PPARα ligands reduce PCB-induced endothelial activation: Possible interactions in inflammation and atherosclerosis

Cardiovascular Toxicology

Volumn 7, Issue 4, 2007, Pages 264-272

  Arzuaga, Xabier ^a   Reiterer, Gudrun ^a,b   Majkova, Zuzana ^a   Kilgore, Michael W ^b   Toborek, Michal ^b,c   Hennig, Bernhard ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

AHR; Atherosclerosis; COX 2; CYP1A1; Inflammation; PCB; PPAR ; PPAR ; Vascular endothelial cells; VCAM 1

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CYCLOOXYGENASE 2; CYTOCHROME P450 1A1; LIGAND; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; POLYCHLORINATED BIPHENYL; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CHEMICALLY INDUCED DISORDER; CORONARY ARTERY DISEASE; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; ENDOTHELIUM CELL; INFLAMMATION; METABOLISM; PATHOLOGY; PHYSIOLOGY; POLLUTANT; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SWINE; VASCULAR ENDOTHELIUM;

ANIMALS; CELLS, CULTURED; CORONARY ARTERY DISEASE; CYCLOOXYGENASE 2; CYTOCHROME P-450 CYP1A1; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; ENVIRONMENTAL POLLUTANTS; GENES, REPORTER; INFLAMMATION; LIGANDS; POLYCHLORINATED BIPHENYLS; PPAR ALPHA; RECEPTORS, ARYL HYDROCARBON; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SWINE; VASCULAR CELL ADHESION MOLECULE-1;

EID: 39049122328     PISSN: 15307905     EISSN: 15590259     Source Type: Journal    
DOI: 10.1007/s12012-007-9005-8     Document Type: Article

References (56)

