Arthritis Rheum 2001; 44: 2065-71.
6. Messier SP, Loeser RE, Hoover JL, Semble EL, Wise CM. Osteoarthritis of the knee: effects on gait, strength, and flexibility. Arch Phys Med Rehab 1992; 73: 29-36.
7. Tinetti ME, Inouye SK, Gill TM, Doucette JT. Shared risk factors for falls, incontinence, and functional dependence. Unifying the approach to geriatric syndromes. JAMA 1995; 273: 1348-53.
8. Ho SC, Woo J, Chan SS, Yuen YK, Sham A. Risk factors for falls in the Chinese elderly population. J Gerontol A Biol Sci Med Sci 1996; 51: M195-8.
9. Creamer P, Hochberg MC. Osteoarthritis. Lancet 1997; 350: 503-9.
10. Loeser RF. Aging and the etiopathogenesis and treatment of osteoarthritis. Rheum Dis Clin North Am 2000; 26: 547-67.
11. Felson DT, Naimark A, Anderson J, Kazis L, Castelli W, Meenan RF. The prevalence of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study. Arthritis Rheum 1987; 30: 914-8.
12. Jordan JM, Luta G, Renner JB, Linder GF, Dragomir A, Hochberg MC, et al. Self-reported functional status in osteoarthritis of the knee in a rural southern community: the role of sociodemographic factors, obesity, and knee pain. Arthritis Care Res 1996; 9: 273-8.
13. Davis MA, Ettinger WH, Neuhaus JM, Hauck WW. Sex differences in osteoarthritis of the knee. The role of obesity. Am J Epidemiol 1988; 127: 1019-30.
14. Oliveria SA, Felson DT, Reed JI, Cirillo PA, Walker AM. incidence of symptomatic hand, hip, and knee osteoarthritis among patients in a health maintenance organization. Arthritis Rheum 1995; 38: 1134-41.
15. Felson DT, Zhang Y, Hannan MT, Naimark A, Weissman BN, Aliabadi P, et al. The incidence and natural history of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study. Arthritis Rheum 1995; 38: 1500-5.
16. Felson D, Zhang Y. An update on the epidemiology of knee and hip osteoarthritis with a view to prevention. Arthritis Rheum 1998; 41: 1343-6.
17. Nevitt M, Felson D. Sex hormones and the risk of osteoarthritis in women: epidemiological evidence. Ann Rheum Dis 1996; 55: 673-7.
18. Spector TD, Nandra D, Hart DJ, Doyle DV. Is hormone replacement therapy protective for hand and knee osteoarthritis in women? The Chingford study. Ann Rheum Dis 1997; 56: 432-4.
19. Zhang Y, McAlindon TE, Hannan MT, Chaisson CE, Klein R, Wilson PW, et al. Estrogen replacement therapy and worsening of radiographic knee osteoarthritis: the Framingham Study. Arthritis Rheum 1998; 41: 1867-73.
20. Felson DT, Anderson JJ, Naimark A, Walker AM, Meenan RF. obesity and knee osteoarthritis. The Framingham Study. Ann Intern Med 1988; 109: 18-24.
21. Felson DT, Zhang Y, Hannan MT, Naimark A, Weissman B, Aliabadi P, et al. Risk factors for incident radiographic knee osteoarthritis in the elderly: the Framingham Study. Arthritis Rheum 1997; 40: 728-33.
22. McAlindon TE, Wilson PW, Aliabadi P, Weissman B, Felson DT. Level of physical activity and the risk of radiographic and symptomatic knee osteoarthritis in the elderly: the Framingham study. Am J Med 1999; 106: 151-7.
23. Roos H, Adalberth T, Dahlberg L, Lohmander LS. Osteoarthritis of the knee after injury to the anterior cruciate ligament or meniscus: the influence of time and age. Osteoarthritis Cartilage 1995; 3: 261-7.
24. Roos H, Lauren M, Adalberth T, Roos EM, Jonsson K, Lohmander LS. Knee osteoarthritis after meniscectomy: prevalence of radiographic changes after twenty-one years, compared with matched controls. Arthritis Rheum 1998; 41: 687-93.
