Bioinformatic and expression analysis of the putative gliotoxin biosynthetic gene cluster of Aspergillus fumigatus

FEMS Microbiology Letters

Volumn 248, Issue 2, 2005, Pages 241-248

  Gardiner, Donald M ^a   Howlett, Barbara J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Aspergillosis; Epipolythiodioxopiperazine; Peptide synthetase; qRT PCR; RIP mutation; Sirodesmin

Indexed keywords

GLIOTOXIN;

ARTICLE; ASPERGILLUS FUMIGATUS; BIOINFORMATICS; COMPARATIVE STUDY; CONTROLLED STUDY; FUNGAL GENE; GENE CLUSTER; GENE CONTROL; GENE EXPRESSION; GENE SEQUENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ASPERGILLUS FUMIGATUS; COMPUTATIONAL BIOLOGY; GENE EXPRESSION REGULATION, FUNGAL; GENES, FUNGAL; GLIOTOXIN; LIGASES; MULTIGENE FAMILY;

ANIMALIA; ASPERGILLUS FUMIGATUS; FUNGI; LEPTOSPHAERIA MACULANS;

EID: 21744453939     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.femsle.2005.05.046     Document Type: Article

References (27)

1. D.T. Shah, D.D. Glover, and B. Larsen In situ mycotoxin production by Candida albicans in women with vaginitis Gynecol. Obstet. Invest. 39 1995 67 69
2. S.E. Wilhite, R.D. Lumsden, and D.C. Straney Peptide synthetase gene in Trichoderma virens Appl. Environ. Microbiol. 67 2001 5055 5062
3. J.C. Macdonald, and G.P. Slater Biosynthesis of gliotoxin and mycelianamide Can. J. Biochem. 53 1975 475 478
4. D.M. Gardiner, P. Waring, and B.J. Howlett The epipolythiodioxopiperazine (ETP) class of fungal toxins: distribution, mode of action, functions and biosynthesis Microbiol 151 2005 1021 1032
5. R. Munday Studies on the mechanism of toxicity of the mycotoxin sporidesmin. Generation of hydroxyl radicals by sporidesmin J. Appl. Toxicol. 7 1987 17 22
6. C.L.L. Chai, and P. Waring Redox sensitive epidithiodioxopiperazines in biological mechanisms of toxicity Redox Report 5 2000 257 264
7. P.H. Bernardo, N. Brasch, C.L. Chai, and P. Waring A novel redox mechanism for the glutathione-dependent reversible uptake of a fungal toxin in cells J. Biol. Chem. 278 2003 46549 46555
8. P. Sutton, P. Waring, and A. Mullbacher Exacerbation of invasive aspergillosis by the immunosuppressive fungal metabolite, gliotoxin Immunol. Cell Biol. 74 1996 318 322
9. P. Sutton, N.R. Newcombe, P. Waring, and A. Mullbacher In vivo immunosuppressive activity of gliotoxin, a metabolite produced by human pathogenic fungi Infect. Immun. 62 1994 1192 1198
10. A.M. Hurne, C.L.L. Chai, K. Moerman, and P. Waring Influx of calcium through a redox-sensitive plasma membrane channel in thymocytes causes early necrotic cell death induced by the epipolythiodioxopiperazine toxins J. Biol. Chem. 277 2002 31631 31638
11. P. Waring, R.D. Eichner, A. Mullbacher, and A. Sjaarda Gliotoxin induces apoptosis in macrophages unrelated to its antiphagocytic properties J. Biol. Chem. 263 1988 18493 18499
12. D.M. Gardiner, A.J. Cozijnsen, L.M. Wilson, M.S.C. Pedras, and B.J. Howlett The sirodesmin biosynthetic gene cluster of the plant pathogenic fungus Leptosphaeria maculans Mol. Microbiol. 53 2004 1307 1318
13. D.M. Gardiner, R.S. Jarvis, and B.J. Howlett The ABC transporter gene in the sirodesmin biosynthetic gene cluster of Leptosphaeria maculans is not essential for sirodesmin production but facilitates self-protection Fungal Genet. Biol. 42 2005 257 263
14. P.Y. Muller, H. Janovjak, A.R. Miserez, and Z. Dobbie Processing of gene expression data generated by quantitative real-time RT-PCR Biotechnology 32 2002 1372 1379
15. E.B. Cambareri, B.C. Jensen, E. Schabtach, and E.U. Selker Repeat-induced G-C to A-T mutations in Neurospora Science 244 1989 1571 1575
16. T. Correia, N. Grammel, I. Ortel, U. Keller, and P. Tudzynski Molecular cloning and analysis of the ergopeptine assembly system in the ergot fungus Claviceps purpurea Chem. Biol. 10 2003 1281 1292
17. A.K. Bose, K.G. Das, P.T. Funke, I. Kugajevsky, O.P. Shukla, K.S. Khanchandani, and R.J. Suhadolnik Biosynthetic studies on gliotoxin using stable isotopes and mass spectral methods J. Am. Chem. Soc. 90 1968 1038 1041
18. A. Watanabe, K. Kamei, T. Sekine, M. Waku, K. Nishimura, M. Miyaji, and T. Kuriyama Immunosuppressive substances in Aspergillus fumigatus culture filtrate J. Infect. Chemother. 9 2003 114 121
19. G.W. Kirby, and D.J. Robins The biosynthesis of gliotoxin and related epipolythiodioxopiperazines P.S. Steyn The biosynthesis of mycotoxins 1980 Academic Press New York 301 326
20. J.-P. Ferezou, A. Quesneau-Thierry, C. Servy, E. Zissmann, and M. Barbier Sirodesmin PL Biosynthesis in Phoma lingam Tode J. Chem. Soc., Perkin Trans. 1 1980 1739 1746
21. V.M. dos Santos, J.W. Dorner, and F. Carreira Isolation and toxigenicity of Aspergillus fumigatus from moldy silage Mycopathology 156 2003 133 138
22. S.E. Wilhite, and D.C. Straney Timing of gliotoxin biosynthesis in the fungal biological control agent Gliocladium virens (Trichoderma virens) Appl. Microbiol. Biotechnol. 45 1996 513 518
23. D.W. Brown, J.H. Yu, H.S. Kelkar, M. Fernandes, T.C. Nesbitt, N.P. Keller, T.H. Adams, and T.J. Leonard Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans Proc. Natl. Acad. Sci. USA 93 1996 1418 1422
24. R.H. Proctor, D.W. Brown, R.D. Plattner, and A.E. Desjardins Co-expression of 15 contiguous genes delineates a fumonisin biosynthetic gene cluster in Gibberella moniliformis Fungal Genet. Biol. 38 2003 237 249
25. D.J. Allocco, I.S. Kohane, and A.J. Butte Quantifying the relationship between co-expression, co-regulation and gene function BMC Bioinform. 5 2004 18
26. J. Ihmels, S. Bergmann, and N. Barkai Defining transcription modules using large-scale gene expression data Bioinformatics 20 2004 1993 2003
27. D.J. Oliver, B. Nikolau, and E.S. Wurtele Functional genomics: high-throughput mRNA, protein, and metabolite analyses Metab. Eng. 4 2002 98 106