Kadota Fund International Forum 2004. Application of thermal stress for the improvement of health, 15-18 June 2004, Awaji Yumebutai International Conference Center, Awaji Island, Hyogo, Japan. Final Report

International Journal of Hyperthermia

Volumn 24, Issue 2, 2008, Pages 123-140

  Sugahara, Tsutomu ^a   Van Der Zee, J ^b   Kampinga, Harm ^e   Vujaskovic, Zeliko ^c   Kondo, Motoharu ^d   Ohnishi, Takeo ^f   Li, Gloria ^g   Park, Heon ^h   Leeper, Dennis ⁱ   Ostapenko, Valentina ^j   Repasky, Elizabeth ^k   Watanabe, Masami ^l   Song, Chang ^m  

^a Japan Foundation for Aging and Health   (Japan)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d Aino Hospital   (Japan)

^e UNIVERSITY OF GRONINGEN   (Netherlands)

^f NARA MEDICAL UNIVERSITY   (Japan)

^g MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^h Inha University   (South Korea)

ⁱ THOMAS JEFFERSON UNIVERSITY   (United States)

^j Shouseikai Nishide Hospital   (Japan)

^k ROSWELL PARK CANCER INSTITUTE   (United States)

^l NAGASAKI UNIVERSITY   (Japan)

^m UNIVERSITY OF MINNESOTA   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ALKYLATING AGENT; BETA LAPACHONE; CHAPERONE; DOUBLE STRANDED DNA; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 70; INTERFERON; INTERLEUKIN 12; MITOMYCIN C; PLATINUM DERIVATIVE;

BLOOD VESSEL INJURY; CANCER CHEMOTHERAPY; CANCER CONTROL; CANCER IMMUNOTHERAPY; CANCER PAIN; CANCER PALLIATIVE THERAPY; CANCER RADIOTHERAPY; CANCER THERAPY; CELL DEATH; CHEMOSENSITIZATION; CHROMATIN STRUCTURE; CLINICAL EFFECTIVENESS; CLINICAL TRIAL; CONFERENCE PAPER; CONSENSUS DEVELOPMENT; CYTOLOGY; CYTOTOXICITY; DNA STRAND BREAKAGE; DRUG MECHANISM; DRUG POTENTIATION; DRUG SENSITIZATION; GENE ACTIVATION; GENE THERAPY; HEAT; HEAT SHOCK RESPONSE; HEPATITIS C; HUMAN; HYPERTHERMIA; HYPERTHERMIC THERAPY; INTERNATIONAL COOPERATION; JAPAN; MOLECULAR MECHANICS; NEOPLASM; NONHUMAN; PROMOTER REGION; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN FUNCTION; RADIOSENSITIVITY; RADIOSENSITIZATION; TEMPERATURE STRESS; THERMOMETRY; TREATMENT RESPONSE; TUMOR BLOOD FLOW; TUMOR IMMUNITY;

COMBINED MODALITY THERAPY; DRUG THERAPY; GENE THERAPY; HUMANS; HYPERTHERMIA, INDUCED; IMMUNOTHERAPY; NEOADJUVANT THERAPY; NEOPLASMS; RADIOTHERAPY;

EID: 39549111024     PISSN: 02656736     EISSN: 14645157     Source Type: Journal    
DOI: 10.1080/02656730701883675     Document Type: Conference Paper

References (94)

