Oxidative stress and c-Jun-amino-terminal kinase activation involved in apoptosis of primary astrocytes induced by disulfiram-Cu2+ complex

European Journal of Pharmacology

Volumn 414, Issue 2-3, 2001, Pages 177-188

  Chen, Sung Ho ^a   Liu, Shing Hwa ^a   Liang, Yu Chih ^a   Lin, Jen Kun ^a   Lin Shiau, Shoei Yn ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Bathocuproine disulfonate; c Jun amino terminal kinase (JNK); Caspase 3; Disulfiram; Membrane potential; Oxidative stress

Indexed keywords

CASPASE 3; COPPER COMPLEX; DISULFIRAM; DISULFIRAM COPPER; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ALCOHOLISM; ANIMAL CELL; APOPTOSIS; ARTICLE; ASTROCYTE; CELL VIABILITY; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPATHOLOGY; CYTOTOXICITY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME DEGRADATION; MEMBRANE POTENTIAL; NERVE FIBER DEGENERATION; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; ASTROCYTES; CASPASE 3; CASPASES; CELLS, CULTURED; CEREBRAL CORTEX; COPPER; DISULFIRAM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; ENZYME INHIBITORS; FREE RADICALS; GLUTATHIONE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MEMBRANE POTENTIALS; MITOGEN-ACTIVATED PROTEIN KINASES; OXIDATIVE STRESS; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, WISTAR;

EID: 0035794002     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)00792-0     Document Type: Article

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