25. Slemenda C, Brandt KD, Heilman DK, Mazzuca S, Braunstein EM, Katz BP, et al. Quadriceps weakness and osteoarthritis of the knee. Ann Intern Med 1997; 127: 97-104.
26. Pai YC, Rymer WZ, Chang RW, Sharma L. Effect of age and osteoarthritis on knee proprioception. Arthritis Rheum 1997; 140: 2260-5.
27. Buckwalter J, Mankin H. Articular cartilage: Part II. Degeneration and osteoarthrosis, repair, regeneration, and transplantation. J Bone Joint Surg 1997; 79A: 612-7.
28. Ryu J, Treadwell BV, Mankin HJ. Biochemical and metabolic abnormalities in normal and osteoarthritic human articular cartilage. Arthritis Rheum 1984; 27: 49-54.
29. Pelletier JP, Martel-Pelletier J, Howell DS. Etiopathogenesis of osteoarthritis. In: Koopman WJ, ed. Arthritis and Allied Conditions: A Textbook of Rheumatology, 13th edition. Baltimore: Williams & Wilkins, 1997; 1969.
30. Tortorella MD, Burn TC, Pratta MA, Abbaszade I, Hollis JM, Liu R, et al. Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins. Science 1999; 284: 1664-6.
31. Dean DD, Martel-Pelletier J, Pelletier JP, Howell DS, Woessner JF Jr. Evidence for metalloproteinase and metalloproteinase inhibitor imbalance in human osteoarthritic cartilage. J Clin Invest 1989; 84: 678-85.
32. Sharif M, Whitehouse A, Sharman P, Perry M, Adams M. Increased apoptosis in human osteoarthritic cartilage corresponds to reduced cell density and expression of caspase-3. Arthritis Rheum 2004; 50: 507-15.
33. Martin J, Ellerbroek S, Buckwalter J. Age-related decline in chondrocyte response to insulin-like growth factor-I: the role of growth factor binding proteins. J Orthop Res 1997; 15: 491-7.
34. Guerne PA, Blanco F, Kaelin A, Desgeorges A, Lotz M. Growth factor responsiveness of human articular chondrocytes in aging and development. Arthritis Rheum 1995; 38: 960-8.
35. Barone-Varelas J, Schnitzer TJ, Meng Q, Otten L, Thonar EJ. Age-related differences in the metabolism of proteoglycans in bovine articular cartilage explants maintained in the presence of insulin-like growth factor 1. Connect Tissue Res 1991; 26: 101-20.
36. Westacott CI, Sharif M. Cytokines in osteoarthritis: mediators or markers of joint destruction? Semin Arthritis Rheum 1996; 25: 254-60.
37. Dodge GR, Foole AR. Immunohistochemical detection and immunochemical analysis of type 2 collagen degradation in human normal, rheumatoid, and osteoarthritic articular cartilages and in explants of bovine articular cartilage cultured with interleukin-1. J Clin Invest 1989; 83: 647-53.
38. Bailey A, Mansell J. Do subchondral bone changes exacerbate or precede articular cartilage destruction in osteoarthritis of the elderly? Gerontology 1997; 43: 296-301.
39. Carlson CS, Loeser RF, Purser CB, Gardin JF, Jerome CP. Osteoarthritis in cynomolgus macaques. III: Effects of age, gender, and subchondral bone thickness on the severity of disease. J Bone Miner Res 1996; 11: 1209-17.
40. Radin E, Paul I, Rose R. Role of mechanical factors in pathogenesis of primary osteoarthritis. Lancet 1972; 2: 519-23.
41. Moskowitz RW, Holderbaum D. Clinical and laboratory findings in osteoarthritis. In: Koopman WJ, ed. Arthritis and Allied Conditions: A Textbook of Rheumatology, 13th edition. Baltimore: Williams & Wilkins, 2001; 2216.
42. Schumacher HR, Gordon G, Paul H, Reginato AJ. Osteoarthritis, crystal deposition, and inflammation. Semin Arthritis Rheum 1971; 1: 116-20.
43. Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, et al. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association, Arthritis Rheum 1986; 29: 1039-49.
44. Jordan KM, Arden NK, Doherty M, Bannwarth B, Bijlsma JW, Dieppe P, et al. EULAR Recommendations 2003: an evidence-based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies including Therapeutic Trials (ESCISIT). Ann Rheum Dis 2003; 62: 1145-55.
45. Hochberg MC, Altman RD, Brandt KD, Clark BM, Dieppe PA, Griffin MR, et al. Guidelines for the medical management of osteoarthritis. Part II. Osteoarthritis of the knee. American College of Rheumatology. Arthritis Rheum 1995; 38: 1541-6.
46. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines. Recommendation for the medical management of osteoarthritis of the hip and knee: 2000 update. Arthritis Rheum 2000; 43: 1905-15.
47. Felson DT, Zhang Y, Anthony JM, Naimark A, Anderson JJ. Weight loss reduces the risk for symptomatic knee osteoarthritis in women. The Framingham Study. Ann Intern Med 1992; 116: 535-9.
48. Fisher NM, Gresham GE, Abrams M, Hicks J, Horrigan D, Pendergast DR. Quantitative effects of physical therapy on muscular and functional performance in subjects with osteoarthritis of the knees. Arch Phys Med Rehabil 1993; 74: 840-7.
49. Fiatarone MA, Marks EC, Ryan ND, Meredith CN, Lipsitz LA, Evans WJ. High-intensity strength training in nonagenarians. Effects on skeletal muscle. JAMA 1990; 263: 3029-34.
50. Morganti CM, Nelson ME, Fiatarone MA, Dallal GE, Economos CD, Crawford BM, et al. Strength improvements with 1 year of progressive resistance training in older women. Med Sci Sports Exerc 1995; 27: 906-12.
51. Ettinger WH Jr, Burns R, Messier SP, Applegate W, Rejeski WJ, Morgan T, et al. A randomized trial comparing aerobic exercise and resistance exercise with a health education program in older adults with knee osteoarthritis. The Fitness Arthritis and Seniors Trial (FAST). JAMA 1997; 277: 25-31.
52. Exercise prescription for older adults with osteoarthritis pain: consensus practice recommendations. A supplement to the AGS Clinical Practice Guidelines on the management of chronic pain in older adults. J Am Geriatr Soc 2001; 49: 808-13.
53. Rene J, Weinberger M, Mazzuca SA. Reduction of joint pain in patients with knee osteoarthritis who have received monthly telephone calls from lay personnel and whose medical treatment regimens have remained stable. Arthritis Rheum 1992; 35: 511-6.
54. Weinberger M, Hiner SL, Teirney WM. improving functional status in arthritis: the effect of social support. Soc Sci Med 1986; 23: 899-905.
55. Lin EH, Katon W, Von Korff M, Tang L, Williams JW Jr, Kroenke K, et al. Effect of improving depression care on pain and functional outcomes among older adults with arthritis: a randomized controlled trial. JAMA 2003; 290: 2428-9.
56. Fransen M, Crosbie J, Edmonds J. Physical therapy is effective for patients with osteoarthritis of the knee: a randomized controlled clinical trial. J Rheumatol 2001; 28: 156-61.
57. Huang MH, Lin YS, Lee CL, Yang RC. Use of ultrasound to increase effectiveness of isokinetic exercise for knee osteoarthritis. Arch Phys Med Rehabil 2005; 86: 1545-51.
58. Draper ER, Cable JM, Sanchez-Ballester J, Hunt N, Robinson JR, Strachan RK. Improvement in function after valgus bracing of the knee. An analysis of gait symmetry. J Bone joint Surg Br 2000; 82: 1001-5.
59. Bradley JD, Brandt KD, Katz BP, Kalasinski LA, Ryan SI. Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee. N Engl J Med 1991; 325: 87-91.
60. Williams HJ, Ward JR, Egger MJ, Neuner R, Brooks RH, Clegg DO, et al. Comparison of naproxen and acetaminophen in a two-year study of treatment of osteoarthritis of the knee. Arthritis Rheum 1993; 36: 1196-206.
