MCF-7 and T47D human breast cancer cells contain a functional peroxisomal response

Molecular and Cellular Endocrinology

Volumn 129, Issue 2, 1997, Pages 229-235

  Kilgore, Michael W ^a   Tate, Patricia L ^a   Rai, Sudha ^a   Sengoku, Eiichi ^a   Price, Thomas M ^a  

^a CLEMSON UNIVERSITY   (United States)

Author keywords

Human breast cancer; MCF 7 cells; Peroxisomal proliferator; PPAR

Indexed keywords

MESSENGER RNA; PEROXISOME PROLIFERATOR; RETINOIC ACID RECEPTOR;

ARTICLE; CANCER CELL; GENETIC TRANSCRIPTION; HORMONE RESPONSIVE ELEMENT; HUMAN; HUMAN CELL; PEROXISOME; PRIORITY JOURNAL;

BLOTTING, NORTHERN; BREAST NEOPLASMS; GENE EXPRESSION REGULATION; HUMANS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0031010364     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(97)04057-4     Document Type: Article

References (23)

1. Reedy, J.K. and Mannaerts G.P. (1994) Peroxisomal lipid metabolism. Annu. Rev. Nutr. 14, 343-70.
2. Kliewer, S.A., Forman, B.M., Blumberg, B., Ong, E.S., Borgmeyer, U., Manelsdorf, D.J., Umesono, K. and Eveans. R.M. (1994) Differential expressin and activation of a family of murine peroxisome proliferator-activated receptors. Proc. Natl. Acad. Sci. USA. 91, 7355-7359.
3. Issemann, I. and Green, S. (1990) Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347, 645-650.
4. Yu, V.C., Delsert, C., Andersen, B., Holloway, J.M., Devary, O.V., Naar, A.M., Kim, S.Y., Boulin, J.M., Glass C.K. and Rosenfeld M.G. (1991) RXRβ: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements. Cell 67: 1251-66
5. Göttlicher, M., Demoz, A., Svensson, D., Tollet, P., Berge, R.K. and Gustafsson, J.-Å. (1993) Structural and metabolic requiremnts for activation of the peroxisomal-proliferator-activted receptro. Biochem. Pharmacol. 46, 2177-2184.
6. Tugwood, J.D., Issemann, I., Anderson, R.G., Bundell, K.R., McPheat, L.W. and Green, S. (1992) The mouse peroxisome proliferator acitvated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene. EMBO J. 11(2), 433-439.
7. Bardot, O., Aldridge, T.C., Latruffe, N. and Green, S. (1993) PPAR-RXR heterodimer activates a peroxisome proliferator response element upstream of the bifunctional enzyme gene. Biochem. Biophys. Res. Commun. 192, 37-45.
8. Muerhoff, A.S., Griffin, K.J. and Johson, E.F. (1992) The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid ω-hydroxylase, by clofibric acid. J. Biol. Chem. 267, 19051-19053.
9. Marcus, S.L., Miyata, K.S., Zhang, B., Subramine, S., Capone, J.P., and Rachubinski, R.A. (1993) Diverse peroxisome proliferator-activated receptors bind to the peroxisome proliferator-responsive elements of the rat hydratase/dehydrogenase and fatty acyl-CoA oxidase genes but differentially induce expression. Proc. Natl. Acad. Sci. USA 90, 5723-5727.
10. Kliewer, S.A., Umesono, K., Noonan, D.J., Heyman, R.A. and Evans, R.M. (1992) Convervence of the 9-cis retionic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature 358, 771-774.
11. Tontonoz, P., Hu, E., Graves, R.A., Budavari, A.I., and Spiegelman (1994) mPPARg2: tissiue-specific regulator of an adipocyte enhancer. Genes Dev. 8, 1224-1234.
12. Tontonoz, P., Hu, E. and Spiegelman, B.M. (1995) Regulation of adipocyte gene expression and differentiation by peroxisome proliferator activated receptor γ. Curr. Opin. Genet. Dev. 5, 571-576.
13. Zhu, Y., Alvares, K., Huang, Q., Rao, M.S. and Reddy, J.K. (1993) Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver. J. Biol. Chem. 286, 26 817-26 820.
14. Göttlicher, M., Widmark, E., Li, Q., and Gustafsson, J.A. (1992) Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor. Proc. Nal. Acad. Sci. USA 89, 4653-4657.
15. Sher T., Yi, H. F., McBride, O.W. and Gonzales, F.J. (1993) cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor. Biocheimistry 32, 5598-5604.
16. Greene, M.E., Blumberg, B., McBride, W.O., Yi, H.F., Kronquist, K., Kwan, K., Hsieh, L., Greene, G., and Nimer, S.D. (1995) Isolation of the humand peroxisome proliferator activted receptro gamma cDNA: expression in hematopoietic cells and chromasomal mapping. Gene Expression 4, 281-299.
17. Elbrecht, A., Chen, Y., Cullinan, C.A., Hayes, N., Leibowitz, M.D., Moller, D.E. and Berger, J. (1996) Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors γ1 and γ2. Biochem. Biophys. Res. Commun. 224, 431-437 [96295505]
18. Dryer, C., Krey, G., Keller, H., Givel, F., Helftenbein, G. and Wahil, W. (1992) Control of the peroxisomal β-oxidation pathway by a novel member of nuclear hormone receptor. Cell 68, 879-887.
19. Schmidt, A., Endo, N., Rutledge, S.J., Vogel, R., Shinar, D. and Rodan, G.A. (1992) Identification of a new member of ther steroid hormone receptor superfamily that is activated by a peroxisoma proliferator and fatty acids. Mol. Endocrinol. 6, 1634-1641.
20. Kliewer, S.A., Umesono, K., Noonan, D.J., Heymen, R.A. and Evans, R.M. (1994) Convergance of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptros. Nature 358, 771-774.
21. Marcus, S.L., Miyata, K.S., Zhang, B., Subramani, S., Rachubinski, R.A. and Capone, J.P. (1993) Diverse peroxisome proliferator-activated receptors bind to the peroxisome proliferator-responsive elements of the rat hydratase/dehydrogenase and fatty acyl-CoA oxidase genes but differentially induce expression. Proc. Natl. Acad. Sci. USA 90, 5723-5727.
22. Keller, H., Dryer, S., Mahfoudi, A.,J., Ozato, K. and Wahli, W. (1993) Fatty acids and retinoids control lipid metabolism through activation of peroxisomal proliferatror-activated receptor-retinoid X receptor hererodime. Proc. Natl. Acad. Sci. USA 90, 2160-2164.
23. 2 is a ligand for the adipocyte determination factor PPARγ. Cell 83, 803-812.