1. Gustavsson, P., & Hogstedt, C. (1997). A cohort study of Swedish capacitor manufacturing workers exposed to polychlorinated biphenyls (PCBs). American Journal of Industrial Medicine, 32, 234-239. (Pubitemid 27351681)
2. Pelclova, D., Fenclova, Z., Preiss, J., Prochazka, B., Spacil, J., Dubska, Z., Okrouhlik, B., Lukas, E., & Urban, P. (2002). Lipid metabolism and neuropsychological follow-up study of workers exposed to 2,3,7,8- tetrachlordibenzo-p-dioxin. International Archives of Occupational and Environmental Health, 75(Suppl), S60-S66. (Pubitemid 36075166)
3. Bertazzi, P. A., Bernucci, I., Brambilla, G., Consonni, D., & Pesatori, A. C. (1998). The Seveso studies on early and long-term effects of dioxin exposure: A review. Environmental Health Perspectives, 106(Suppl 2), 625-633. (Pubitemid 28256770)
4. Pesatori, A. C., Zocchetti, C., Guercilena, S., Consonni, D., Turrini, D., & Bertazzi, P. A. (1998). Dioxin exposure and nonmalignant health effects: A mortality study. Occupational and Environmental Medicine, 55, 126-131. (Pubitemid 28179991)
5. Sergeev, A. V., & Carpenter, D. O. (2005). Hospitalization rates for coronary heart disease in relation to residence near areas contaminated with persistent organic pollutants and other pollutants. Environmental Health Perspectives, 113, 756-761. (Pubitemid 40862189)
6. Lusis, A. J. (2000). Atherosclerosis. Nature, 407, 233-241.
7. Libby, P. (2002). Inflammation in atherosclerosis. Nature, 420, 868-874.
8. Slim, R., Toborek, M., Robertson, L. W., & Hennig, B. (1999). Antioxidant protection against PCB-mediated endothelial cell activation. Toxicological Sciences, 52, 232-239. (Pubitemid 30017599)
9. Hennig, B., Meerarani, P., Slim, R., Toborek, M., Daugherty, A., Silverstone, A. E., & Robertson, L. W. (2002). Proinflammatory properties of coplanar PCBs: In vitro and in vivo evidence. Toxicology and Applied Pharmacology, 181, 174-183. (Pubitemid 34757087)
10. Kougias, P., Chai, H., Lin, P. H., Yao, Q., Lumsden, A. B., & Chen, C. (2005). Effects of adipocyte-derived cytokines on endothelial functions: Implication of vascular disease. The Journal of Surgical Research, 126, 121-129. (Pubitemid 40726256)
11. Colombo, P. C., Banchs, J. E., Celaj, S., Talreja, A., Lachmann, J., Malla, S., DuBois, N. B., Ashton, A. W., Latif, F., Jorde, U. P., Ware, J. A., & LeJemtel, T. H. (2005). Endothelial cell activation in patients with decompensated heart failure. Circulation, 111, 58-62. (Pubitemid 40070844)
12. Vogel, C. F., Sciullo, E., & Matsumura, F. (2004). Activation of inflammatory mediators and potential role of ah-receptor ligands in foam cell formation. Cardiovascular Toxicology, 4, 363-373. (Pubitemid 39552105)
13. Ross, R. (1999). Atherosclerosis - an inflammatory disease. The New England Journal of Medicine, 340, 115-126.
14. Ramadass, P., Meerarani, P., Toborek, M., Robertson, L. W., & Hennig, B. (2003). Dietary flavonoids modulate PCB-induced oxidative stress, CYP1A1 induction, and AhR-DNA binding activity in vascular endothelial cells. Toxicological Sciences, 76, 212-219. (Pubitemid 37361900)
15. Matsumura, F. (2003). On the significance of the role of cellular stress response reactions in the toxic actions of dioxin. Biochemical Pharmacology, 66, 527-540.
16. Shertzer, H. G., Nebert, D. W., Puga, A., Ary, M., Sonntag, D., Dixon, K., Robinson, L. J., Cianciolo, E., & Dalton, T. P. (1998). Dioxin causes a sustained oxidative stress response in the mouse. Biochemical and Biophysical Research Communications, 253, 44-48. (Pubitemid 29015597)
17. Celander, M., & Forlin, L. (1995). Decreased responsiveness of the hepatic cytochrome-P450 1a1 system in rainbow-trout (Oncorhynchus-Mykiss) after prolonged exposure to Pcb. Aquatic Toxicology, 33, 141-153.
18. Hennig, B., Ettinger, A. S., Jandacek, R. J., Koo, S., McClain, C., Seifried, H., Silverstone, A., Watkins, B., & Suk, W. A. (2007). Using nutrition for intervention and prevention against environmental chemical toxicity and associated diseases. Environmental Health Perspectives, 115, 493-495. (Pubitemid 46591102)
19. Issemann, I., & Green, S. (1990). Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature, 347, 645-650.
20. Tugwood, J. D., Issemann, I., Anderson, R. G., Bundell, K. R., McPheat, W. L., & Green, S. (1992). The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene. The EMBO Journal, 11, 433-439.
21. Israelian-Konaraki, Z., & Reaven, P. D. (2005). Peroxisome proliferator-activated receptor-alpha and atherosclerosis: From basic mechanisms to clinical implications. Cardiology, 103, 1-9. (Pubitemid 39541239)
