메뉴 건너뛰기




Volumn 197, Issue 1, 2008, Pages 355-362

Tesaglitazar, a dual peroxisome proliferator-activated receptor α/γ agonist, improves apolipoprotein levels in non-diabetic subjects with insulin resistance

Author keywords

Apolipoprotein; Atherosclerosis; Dyslipidaemia; Hypertriglyceridaemia; Insulin resistance; Peroxisome proliferator activated receptor

Indexed keywords

APOLIPOPROTEIN; APOLIPOPROTEIN B; APOLIPOPROTEIN C3; CHOLESTEROL; FAS ANTIGEN; LOW DENSITY LIPOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PLACEBO; TESAGLITAZAR; TRIACYLGLYCEROL;

EID: 39449103963     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2007.05.029     Document Type: Article
Times cited : (31)

References (32)
  • 1
    • 0035909074 scopus 로고    scopus 로고
    • Hypertriglyceridemic hyperapob: the unappreciated atherogenic dyslipoproteinemia in type 2 diabetes mellitus
    • Sniderman A.D., Scantlebury T., and Cianflone K. Hypertriglyceridemic hyperapob: the unappreciated atherogenic dyslipoproteinemia in type 2 diabetes mellitus. Ann Intern Med 135 (2001) 447-459
    • (2001) Ann Intern Med , vol.135 , pp. 447-459
    • Sniderman, A.D.1    Scantlebury, T.2    Cianflone, K.3
  • 2
    • 0029832009 scopus 로고    scopus 로고
    • Apolipoprotein A-I and B levels and the risk of ischemic heart disease during a five-year follow-up of men in the Quebec cardiovascular study
    • Lamarche B., Moorjani S., Lupien P.J., et al. Apolipoprotein A-I and B levels and the risk of ischemic heart disease during a five-year follow-up of men in the Quebec cardiovascular study. Circulation 94 (1996) 273-278
    • (1996) Circulation , vol.94 , pp. 273-278
    • Lamarche, B.1    Moorjani, S.2    Lupien, P.J.3
  • 3
    • 0038222533 scopus 로고    scopus 로고
    • LDL containing apolipoprotein CIII is an independent risk factor for coronary events in diabetic patients
    • Lee S.J., Campos H., Moye L.A., and Sacks F.M. LDL containing apolipoprotein CIII is an independent risk factor for coronary events in diabetic patients. Arterioscler Thromb Vasc Biol 23 (2003) 853-858
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 853-858
    • Lee, S.J.1    Campos, H.2    Moye, L.A.3    Sacks, F.M.4
  • 4
    • 0034680309 scopus 로고    scopus 로고
    • VLDL, apolipoproteins B, CIII, and E, and risk of recurrent coronary events in the Cholesterol And Recurrent Events (CARE) trial
    • Sacks F.M., Alaupovic P., Moye L.A., et al. VLDL, apolipoproteins B, CIII, and E, and risk of recurrent coronary events in the Cholesterol And Recurrent Events (CARE) trial. Circulation 102 (2000) 1886-1892
    • (2000) Circulation , vol.102 , pp. 1886-1892
    • Sacks, F.M.1    Alaupovic, P.2    Moye, L.A.3
  • 5
    • 0345711503 scopus 로고    scopus 로고
    • Apolipoprotein(B) identifies dyslipidemic phenotypes associated with cardiovascular risk in normocholesterolemic type 2 diabetic patients
    • Wagner A.M., Perez A., Calvo F., et al. Apolipoprotein(B) identifies dyslipidemic phenotypes associated with cardiovascular risk in normocholesterolemic type 2 diabetic patients. Diabetes Care 22 (1999) 812-817
    • (1999) Diabetes Care , vol.22 , pp. 812-817
    • Wagner, A.M.1    Perez, A.2    Calvo, F.3
  • 6
    • 0035894648 scopus 로고    scopus 로고
    • High apolipoprotein B, low apolipoprotein A-I, and improvement in the prediction of fatal myocardial infarction (AMORIS study): a prospective study
    • Walldius G., Jungner I., Holme I., et al. High apolipoprotein B, low apolipoprotein A-I, and improvement in the prediction of fatal myocardial infarction (AMORIS study): a prospective study. Lancet 358 (2001) 2026-2033
    • (2001) Lancet , vol.358 , pp. 2026-2033
    • Walldius, G.1    Jungner, I.2    Holme, I.3
  • 7
    • 33645096052 scopus 로고    scopus 로고
    • Apo B versus cholesterol in estimating cardiovascular risk and in guiding therapy: report of the thirty-person/ten-country panel