1. (1990) International Concensus Meeting on Hyperthermia: Final report. Int J Hyperthermia, 6, pp. 837-877.
2. Jorritsma, JB and Konings, AW (1984) The occurrence of DNA strand breaks after hyperthermic treatments of mammalian cells with and without radiation. Radiat Res, 98, pp. 198-208.
3. Takahashi, A., Matsumoto, H., Nagayama, K., Kitano, M., Hirose, S., Tanaka, H., Mori, E., Yamakawa, N., Yasumoto, J. and Yuki, K. (2004) Evidence for the involvement of double-strand breaks in heat-induced cell killing. Cancer Res, 64, pp. 8839-8845.
4. Konings, AWT (1988) Membranes as targets for hyperthermic cell killing. Cancer Res, 109, pp. 9-22.
5. Dewey, WC (1994) Arrhenius relationships from the molecule and cell to the clinic. Int J Hyperthermia, 10, pp. 457-483.
6. Lepock, JR, Frey, HE and Ritchie, KP (1993) Protein denaturation in intact hepatocytes and isolated cellular organelles during heat shock. J Cell Biol, 122, pp. 1267-1276.
7. Burgman, PWJJ and Konings, AWT (1992) Heat induced protein denaturation in the particulate fraction of HeLa S3 cells: Effects of thermotolerance. J Cell Physiol, 153, pp. 88-94.
8. Spiro, IJ, Denman, DL and Dewey, WC (1982) Effect of hyperthermia on CHO DNA polymerases a and b. Radiat Res, 89, pp. 134-149.
9. Bensaude, O., Pinto, M., Dubois, M-F, Nguyen, VT and Morange, M. (1990) Protein denaturation during heat shock and related stress. Stress Proteins, 8, pp. 89-99.
10. Kampinga, HH (1993) Thermotolerance in mammalian cells. Protein denaturation and aggregation, and stress proteins. J Cell Sci, 104, pp. 11-17.
11. Lepock, JR (2004) Role of nuclear protein denaturation and aggregation in thermal radiosensitization. Int J Hyperthermia, 20, pp. 115-130.
12. Roti, JL Roti and Laszlo, A. (1988) The effects of hyperthermia on cellular macromolecules. Thermal effects on cells and tissues, pp. 13-98. VSP, Utrecht
13. Borrelli, MJ, Stafford, DM, Rausch, CM, Lepock, JR, Lee, YJ and Corry, PM (1992) Reduction of levels of nuclear-associated protein in heated cells by cycloheximide, D2 O, and thermotolerance. Radiat Res, 131, pp. 204-213.
14. Lepock, JR, Cheng, KH, Al-Qysi, H. and Kruuv, J. (1983) Thermotropic lipid and protein transitions in Chinese hamster lung cell membranes: Relationship to hyperthermic cell killing. Can J Biochem Cell Biol, 61, pp. 421-427.
15. Michels, AA, Kanon, B., Ohtsuka, K., Konings, AWT, Bensaude, O. and Kampinga, HH (1997) Hsp70 and Hsp40 chaperone activities in the cytoplasm and the nucleus of mammalian cells. J Biol Chem, 272, pp. 33283-33289.
16. Stege, GJ, Li, GC, Li, L., Kampinga, HH and Konings, AW (1994) On the role of hsp72 in heat-induced intranuclear protein aggregation. Int J Hyperthermia, 10, pp. 659-674.
17. Lepock, JR, Frey, HE, Heynen, ML, Senisterra, GA and Warters, RL (2001) The nuclear matrix is a thermolabile cellular structure. Cell Stress & Chaperones, 6, pp. 136-147.
18. Roti, JL Roti, Kampinga, HH, Malyapa, RS, Wright, WD, vanderWaal, RP and Xu, M. (1998) Nuclear matrix as a target for hyperthermic killing of cancer cells. Cell Stress & Chaperones, 3, pp. 245-255.
19. Kampinga, HH, Turkel-Uygur, N., Roti, JL Roti and Konings, AWT (1989) The relationship of increased nuclear protein content induced by hyperthermia to killing of HeLa S3 cells. Radiat Res, 117, pp. 511-522.
20. Rogakou, EP, Boon, C., Redon, C. and Bonner, WM (1999) Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol, 146, pp. 905-916.
21. Raaphorst, GP, Vadasz, JA and Azzam, EI (1984) Thermal sensitivity and radiosensitization in V79 cells after BrdUrd or IdUrd incorporation. Radiat Res, 98, pp. 167-175.