22. Mishra, A., Chaudhary, A., & Sethi, S. (2004). Oxidized omega-3 fatty acids inhibit NF-kappaB activation via a PPARalpha-dependent pathway. Arteriosclerosis, Thrombosis, and Vascular Biology, 24, 1621-1627. (Pubitemid 39180885)
23. Zambon, A., Gervois, P., Pauletto, P., Fruchart, J. C., & Staels, B. (2006). Modulation of hepatic inflammatory risk markers of cardiovascular diseases by PPAR-alpha activators: Clinical and experimental evidence. Arteriosclerosis, Thrombosis, and Vascular Biology, 26, 977-986. (Pubitemid 43732101)
24. Delerive, P., Fruchart, J. C., & Staels, B. (2001). Peroxisome proliferator-activated receptors in inflammation control. The Journal of Endocrinology, 169, 453-459. (Pubitemid 32536978)
25. Toborek, M., Lee, Y. W., Kaiser, S., & Hennig, B. (2002). Measurement of inflammatory properties of fatty acids in human endothelial cells. Methods in Enzymology, 352, 198-219. (Pubitemid 41103184)
26. Jensen, A. A. (1989). Halogenated biphenyls, terphenyls, naphthalenes, dibenzodioxins and related products. Amsterdam: Elsevier Science Publishers.
27. Stegeman, J. J., Hahn, M. E., Weisbrod, R., Woodin, B. R., Joy, J. S., Najibi, S., & Cohen, R. A. (1995). Induction of cytochrome P4501A1 by aryl hydrocarbon receptor agonists in porcine aorta endothelial cells in culture and cytochrome P4501A1 activity in intact cells. Molecular Pharmacology, 47, 296-306.
28. Kilgore, M. W., Tate, P. L., Rai, S., Sengoku, E., & Price, T. M. (1997). MCF-7 and T47D human breast cancer cells contain a functional peroxisomal response. Molecular and Cell Endocrinology, 129, 229-235. (Pubitemid 27281538)
29. Korashy, H. M., & El-Kadi, A. O. (2006). The role of aryl hydrocarbon receptor in the pathogenesis of cardiovascular diseases. Drug Metabolism Reviews, 38, 411-450.
30. Whitlock, J. P., Jr. (1999). Induction of cytochrome P4501A1. Annual Review of Pharmacology and Toxicology, 39, 103-125.
31. Morishima, A., Ohkubo, N., Maeda, N., Miki, T., & Mitsuda, N. (2003). NFkappaB regulates plasma apolipoprotein A-I and high density lipoprotein cholesterol through inhibition of peroxisome proliferator-activated receptor alpha. The Journal of Biological Chemistry, 278, 38188-38193. (Pubitemid 37221707)
32. Reynders, V., Loitsch, S., Steinhauer, C., Wagner, T., Steinhilber, D., & Bargon, J. (2006). Peroxisome proliferator-activated receptor alpha (PPAR alpha) down-regulation in cystic fibrosis lymphocytes. Respiratory Research, 7, 104.
33. Leopold, J. A., & Loscalzo, J. (2005). Oxidative enzymopathies and vascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 25, 1332-1340.
34. Burleigh, M. E., Babaev, V. R., Oates, J. A., Harris, R. C., Gautam, S., Riendeau, D., Marnett, L. J., Morrow, J. D., Fazio, S., & Linton, M. F. (2002). Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice. Circulation, 105, 1816-1823. (Pubitemid 34408892)
35. Puga, A., Hoffer, A., Zhou, S., Bohm, J. M., Leikauf, G. D., & Shertzer, H. G. (1997). Sustained increase in intracellular free calcium and activation of cyclooxygenase-2 expression in mouse hepatoma cells treated with dioxin. Biochemical Pharmacology, 54, 1287-1296. (Pubitemid 27521039)
36. Delerive, P., Martin-Nizard, F., Chinetti, G., Trottein, F., Fruchart, J. C., Najib, J., Duriez, P., & Staels, B. (1999). Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway. Circulation Research, 85, 394-402. (Pubitemid 29409616)
37. Delerive, P., Gervois, P., Fruchart, J. C., & Staels, B. (2000). Induction of IkappaBalpha expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-alpha activators. The Journal of Biological Chemistry, 275, 36703-36707. (Pubitemid 32002075)
38. Kleemann, R., Gervois, P. P., Verschuren, L., Staels, B., Princen, H. M., & Kooistra, T. (2003). Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFkappa B-C/EBP-beta complex formation. Blood, 101, 545-551. (Pubitemid 36077576)
39. Gervois, P., Kleemann, R., Pilon, A., Percevault, F., Koenig, W., Staels, B., & Kooistra, T. (2004). Global suppression of IL-6-induced acute phase response gene expression after chronic in vivo treatment with the peroxisome proliferator-activated receptor-alpha activator fenofibrate. The Journal of Biological Chemistry, 279, 16154-16160. (Pubitemid 38509307)
40. Shaban, Z., El-Shazly, S., Ishizuka, M., Kimura, K., Kazusaka, A., & Fujita, S. (2004). PPARalpha-dependent modulation of hepatic CYP1A by clofibric acid in rats. Archives of Toxicology, 78, 496-507. (Pubitemid 39350145)