    • Barter P.J., Ballantyne C.M., Carmena R., et al. Apo B versus cholesterol in estimating cardiovascular risk and in guiding therapy: report of the thirty-person/ten-country panel. J Intern Med 259 (2006) 247-258
    • (2006) J Intern Med , vol.259 , pp. 247-258
    • Barter, P.J.1    Ballantyne, C.M.2    Carmena, R.3
  • 8
    • 0033580591 scopus 로고    scopus 로고
    • Thrombogenic factors and recurrent coronary events
    • Moss A.J., Goldstein R.E., Marder V.J., et al. Thrombogenic factors and recurrent coronary events. Circulation 99 (1999) 2517-2522
    • (1999) Circulation , vol.99 , pp. 2517-2522
    • Moss, A.J.1    Goldstein, R.E.2    Marder, V.J.3
  • 9
    • 33644861577 scopus 로고    scopus 로고
    • Increased small low-density lipoprotein particle number: a prominent feature of the metabolic syndrome in the Framingham Heart Study
    • Kathiresan S., Otvos J.D., Sullivan L.M., et al. Increased small low-density lipoprotein particle number: a prominent feature of the metabolic syndrome in the Framingham Heart Study. Circulation 113 (2006) 20-29
    • (2006) Circulation , vol.113 , pp. 20-29
    • Kathiresan, S.1    Otvos, J.D.2    Sullivan, L.M.3
  • 10
    • 39449100147 scopus 로고    scopus 로고
    • Mora S, Szklo M, Otvos JD, et al. LDL particle subclasses, LDL particle size, and carotid atherosclerosis in the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis 2006;June 9 [Epub ahead of print].
    • Mora S, Szklo M, Otvos JD, et al. LDL particle subclasses, LDL particle size, and carotid atherosclerosis in the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis 2006;June 9 [Epub ahead of print].
  • 11
    • 33645741889 scopus 로고    scopus 로고
    • Low-density lipoprotein and high-density lipoprotein particle subclasses predict coronary events and are favorably changed by gemfibrozil therapy in the Veterans Affairs High-Density Lipoprotein Intervention Trial
    • Otvos J.D., Collins D., Freedman D.S., et al. Low-density lipoprotein and high-density lipoprotein particle subclasses predict coronary events and are favorably changed by gemfibrozil therapy in the Veterans Affairs High-Density Lipoprotein Intervention Trial. Circulation 113 (2006) 1556-1563
    • (2006) Circulation , vol.113 , pp. 1556-1563
    • Otvos, J.D.1    Collins, D.2    Freedman, D.S.3
  • 12
    • 0032816777 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis
    • Fruchart J.C., Duriez P., and Staels B. Peroxisome proliferator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis. Curr Opin Lipidol 10 (1999) 245-257
    • (1999) Curr Opin Lipidol , vol.10 , pp. 245-257
    • Fruchart, J.C.1    Duriez, P.2    Staels, B.3
  • 13
    • 20044396568 scopus 로고    scopus 로고
    • Regulation of human apoA-I by gemfibrozil and fenofibrate through selective peroxisome proliferator-activated receptor alpha modulation
    • Duez H., Lefebvre B., Poulain P., et al. Regulation of human apoA-I by gemfibrozil and fenofibrate through selective peroxisome proliferator-activated receptor alpha modulation. Arterioscler Thromb Vasc Biol 25 (2005) 585-591
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 585-591
    • Duez, H.1    Lefebvre, B.2    Poulain, P.3
  • 14
    • 33745957332 scopus 로고    scopus 로고
    • Improvement of glycemic control, triglycerides, and HDL cholesterol levels with muraglitazar, a dual (alpha/gamma) peroxisome proliferator-activated receptor activator, in patients with type 2 diabetes inadequately controlled with metformin monotherapy: a double-blind, randomized, pioglitazone-comparative study
    • Kendall D.M., Rubin C.J., Mohideen P., et al. Improvement of glycemic control, triglycerides, and HDL cholesterol levels with muraglitazar, a dual (alpha/gamma) peroxisome proliferator-activated receptor activator, in patients with type 2 diabetes inadequately controlled with metformin monotherapy: a double-blind, randomized, pioglitazone-comparative study. Diabetes Care 29 (2006) 1016-1023