22. Wong, RSL and Dewey, WC (1993) Molecular mechanisms for the induction of chromosomal aberrations in CHO cells heated in S phase. Environ Mol Mutagen, 22, pp. 257-263.
23. Ritossa, F. (1996) Discovery of the heat shock response. Cell Stress & Chaperones, 23, pp. 197-198.
24. Tissieres, A., Mitchell, HK and Tracy, UM (1974) Protein synthesis in salivary glands of Drosophila melanogaster: Relation to chromosome puffs. J Mol Biol, 84, pp. 389-398.
25. Li, GC, Mivechi, NF and Weitzel, G. (1995) Heat shock proteins, thermotolerance, and their relevance to clinical hyperthermia. Int J Hyperthermia, 11, pp. 459-488.
26. Morimoto, RI (1998) Regulation of the heat shock transcriptional response: Cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. Genes & Dev, 12, pp. 3788-3796.
27. Satyal, SH, Chen, D., Fox, SG, Kramer, JM and Morimoto, RI (1998) Negative regulation of the heat shock transcriptional response by HSBP1. Genes & Dev, 12, pp. 1962-1974.
28. Ellis, RJ and Van der Vies, SM (1991) Molecular chaperones. Annu Rev Biochem, 60, pp. 321-347.
29. Hartl, FU (1996) Molecular chaperones in cellular protein folding. Nature, 381, pp. 571-580.
30. Picard, D. (2002) Heat-shock protein 90, a chaperone for folding and regulation. Cell Mol Life Sci, 59, pp. 1640-1648.
31. Neckers, L. and Ivy, SP (2003) Heat shock protein 90. Curr Opin Oncol, 15, pp. 419-424.
32. Li, GC, Li, L., Liu, Y-K, Mak, JY, Chen, L. and Lee, WMF (1991) Thermal response of rat fibroblasts stably transfected with the human 70-kDa heat shock protein-encoding gene. Proc Natl Acad Sci USA, 88, pp. 1681-1685.
33. Nollen, EA, Brunsting, JF, Roelofsen, H., Weber, LA and Kampinga, HH (1999) In vivo chaperone activity of heat shock protein 70 and thermotolerance. Mol Cell Biol, 19, pp. 2069-2079.
34. Landry, J., Chretien, P., Lambert, H., Hickey, E. and Weber, LA (1989) Heat shock resistance conferred by expression of the human hsp27 gene in rodent cells. J Cell Biol, 109, pp. 7-15.
35. Minami, Y., Hohfeld, J., Ohtsuka, K. and Hartl, FU (1996) Regulation of the heat-shock protein 70 reaction cycle by the mammalian DnaJ homolog, Hsp40. J Biol Chem, 271, pp. 19617-19624.
36. Hohfeld, J., Minami, Y. and Hartl, FU (1995) Hip, a novel cochaperone involved in the eukaryotic Hsc70/Hsp40 reaction cycle. Cell, 83, pp. 589-598.
37. Takayama, S., Bimston, DN, Matsuzawa, S., Freeman, BC, Aime-Sempe, C., Xie, Z., Morimoto, RI and Reed, JC (1997) BAG-1 modulates the chaperone activity of Hsp70/Hsc70. EMBO J, 16, pp. 4887-4896.
38. Nollen, EA, Brunsting, JF, Song, J., Kampinga, HH and Morimoto, RI (2000) Bag1 functions in vivo as a negative regulator of Hsp70 chaperone activity. Mol Cell Biol, 20, pp. 1083-1088.
39. Nollen, EA, Kabakov, AE, Brunsting, JF, Kanon, B., Höhfeld, J. and Kampinga, HH (2001) Modulation of in vivo HSP70 chaperone activity by Hip and Bag-1. J Biol Chem, 276, pp. 4677-4682.
40. Jaattela, M. (1999) Escaping cell death: Survival proteins in cancer. Exp Cell Res, 248, pp. 30-43.
41. Beere, HM, Wolf, BB, Cain, K., Mosser, DD, Mahboubi, A., Kuwana, T., Tailor, P., Morimoto, RI, Cohen, GM and Green, DR (2000) Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nat Cell Biol, 2, pp. 469-475.
42. Gabai, VL, Meriin, AB, Yaglom, JA, Volloch, VZ and Sherman, MY (1998) Role of Hsp70 in regulation of stress-kinase JNK: Implications in apoptosis and aging. FEBS Lett, 438, pp. 1-4.
43. Nylandsted, J., Gyrd-Hansen, M., Danielewicz, A., Fehrenbacher, N., Lademann, U., Hoyer-Hansen, M., Weber, E., Multhoff, G., Rohde, M. and Jaattela, M. (2004) Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization. J Exp Med, 200, pp. 425-435.