41. Andrysik, Z., Vondracek, J., Machala, M., Krcmar, P., Svihalkova-Sindlerova, L., Kranz, A., Weiss, C., Faust, D., Kozubik, A., & Dietrich, C. (2007). The aryl hydrocarbon receptor-dependent deregulation of cell cycle control induced by polycyclic aromatic hydrocarbons in rat liver epithelial cells. Mutation Research, 615, 87-97. (Pubitemid 46054083)
42. Fallone, F., Villard, P. H., Decome, L., Seree, E., Meo, M., Chacon, C., Durand, A., Barra, Y., & Lacarelle, B. (2005). PPARalpha activation potentiates AhR-induced CYP1A1 expression. Toxicology, 216, 122-128. (Pubitemid 41712001)
43. Hanlon, P. R., Ganem, L. G., Cho, Y. C., Yamamoto, M., & Jefcoate, C. R. (2003). AhR- and ERK-dependent pathways function synergistically to mediate 2,3,7,8-tetrachlorodibenzo-p-dioxin suppression of peroxisome proliferator-activated receptor-gamma1 expression and subsequent adipocyte differentiation. Toxicology and Applied Pharmacology, 189, 11-27. (Pubitemid 36561601)
44. Alexander, D. L., Ganem, L. G., Fernandez-Salguero, P., Gonzalez, F., & Jefcoate, C. R. (1998). Aryl-hydrocarbon receptor is an inhibitory regulator of lipid synthesis and of commitment to adipogenesis. Journal of Cell Science, 111(Pt 22), 3311-3322. (Pubitemid 28563034)
45. Hennig, B., Reiterer, G., Majkova, Z., Oesterling, E., Meerarani, P., & Toborek, M. (2005). Modification of environmental toxicity by nutrients: Implications in atherosclerosis. Cardiovascular Toxicology, 5, 153-160. (Pubitemid 41058629)
46. Cimafranca, M. A., Hanlon, P. R., & Jefcoate, C. R. (2004). TCDD administration after the pro-adipogenic differentiation stimulus inhibits PPARgamma through a MEK-dependent process but less effectively suppresses adipogenesis. Toxicology and Applied Pharmacology, 196, 156-168. (Pubitemid 38393703)
47. Poynter, M. E., & Daynes, R. A. (1998). Peroxisome proliferator-activated receptor alpha activation modulates cellular redox status, represses nuclear factor-kappaB signaling, and reduces inflammatory cytokine production in aging. The Journal of Biological Chemistry, 273, 32833-32841. (Pubitemid 28557672)
48. El Midaoui, A., Wu, L., Wang, R., & de Champlain, J. (2006). Modulation of cardiac and aortic peroxisome proliferator-activated receptor-gamma expression by oxidative stress in chronically glucose-fed rats. American Journal of Hypertension, 19, 407-412.
49. Kim, M. S., Sweeney, T. R., Shigenaga, J. K., Chui, L. G., Moser, A., Grunfeld, C., & Feingold, K. R. (2007). Tumor necrosis factor and interleukin 1 decrease RXRalpha, PPARalpha, PPARgamma, LXRalpha, and the coactivators SRC-1, PGC-1alpha, and PGC-1beta in liver cells. Metabolism, 56, 267-279. (Pubitemid 46084934)
50. Gearing, K. L., Crickmore, A., & Gustafsson, J. A. (1994). Structure of the mouse peroxisome proliferator activated receptor alpha gene. Biochemical and Biophysical Research Communications, 199, 255-263. (Pubitemid 24179942)
51. Chew, C. H., Samian, M. R., Najimudin, N., & Tengku-Muhammad, T. S. (2003). Molecular characterisation of six alternatively spliced variants and a novel promoter in human peroxisome proliferator-activated receptor alpha. Biochemical and Biophysical Research Communications, 305, 235-43. (Pubitemid 36555458)
52. Khan, S., Barhoumi, R., Burghardt, R., Liu, S., Kim, K., & Safe, S. (2006). Molecular mechanism of inhibitory aryl hydrocarbon receptor-estrogen receptor/Sp1 cross talk in breast cancer cells. Molecular Endocrinology, 20, 2199-2214. (Pubitemid 44286714)
53. Tsuchiya, Y., Nakajima, M., & Yokoi, T. (2003). Critical enhancer region to which AhR/ARNT and Sp1 bind in the human CYP1B1 gene. Journal of Biochemistry (Tokyo), 133, 583-592. (Pubitemid 36759465)
54. Delerive, P., De Bosscher, K., Besnard, S., Vanden Berghe, W., Peters, J. M., Gonzalez, F. J., Fruchart, J. C., Tedgui, A., Haegeman, G., & Staels, B. (1999). Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappaB and AP-1. The Journal of Biological Chemistry, 274, 32048-32054.
55. Nakajima, A., Wada, K., Miki, H., Kubota, N., Nakajima, N., Terauchi, Y., Ohnishi, S., Saubermann, L. J., Kadowaki, T., Blumberg, R. S., Nagai, R., & Matsuhashi, N. (2001). Endogenous PPAR gamma mediates anti-inflammatory activity in murine ischemia-reperfusion injury. Gastroenterology, 120, 460-469. (Pubitemid 32147643)
56. Corti, R., Osende, J., Hutter, R., Viles-Gonzalez, J. F., Zafar, U., Valdivieso, C., Mizsei, G., Fallon, J. T., Fuster, V., & Badimon, J. J. (2007). Fenofibrate induces plaque regression in hypercholesterolemic atherosclerotic rabbits: In vivo demonstration by high-resolution MRI. Atherosclerosis, 190, 106-113. (Pubitemid 44908325)