61. American Geriatrics Society Panel on Chronic Pain in Older Persons. The management of chronic pain in older persons. J Am Geriatr Soc 1998; 46: 635-9.
62. Raffa RB, Friderichs E. The basic science aspect of tramadol hydrochloride. Pain Rev 1996; 3: 249-71.
63. Emkey R, Rosenthal N, Wu SC, Jordan D, Kamin M; CAPSS-114 Study Group. Efficacy and safety of tramadol/acetaminophen tablets (Ultracet) as add-on therapy for osteoarthritis pain in subjects receiving a COX-2 non-steroidal antiinflammatory drug: a multicenter, randomized, double-blind, placebo-controlled trial. J Rheumatol 2004; 31: 150-6.
64. Bellamy N, Campbell J, Robinson V, Gee T, Bourne R, Wells G. Intra-articular corticosteroid for treatment of osteoarthritis of the knee. Cochrane Database Syst Rev 2006; 2: CD005328.
65. Arroll B, Goodyear-Smith F. Corticosteroid injections for osteoarthritis of the knee: meta-analysis. BMJ 2004; 328: 869-74.
66. Fries J, Williams C, Bloch D. The relative toxicity of non-steroidal anti-inflammatory d rugs. Arthritis Rheum 1991; 34: 1353-8.
67. Smalley WE, Ray WA, Daugherty JR, Griffin MR. Nonsteroidal anti-inflammatory drugs and the incidence of hospitalizations for peptic ulcer disease in elderly persons. Am J Epidemiol 1995; 141: 539-45.
68. Gurwitz JH, Avorn J, Ross-Degnan D, Lipsitz LA. Nonsteroidal anti-inflammatory drug-associated azotemia in the very old. JAMA 1990; 264: 471-5.
69. Hawkey CJ. COX-2 inhibitors. Lancet 1999; 353: 307-14.
70. Singh G, Fort JG, Goldstein JL, Levy RA, Hanrahan PS, Bello AE, et al. Celecoxib versus naproxen and diclofenac in osteoarthritis patients: SUCCESS-1 Study. Am J Med 2006; 119: 255-66.
71. Bjordal JM, Ljunggren AE, Klovning A, Slordal L. Nonsteroidal anti-inflammatory drugs, including cyclooxygenase-2 inhibitors, in osteoarthritic knee pain: meta-analysis of randomized placebo-controlled trials. BMJ 2004; 329: 1317.
72. Mamdani M, Rochon PA, Juurlink DN, Kopp A, Anderson GM, Naglie G, et al. Observational study of upper gastrointestinal haemorrhage in elderly patients given selective cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs. BMJ 2002; 325: 624.
73. Yen ZS, Lai MS, Wang CT, Chen LS, Chen SC, Chen WJ, et al. Cost-effectiveness of treatment strategies for osteoarthritis of the knee in Taiwan. J Rheumatol 2004; 31: 1797-803.
74. Couzin J. Drug safety. Withdrawal of Vioxx casts a shadow over COX-2 inhibitors. Science 2004; 306: 384-5.
75. Bresalier RS, Sandler RS, Quan H, Bolognese JA, Oxenius B, Horgan K, et al; Adenomatous Polyp Prevention on Vioxx (APPROVe) Trial Investigators. Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. N Engl J Med 2005; 352: 1092-102.
76. Lin J, Zhang W, Jones A, Doherty M. Efficacy of topical non-steroidal anti-inflammatory drugs in the treatment of osteoarthritis: meta-analysis of randomized controlled trials. BMJ 2004; 329: 324-7.
77. Deal CL, Schnitzer TJ, Lipstein E, Seibold JR, Stevens RM, Levy MD, et al. Treatment of arthritis with topical capsaicin: a double-blind trial. Clin Ther 1991; 13: 383-95.