44. Michels, AA, Nguyen, VT, Konings, AW, Kampinga, HH and Bensaude, O. (1995) Thermostability of a nuclear-targeted luciferase expressed in mammalian cells-Destabilizing influence of the intranuclear microenvironment. Eur J Biochem, 234, pp. 382-389.
45. Roti, JL Roti and Winward, RT (1978) The effects of hyperthermia on the protein-to-DNA ratio of isolated HeLa cell chromatin. Radiat Res, 74, pp. 159-169.
46. Tomasovic, SP, Turner, GN and Dewey, WC (1978) Effect of hyperthermia on nonhistone proteins isolated with DNA. Radiat Res, 73, pp. 535-552.
47. Kampinga, HH and Dikomey, E. (2001) Hyperthermic radiosensitization: Mode of action and clinical relevance. Int J Radiat Biol, 77, pp. 399-408.
48. Vidair, CA, Huang, RN and Doxsey, SJ (1996) Heat shock causes protein aggregation and reduced protein solubility at the centrosome and other cytoplasmic locations. Int J Hyperthermia, 12, pp. 681-695.
49. Nakahata, K., Miyakoda, M., Suzuki, K., Kodama, S. and Watanabe, M. (2002) Heat shock induces centrosomal dysfunction, and causes non-apoptotic mitotic catastrophe in human tumour cells. Int J Hyperthermia, 18, pp. 332-343.
50. Matsumoto, H., Takahashi, A., Wang, X., Ohnishi, K. and Ohnishi, T. (1997) Transfection of p53-knockout mouse fibroblasts with wild-type p53 increases the thermosensitivity and stimulates apoptosis induced by heat stress. Int J Radiat Oncol Biol Phys, 38, pp. 1089-1095.
51. Li, FJ, Kondo, T., Zhao, QL, Hayashi, Y., Ogawa, R., Cui, ZG and Feril Jr., LB (2003) A lipophilic free radical initiator, 2,2′-azobis (2,4-dimethylvaleronitrile) (AMVN) enhances caspase-dependent apoptosis induced by hyperthermia. Int J Hyperthermia, 19, pp. 165-177.
52. Dewey, WC and Sapareto, SA (1978) Radiosensitization by hyperthermia occurs through an increase in chromosomal aberrations. Cancer Therapy by Hyperthermia and Radiation, pp. 149-150. Munich, Urban & Schwarzenberg
53. Kampinga, HH, Hiemstra, YS, Konings, AW and Dikomey, E. (1997) Correlation between slowly repairable double-strand breaks and thermal radiosensitization in the human HeLa S3 cell line. Int J Radiat Biol, 72, pp. 293-301.
54. Li, CY and Dewhirst, MW (2002) Hyperthermia-regulated immunogene therapy. Int J Hyperthermia, 18, pp. 586-596.
55. Huang, Q., Hu, JK, Lohr, F., Zhang, L., Braun, R. and Lanzen, J. (2000) Heat-induced gene expression as a novel targeted cancer gene therapy strategy. Cancer Res, 60, pp. 3435-3439.
56. Siddiqui, F., Li, CY, Larue, SM, Poulson, JM, Avery, PR, Pruitt, AF, Zhang, X., Ulrich, RL, Threall, DE, Dewhirst, MW and Hauck, ML (2007) A phase 1 trial of hyperthermia-induced interleukin-12 gene therapy in spontaneously arising feline soft tissue sarcomas. Mol Cancer Ther, 6, pp. 380-389.
57. Siddiqui, F., Li, CY, Zhang, X., Larue, SM, Dewhirst, MW, Ulrich, RL and Avery, PR (2006) Characterization of a recombinant adenovirus vector encoding heat-inducible feline interleukin-12 for use in hyperthermia-induced gene-therapy. Int J Hyperthermia, 22, pp. 117-134.
58. Siddiqui, F., Ehrhart, AEJ, Charles, B., Laura, C., Li, CY, Zhang, X., Larue, SM, Avery, PR, Dewhirst, MW and Ulrich, RL (2006) Anti-angiogenic effects of interleukin-12 delivered by a novel hyperthermia induced gene construct. Int J Hyperthermia, 22, pp. 587-606.
59. Arimura, M., Suzuki, K. and Watanabe (2004) New hyperthermic cancer therapy using the heat- inducible p53 gene. The Kadota Fund International Forum, 81