    • (2006) Diabetes Care , vol.29 , pp. 1016-1023
    • Kendall, D.M.1    Rubin, C.J.2    Mohideen, P.3
  • 15
    • 0034002929 scopus 로고    scopus 로고
    • Apolipoprotein B metabolism and the distribution of VLDL and LDL subfractions
    • Packard C.J., Demant T., Stewart J.P., et al. Apolipoprotein B metabolism and the distribution of VLDL and LDL subfractions. J Lipid Res 41 (2000) 305-318
    • (2000) J Lipid Res , vol.41 , pp. 305-318
    • Packard, C.J.1    Demant, T.2    Stewart, J.P.3
  • 16
    • 24944505598 scopus 로고    scopus 로고
    • Tesaglitazar, a novel dual peroxisome proliferator-activated receptor α/γ agonist, dose-dependently improves the metabolic abnormalities associated with insulin resistance in a non-diabetic population
    • Fagerberg B., Edwards S., Halmos T., et al. Tesaglitazar, a novel dual peroxisome proliferator-activated receptor α/γ agonist, dose-dependently improves the metabolic abnormalities associated with insulin resistance in a non-diabetic population. Diabetologia 48 (2005) 1716-1725
    • (2005) Diabetologia , vol.48 , pp. 1716-1725
    • Fagerberg, B.1    Edwards, S.2    Halmos, T.3
  • 17
    • 33846028506 scopus 로고    scopus 로고
    • Effect of tesaglitazar, a dual PPARα/γ agonist, on glucose and lipid abnormalities in patients with type 2 diabetes: a 12-week dose-ranging trial
    • Goldstein B., Rosenstock J., Anzalone D., Tou C., and Ohman K.P. Effect of tesaglitazar, a dual PPARα/γ agonist, on glucose and lipid abnormalities in patients with type 2 diabetes: a 12-week dose-ranging trial. Curr Med Res Opin 22 12 (2006) 2575-2590
    • (2006) Curr Med Res Opin , vol.22 , Issue.12 , pp. 2575-2590
    • Goldstein, B.1    Rosenstock, J.2    Anzalone, D.3    Tou, C.4    Ohman, K.P.5
  • 18
    • 0029907824 scopus 로고    scopus 로고
    • Insulin sensitivity and abdominal obesity in African-American, Hispanic, and non-Hispanic white men and women. The Insulin Resistance and Atherosclerosis Study
    • Karter A.J., Mayer-Davis E.J., Selby J.V., et al. Insulin sensitivity and abdominal obesity in African-American, Hispanic, and non-Hispanic white men and women. The Insulin Resistance and Atherosclerosis Study. Diabetes 45 (1996) 1547-1555
    • (1996) Diabetes , vol.45 , pp. 1547-1555
    • Karter, A.J.1    Mayer-Davis, E.J.2    Selby, J.V.3
  • 19
    • 0043025606 scopus 로고    scopus 로고
    • Increased visceral fat and serum levels of triglyceride are associated with insulin resistance in Japanese metabolically obese, normal weight subjects with normal glucose tolerance
    • Katsuki A., Sumida Y., Urakawa H., et al. Increased visceral fat and serum levels of triglyceride are associated with insulin resistance in Japanese metabolically obese, normal weight subjects with normal glucose tolerance. Diabetes Care 26 (2003) 2341-2344
    • (2003) Diabetes Care , vol.26 , pp. 2341-2344
    • Katsuki, A.1    Sumida, Y.2    Urakawa, H.3
  • 20
    • 0036092239 scopus 로고    scopus 로고
    • Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes
    • McGarry J.D. Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 51 (2002) 7-18
    • (2002) Diabetes , vol.51 , pp. 7-18
    • McGarry, J.D.1
  • 21
    • 0031014830 scopus 로고    scopus 로고
    • Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
    • Boden G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 46 (1997) 3-10
    • (1997) Diabetes , vol.46 , pp. 3-10
    • Boden, G.1
  • 22
    • 0032506273 scopus 로고    scopus 로고
    • Mechanism of action of fibrates on lipid and lipoprotein metabolism
    • Staels B., Dallongeville J., Auwerx J., et al. Mechanism of action of fibrates on lipid and lipoprotein metabolism. Circulation 98 (1998) 2088-2093
    • (1998) Circulation , vol.98 , pp. 2088-2093
    • Staels, B.1    Dallongeville, J.2    Auwerx, J.3
  • 23
    • 0037151095 scopus 로고    scopus 로고