78. Verbruggen G. Chondroprotective drugs in degenerative joint diseases. Rheumatology (Oxford) 2006; 45: 129-38.
79. Brandt KD, Mazzuca SA, Katz BP, Lane KA, Buckwalter KA, Yocum DE, et al. Effects of doxycycline on progression of osteoarthritis: results of a randomized, placebo-controlled, double-blind trial. Arthritis Rheum 2005; 52: 2015-25.
80. Brandt KD, Mazzuca SA. Experience with a placebo-controlled, randomized clinical trial of a disease-modifying drug for osteoarthritis: the doxycycline trial. Rheum Dis Clin North Am 2006; 32: 217-34.
81. Richy F, Bruyere O, Ethgen O, Cucherat M, Henrotin Y, Reginster JY. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Arch intern Med 2003; 163: 1514-22.
82. Towheed TE, Maxwell L, Anastassiades TP, Shea B, Houpt J, Robinson V, et al. Glucosamine therapy for treating osteoarthritis. Cochrane Database Syst Rev 2005; 2: CD002946.
83. Michel BA, Stucki G, Frey D, De Vathaire F, Vignon E, Bruehlmann P, et al. Chondroitins 4 and 6 sulfate in osteoarthritis of the knee: a randomized, controlled trial. Arthritis Rheum 2005; 52: 779-86.
84. Clegg DO, Reda DJ, Harris CL, Klein MA, O'Dell JR, Hooper MM, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 2006; 354: 795-808.
85. Spencer CM, Wilde MI. Diacerein. Drugs 1997; 53: 98-107.
86. Pelletier JP, Mineau F, Fernandes JC, Duval N, Martel-Pelletier J. Diacerhein and rhein reduce the interleukin 1-beta-stimulated inducible nitric oxide synthesis level and activity while stimulating cyclooxygenase-2 synthesis in human osteoarthritis chondrocytes. J Rheumatol 1998; 25: 2417-24.
87. Yaron M, Shirazi I, Yaron I. Anti-interleukin-1 effects of diacerein and rhein in human osteoarthritis synovial tissue and cartilage cultures. Osteoarthritis Cartilage 1999; 7: 272-8.
88. Fidelix TS, Soares BG, Trevisani VF. Diacerein for osteoarthritis. Cochrane Database Syst Rev 2006; 1: CD005117.
89. Cake MA, Read RA, Guillou B, Ghosh P. Modification of articular cartilage and subchondral bone pathology in an ovine meniscectomy model of osteoarthritis by avocado and soya unsaponifiables (ASU). Osteoarthritis Cartilage 2000; 8: 404-11.
90. Ernst E. Avocado-soybean unsaponifiables (ASU) for osteoarthritis - a systematic review. Clin Rheumatol 2003; 22: 285-8.
91. Abatangelo G, O'Regan M. Hyaluronan: biological role and function in articular joints. Eur J Rheumatol Inflamm 1995; 15: 9-16.
92. Takahashi K, Hashimoto S, Kubo T, Hirasawa Y, Lotz M, Amiel D. Effect of hyaluronan on chondrocyte apoptosis and nitric oxide production in experimentally induced osteoarthritis. J Rheumatol 2000; 27: 1713-20.
93. Adams ME, Atkinson MH, Lussier AJ, Schulz JI, Siminovitch KA, Wade JP, et al. The role of viscosupplementation with hylan G-F 20 (Synvisc) in the treatment of osteoarthritis of the knee: a Canadian multicenter trial comparing hylan G-F 20 alone, hylan G-F 20 with nonsteroidal anti-inflammatory drugs (NSAIDs) and NSAIDs alone. Osteoarthritis Cartilage 1995; 3: 213-25.
94. Day R, Brooks P, Conaghan PG, Petersen M; Multicenter Trial Group. A double-blind, randomized, multicenter, parallel group study of the effectiveness and tolerance of intraarticular hyaluronan in osteoarthritis of the knee. J Rheumatol 2004; 31: 775-82.
95. Dieppe P, Basler HD, Chard J, Croft P, Dixon J, Hurley M, et al. Knee replacement surgery for osteoarthritis: effectiveness, practice variations, indications and possible determinants of utilization. Rheumatology (Oxford) 1999; 38: 73-83.