60. Blackburn, RV, Galoforo, SS, Corry, PM and Lee, YJ (1998) Adenoviral-mediated transfer of a heat-inducible double suicide gene into prostate carcinoma cells. Cancer Res, 58, pp. 1358-1362.
61. Borrelli, MJ, Schoenherr, DM, Wong, A., Bernock, LJ and Corry, PM (2001) Heat-activated transgene expression from adenovirus vectors infected into human prostate cancer cells. Cancer Res, 61, pp. 1113-1121.
62. Lohr, F., Hu, K., Huang, Q., Zhang, L., Samulski, TV, Dewhirst, MW and Li, CY (2000) Enhancement of radiotherapy by hyperthermia-regulated gene therapy. Int J Radiat Oncol Biol Phys, 48, pp. 1513-1518.
63. Li, GC, He, F., Shao, X., Urano, M., Shen, L., Kim, D., Borrelli, M., Leibel, SA, Gutin, PH and Ling, CC (2003) Adenovirus-mediated heat-activated antisense ku70 expression radiosensitizes tumor cell in vitro and in vivo. Cancer Res, 633, pp. 268-3274.
64. Park, HJ, Choi, EK, Choi, J., Ahn, KJ, Kim, EJ and Ji, IM (2005) Heat-induced up-regulation of NAD(P)H:QUinone Oxidoreductase potentiates antisequence effects of B-lapachone. Clin Cancer Res, 11, pp. 8866-8871.
65. Ueda, H., Tanaka, H., Kida, Y., Ichinose, M., Ostapenko, VV, Miyano, M., Nishide, I. and Yukawa, S. (2004) Local hyperthermia induces expression IFNAR1 in liver of patient with chronic hepatitis C. The Kadota Fund International Forum, 63 63
66. Repasky, E. and Issels, R. (2002) Physiological consequences of hyperthermia: Heat, heat shock proteins and the immune response. Int J Hyperthermia, 18, pp. 486-489.
67. Calderwood, SK, Theriault, JR and Gong, J. (2005) How is the immune response affected by hyperthermia and heat shock proteins?. Int J Hyperthermia, 21, pp. 713-716.
68. Wang, XY, Li, Y., Yang, G. and Subjeck, JR (2005) Current ideas about applications of heat shock proteins in vaccine design and immunotherapy. Int J Hyperthermia, 21, pp. 717-722.
69. Manjili, MH, Wang, XY, Park, J., MacDonald, IJ, Li, Y., Van Schie, CAA and Subjeck, JR (2002) Cancer immunotherapy: Stress proteins and hyperthermia. Int J Hyperthermia, 18, pp. 506-520.
70. Calderwood, SK and Asea, A. (2002) Targeting HSP70-induced thermotolerance for design of thermal sensitizers. Int J Hyperthermia, 18, pp. 597-608.
71. Menoret, A., Chaillot, D., Callahan, M. and Jacquin, C. (2002) Hsp70, an immunological actor playing with the intracellular self under oxidative stress. Int J Hyperthermia, 18, pp. 490-505.
72. Milani, V., Noessner, E., Ghose, S., Kuppner, M., Ahrens, B., Scharner, A., Gastpar, R. and Issels, RD (2002) Heat shock protein 70: Role in antigen presentation and immune stimulation. Int J Hyperthermia, 18, pp. 563-575.
73. Miyazawa, M., Kawahara, S., Kida, Y. and Ostrapenka, V. (2004) Activation of peripheral blood T lymphocytes and induction of CD16+ immature monocytes by a regional hyperthermic treatment of the upper abdomen.p. Page 61. The Kadota Fund International Forum
74. Ostberg, JR, Kaplan, KC and Repasky, EA (2002) Induction of stress proteins in a panel of mouse tissues by fever-range whole body hyperthermia. Int J Hyperthermia, 18, pp. 552-562.
75. Hah, A., Unger, E., Bain, MD, Bruce, R., Bodkin, J., Ginnetti, J., Wang, WC, Seon, B., Stewart, CC and Evan, SS (2002) Cytokine and adhesion molecule expression in primary human endothelial cells stimulated with fever-range hyperthermia. Int J Hyperthermia, 18, pp. 534-551.
76. Gorter, RW, Pulido, E. and Butorac, M. (2004) Fever-range, total-body hyperthermia in combination with autologous dendritic cells in cancer patients. The Kadota Fund International Forum, 41
