Inhibitory effects of ginsenoside-Rb1 on activation of the 12-O-tetradecanoylphorbol 13-acetate-induced cyclooxygenase-2 promoter

Planta Medica

Volumn 72, Issue 3, 2006, Pages 272-275

  Park, Wankyu ^a   Lim, Wonchung ^a   Cho, Jungyoon ^a   Inoue, Hiroyasu ^b   Rhyu, Mee Ra ^c   Lee, YoungJoo ^a  

^a Sejong University   (South Korea)

^b NARA WOMEN'S UNIVERSITY   (Japan)

^c Korea Food Research Institute   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; CYCLOOXYGENASE 2; GINSENOSIDE RB 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; PHORBOL 13 ACETATE 12 MYRISTATE;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG INHIBITION; DRUG STRUCTURE; ELECTROPORATION; GENE EXPRESSION; GENE MUTATION; NONHUMAN; PROTEIN BINDING; TRANSCRIPTION INITIATION;

ANIMALS; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CERCOPITHECUS AETHIOPS; COS CELLS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; ENZYME ACTIVATION; GINSENOSIDES; HUMANS; MICE; PANAX; PHYTOTHERAPY; TETRADECANOYLPHORBOL ACETATE;

ANIMALIA;

EID: 33645004900     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-873172     Document Type: Article

References (21)

1. Attele AS, Wu JA, Yuan CS. Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol 1999; 58: 1685-93
2. Liu WK, Xu SX, Che CT. Anti-proliferative effect of ginseng saponins on human prostate cancer cell line. Life Sci 2000; 67: 1297-306
3. Yoon M, Lee H, Jeong S, Kim JJ, Nicol CJ, Nam KW et al. Peroxisome proliferator-activated receptor alpha is involved in the regulation of lipid metabolism by ginseng. Br J Pharmacol 2003; 138: 1295-302
4. Shibata S. Chemistry and cancer preventing activities of ginseng saponins and some related triterpenoid compounds. J Korean Med Sci 2001; 16(Suppl): S28-S37
5. Morschl E, Bretus I, Nemcsik J, Laszlo F, Pavo I. Estrogen-mediated upregulation of the Ca-dependent constitutive nitric oxide synthase in the rat aorta and heart. Life Sci 2000; 68: 49-55
6. Scott CI, Colligan PB, Ren BH, Ren J. Ginsenosides Rb1 and Re decrease cardiac contraction in adult rat ventricular myocytes: role of nitric oxide. Br J Pharmacol 2001; 134: 1159-65
7. Kim HS, Zhang YH, Fang LH, Lee MK. Effects of ginsenosides on bovine adrenal tyrosine hydroxylase. J Ethnopharmacol 1999; 66: 107-11
8. Cho JY, Park WK, Lee SG, Ahn WS, Lee YJ. Ginsenoside-Rb1 from Panax ginseng C.A. Meyer activates estrogen receptor-alpha and -beta, independent of ligand binding. J Clin Endocrinol Metab 2004; 89: 3510-5
9. Funk CD, Funk LB, Kennedy ME, Pong AS, Fitzgerald GA. Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment. FASEB J 1991; 5: 2304-12
10. Smith WL, DeWitt DL, Garavito RM. Cyclooxygenases: structural, cellular, and molecular biology. Annu Rev Biochem 2000; 69: 45-82
11. Chen CC, Sun YT, Chen JJ, Chiu KT. TNF-alpha-induced cyclooxygenase-2 expression in human lung epithelial cells: involvement of the phospholipase C-gamma 2, protein kinase C-alpha, tyrosine kinase, NF-kappa B-inducing kinase, and I-kappa B kinase 1/2 pathway. J Immunol 2000; 165: 2719-28
12. Chen Y, Yang L, Lee TJ. Oroxylin A inhibition of lipopolysaccharide- induced iNOS and COX-2 gene expression via suppression of nuclear factor-kappaB activation. Biochem Pharmacol 2000; 59: 1445-57
13. Sirois J, Levy LO, Simmons DL, Richards JS. Characterization and hormonal regulation of the promoter of the rat prostaglandin endoperoxide synthase 2 gene in granulosa cells. Identification of functional and protein-binding regions. J Biol Chem 1993; 268: 12199-206
14. Saunders MA, Sansores-Garcia L, Gilroy DW, Wu KK. Selective suppression of CCAAT/enhancer-binding protein beta binding and cyclooxygenase-2 promoter activity by sodium salicylate in quiescent human fibroblasts. J Biol Chem 2001; 276: 18897-904
15. Wang CY, Lei HJ, Huang CY, Zhang Z, Mukherjee AB, Yuan CJ. Induction of cyclooxygenase-2 by staurosporine through the activation of nuclear factor for IL-6 (NF-IL6) and activator protein 2 (AP2) in an osteoblast-like cell line. Biochem Pharmacol 2002; 64: 177-84
16. Yamamoto K, Arakawa T, Ueda N, Yamamoto S. Transcriptional roles of nuclear factor κB and nuclear factor-interleukin-6 in the tumor necrosis factor α-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells. J Biol Chem 1995; 270: 31315-20
17. Inoue H, Umesono K, Nishimori T, Hirata Y, Tanabe T. Glucocorticoid- mediated suppression of the promoter activity of the cydooxygenase-2 gene is modulated by expression of its receptor in vascular endothelial cells. Biochem Biophys Res Commun 1999; 254: 292-8
18. Hattori T, Ohoka N, Hayashi H, Onozaki K. C/EBP homologous protein (CHOP) up-regulates IL-6 transcription by trapping negative regulating NF-IL6 isoform. FEBS Lett 2003; 541: 33-9
19. Lee AK, Sung SH, Kim YC, Kim SG. Inhibition of lipopolysaccharide- inducible nitric oxide synthase, TNF-α and COX-2 expression by sauchinone effects on 1-κBa phosphorylation, C/EBP and AP-1 activation. Br J Pharmacol 2003; 139: 11-20
20. Wardlaw SA, Zhang N, Belinsky SA. Transcriptional regulation of basal cyclooxygenase-2 expression in murine lung tumor-derived cell lines by CCAAT/enhancer-binding protein and activating transcription factor/cAMP response element-binding protein. Mol Pharmacol 2002; 62: 326-33
21. Faussner A, Bauer A, Kalatskaya I, Jochum M, Fritz H. Expression levels strongly affect ligand-induced sequestration of B2 bradykinin receptors in transfected cells. Am J Physiol Heart Circ Physiol 2003; 284: 1892-8