    • Influence of peroxisome proliferator-activated receptor alpha agonists on the intracellular turnover and secretion of apolipoprotein (Apo) B-100 and ApoB-48
    • Linden D., Lindberg K., Oscarsson J., et al. Influence of peroxisome proliferator-activated receptor alpha agonists on the intracellular turnover and secretion of apolipoprotein (Apo) B-100 and ApoB-48. J Biol Chem 277 (2002) 23044-23053
    • (2002) J Biol Chem , vol.277 , pp. 23044-23053
    • Linden, D.1    Lindberg, K.2    Oscarsson, J.3
  • 24
    • 19944379835 scopus 로고    scopus 로고
    • Beneficial effects of fenofibrate to improve endothelial dysfunction and raise adiponectin levels in patients with primary hypertriglyceridemia
    • Koh K.K., Han S.H., Quon M.J., Yeal A.J., and Shin E.K. Beneficial effects of fenofibrate to improve endothelial dysfunction and raise adiponectin levels in patients with primary hypertriglyceridemia. Diabetes Care 28 (2005) 1419-1424
    • (2005) Diabetes Care , vol.28 , pp. 1419-1424
    • Koh, K.K.1    Han, S.H.2    Quon, M.J.3    Yeal, A.J.4    Shin, E.K.5
  • 25
    • 0033964873 scopus 로고    scopus 로고
    • Effects of gemfibrozil on insulin sensitivity and on haemostatic variables in hypertriglyceridemic patients
    • Mussoni L., Mannucci L., Sirtori C., et al. Effects of gemfibrozil on insulin sensitivity and on haemostatic variables in hypertriglyceridemic patients. Atherosclerosis 148 (2000) 397-406
    • (2000) Atherosclerosis , vol.148 , pp. 397-406
    • Mussoni, L.1    Mannucci, L.2    Sirtori, C.3
  • 26
    • 0033857387 scopus 로고    scopus 로고
    • Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists
    • Olefsky J.M. Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists. J Clin Invest 106 (2000) 467-472
    • (2000) J Clin Invest , vol.106 , pp. 467-472
    • Olefsky, J.M.1
  • 27
    • 0032418940 scopus 로고    scopus 로고
    • Role of apolipoprotein CIII in triglyceride-rich lipoprotein metabolism
    • Fredenrich A. Role of apolipoprotein CIII in triglyceride-rich lipoprotein metabolism. Diabetes Metab 24 (1998) 490-495
    • (1998) Diabetes Metab , vol.24 , pp. 490-495
    • Fredenrich, A.1
  • 29
    • 0034097892 scopus 로고    scopus 로고
    • Triglycerides, apo C3 and Lp B:C3 and cardiovascular risk in type II diabetes
    • Gervaise N., Garrigue M.A., Lasfargues G., and Lecomte P. Triglycerides, apo C3 and Lp B:C3 and cardiovascular risk in type II diabetes. Diabetologia 43 (2000) 703-708
    • (2000) Diabetologia , vol.43 , pp. 703-708
    • Gervaise, N.1    Garrigue, M.A.2    Lasfargues, G.3    Lecomte, P.4
  • 30
    • 0035138625 scopus 로고    scopus 로고
    • PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway
    • Chinetti G., Lestavel S., Bocher V., et al. PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway. Nat Med 7 (2001) 53-58
    • (2001) Nat Med , vol.7 , pp. 53-58
    • Chinetti, G.1    Lestavel, S.2    Bocher, V.3
  • 31
    • 0037423555 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha reduces cholesterol esterification in macrophages
    • Chinetti G., Lestavel S., Fruchart J.C., Clavey V., and Staels B. Peroxisome proliferator-activated receptor alpha reduces cholesterol esterification in macrophages. Circ Res 92 (2003) 212-217
    • (2003) Circ Res , vol.92 , pp. 212-217
    • Chinetti, G.1    Lestavel, S.2    Fruchart, J.C.3    Clavey, V.4    Staels, B.5
  • 32
    • 0036177348 scopus 로고    scopus 로고
    • Can measurement of serum apolipoprotein B replace the lipid profile monitoring of patients with lipoprotein disorders?
    • Miremadi S., Sniderman A., and Frohlich J. Can measurement of serum apolipoprotein B replace the lipid profile monitoring of patients with lipoprotein disorders?. Clin Chem 48 (2002) 484-488
    • (2002) Clin Chem , vol.48 , pp. 484-488
    • Miremadi, S.1    Sniderman, A.2    Frohlich, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.