77. Kosaka, M., Yamane, M., Oppermann, S. and Simon, CE (2004) Physiology and pathophysiology of hyperthermia viewed from hyperthermic oncology. The Kadota Fund International Forum, 75
78. Pritchard, MT, Xu, Y., Kraybill, W. and Repasky, EA (2004) The anti-tumor effects of interleukin-12 or DOXIL are each enhanced by addition of mild (fever-range) thermal therapy. The Kadota Fund International Forum, 65
79. Bull, JMC, Scott, GL, Strebel, FR, Oliver, DH, Raval, B. and Steven, M. (2004) Results of a phase I clinical trial using fever-range whole-body hyperthermia (FR-WB-TT) + cisplatin (CIS) + gemcitabine (GEM) + metronomic low-dose interferon-a (IFN-oe) and description of a phase II clinical trial to treat locally advanced and inoperable pancreas cancer. The Kadota Fund International Forum, 77
80. Song, CW (1984) Effect of local hyperthermia on blood flow and microenvironment: A review. Cancer Res, 44, pp. 4721s-4730s.
81. Reinhold, HS (1988) Physiological effects of hyperthermia. Recent Results Cancer Res, 107, pp. 32-43.
82. Song, CW, Park, H. and Griffin, RJ (2001) Improvement of tumor oxygenation by mild hyperthermia. Radiat Res, 155, pp. 512-528.
83. Shakil, A., Osborn, JL and Song, CW (1999) Changes in oxygenation status and blood flow in a rat tumor model by mild temperature hyperthermia. Int J Radiat Oncol Biol Phys, 43, pp. 859-865.
84. Iwata, K., Shakil, A., Hur, WJ, Makepeace, CM, Griffin, RJ and Song, CW (1996) Tumour pO2 can be increased markedly by mild hyperthermia. Br J Cancer, 74, pp. 217-221.
85. Song, CW, Shakil, A., Griffin, RJ and Okajima, K. (1997) Improvement of tumor oxygenation status by mild temperature hyperthermia alone or in combination with carbogen. Semin Oncol, 24, pp. 626-632.
86. Okajima, K., Griffin, RJ, Iwata, K., Shakil, A. and Song, CW (1998) Tumor oxygenation after mild-temperature hyperthermia in combination with carbogen breathing: Dependence on heat dose and tumor type. Radiat Res, 149, pp. 294-299.
87. Vujaskovic, Z., Poulson, JM, Gaskin, AA, Thrall, DE, Page, RL, Charles, HC, MacFall, JR, Brizel, DM, Meyer, RE and Dewhirst, MW (2000) Temperature-dependent changes in physiologic parameters of spontaneous canine soft tissue sarcomas after combined radiotherapy and hyperthermia treatment. Int J Radiat Oncol Biol Phys, 46, pp. 179-186.
88. Dewhirst, MW (1996) Radiation therapy and hyperthermia improve the oxygenation of human soft tissue sarcomas. Cancer Res, 56, pp. 5347-5350.
89. Jones, EL, Prosnitz, LR, Dewhirst, MW, Marcom, PK, Hardenbergh, PH, Marks, LB, Brizel, DM and Vujaskovic, Z. (2004) Thermochemoradiotherapy improves oxygenation in locally advanced breast cancer. Clin Cancer Res, 10, pp. 4287-4293.
90. Vujaskovic, Z. and Song, CW (2004) Physiological mechanisms underlying heat-induced radiosensitization. Int J Hyperthermia, 20, pp. 163-174.
91. Inch, WR, McCredie, JA and Sutherland, RM (1970) Effect of duration of breathing 95% oxygen plus 5% carbon dioxide before X-irradiation on cure of C3H mammary tumor. Cancer, 25, pp. 926-931.
92. Siemann, DW, Hill, RP and Bush, RS (1997) The importance of pre-irradiation breathing times of oxygen and carbogen (5% CO2, 95% O2) on the in vivo radiation response of a murine sarcoma. Int J Radiat Biol Phys, 2, pp. 903-911.
93. Griffin, RJ, Okajima, K., Barrios, B. and Song, CW (1996) Mild temperature hyperthermia combined with carbon breathing increases tumor partial pressure of oxygen (pO2) and radiosensitivity. Cancer Res, 56, pp. 5590-5593.
94. Griffin, RJ, Ogawa, A., Williams, BW and Song, CW (2005) Hyperthermic enhancement of tumor radiosensititization strategies. Immunol Inves, 34, pp. 343-359.